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Cyproterone Acetate/Ethinylestradiol

Co-Cyprindiol is a hormonal treatment for female acne and excess hair. It is the generic version of Dianette.

Renewing your prescription to buy Co-Cyprindiol online is simple. Take our questionnaire to start your consultation. Approved orders are shipped by special next-day courier.

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The price below are inclusive of your consultation, prescription, the medicine itself and secure next-day shipping from our UK pharmacy.

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Co-Cyprindiol is a hormonal treatment for female acne and excess hair. It is the generic version of Dianette.

Renewing your prescription to buy Co-Cyprindiol online is simple. Take our questionnaire to start your consultation. Approved orders are shipped by special next-day courier.

This content was reviewed by a clinician on

26 April 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 26 April 2022
Product information


Co-Cyprindiol is a medication used to treat acne which has not responded to antibiotics. It is the generic version of Dianette, and contains the same active constituents. In addition to relieving acne, it is also adept at reducing excess hair growth, and its hormonal qualities also provide contraceptive cover. This pill should not, however, be relied upon as a sole contraceptive measure. It is recommended that users employ a barrier method in addition. You can only buy Co-Cyprindiol in the UK on prescription, and it is only suitable for women.

  1. Treats cases resistant to antibiotics
  2. Also acts as a contraceptive
  3. Also effective at reducing excess hair growth

Acne is a condition defined by the appearance of spots on the skin. These can vary in their size and severity. Blackheads and whiteheads tend to be smaller, and not as serious; whereas larger spots or pustules may be more noticeable. They can appear just about anywhere on the skin, but are more likely to develop on the face, back, shoulders or chest. The most severe forms of acne are nodules or cysts, which are large, painful, and can leave behind scars.

It is thought that most people will develop acne in some form at least once in their lives. The condition is more common in persons between the ages of 14 and 18, but most cases will diminish in severity with age, before disappearing. Some cases of teenage acne may carry over into adulthood and recur intermittently, but this is rare.

When acne occurs in adult women, it may be a sign of a hormonal imbalance. Some women, for instance, may be more prone to acne when expecting their period. For others, it may develop during the early stages of pregnancy. Spots occur when the follicles in the skin become blocked with a substance called sebum. This is generated by sebaceous glands, and helps to keep the skin and hair healthy. However, a high level of androgens can cause these glands to produce too much sebum, leading to blocked pores, and acne.

Co-Cyprindiol is a combination treatment containing two hormones, cyproterone and ethinylestradiol. As a synthetic form of progesterone, cyproterone reduces the amount of androgens in the body, thus decreasing their effect on the sebaceous glands. Ethinylestradiol, an oestrogen-derivative, is also supplied in addition to provide hormonal balance.

Patients looking to use Co-Cyprindiol for the first time should speak to their GP or practice nurse before doing so. Following an assessment of your symptoms, they will be able to issue a prescription for this treatment where appropriate.

You can renew your prescription for Co-Cyprindiol and buy it online using our secure pharmacy platform. Take our questionnaire to start your consultation. Your case will be reviewed by a practising doctor or UK pharmacy prescriber, who will generate a prescription for you if suitable. Once this has been fulfilled at our UK pharmacy, your treatment will be shipped to you via next-day delivery.

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Page last reviewed:  26/04/2022


It is crucial to follow the directions provided with this item. Doing so will help you to limit the risk of side effects and facilitate the efficacy of the treatment. Prior to use, read the instructions in the patient information leaflet carefully.

  1. Take as prescribed.
  2. Please note that in addition to treating acne, the hormones in this pill also work as a contraceptive method. Therefore, they should not be used in conjunction with other contraceptive pills. Co-Cyprindiol should not be used as a sole contraceptive measure, however. In addition to taking these pills, it is advisable to use a barrier method such as a condom.
  3. Start this pill on the first day of your period.
  4. If you are already taking a different hormonal contraceptive, have recently given birth, or have had a miscarriage, you should consult your doctor before taking this pill. They may need to issue specific instructions.
  5. The dose is one tablet at the same time each day.
  6. Swallow your tablet whole with a glass of water.
  7. The 21-day pill is taken for the first three weeks of the menstrual cycle, followed by seven pill free days. Administration commences again the following day for three weeks, and so on.
  8. Never exceed the prescribed dose.
  9. If you miss a dose, do not compensate with a double dose. Refer to the leaflet provided for specific instructions on what to do next. Those who are still unsure should consult their doctor.

The above is only intended as a guide. More detailed instructions can be found in the leaflet supplied with the pill.

Page last reviewed:  26/04/2022
Please read the patient information leaflet for this medicine fully before use:

Co-Cyprindiol 2mg/35mcg

Dianette 2mg/35mcg

Side effects & Warnings

Side effects

Not everyone who uses this treatment will get side effects. However, it’s still important to be aware of the possible side effects, so that you can bring these to the attention of your doctor if they occur.

Let your doctor know right away if you notice any signs of:

  • an allergic reaction, such as swelling of the lips, mouth, throat or face, or hives;
  • a blood clot, such as sharp pains or chest tightness;
  • heart attack or stroke;
  • worsening migraine;
  • liver problems, such as jaundice, severe stomach pain or itching;
  • cervical cancer, such as vaginal discharge with blood or pelvic pain;
  • breast cancer, such as a lump or dimple in the skin or nipple changes;
  • or depression.

More information on these can be found in the patient information leaflet.

Common (1 in 10 people or less):

Breast pain or tenderness, depressed mood, headaches, mood swings, nausea, stomach pain, or weight fluctuations.

Uncommon (1 in 100 people or less):

Breast enlargement, loss of libido, fluid retention, migraine, skin rash or rashes, diarrhoea or vomiting, or urticaria.

Rare (1 in 1,000 people or less):

Discharge from the breasts, erythema multiforme, hypersensitivity, intolerance to contact lenses, increase in libido, skin problems, thromboembolic problems, vaginal discharge or weight loss.

Other side effects:

Bleeding between periods, chloasma, Crohn’s disease or ulcerative colitis, liver or kidney problems, angioedema, otosclerosis, cervical cancer.

This is not a complete list of side effects. Consult the leaflet provided for more.


Taking it with other medicines

If you are taking any other treatments, let your prescriber know when filling in our questionnaire. It is particularly important to inform them if you are taking any of the following: carbamazepine; ciclosporin; lamotrigine; nelfinavir; nevirapine; oxcarbazepine; felbamate; griseofulvin; phenytoin; primidone; rifampicin; ritonavir; phenobarbital; topiramate; antibiotics; anticonvulsants; antifungals; liver enzyme inducers; non-nucleoside reverse transcriptase inhibitors; antiretrovirals; barbiturates; St John’s wort; cytochrome P450 enzyme inducers; other oral contraceptives; or protease inhibitors.

Conditions to look out for

Do not use this treatment if you have or have ever had: a blood clot; heart attack or stroke; any condition which puts you at increased risk of blood clots; any condition which increases your susceptibility to heart attacks; protein C deficiency; migraine; sickle cell anaemia; breast, endometrial or cervical cancer; unexplained vaginal bleeding; jaundice; liver tumour or disease; depression; problems with speech, or sensory difficulties; or pruritus, herpes or deafness during pregnancy.

It may also not be suitable for those with a history of: heart disease in their family; varicose veins; diabetes; high blood pressure; epilepsy; deafness; multiple sclerosis; porphyria; calcium deficiency; Sydenham’s chorea; breast disease; heart or blood vessel disease; liver or kidney problems; obesity; intolerance to contact lenses; lupus; asthma; uterine fibroids; gallstones; chloasma; or phlebitis.

Regular check-ups

You will need to return to your doctor for regular check-ups whilst taking this medication.

Pregnancy and breastfeeding

This medication should not be used by those who are pregnant, breastfeeding or planning to become pregnant. If you become pregnant whilst using this medication, stop using it and speak to your doctor.

Lactose intolerance

This medication contains lactose. If you have a sugar intolerance you should speak to your GP before commencing treatment.

Contraception and cancer risks

You can find more information regarding this medication and cancer risks in the patient information leaflet.

Sunbeds and ultraviolet sun lamps

Avoid sunbeds and prolonged sun exposure whilst using this product. 

Page last reviewed:  26/04/2022
Please read the patient information leaflet for this medicine fully before use:

Co-Cyprindiol 2mg/35mcg

Dianette 2mg/35mcg


Can I still drink alcohol?

Yes. It is unlikely that the consumption of alcohol will affect the sufficiency of this treatment.

Will I still be able to drive?

Yes. Your capacity to drive should not be inhibited. However, if you notice any side effects which might restrict your judgment or motor skills, you should refrain from driving and inform your doctor.

Can I take the medicine while pregnant?

This treatment must not be taken by anyone who is pregnant, planning to become pregnant or is breastfeeding.

How should I store it?

In a safe place, out of the reach of children, at a temperature below 30°C.

Am I allergic to anything in the medicine?

This drug contains the following: cyproterone acetate, ethinylestradiol, lactose monohydrate, maize starch, povidone K25, talcum, magnesium stearate, macrogol 6000, sucrose, calcium carbonate (E170), povidone K90, titanium dioxide (E171), glycerol 85% (E422), montan glycol wax and iron oxide pigment (E172).

Do not take it if you are allergic to any of these ingredients.

Is it available over-the-counter?

A prescription is required before purchase of Co-Cyprindiol can be made in person or online. This is so that a doctor can assess your suitability for the treatment prior to issue.

Is it right for me?

Talk to your GP if you have acne which is persistent or will not respond to non-prescription treatment. They may be able to help you find a suitable solution, and initiate a prescription where required.

To renew your Co-Cyprindiol prescription online, take our consultation. Once your order has been approved by one of our doctors or pharmacy prescribers, your treatment will be dispensed at our UK pharmacy and delivered to your chosen address by tracked next-day parcel.

Page last reviewed:  26/04/2022
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