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Duac Once Daily (Gel)

Clindamycin/Benzoyl Peroxide

(PLEASE NOTE that the picture displays the NEW PACKAGING for this product. The medicine contained inside is the same and performs the same function.)

Duac gel combines two active ingredients to fight acne. Manufactured by Stiefel, it is produced in two available strengths.

Please note that Duac is not available to buy from our pharmacy.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

11 August 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 11 August 2021
Product information

Duac Gel

Duac Once Daily Gel is manufactured by Stiefel to treat acne symptoms. The off-white gel contains the following two active ingredients: clindamycin which is an antibiotic and benzoyl peroxide which is from the group of medicines known as keratolytic. A thin layer of the product is applied to the affected area once a day, usually in the evening.

  1. Applied once-a-day
  2. Reliable branded treatment
  3. Contains two active ingredients

Acne is a very common, non-contagious skin condition which many people contract at some point during their lives. It causes the skin to develop spots mostly found on the face, back and chest. The severity of the condition can vary greatly from small spots, known as whiteheads and blackheads, up to large and painful pustules or cysts. It is estimated by the NHS that around 80 percent of people aged between 11 and 30 years are affected by acne. Some people may see an improvement by introducing a twice daily cleansing schedule or the condition may be mild enough that it can be self managed at home. Those with acne should avoid using too many cosmetics and squeezing their spots. Squeezing spots can cause permanent scarring and have a negative effect on self esteem. Acne symptoms often improve with age. However, some adults are known to continue with the condition.

There are many treatments available to combat acne. Duac is a topically applied antibiotic. Duac uses two active ingredients clindamycin and benzoyl peroxide. Clindamycin is an antibiotic that kills off the bacteria that feeds on sebum, the substance produced by the skin’s sebaceous glands. The bacteria’s waste products and fatty acids irritate the sebaceous glands and cause them to become inflamed. This is when a spot forms. Clindamycin disrupts the bacteria’s ability to make an essential protein it needs for reproduction and therefore cannot survive. Benzoyl peroxide is a keratolytic medication which encourages the top layer of skin to shed. This helps reduce comedones, also known as blackhead and whiteheads, and prevents further breakouts. When using Duac Once Daily it may take between two and five weeks before any improvements are noted. If no improvement at all is seen then it might be pertinent to seek further advice from a healthcare professional.

Please note that Duac is an antibiotic and not available to buy from our UK pharmacy. If you have acne which has not responded to other treatments, or think you may have an infection, you should see your GP in person.

Page last reviewed:  11/08/2021


To achieve the best results from your medication you should carefully follow the instructions provided by your prescribing clinician. If you are not entirely sure, check with your doctor before commencing treatment.

  1. Use once a day, in the evening. 
  2. Remove all traces of make up. 
  3. Wash the affected area of skin and pat dry. 
  4. Use your fingertips to gently rub a thin layer of gel onto all areas of skin which have acne. Do not limit treatment to single spots. 
  5. A sufficient amount of gel for your face should only be one fingertip’s worth (from the tip of the finger to the first joint). 
  6. Wash your hands after each use. 
  7. If you develop excessive skin dryness or peeling you may want to apply the treatment less frequently. You can also use an oil-free, hypoallergenic and fragrance-free moisturiser on the area to try and combat this side effect.

The above instructions are only meant as a guide. You should consult the patient information leaflet for further details.

Download Duac 10-30 PDF
Download Duac 10-50 PDF

Page last reviewed:  11/08/2021
Please read the patient information leaflet for this medicine fully before use:

Duac 1%/3%

Duac 1%/5%

Side effects & Warnings

Side effects

You may experience side effects when using Duac. It is important to be fully aware of the potential reactions in case you need to seek medical advice. The medicine’s enclosed patient information guide provides a full and comprehensive list of side effects.

Very common (1 in 10 people or more):
Redness, dryness, itching or peeling.

Common (1 in 10 people or fewer):
Headache, burning at application site, increased sensitivity to sunlight or a rash.

Uncommon (1 in 100 people or fewer):
Tingling or worsening of acne.

Frequency unknown:
Diarrhoea, stomach pains, inflammation of the intestine, discolouration of the skin or hives.

The list of side effects you read here is not comprehensive. If you have any concerns regarding the side effects you should consult the patient information leaflet or speak to your prescriber.

Taking it with other medications

Please inform your GP if you are using any other treatments during your consultation. This is so they can assess whether there are any possible interactions which could reduce the suitability of this product. This includes but is not limited to: other skin antibiotics; medicated cleansers; products which contain large amount of alcohol; tretinoin; isotretinoin; tazarotene; dapsone; sulfacetamide and products that contain erythromycin. 

Please also disclose to your prescriber if you are due to have surgery.

Conditions to look out for

Disclose during consultation if you have or have ever had any of the following: gut problems; regional enteritis ulcerative colitis or antibiotic-associated colitis.

Page last reviewed:  11/08/2021
Please read the patient information leaflet for this medicine fully before use:

Duac 1%/3%

Duac 1%/5%


Can I still drink alcohol?

You should take care when drinking alcohol and make sure that it does not interfere with your treatment plan. This medicine can interact with other anti-acne products that contain alcohol.

Will I still be able to drive?

All medications have the ability to cause side effects. You should assess whether this product affects your driving before doing so.

Can I take this medicine while pregnant?

Speak to your doctor or pharmacist before commencing treatment if you are pregnant, trying to get pregnant or are breastfeeding.

How should I store it?

Keep all medications away from children. Store below 25°C and throw away after 3 months.

Am I allergic to anything in the medicine?

You should not use this product if you have allergies to any of the following ingredients: clindamycin phosphate, hydrous benzoyl peroxide, carbomer, dimeticone, disodium lauryl sulfosuccinate, disodium edetate, glycerol, silica, colloidal hydrated, poloxamer 182, purified water and sodium hydroxide.

Is it available over-the-counter?

No. Duac Gel is only available on prescription. 

Is it right for me?

If you are experiencing acne and other treatments have not worked, or if you think you may have an infection, you should speak to your doctor in person. They will examine your symptoms and help you to identify a suitable course of treatment.  

Page last reviewed:  11/08/2021
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