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Tetralysal is a capsule treatment for acne marketed by Galderma. It is an antibiotic which works by combating the bacteria responsible for infection.

We do not offer this product via our online service. Speak to your GP in person if you are experiencing acne symptoms which are not responding to your usual treatment.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

05 January 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 05 January 2021
Product information

Tetralysal is an antibiotic treatment used to relieve acne, but it is also sometimes issued to medicate other types of infection. It works by tackling the bacteria responsible. In the UK, Tetralysal is licensed by Galderma, and is only available to buy on prescription. Length of treatment usually depends on the severity of acne present.

  1. One a day dose
  2. Fights acne symptoms
  3. Reduces skin inflammation

Nearly everyone will experience some form of acne in their lives at least once. There are a number of reasons why it might occur. The hormonal changes experienced during adolescence and young adulthood often provide an optimal breeding ground. It is also common among women who are in the early stages of pregnancy, or are expecting their period. Sometimes, spots may arise as a side effect of medication, such as steroids or contraceptive pills.

Acne is characterised by the appearance of spots on the skin, to varying degrees. These may be small, and take the form of blackheads or whiteheads. In other cases, they may be slightly larger and contain a small amount of pus. More severe types of acne may cause stubborn and uncomfortable nodules and cysts.

It is caused by the overproduction by the sebaceous glands of a substance called sebum. This oily chemical is an essential component in helping to keep the skin and hair healthy and lubricated. But an abundance of it can be detrimental, causing inflammation of the sebaceous glands, resulting in small spots. Infection can also result, as otherwise harmless bacteria called propionibacterium acne can develop to high levels by feeding on excess sebum. This also encourages inflammation and the formation of spots.

The main ingredient in Tetralysal is lymecycline. When treating acne, this functioning agent works by limiting the generation of bacterial growth proteins. In doing this, the medication prevents the bacteria from spreading further and manages it down to normal levels. This allows the body to fight off the infection, and acne clears up.

We do not provide this item through our clinic service. If you have acne symptoms or are concerned that you may have an infection, make an appointment with your GP. They will be able to help you get the treatment you need.

Page last reviewed:  05/01/2021


Make sure you follow the instructions issued by your prescriber when using this treatment, and read the guidelines in the patient information leaflet carefully. This will help you to reduce the likelihood of side effects and maximise the efficacy of the medication.

  1. Take as prescribed.
  2. For acne, this will likely be one tablet per day.
  3. It is recommended that you take the pill every morning.
  4. Duration of treatment is dependent on the severity of acne symptoms. For regular cases, this period may be around 8 weeks.
  5. Swallow tablets whole with a glass of water.
  6. Never take more than the prescribed amount.
  7. If you forget to take it, do so when you remember and carry on the treatment as normal. However, if it is time for your next dose, skip the one you have missed, and take your next dose at the scheduled time.

This is not a comprehensive list of the directions you will need to follow when taking these capsules. Refer to the leaflet supplied for more information.

Download PDF

Page last reviewed:  05/01/2021
Please read the patient information leaflet for this medicine fully before use:

Tetralysal 300mg

Side effects & Warnings

Side effects

Inform your doctor right away if you notice any signs of an allergic reaction, such as swelling of the face lips or tongue, or hives, or any other side effects which become serious.

Common (1 in 10 people or less):
Headache, stomach pain, feeling or being sick, or diarrhoea.

Frequency unknown:
Skin irritation including peeling or blistering, ulcerations or lesions on the mouth, lips, genitals or on the anus, sight problems, dizziness, jaundice, inflammation of the liver, photosensitivity, increased cranial pressure, blood cell abnormalities, upper abdominal pain, altered liver function, fever, itchiness, skin rash, or inflammation of the intestines.

This is only a summary of the side effects associated with this product. More information can be found in the supplied leaflet.

Taking it with other medicines

Disclose any information relating to other medications you are using to your prescriber. It is particularly important to inform your prescriber if you are using any of the following: blood thinners such as warfarin; diuretics; or other drugs to treat acne.

It is advisable to wait for at least two hours after taking this treatment before having: indigestion remedies; ulcer healing drugs; quinapril; or calcium, aluminium, magnesium, zinc or iron supplements.

The function of contraceptive pills may also be inhibited by this product. Use of a barrier method is therefore recommended. Further guidance is available from your doctor or pharmacist.

Conditions to look out for

If you have ever had kidney disease, you should not take this treatment. Those with a history of liver problems, myasthenia gravis or lupus may also be not be suitable.

Page last reviewed:  05/01/2021
Please read the patient information leaflet for this medicine fully before use:

Tetralysal 300mg


Can I still drink alcohol?

Yes. The treatment is not thought to interact with alcohol or be rendered any less effective.

Will I still be able to drive?

Yes. It is not likely that your capacity to drive will be affected. However, you should not drive if you notice any side effects which may reduce your ability to do so safely, and contact your doctor immediately.

Can I take the medicine while pregnant?

It is not suitable for those who are pregnant, trying to become pregnant or are breastfeeding.

How should I store it?

It should not be stored above 25°C.

Am I allergic to anything in the medicine?

This medication contains: lymecycline, magnesium stearate, colloidal hydrated silica, gelatin, titanium dioxide (E171), erythrosine (E127), quinoline yellow (E104) and indigotine (E132).

If you are allergic to any of these ingredients, do not use it.

Is it available over-the-counter?

You can only buy Tetralysal online or in person after first consulting with a doctor. Take our questionnaire to see if you are suitable.

Is it right for me?

This antibiotic is not available through our online pharmacy.

If you aren’t currently taking acne treatment, see your GP. They will be able to decide on the best course of treatment for you, and initiate a prescription if necessary.

Page last reviewed:  05/01/2021
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