• Amlodipine

Istin is a tablet medication for angina made by Pfizer. It is a calcium-channel blocker, which works by easing blood supply to and from the heart.

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This dose contains 5mg of amlodipine, and is usually prescribed as a starting course. It is taken once a day.

28 Pills - £42.00

In some cases, a doctor may decide to increase the dose to 10mg. One tablet a day is taken.

28 Pills - £51.00
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Istin is a tablet manufactured by Pfizer, used to treat angina pectoris. The tablet is taken once a day and works by facilitating the flow of blood to the heart, and reducing chest pain. Medicines of this kind are known as calcium-channel blockers. It is also useful at treating hypertension. Before you buy Istin in the UK, you will need a prescription from a doctor.

Angina is a condition characterised by tightness and dull pain in the chest. This discomfort can also sometimes extend to the left arm, the neck, and the jaw. Pain takes on the form of an attack, which, in stable angina, occurs in response to physical strain or stress. Unstable angina cases are less predictable, and attacks may be the result of a less obvious initiating factor.

The condition is more common in people who are aged 55 over. In the UK, angina affects one in twelve men and one in thirty women in their late 50s and early 60s. Lifestyle habits, such as smoking, eating an unhealthy diet, and not getting enough exercise can all contribute to the condition. Symptoms result from the hardening and clogging up of the arteries which supply the heart. This can restrict blood flow and induce a decrease in oxygen supply, causing the heart to strain trying to get the oxygen it requires.

Certain factors, such as having diabetes or high blood pressure, can increase a person’s risk of developing angina, as can having a family history of heart problems. Having a healthy and balanced diet, getting regular exercise, and stopping smoking are all recommended prevention measures.

How angina is treated depends on the severity of the condition. Those who have unstable angina, where attacks may persist even after a period of rest, should seek immediate medical advice. For cases of stable angina, a doctor may issue a prescription treatment to limit the risk of an attack.

The active constituent in Istin is a substance called amlodipine, which is a type of medicine called a calcium antagonist. In reducing the provision of calcium to the arterial muscle walls, amlodipine helps the vessels to relax and widen, and this increases blood flow to and from the heart. As a result, the heart doesn’t have to beat with as much force to get the oxygen it needs. Tightness and pain is then reduced.

Getting access to the prescription item you need is simple with our online service. Our repeat ordering facility enables you to get the medicine you need delivered to your door. All you need to do is take our questionnaire and a doctor will review your responses. Once confirmed as suitable, your order will be sent electronically to our dispensing pharmacy. Special courier is used to deliver all items, so that you don’t have to wait to start using your medication.

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How to use Istin

Following the instructions issued to you by your doctor is vital when using this or any other treatment. Doing so will help you to eliminate the risk of side effects, and enable the medication to work at it’s most effective. You should also read the patient information leaflet carefully prior to use.

  1. Take as directed.
  2. For angina, this will typically be one 5mg tablet a day to begin with.
  3. Your doctor may choose to increase this to one 10mg tablet a day.
  4. Swallow tablets whole with water.
  5. Do not take with grapefruit juice.
  6. Never take more than the prescribed amount.
  7. If you miss a dose, skip it and take your next one at the scheduled time. Do not make up for a missed dose with a double dose.

The above is only intended as a guide. More detailed instructions can be found in the leaflet supplied.

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Istin side effects

If you notice any signs of the following, tell your doctor right away: worsening of angina symptoms; heart attack or irregular heartbeat; an allergic reaction, such as sudden wheeziness, chest pain, shortness of breath, swollen eyelids, tongue, throat, face or lips, skin rash, hives, severe itching, blistering, or peeling; or an inflamed pancreas, such as stomach pain which may reach through to the back.

Very common (1 in 10 people or more):
Ankle swelling.

Common (1 in 10 people or less):
Headache, dizziness, sleepiness, palpitations, flushing, abdominal pain, feeling or being sick, irregular bowel frequency, diarrhoea, constipation, indigestion, tiredness, weakness, sight problems, or muscle cramps.

Uncommon (1 in 100 people or less):
Mood swings, anxiety, depression, sleeplessness, trembling, taste abnormalities, drop in blood pressure, fainting, numbness or tingling sensation in the limbs, loss of pain sensation, tinnitus, inflammation of the lining of the nose, cough, hair loss, dry mouth, increased sweating, itchy skin, red patches on skin, skin discolouration, increased urinary frequency, problems getting or maintaining an erection, joint or muscle pain, back pain or weight fluctuations.

Rare (1 in 1,000 people or less):

Very rare (1 in 10,000 people or less):
Reduction in numbers of white blood cells, decrease in blood platelets which may cause bruising or bleeding, hyperglycaemia, nerve problems, swollen gums, gastritis, liver inflammation, increased muscle tension, photosensitivity, or tremors.

This is not a complete list of the side effects associated with this product. For a more detailed account, please refer to the leaflet provided.

Taking it with other medicines

Let your doctor know when taking our medical questionnaire if you are taking any other treatments, as they may interact with this product and affect its function. This particularly applies to the following: ketoconazole or itraconazole; ritonavir, indinavir or nelfinavir; rifampicin, erythromycin or clarithromycin; other blood pressure drugs; St John’s wort; verapamil or diltiazem; dantrolene; tacrolimus; simvastatin; or cyclosporine.

Conditions to look out for

Do not use this product if you have: severe low blood pressure; aortic stenosis; cardiogenic shock; or heart failure following a heart attack.

It is also important to let your doctor know if you: have recently had a heart attack; have heart problems of any kind; are hypertensive; have liver disease; or are elderly.

Q&A: our Istin discussion forum

Can I still drink alcohol?

It depends on the advice of your doctor. Those who intend to drink alcohol should ask their prescriber before taking this medication.

Will I still be able to drive?

Yes, provided you experience no side effects. However, it will be necessary to see how this drug affects you first before attempting to drive, as it may inhibit your capacity to do so safely. If it does, refrain from driving and speak to your doctor.

Can I take the medicine while pregnant?

This product may not be suitable for those who are pregnant or breastfeeding. Check with your doctor of family planning nurse prior to use.

How should I store it?

Keep the tablets in a safe place below 25°C.

Am I allergic to anything in the medicine?

These tablets contain: amlodipine, calcium hydrogen phosphate anhydrous, magnesium stearate, microcrystalline cellulose and sodium starch glycolate Type A.

Do not take them if you are allergic to any of the above ingredients.

Is it available over-the-counter?

You will require a prescription in order to be able to buy Istin online or in person. This can be obtained through completion of our doctor-reviewed health assessment.

Is it right for me?

Our repeat service is the ideal solution for those looking to get regular prescription treatment delivered to their home. Fill in our medical questionnaire, and one of our qualified physicians will review your case. If suitable, an electronic prescription will be issued and sent to our UK-based pharmacy to be dispensed. Orders are shipped by secure courier, so that you can be sure your items will arrive on time and safely.

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Delivery on all items is included in the price. After your order has been dispatched, you’ll be supplied with a tracking number, allowing you to follow the progress of your items every step of the way. We deliver to anywhere in the UK, so whether you’re in London, Birmingham, Manchester, Glasgow or Cardiff, your order will be at your door within just 24 hours of approval from our doctor.

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