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Salmeterol Xinafoate

Serevent is a long-acting reliever treatment for asthma. It gets to work in 10-20 minutes and its effects can last for over 12 hours.

This item is not available to buy from our online pharmacy. We recommend that you see your GP in person to be prescribed Serevent.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

27 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 27 August 2020
Product information

Serevent is a type of asthma treatment called a reliever, and is manufactured by GlaxoSmithKline. It is different to other relievers as one dose has a long-acting effect on symptoms, lasting for over 12 hours in some cases. The product is supplied in two different devices: as an Evohaler, which contains a canister and is similar to a conventional inhaler; and an Accuhaler, which contains a powder.

  1. Most people in the UK are no stranger to asthma, and are aware of its effects. 
  2. Around 5.5 million people receive treatment for the condition, so its likely that even if you don’t have it, you know someone who does. 
  3. It affects the respiratory system, and is characterised by difficulty breathing, coughing, and wheezing. 
  4. These generally occur following exposure to a trigger, which is often an airborne irritant such as smoke, pollen, or dust particles; but cold air can exacerbate it too.
  5. Many people may also experience symptoms during exercise, or periods of emotional distress.

It isn’t fully understood why some people are more susceptible to asthma than others. Genetics are thought to play a part, as it has been found that those with a family history of the condition are more likely to get it. Environmental factors, such as persistent exposure to potential irritants during childhood, or a lack thereof, are also pointed to by experts as possible causes.

The catalyst for asthma symptoms is the immune system. It responds to these irritants by releasing a chemical which results in inflammation in the bronchi, which are the small pipes connecting the lungs to the trachea, or windpipe. When these become inflamed, the surrounding muscle walls tense up, and this narrows the airways. In some cases, inflammation can cause an increase in the production of phlegm, and this serves to further obstruct and hinder breathing.

Salmeterol, which is the functioning component in Serevent, works by acting on beta-2 receptors. This relaxes muscle walls in the affected area, and helps the narrowed airways to dilate, thus expediting smoother breathing patterns, and reducing symptoms.

We do not currently offer asthma treatments online. We advise that you see your GP in person to discuss the most suitable treatment options.

Page last reviewed:  27/08/2020


It is essential to adhere to the guidelines set out by your prescriber when using this product, and to follow the instructions provided in the supplied leaflet. Doing this will assist you in maximising the performance of the treatment, and averting possible side effects.

  1. Administer in the manner directed by your doctor.
  2. For Serevent Evohaler, this may be two puffs, twice per day.
  3. For Serevent Accuhaler, a recommended starting dose may be one puff twice per day.
  4. Your doctor may suggest doubling the above doses if your symptoms are severe.
  5. The dose should remain active for 12 hours.
  6. Do not exceed the stated dose.
  7. The Evohaler is a more traditional style of inhaler, supplied with a pressurised canister which you will be required to press down during use.
  8. The Accuhaler is a powdered dose, which is administered through a slightly different device. This is simply breathed in through a mouthpiece and does not require you to press a button.
  9. Detailed instructions on how to use these appliances can be obtained from the respective patient information leaflets.
  10. Never take more than the amount your doctor has told you to.
  11. If you forget to take your dose as scheduled, do not make up for it by doubling up on your next one. Simply continue your course as normal, and contact your doctor or asthma nurse if you are concerned.

The information provided here is intended as a guide only. Refer to the directions supplied with the product before use.

Download Serevent Evohaler PDF

Download Serevent Accuhaler PDF

Page last reviewed:  27/08/2020
Please read the patient information leaflet for this medicine fully before use:

Serevent Accuhaler 50mcg

Serevent Evohaler 25mcg

Side effects & Warnings

Side effects

Prior to use, it is important to be aware of the potential side effects your treatment may cause. If you notice anything which might be a sign of an allergic reaction, or if after using the medication your symptoms become worse, seek medical advice right away.

Common (1 in 10 patients or less):

Muscle cramps, feeling shaky, fast or uneven heartbeat, or headache.

Uncommon (1 in 100 people or less):

Rash, anxiety.

Rare (1 in 1,000 people or less):

Dizziness, insomnia, reduced levels of potassium in your blood resulting in muscle weakness or cramp.

Very rare (1 in 10,000 people or less):

Increases in blood sugar levels, sore mouth or throat, aching, swollen joints, or chest pain.

This is not a complete list of the side effects this treatment may cause. Refer to the patient information leaflet for more information.

Taking it with other medicines

Serevent may cause interactions when used with other medicinal products, so it is essential to inform your doctor if you are using any other treatments during consultation.

This drug may influence the function of the following, or vice versa: ketoconazole, itraconazole, or other antifungals; ritonavir; beta-blockers such as atenolol, propranolol and sotalol; or diuretics.

Conditions to look out for

Disclose your medical history to your prescriber before using this product. It is not suitable for those with an intolerance to lactose. It may also not be issued or only issued with close supervision to those who have or have ever had: an overactive thyroid gland; diabetes mellitus; or heart disease, including an irregular or fast heartbeat.

Pregnancy and breastfeeding

Talk to your doctor before taking this treatment if you are pregnant, breastfeeding or trying to conceive.

Driving and using machinery

Serevent is not likely to cause problems with your ability to drive or operate machines.

Page last reviewed:  27/08/2020
Please read the patient information leaflet for this medicine fully before use:

Serevent Accuhaler 50mcg

Serevent Evohaler 25mcg


Can I still drink alcohol?

Yes. Alcohol is not known to interfere with the function of Serevent.

Will I still be able to drive?

Yes. Your driving is not likely to be affected. But you should avoid driving if you experience any side effects which may make doing so unsafe, and contact your doctor.

Can I use this medicine while pregnant?

If you are pregnant or breastfeeding, you should talk to your doctor before using this treatment.

How do I store it?

In a safe environment, below 30°C. Keep away from sharp objects as these may pierce the pressurised canister.

Am I allergic to anything in the medicine?

Serevent Evohaler contains salmeterol and norflurane; whereas the Accuhaler consists of salmeterol and lactose. Do not use these products if you allergic to any containing ingredients.

Is it available over-the-counter?

You can only purchase Serevent in the UK if you have a prescription for it. This can be obtained via our simple online consultation process.

Is it right for me?

Following your periodic asthma review, your doctor or respiratory nurse will discuss treatment options with you, and initiate a prescription for the most appropriate medication. 

To find out more about whether Serevent is the right medication for you, speak to your GP or specialist.



Page last reviewed:  27/08/2020 is rated 4.9 out of 5 by 3256 customers on TrustPilot!
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