Registered Pharmacy
24hr Free Delivery
No Registration Needed
Sayana Press

Sayana Press

Medroxyprogesterone acetate (MPA)

Sayana Press is a ready-to-use birth control injection that is administered every three months.

If you would like to buy Sayana Press online, simply fill in our contraception questionnaire and our GMC-registered doctor or GPhC-registered prescribers will review your case, and provide suitable options for you. 

+3200 Trustpilot reviews

This content was reviewed by a clinician on

06 November 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 06 November 2020
Product information

Sayana Press is an injectable birth control option for women that is ready to use and can be self-injected. The active ingredient in the Sayana Press injections is called medroxyprogesterone acetate (MPA). This ingredient is different, but has similarities to progesterone, a natural hormone.  The medication is self-injected once every 12 or 13 weeks in order to be effective. Pfizer market the Sayana Press medication, the first contraceptive of its kind in the UK that can be self-injected. 

Each month, the female body goes through various phases to prepare for conception. Ovulation - the process in which an egg is released by the ovary - plays a key part in the start of pregnancy. Once the egg has been produced, it is fit to be fertilised by sperm.

What happens to the egg next will depend on whether or not sperm makes successful contact. If it does, the impregnated egg moves along to the uterus and secures itself to the endometrium, before beginning its development into a baby. Otherwise, an unfertilised egg will simply reduce once it reaches the uterus and be excreted along with the endometrium, during menstruation.

The Sayana Press injection acts by preventing the egg from developing fully and being released during the menstrual cycle. As the egg will not be released whilst Sayana Press is active in the body, sperm cannot fertilise it. Therefore, pregnancy is much less likely. 

Sayana Press is a quick and convenient method of contraception for women. Should you choose to use Sayana Press as your means of contraception, you will likely need to have an examination and your first injection will need to be administered by a healthcare professional. A contraceptive like Sayana Press is used to prevent pregnancy but it is not an effective method to protect you against sexually transmitted infections like HIV. You can reduce your risk of contracting STIs through correct and consistent use of male or female condoms. 

In cases where Sayana Press is not suitable (for instance, if the patient is allergic to one of more of the ingredients within the medicine), an alternative might be suggested such as a combined pill, contraceptive patch or diaphragm. 

Sayana Press is available to buy from our safe and secure online pharmacy. Once you have filled in our simple questionnaire, you can choose to buy Sayana Press. Your questionnaire will be reviewed by our GMC-registered doctor, clinician or practitioner and if approved, your order will be passed to our GPhC-registered pharmacy. Your order will be dispatched by a courier service. 

Select dose
Page last reviewed:  06/11/2020

When you use this medicine, make sure you follow the instructions provided by your prescriber, and that you read the information leaflet supplied. Doing so will help to lower the risk of potential side effects, and enable you to get the best out of your medicine.

  1. You may need to have a physical examination before you start taking Sayana Press.
  2. The first time you use the injection, you should not be alone. It should be given to you by a healthcare professional like a doctor or nurse.
  3. Do not refrigerate the medicine - it will need to be at room temperature to be administered.
  4. Hold the injector firmly and shake it for at least 30 seconds to mix the medicine.
  5. Inject Sayana Press into either your abdomen or upper thigh. Each time you inject Sayana Press, you should alternate between the injection sites. 
  6. In order to push out the medicine, you will need to apply a slow and even pressure to the injector for around 7 seconds. 
  7. It is key that the used injections are disposed of correctly after use. Check with your local authority on the best way to throw out used injections. Do not dispose of the injections into household waste after use. 

Consult the leaflet provided for further information.

Page last reviewed:  06/11/2020
Please read the patient information leaflet for this medicine fully before use:
Side effects

Sayana Press can cause side effects but not everyone will experience them. If you notice any side effects while using this medicine, it is important to seek medical advice immediately. 

Common (affecting 1 in 10 people)

Weight increase, abdominal cramps, nausea, acne, very light or no period, unexpected bleeding, irregular periods, period pain, depression, tiredness, breast tenderness, headache, irritability, anxiety, difficulty sleeping, decreased sexual feeling, vaginal itching, mood changes, dizziness, back pain, pain in limbs, abnormal cervical smear.

Uncommon (affecting 1 in 100 people)

Drug allergy, hirsutism, bloating, fluid retention, vaginal discharge, vaginal dryness, pain during sex, ovarian cyst, pelvic pain, premenstrual syndrome, change in breast size, milky discharge from breasts in women who are not breast-feeding, change in appetite, muscle cramps, joint pain, sleepiness, migraine, vertigo, hot flushes, fever, high blood pressure, rapid heart rate, varicose veins, rash, itching, hives, hair loss, skin irritation, bruising, facial discoloration, inflammation in the veins, nervousness, loss of bone mineral density, decreased glucose tolerance, emotional disturbance, inability to achieve a sexual climax, abnormal liver function test results. 

Rare (affecting 1 in 1,000 people)

Breast cancer, weakness, weight decrease, deformation of skin at the injection site. 

Unknown cases

Osteoporosis and osteoporotic fractures, seizures, jaundice, skin stretch marks.

Please note this is not an exhaustive list of the possible side effects of using Sayana Press. For further information, please consult the patient information leaflet. If you experience any side effects, or notice anything unusual while taking Sayana Press, please see your doctor or healthcare professional immediately.

Taking Sayana Press with other medications

If you are taking or have recently taken other medicines, please tell your doctor during consultation. 

Blood thinning medications, known as anticoagulants, can interact with Sayana Press. 

Conditions to look out for

It is important to disclose whether you have been affected by the following conditions, as taking a hormone contraception can make them worse or it may not be suitable. 

Affected conditions include: migraine headaches; diabetes or a family history of diabetes; history of heart disease or cholesterol problems including any family history, past history of depression; irregular, light, or heavy menstrual periods; an unusual breast x-ray, fibrocystic breast disease, breast nodules or lumps, or bleeding from your nipples; a stroke; family history of breast cancer; kidney disease; high blood pressure; asthma; epilepsy.

Pregnancy and breastfeeding

This medication should not be used if you are pregnant. If, at any point, you feel you may have become pregnant whilst using this medication, it is important to let your doctor know immediately. 

The injection should be taken no sooner than six weeks after childbirth, if you are breastfeeding. The medication can be passed to babies through breast milk but no harmful effects have been found in children. 

Driving and using machinery

Taking Sayana Press will not affect your ability to drive or use machinery. 

Allergy information

Sayana Press contains sodium, methyl parahydroxybenzoate (E218) & propyl parahydroxybenzoate (E216). These ingredients could cause an allergic reaction. Please note that the reactions could be delayed too.

Page last reviewed:  06/11/2020
Please read the patient information leaflet for this medicine fully before use:

Can I still drink alcohol? 

Alcohol can interact with certain medicines, reducing their effectiveness. However, there is nothing to suggest drinking alcohol will alter the effectiveness of Sayana Press. 

Can I still drive?

Your capacity to drive will not be affected by using Sayana Press. 

Pregnancy or breastfeeding?

Do not use Sayana Press if you are pregnant, and if you think you have fallen pregnant since using the medication, please inform your doctor immediately.

It is safe to breastfeed whilst taking Sayana Press injections, but you should start no sooner than six weeks after childbirth when the baby is more developed. It is possible for the medication to be passed onto the infant during breastfeeding. However, it is positive to note that there haven’t been any harmful side effects discovered in children. 

How should I store it?

This medication should be kept out of a child’s reach. Sayana Press must be used at room temperature so it is important that you do not freeze or refrigerate the injections. Take note of the expiry date listed on the injector, foil pouch and carton - if the date has passed, do not use the injection. The date will refer to the last day of the month. 

How should I dispose of the injection?

You should dispose of Sayana Press carefully and properly. Each injection is for one use only - do not reuse the injection. It should not be disposed of into household waste. You should use a special container in order to dispose of the used injection. Speak to your local authority about the requirements for disposing used injections. If you are unsure, please ask for guidance on how to dispose of Sayana Press after use. 

Is there anything in the medicine that I could be allergic to?

There are potential allergy concerns with using Sayana Press. If you have an allergy to medroxyprogesterone acetate (MPA), sodium, methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216), you should not use Sayana Press as your method of contraception.

In extreme cases, you could have a serious allergic reaction to the medicine - if this does occur, it’s imperative that you seek medical help. Symptoms of a serious allergic reaction include: trouble breathing; feeling dizzy; feeling wheezy all of a sudden; coming out in a skin rash or hives; your lips, throat face or eyelids swelling up. 

Is Sayana Press available over the counter?

No, you can only buy Sayana Press in the UK if you have a prescription from a registered doctor. Our service enables a doctor to issue a prescription.

How do I buy Sayana Press online?

If you haven’t used Sayana Press before, you may need to have a physical examination before you start using the medication. 

Please note, we can fulfill an order for Sayana Press after our simple questionnaire has been filled in and reviewed by one of our prescribers. We offer consultations with UK doctors if you want to buy Sayana Press online and our dispensing pharmacy is regulated by the CQC and GPhC. 

Page last reviewed:  06/11/2020 is rated 4.9 out of 5 by 3209 customers on TrustPilot!
A simple process
Getting the treatment you need has never been easier with our speedy and simple online service.
  • Search for your medicine

    Find the treatment you need.
  • Fill in a simple questionnaire

    A GMC-registered doctor or a pharmacy prescriber will review your answers.
  • 24h delivery to your door

    Next-day delivery. Every order is sent by tracked courier.
  • Repeat ordering is easy

    We keep your details secure so you can reorder with ease.

No matches found. You can find all our treatments here