• Ethinylestradiol/Levonorgestrel

TriRegol is a pill used to provide contraception, which is marketed for sale in the UK by Consilient Healthcare. It is a triphasic tablet, comprising of two man-made hormones.

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30mcg/50mcg; 40mcg/75mcg; 30mcg/125mcg

In each strip of TriRegol is 21 tablets. These consist of 6 pink tablets containing 50 micrograms levonorgestrel and 30 micrograms ethinylestradiol; 5 white tablets containing 75 micrograms levonorgestrel and 40 micrograms ethinylestradiol; and 10 ochre tablets containing 125 micrograms levonorgestrel and 30 micrograms ethinylestradiol.

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TriRegol is a contraceptive pill marketed by Consilient Healthcare. It contains two synthetic hormones, which mimic the action of progesterone and oestrogen in the body. The product is a triphasic pill which is taken for the first 21 days out of the user’s menstrual cycle, and succeeded by seven days where no pill is taken. This process is then repeated the following month.

  1. Easy-to-use pill
  2. Competency rate of 99% 
  3. Helps relieve menstrual pain

In the female body, certain processes are undergone each month to prepare it for pregnancy. Among these is the process of ovulation, which entails the release of an egg from the ovary into the fallopian tube. At this point, the egg is ready to be penetrated by male sperm and fertilised. In cases where the egg is successfully inseminated, it continues its journey to the uterus and attaches to the endometrium, or uterine wall. For this to happen, the lining of the uterine wall must be of a certain consistency. This lining builds up and sheds every month in cycles, resulting in menstrual bleeding.

The above sequences are regulated by progesterone and oestrogen, and only made possible when levels of these hormones rise and fall each month. What the presence of the synthetic versions of these hormones in TriRegol does, is supplement their levels as they naturally decrease. In doing so, ethinylestradiol and levonorgestrel convince the body that ovulation, and the thickening of the uterine wall lining, does not need to take place because it has already happened.

Subsequently, the conditions which make pregnancy possible do not materialise. In addition to these measures, the combined pill also makes cervical fluid denser, so that sperm cannot move around as easily in the neck of the womb and fertilise an egg which has been released.

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How to use TriRegol

For TriRegol to be as effective as possible, and to keep the risk of potential side effects to a reasonable minimum, you should always follow the directions your prescriber has issued and keep to the guidelines in the patient information leaflet.

  1. Apply as prescribed.
  2. This will be one pill taken at the same time each day for 21 days.
  3. Follow this with seven pill-free days, then begin taking it again the following week.
  4. Start the pill on the first day of your period.
  5. Take the tablets in the order marked on the strip by the directional arrows.
  6. Please note that this product is a triphasic pill and must be taken in a certain sequence to ensure maximum efficiency.
  7. If you forget to take your pill, read the leaflet for instructions for guidance on what you should do next. Speak to your doctor or family planning nurse if you need any further advice.
  8. Never take more than your doctor has told you to.

These directions do not constitute detailed instructions. Refer to those in the leaflet supplied before using this treatment.

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TriRegol side effects

Go to your nearest hospital right away if you notice any signs of a blood clot, heart attack, stroke, allergic reaction, breast cancer, or severe liver disease. Details of what these look like can be located in the patient information leaflet.

Very common (1 in 10 women or more):
Tender breasts.

Common (1 in 10 women or less):
Depressive moods, headaches, feeling or being sick, gallstone disease, skin disorders such as acne, brown patches on the face and body similar to those that occur in pregnancy, irregular bleeding, or increase in body weight.

Uncommon (1 in 100 women or less):
Changes in libido, nervousness, or high blood pressure.

Rare (1 in 1000 or less):
Hyperlipidaemia, otosclerosis, a blood clot in vessels, inflammation of the walls of the bowel.

This is not a complete account of the side effects this product may cause. A more detailed index can be found in the leaflet provided.

Taking it with other medicines

Let your prescriber know if you are using other prescription, non-prescription or remedial treatments during consultation. This pill may interact with: antibiotics; antiepileptics; barbiturates; ritonavir; griseofulvin; tricyclic anti-depressants; cyclosporine; or St John’s Wort.

Conditions to look out for

Do not use this tablet if you have a history of the following conditions: any disorder affecting your blood circulation such as blood clots, a heart attack or angina, or a stroke; diabetes with changes to the blood vessels; problems with blood vessels in the eye; high blood pressure; irregular heart rhythm or a heart valve disease; liver disease or tumours; breast cancer or other cancer; or migraines.

It may also not be suitable for you if you have ever had: hypertriglyceridaemia; jaundice; pruritus; gallstones; porphyria; systemic lupus erythematosus; haemolytic uraemic syndrome; Sydenham’s chorea; chloasma; herpes gestationis; otosclerosis; abnormal liver function; Crohn’s disease or ulcerative colitis; or diabetes.

Q&A: our TriRegol discussion forum

Can I still drink alcohol?

Yes. You can still consume alcohol while taking this treatment.

Will I still be able to drive?

Yes, as long as you have no side effects which may make doing so difficult or unsafe. If you do, refrain from driving and seek medical advice immediately.

Can I take the medicine while pregnant?

No. You should not take this combined pill if you are pregnant or think you might be.

It is also not suitable for those who are breastfeeding. Other products, such as the minipill, can provide an effective means of contraception during breastfeeding in some cases.

How should I store it?

Keep in a secure environment, out of the reach of children, below 25°C and away from sources of excessive light or moisture.

Am I allergic to anything in the medicine?

These tablets contain the following ingredients: ethinylestradiol, levonorgestrel, colloidal anhydrous silica, magnesium stearate, talc, maize starch, lactose monohydrate, carmellose sodium, povidone K30, macrogol, copovidone, calcium carbonate, sucrose, red iron oxide (E172), titanium dioxide (E171), and yellow iron oxide (E172). Do not take this pill if you are allergic or unable to tolerate any of these components.

Is it available over-the-counter?

Prior consultation with a doctor is required before you can purchase TriRegol from a UK pharmacy, as they will need to draw up a prescription for you to show that this medication is suitable.

Is it right for me?

Let us help you find out. Take our medical questionnaire today. It only takes a few minutes to fill out, and your answers will be kept confidential. A doctor will review your case, and once your treatment has been approved, you can expect to receive it within one working day from our UK-based pharmacy.

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