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Vildagliptin/Metformin Hydrochloride

Eucreas is a type of drug called an antidiabetic. It contains two ingredients which work by helping to manage blood sugar levels.

Please note that Eucreas is not available to buy through our pharmacy service at this time.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

23 September 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 23 September 2020
Product information

Eucreas is a tablet used to help manage type 2 diabetes. It contains two active ingredients, vildagliptin and metformin. Both of these help the body to produce and make better use of insulin. The tablets are taken, in most cases, twice daily, with or after food. Novartis manufacture and market Eucreas in the UK, and you will need a prescription from a doctor in order to be able to purchase it online or in person.

  1. Two doses available
  2. Effective diabetes treatment
  3. Lowers risk of complications

It is estimated that around 90 per cent of total diabetes cases in the UK, which is around 3 million, fall into the type 2 category. The condition is characterised by an inability to create and utilise insulin in the body. Insulin, which is a hormone generated by the pancreas, is a vital component in the body’s energy distribution. It controls the levels of glucose (or sugar) in the blood, and helps cells to extract it and convert it into energy.

What sets type 2 diabetes apart from type 1 is its period of onset. People with type 1 diabetes will usually develop it earlier on in their lives, and it is the result of the immune system attacking those cells which produce insulin. Type 2 diabetes however, develops at a later stage in life, and your risk of getting it increases the older you get. In those with type 2 diabetes, the body produces some insulin, however it may either not produce enough, or the body’s cells may not be able to use it properly.

The most common symptoms of type 2 diabetes are constantly feeling thirsty or tired, sight problems such as blurred vision caused by dry eyes, dramatic or unexplained drops in weight, or an increased or urgent need to pass urine. Getting treatment for diabetes is important, as it is a condition which can deteriorate over time, and lead to complications. Those with diabetes are more likely to have a heart attack or stroke, experience nerve damage, or develop kidney disease.

Risk factors associated with this illness are numerous. You are more likely to develop the condition if: you have a family history of it; are over 40; are of South Asian or Chinese descent, or if you are of black African or Caribbean origin; or are overweight or obese.

One of the first measures a doctor will take in addressing the condition is a person’s diet. They may suggest a healthier or more balanced regimen when it comes to food, along with a course of regular exercise. Stopping smoking and curbing alcohol intake can also help to reduce the likelihood of complications developing, as well as improving your overall health.

For some however, medication may be necessary, particularly if the condition has been present for some time. This may be issued in the form of antidiabetic drugs, such as metformin. This is an example of a biguanide, and helps to treat diabetes in a variety of ways. It helps to lower the amount of sugar in the blood, by reducing the amount produced by the liver, and facilitating the extraction of glucose from the blood by muscle cells. Metformin also slows the uptake of sugars from food in the intestines.

Those who have taken metformin alone and found it to be ineffective may be advised to use a combination drug, containing another ingredient, to help keep blood sugar levels under control. Eucreas also contains vildagliptin, the primary function of which is to inhibit the enzymatic breaking down of incretin hormones. These hormones help the pancreas respond to food intake by increasing insulin generation. They also play a vital role in limiting the amount of glucose turned out by the liver. In stopping these hormones from being broken down, the drug helps the body to maintain control over blood sugar levels.

Eucreas is not available through our pharmacy. To renew your regular diabetes prescription, we recommend you contact your GP.

Page last reviewed:  23/09/2020


Adhere to the directions issued by your prescriber when taking this medication, and take care to follow the instructions given in the patient information leaflet. Taking these measures will assist you in getting the best possible results from the treatment and lowering the risk of side effects.

  1. Take as directed.
  2. For most cases, this will be one tablet taken twice a day.
  3. One tablet should be taken in the morning, and one in the evening. Swallow whole with water. Take with or after a meal.
  4. You may need to have your liver and kidney function monitored while using this item.
  5. Do not take more than the amount specified by your prescriber.
  6. If you miss a dose, do not make up for it by taking double the amount. If your next dose is due, simply skip the one you have missed and carry on the treatment as normal.

The above is only a guide. Consult the more detailed instructions provided before use.

Download PDF

Page last reviewed:  23/09/2020
Please read the patient information leaflet for this medicine fully before use:

Eucreas 50mg/850mg

Eucreas 50mg/1000mg

Side effects & Warnings

Side effects

It is essential to be aware of the side effects associated with this treatment, as some may necessitate medical attention. Tell your doctor as soon as possible if you notice any signs of: angioedema, such as a swollen face, tongue or throat, difficulty swallowing, difficulty breathing, sudden onset of rash or hives; lactic acidosis; hepatitis, including yellowing of the skin and eyes; or pancreatitis, characterised by persistent pain in the abdomen.

Very common (1 in 10 people or more):

Diarrhoea, nausea, vomiting, pain in and around the stomach, or loss of appetite.

Common (1 in 10 people or less):

Trembling that cannot be controlled, headache, dizziness, metallic taste, or low blood glucose.

Uncommon (1 in 100 people or less):

Joint pain, tiredness, constipation, or swollen hands, ankles or feet.

Very rare (1 in 10,000 people or less):

Sore throat, runny nose, fever, or decreased vitamin B12 levels.

This is not a complete list of side effects. If you notice any of the above or anything at all unusual, talk to your doctor. More detailed information on side effects can be found in the leaflet.

Taking it with other medicines

During consultation, let your prescriber know if you are using any other treatments. The following may affect how this product works: glucocorticoids; beta-2 agonists; other drugs for diabetes; diuretics; ACE inhibitors; or drugs affecting the thyroid or nervous system.

Conditions to look out for

This medication should not be used by those who: have or have had serious complications related to diabetes, such as diabetic ketoacidosis; have recently had a heart attack or other heart problems; are due to have a contrast x-ray; have kidney problems; have a severe infection; or are seriously dehydrated.

It may also not be suitable for those: with liver problems; who drink alcohol excessively; who are breastfeeding; with a disease of the pancreas; taking sulphonylurea; who have previously taken vildagliptin but had to stop due to liver disease: or who are due to have surgery. 

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, do not take Eucreas. If you are planning to become pregnant, ask your doctor for advice before using this medicine.

Driving and using machines

Do not drive or operate machinery if you become dizzy while taking Eucreas.

Food, drink and alcohol

Excessive alcohol consumption can increase the risk of side effects, and should be avoided.

Lactic acidosis

Please refer to the leaflet provided for detailed guidance on lactic acidosis before using this treatment.

Page last reviewed:  23/09/2020
Please read the patient information leaflet for this medicine fully before use:

Eucreas 50mg/850mg

Eucreas 50mg/1000mg


Can I still drink alcohol?

Alcohol may increase the risk of lactic acidosis. Do not drink excessive amounts while using this treatment.

Will I still be able to drive?

Yes, but if you notice any side effects which may make driving unsafe, refrain from doing so and let your doctor know immediately.

Can I take the medicine while pregnant?

It is not suitable for use during pregnancy or breastfeeding.

How should I store it?

Keep it in a safe place below 30°C.

Am I allergic to anything in the medicine?

This drug contains: vildagliptin, metformin hydrochloride, hydroxypropylcellulose, magnesium stearate, hypromellose, titanium dioxide (E171), yellow iron oxide (E172), macrogol 4000 and talc.

Do not take it if you are allergic to any of these ingredients.

Is it available over-the-counter?

It is not possible to buy Eucreas online without a prescription. See your GP to be prescribed this item.

Is it right for me?

Talk to your GP or consultant if you are concerned that your current treatment isn’t working as well as it should, or if you would like to know more about other diabetes medicines.

We do not offer Eucreas through our online service.

Page last reviewed:  23/09/2020
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