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Sitagliptin/Metformin Hydrochloride

Janumet is a combined tablet treatment for type-2 diabetes. Two classes of ingredients are contained in it, and these work by assisting the body to produce and better utilise insulin.

We do not provide this medication through our site. Refer to your GP to have your prescription for this item renewed.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

31 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 31 August 2020
Product information

Janumet is a prescription tablet used to treat diabetes, made by Merck Sharp and Dohme, or MSD. Its two main active ingredients work by: helping the body to produce insulin; making the body’s cells more receptive insulin; and limiting the amount of glucose made by the liver. The standard course of treatment is one tablet, taken twice a day with or after food.

  1. Effective treatment for diabetes
  2. Twice daily dose
  3. Made and marketed by MSD

Type-2 diabetes accounts for an estimated nine tenths of all diabetes cases in the UK. It’s a staggering figure, given that around 3 million people in total are suspected to have diabetes of some form in this country. A progressive condition, type-2 diabetes is slightly different from type-1, in both its biological traits and its onset.

Glucose, which is a type of sugar, is required by the body for regular healthy function. These are absorbed through food in the intestine and produced by the liver, and eventually make their way into the bloodstream. Insulin is a chemical which plays an integral role in extracting these sugars and delivering them to the areas of the body that need them.

Someone with type-1 diabetes will usually not produce any insulin at all, due to the immune system attacking those pancreatic cells which make it; whereas a person with type-2 may generate insulin to a certain extent, but not enough to be able to cope with the amount of glucose in the blood. The onset of type-1 usually takes place during a person’s teenage years, while type-2 is much more likely to manifest in those aged 40 and over.

Causes of the condition are never usually one particular factor. In fact, there are a number of habits and general health traits which might make a person more susceptible to type-2 diabetes. These include having a family history of the condition or being overweight or obese. Persons from certain ethnic background are also more likely to develop the condition. It has a rate of incidence in South Asian and Chinese persons which is higher than that of UK persons, and also higher in persons of Black African or Caribbean origin.

What makes the condition a potentially dangerous one is its gradual nature of commencement. Often, someone with type-2 diabetes might live with the condition for years, before it is discovered. Symptoms include dryness in the eyes, which can induce sight problems of varying degrees; feeling tired; and an increased need or urgency to pass urine. Left untreated, the condition can lead to the development of serious health issues, such as kidney failure and heart disease, so seeking treatment as soon as possible is important.

Upon diagnosis, one of the first things a doctor will address when deciding on the best course of treatment is the patient’s lifestyle. Reducing alcohol intake, stopping smoking, and taking measures to lose weight are also possible courses of action. They may choose to suggest a particular diet plan, and advise a programme of exercise.

In some cases however, the above may not be sufficient enough to slow down the progression of the condition, or bring blood sugar levels under control. Prescription treatment in these instances may be necessary. Janumet is one such treatment, and as a combination medication, this is intended for use in those cases where a single-agent option has not produced the desired results.

The functioning constituents of Janumet are sitagliptin and metformin hydrochloride. Belonging to the biguanide category of drugs, metformin works by: inhibiting the generation of sugar by the liver; increasing the receptiveness of muscular cells to insulin in the body; and decelerates glucal absorption from food in the gut. Sitagliptin is a type of protein inhibitor. Its function is to prevent the breaking down of certain hormones which encourage the pancreas to produce insulin, and to also limit the output of sugar by liver cells.

Janumet is not available to buy through our online pharmacy. See your GP if you are looking to renew your prescription for this item.

Page last reviewed:  31/08/2020


Take care to follow the directions issued by your prescribing doctor when using this treatment, and read the instructions provided in the leaflet carefully prior to use. This will help you to reduce the likelihood of side effects and optimise the efficacy of the product.

  1. Use as prescribed.
  2. In most cases, this will be one tablet taken twice daily.
  3. Swallow hole with water.
  4. To aid digestion, it is better to take your tablet with a meal.
  5. Maintain the diet specified for you by your doctor if you have been issued with one.
  6. If you are due to have tests or surgery, your administration may need to be adjusted to accommodate this.
  7. Never take more than the amount prescribed by your doctor.
  8. Forgotten doses should not be compensated for with double doses. In the event that you miss a dose, try to take it with food as soon as you remember. If this is not possible because your next dose is due, skip the one you have missed and carry on the course as normal.

This does not constitute a detailed list of directions. For more comprehensive instructions, you should refer to the leaflet supplied with the product.

Download PDF

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Janumet 50mg/1000mg

Side effects & Warnings

Side effects

It is crucial to be aware of potential side effects this item may cause prior to use, so that you can act accordingly in the event that they occur. Let your doctor or nearest hospital know right away if you experience any signs of the following: pancreatitis, such as severe stomach pain which travels through to the back; lactic acidosis, including feeling or being sick, stomach ache, muscular cramps, unexplained weight loss, rapid breathing, or feeling cold or uncomfortable; or an allergic reaction, such as a skin rash, hives, and swelling of the face, lips, tongue, or throat.

Common (1 in 10 people or less):

Low blood sugar, flatulence, feeling or being sick.

Uncommon (1 in 100 people or less):

Stomach ache, diarrhoea, constipation, drowsiness, dizziness, headache, dry mouth, infection of the upper respiratory tract, stuffy or runny nose, sore throat, or arm or leg pain.

The above is only a summary of the side effects this treatment may cause. For more detailed information, refer to the leaflet provided.

Taking it with other medicines

Inform your doctor of any other treatments you are taking, as these may affect your capacity to use this product. It may not be suitable for those who are taking: corticosteroids; ACE inhibitors; diuretics; beta-sympathomimetics; iodinated contrast agents or alcohol-containing medicines; cimetidine; or digoxin.

Conditions to look out for

Tell your prescriber about any medical conditions you have or have had in the past. Do not take this treatment if you: have ever had diabetic ketoacidosis or a diabetic coma; have problems with your kidneys; have a severe infection or are dehydrated; are going to have an X-ray where you will be injected with a dye; have recently had a heart attack or have severe circulatory problems; have liver problems; drink alcohol to excess, be it every day or only from time to time; or are breast-feeding.

It may also not be suitable for those with a history of; pancreatitis; gallstones; or type 1 diabetes; or those who are due to have an operation under general anaesthetic. 

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, do not take Janumet. Ask your doctor for advice if you are trying to conceive.

Driving and using machinery

Do not drive or operate machinery if you become dizzy, or experience any side effects which may affect your concentration.

Food, drink and alcohol

You should avoid consuming excessive amounts of alcohol, as it may heighten the risk of side effects.

Lactic acidosis

Refer to the leaflet supplied for more information on lactic acidosis.

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Janumet 50mg/1000mg


Can I still drink alcohol?

Excessive levels of alcohol consumption should be avoided when taking this treatment, as it may increase the risk of harmful side effects.

Will I still be able to drive?

Yes, provided you experience no side effects which may affect your ability to do so. If you do get any side effects, refrain from driving and let your doctor know immediately.

Can I take the medicine while pregnant?

It is not suitable for use during pregnancy or breastfeeding.

How should I store it?

Keep it in a safe place below 30°C.

Am I allergic to anything in the medicine?

This product contains: sitagliptin, metformin hydrochloride, microcrystalline cellulose (E460), povidone K 29/32 (E1201), sodium lauril sulfate, sodium stearyl fumarate, poly(vinyl alcohol), macrogol 3350, talc (E553b), titanium dioxide (E171), iron oxide red (E172), and iron oxide black (E172).

Do not use it if you are allergic to or unable to tolerate any of the above ingredients.

Is it available over-the-counter?

You will require a prescription in order to be able to buy Janumet. This is so that a doctor can ensure it is suitable prior to use.

Is it right for me?

Which prescription medication you use will be determined by your GP or specialist consultant, following your regular diabetes review.

Janumet is not available on our site. See your GP to get your prescription for this medication.

Page last reviewed:  31/08/2020
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