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Hydrocortisone butyrate

Locoid cream and ointment are corticosteroid treatments for eczema. These topical medications are manufactured and marketed by Astellas. They are used to reduce inflammation caused by skin conditions.

This item is not available from our pharmacy. If you are seeking eczema treatment, speak to your GP.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

31 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 31 August 2020
Product information

Locoid is a topical corticosteroid treatment that is available in cream and ointment forms. It is manufactured by Astellas and used to reduce the unpleasant symptoms caused by skin conditions such as eczema. The active ingredient is hydrocortisone butyrate which reduces the release of the chemicals that cause the skin’s inflammatory response. Locoid treatments are available to buy from our efficient online pharmacy.

  1. Available as a cream or ointment
  2. Applied twice daily
  3. Branded medication

Eczema, also known as dermatitis, is a common skin condition characterised by inflamed, red, dry and thickened patches. In more severe cases people can develop lumps and blisters as well as weeping and crusty areas. Eczema affects people of all ages and is most commonly diagnosed in children. However, one in twelve adults in the UK live with this condition. Eczema tends to affect specific areas of the body; such as the knees, elbows, scalp, hands, cheeks and neck.

Dermatitis occurs when the skin is unable to produce the right amount of fats and oils it needs in order to retain moisture efficiently. This reduces its effectiveness and makes it prone to irritation when it comes into contact with certain substances. Common triggers for the condition include detergents, cold or damp weather, foods, clothing material and hormones. It can be difficult to leave irritated skin alone, resulting in scratching and open wounds which can expose the body to germs.

Eczema can lead to further health complications such as infections, psychological problems and difficulty sleeping. People with eczema might be encouraged to reduce scratching by keeping nails short, wearing thin clothing layers and avoiding their triggers. If their dermatitis is linked to a food allergy then they may need to make adjustments to their diet. Symptoms can improve over time with some cases resolving completely. Locoid corticosteroid treatment is available to help manage the problem and can be bought from our UK-based pharmacy.

Locoid cream and ointment work by stopping the body from releasing chemicals which widen the skin’s blood vessels. This reaction usually causes the person to experience inflammation and itching. Without this chemical being released the symptoms are avoided; leaving the skin free from inflammation and swelling. If Locoid treatment does not successfully reduce the symptoms of your eczema then you should seek further medical advice.

If you would like to know more about whether this treatment can help to relieve your symptoms, speak to your GP. They will be able to discuss the available medicine options with you, and issue a prescription where necessary.

Page last reviewed:  31/08/2020


As with all forms of medication; you should use Locoid as directed by your prescribing doctor. Following their instructions should help you reduce the likelihood of developing side effects, and allow you to get the best results from your treatment.

  1. Do not use more than twice daily.
  2. Apply a thin covering of either the cream or ointment to the affected area of skin. 
  3. Wash your hands after use.

These directions are only a brief summary. Your respective patient information leaflet should provide further guidance should you need it.

Download locoid cream PDF

Download locoid ointment PDF

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Locoid Cream

Locoid Ointment

Side effects & Warnings

Side effects

A small number of people may be hypersensitive to the ingredients in Locoid and develop a worsened skin condition. If this happens you should speak to your doctor. The treatment can cause some unwanted side effects but not everyone will experience them.

Rare (1 in 1000 people or less):

Discolouration of skin, worsening of the skin condition once treatment is stopped, spots on the face or thin or red skin.

Very rare (1 in 10000 people or less):

Decreased release of stress hormones.

Taking it with other medicines

Disclose during consultation whether you are using, are thinking about using, or have recently used any other medications.

Conditions to look out for

This product may not be suitable for you if you have: an untreated infection caused by a virus, bacteria, fungus, yeast or parasites; or you have syphilis or tuberculosis; inflamed skin around the mouth; acne or reddened facial skin.

Pregnancy and breastfeeding

Do not use Locoid unless your doctor thinks it is absolutely necessary if you are pregnant, breastfeeding or planning to get pregnant.

Prolonged use during pregnancy is not recommended. Speak to your doctor for advice before using this treatment.

Driving and using machinery

The use of this product is not likely to cause problems with your driving or ability to operate machines.

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Locoid Cream

Locoid Ointment


Can I still drink alcohol?

Yes. However, you should make sure that your alcohol consumption does not disrupt your regular treatment plan.

Will I still be able to drive?

Locoid treatment should not affect your ability to drive or operate machinery.

Can I take the medicine while pregnant?

No. Speak with your doctor if you think you need to use this treatment but are pregnant, trying to conceive or are breastfeeding.

How should I store it?

Store below 25°C but do not freeze or refrigerate. Keep all medications out of sight and reach of children.

Am I allergic to anything in the medicine?

Locoid Ointment:

Hydrocortisone butyrate, liquid paraffin and polyethylene.

Locoid Cream:

Hydrocortisone butyrate, cetostearyl alcohol, macrogol 25 cetostearyl ether, liquid paraffin, white soft paraffin, propyl parahydroxybenzoate (E216), butyl parahydroxybenzoate (E218), citric acid (E330), sodium citrate (E331) and purified water.

Do not use this product if you are allergic to any of its respective ingredients.

Is it available over-the-counter?

No. You will require a consultation with a doctor before you are able to buy Locoid from a UK pharmacy.

Is it right for me?

Talk to your doctor if you are experiencing eczema symptoms, and want to know more about treatment. If required, they will be able to help you decide on the most appropriate form of medication, and initiate a prescription.

Please note that this item is not currently available through our site.

Page last reviewed:  31/08/2020 is rated 4.9 out of 5 by 3129 customers on TrustPilot!
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