Spedra (avanafil) is an oral medication for erectile dysfunction. It belongs to a group of treatments called PDE-5 inhibitors, which also includes Viagra and Cialis. These drugs are most commonly prescribed treatments for erectile dysfunction due to the fact that they are well tolerated and produce few negative interactions with other medications, and are generally safe for use with some underlying conditions.

However it isn’t suitable for everyone. If you are taking certain medications or having particular health conditions, it might pose a much higher and more serious risk of side effects. So it is important that you inform your prescribing clinician of any other medications that you are taking, in order for them to be able to prescribe Spedra safely, and minimise side effects or serious health risks.

Spedra drug interactions

All substances in the body have the potential to interact with one another, including food, herbal supplements and over the counter medications. For the most part, these can co-exist in the body without causing any concern, but in specific circumstances, these can produce anything from a heightened possibility of side effects to serious health risks.

It is not always possible to predict how a medication will be tolerated by any individual, or whether some known interactions will cause the issues outlined above, but there are drugs that are known to make use of Spedra dangerous. These interactions will be understood by your doctor, who will be able to adjust your treatment accordingly.

Interactions for erectile dysfunction medications

When PDE5 inhibitors were first released onto the market, due to their convenience and effectiveness, they were seen as a major breakthrough in the treatment of erectile dysfunction. 

Oral treatments can cause more issues with drug interactions, however, as they are absorbed entirely into the system, which makes them unsuitable for a minority of people.

Caverject, MUSE and Vitaros belong to a group of medications known as PGE-1 prostaglandins. These have proven to be a well-tolerated alternative to the likes of Viagra and in some cases might even prove more effective. It is therefore important to note that there are many options available to treat erectile dysfunction.

Taking avanafil (Spedra) with other medications

Once you have informed your doctor of any other treatments you are currently taking, including herbal supplements or over the counter medications, they will be able to prescribe you the appropriate drugs for the condition. It is possible that they might alert you to some possible issues with another treatment being used alongside Spedra but still recommend the treatment, perhaps at a lower dosage.

In some circumstances, they will need to weigh up the benefits and risks associated, and may not recommend Spedra and instead suggest an alternative. If you require further data on Spedra, you can always refer to the patient information leaflet that comes with your medication and lists all interactions, as well as contraindications, side effects and their frequency.

The following medications cannot be used alongside Spedra: nitrates, ritonavir, indinavir, saquinavir, nelfinavir, atazanavir, ketoconazole, itraconazole, voriconazole, clarithromycin or telithromycin.

Your doctor may suggest another treatment is more suitable if you are taking any of the following: alpha-blockers, quinidine, procainamide, amiodarone, sotalol, erythromycin, phenobarbital, primidone, carbamazepine, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, verapamil and riociguat.

Spedra with food and drink

Spedra can be taken with or without food, although the time it takes to work can be significantly slower when ingested with a large meal. You should avoid drinking grapefruit juice within 24 hours of taking Spedra.

Alcohol consumption is generally safe alongside this medication, but it can lower blood pressure and cause dizziness. Alcohol can contribute towards ED problems and may render this treatment less effective, so it is not recommended that you consume alcohol while using Spedra.

High alcohol consumption is one of the main causes of erectile dysfunction and your doctor will likely decide to treat this underlying cause before prescribing Spedra if this applies to you.

Page last reviewed:  23/07/2020