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Spedra (avanafil) is a fast-working treatment for erectile dysfunction.

To buy Spedra online, take our questionnaire to start your consultation. All of our orders are reviewed by qualified clinicians. Once approved, your order will be delivered by 24-hour courier in discreet packaging. 

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The price below are inclusive of your consultation, prescription, the medicine itself and secure next-day shipping from our UK pharmacy.

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Spedra (avanafil) is a fast-working treatment for erectile dysfunction.

To buy Spedra online, take our questionnaire to start your consultation. All of our orders are reviewed by qualified clinicians. Once approved, your order will be delivered by 24-hour courier in discreet packaging. 

This content was reviewed by a clinician on

26 April 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 26 April 2022
Product information

What is Spedra Menarini

Spedra is one of the newer treatments available for erectile dysfunction. It was launched in the UK in 2014 by Italian laboratory Menarini. It is marketed in the US as Stendra. The main selling point of this medicine is its rapid response time; in many cases, Spedra tablets have shown noticeable results in as little as 15 minutes, making it quicker on average than other tablets such as Viagra and Levitra. You can buy Spedra online in 50, 100 and 200 mg tablets from our UK pharmacy.

Active ingredient: avanafil

The functioning agent in Spedra is a PDE5 inhibitor called Avanafil. This works in a similar way to sildenafil citrate (Viagra) and vardenafil (Levitra), by limiting the activity of an enzyme present in the body, PDE5.

How does PDE5 affect ED?

Enzymes in the body work to provide balance. In the case of PDE5, the enzyme helps to manage blood flow, and allows blood vessels to tighten and contract. However, erections are enabled by blood rushing to the penis, and when this process becomes interrupted or impaired, erectile problems can often result. Spedra works to reduce the activity of PDE5, thereby permitting blood to rush more freely to the penis during periods of sexual arousal.

How common is ED?

Some men with erectile dysfunction might find the prospect of confronting the condition a daunting one, but it is important to remember that it is very common. Many doctors posit that most men will experience erectile dysfunction at some point in their lives. In the UK, it is estimated that as many as 40 per cent of men over 60 and 50 per cent of men over 70 will run into erectile problems.

Nonetheless, impotence can be tough for men to speak to their doctor about in person. This is why many men looking to buy Spedra or other treatments for erectile dysfunction might do so online.

What causes it?

The possible causes of ED, otherwise known as impotence, are numerous. Conditions like high blood pressure and decreased circulation can lead to ED, making age very much a factor; while lifestyle habits, such as alcohol consumption and drug use can also be contributing factors. Sometimes the condition can be caused by much more simple circumstantial factors, such as stress or anxiety. These are more commonly the cause in younger men, who may feel more pressured to perform sexually during the early stages of a relationship.

How do Spedra tablets work?

The main operating ingredient in Spedra is a substance called avanafil. This belongs to the PDE5 inhibitor class of medicines, which also includes sildenafil and vardenafil. Like Levitra and Viagra, the active component in this treatment works by restraining the function of an enzyme (PDE5).

  1. Easy-to-take single tablet.
  2. Works in just 15-30 minutes.
  3. Can produce effects for up to 5 hours.

An erection is the biological result of a chain of chemical events taking place in the male body, which come about as a result of sexual stimulation. However, certain circumstances can sometimes endeavour to limit this process. Stress, poor dietary habits or diabetes can all result in reduced circulation - and blood flow is a necessary part of the biological process required for an erection.

Enzymes play an important role in how our bodies function. PDE5 works to monitor and keep blood flow under control. PDE5 can also have a restricting effect on blood vessels around the penis, which can lead to weakened erectile activity. By tempering the effects of PDE5, avanafil allows for more consistent blood flow to the penis, granting the user stronger and longer-lasting erections.

What doses of Spedra are available?

Spedra tablets come in three doses (50mg, 100mg and 200mg) all of which are available to buy online from our UK pharmacy. Which strength you are prescribed will largely depend on if you have used impotence treatment before, and how sensitive you are to potential side effects.

  1. Spedra 100mg

The typical starting dose is 100mg, for men who are generally healthy.

  1. Spedra 50mg

In cases where a man has tried the starting dose, found that it worked well, but experienced mild side effects, a doctor might recommend lowering to 50mg, which is the smallest dose.

Typically, when prescribing any medication, a doctor will attempt to offer the lowest dose known to be effective, to help lower the risk of side effects. We recommend that first-time users ordering Spedra through our service start with the 50mg dose.

  1. Spedra 200mg

In other cases, where the starting dose has produced a less than sufficient response, and no side effects have been observed by the patient, then a doctor may recommend increasing to 200mg, which is the highest dose.

What to look for when you buy Spedra online

Buying prescription medicines online in the UK is easy, convenient and safe, but only provided you do so from a GPhC-registered dispensing pharmacy.

So if you're purchasing medication over the internet, always be aware of the following:

Whenever you buy Spedra or any other prescription treatment online, check to make sure the website you are using is affiliated with a registered dispensing pharmacy. You can do this by checking their entry in the GPhC register: in most cases, the site will provide a link to their entry via the green cross logo (as we have done at the top of this page).

Can you get Spedra on the NHS?

Some men are entitled to Spedra on an NHS prescription. However, to be entitled to buy Spedra at the NHS levy, or get it for free, the patient must meet certain medical criteria.

Those searching for Spedra online should be aware that no generic treatment containing avanafil is currently available. Patients should also be aware that the US version known as Stendra is not available to buy in the UK. Here, it will only be sold by registered pharmacies as Spedra. You should never use online pharmacies which offer to sell generic medicines which do not exist or promise to let you buy Spedra or other erectile dysfunction treatments without a prescription. They may be offering counterfeit products and are very likely operating outside the law.

Our service

At Treated.com we work with practising doctors, registered pharmacy prescribers and a UK-based pharmacy to provide the best and safest possible service to our customers. Those who want to find out if Spedra Menarini can help them can take our short medical consultation. If our prescriber is happy that the medication is suitable for you, they will issue a prescription, and we will ship your treatment using our next-day delivery service.

Our UK service operates nationwide meaning that when you buy Spedra online from us, no matter where in the country you are, you can expect to receive your order within just one working day of approval from our doctor.

Select dose
Page last reviewed:  26/04/2022


When taking medication for ED, it is important to do so in the correct manner, in order to help guarantee its effectiveness, and lower the risk of side effects. Please read the patient information leaflet carefully before you buy Spedra and follow the instructions issued by your prescriber when taking it.

  1. Spedra should be taken half an hour before you intend to engage in sexual intercourse.
  2. Take no more than one tablet in any 24-hour period.
  3. Taking Spedra after eating a large meal may slow down its response time.
  4. You and your partner will still need to engage in sexual foreplay for Spedra to be effective.
  5. Never use more than the amount prescribed by your doctor.

You can find more information on the safety leaflet supplied. If you are still unsure about how to use this medicine, speak to your doctor or pharmacist.

Do not take recreational drugs when taking Spedra, as this can be extremely dangerous.

Page last reviewed:  26/04/2022
Side effects & Warnings

Side effects

Our clinical team has your safety as their priority and will never allow you to buy Spedra or any other medicine if they suspect it is unsuitable for you. However, you should be aware that side effects remain a possibility in any situation. Whenever you use medication of any kind, you should familiarise yourself with the potential side effects, so that you can take the most pertinent course of action should they occur.

Common (1 in 10 people):

Headache; facial flushing; stuffy nose.

Uncommon (1 in 100 people):

Dizziness; drowsiness; blocked sinuses; hot flushes; back pain; increased heart rate; blurred vision; indigestion.

Rare (1 in 1000 people):

Abdominal pain; diarrhoea; rash; penile bleeding; gout; flu or flu-like symptoms; muscle ache; increased urinary frequency; skin irritation.

This is not a full account of the possible side effects associated with this medicine. For a more detailed list, please read the safety information leaflet provided with the product, or speak to your GP.

You should see a doctor immediately if you experience any side effects of any kind, including a prolonged erection (priapism).

Taking it with other medicines

It is vital to inform your doctor of which, if any, medications you are already using, as they may preclude your use of this treatment. You should never commence using a new treatment or desist from using an old one in preparation for your consultation without explicit permission from a doctor. This includes prescription treatments, non-prescription treatments and over-the-counter remedies.

The following treatments may make Spedra unsuitable for use: nitrates, HIV/AIDS medicines, antifungals, alpha-blockers, medicines for irregular heartbeat, antibiotics, epilepsy medicines, amprenavir, aprepitant, diltiazem, fluconazole, fosamprenavir, or verapamil.

Never use Spedra in conjunction with other treatments for ED.

Conditions to look out for

Those who have or have had any of the following should not buy Spedra and avoid using the medication: an allergy to any containing ingredients; a heart attack in the last 6 months; severe liver or kidney problems; angina; uncontrolled low or high blood pressure; irregular heartbeat; hereditary eye problems.

Those who have or have had the following should only use this medication with the utmost caution: leukemia; sickle cell anaemia; blood disorder; a susceptibility to priapism; any condition which affects the tissue and form of the penis.

For your own safety, you should always declare your medical history to your prescriber during consultation.

You should not buy Spedra and instead consult your doctor if you have a known allergy to avanafil or any of the other containing ingredients.


In healthy volunteers using 200mg doses of Avanafil, no effects on sperm movement were recorded.

Food, drink and alcohol

When using Spedra, you should avoid consuming grapefruit products for 24 hours prior to taking the medicine.

Because it can increase the likelihood of side effects, it is better not to drink alcohol when using this treatment.

Recreational drugs

Recreational drugs, such as cocaine, amyl nitrates and ecstasy, can cause very dangerous reactions with Spedra. If you are taking Spedra, you must not take any recreational drugs.

Driving and using machinery

Spedra can cause side effects such as dizziness or sight disturbances. Do not drive or operate machines if you are affected by these.

Page last reviewed:  26/04/2022

Can I still drink alcohol?

Drinking alcohol while using Spedra may cause your heart rate to increase, or decrease the efficacy of the medication. We would not advise it.

Is there anything else I should know?

Consuming grapefruit juice may heighten your sensitivity to Spedra. It’s better to avoid drinking this for at least a full 24 hours before using the treatment.

Will I still be able to drive?

If you have taken Spedra and experienced side effects which may have impaired your ability to drive, then you should not drive.

How should I store it?

Below 30°C in a dry storage area, away from moisture and sunlight.

Am I allergic to anything in the medicine?

Spedra tablets contain: Avanafil, mannitol, fumaric acid, hydroxypropyl cellulose, low substituted hydroxypropyl cellulose, calcium carbonate, magnesium stearate and ferric oxide yellow (E172).

Do not buy Spedra or use this treatment if you are allergic to avanafil or any of the other ingredients listed above.

Is it available over-the-counter?

No. Prior consultation with a clinician is required. At Treated.com we offer a service which enables you to consult with a doctor or pharmacy prescriber remotely. If our prescriber approves your order, they will produce a prescription for you.

How can I buy Spedra online?

To discover whether Spedra can work for you and buy this treatment online, take our brief questionnaire. A member of our medical team will review your answers and if they approve your order, your medication will be dispatched via secure courier.

Page last reviewed:  26/04/2022
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