Adenuric

Febuxostat

Adenuric tablets use the active ingredient febuxostat to prevent gout flare-ups. A daily dose can stop sodium urate crystals from building up and reduce symptoms.

Please note that we do not offer this medication on our site. See your GP to be prescribed this item.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.
Description

Adenuric tablets contain the active ingredient febuxostat which works to reduce the amount of uric acid in the bloodstream. It is from the group of medicines known as xanthine oxidase inhibitors and is a preventative treatment for gout. Excess amounts of uric acid can build up and cause microscopic crystals to form in the joints and turn into painful gout symptoms.

The body’s uric acid levels are usually managed by the kidneys so that excess urate is excreted in urine and faeces. However, for some people this process fails to work efficiently, leaving a higher amount of urate in the blood and in some cases it can no longer stay soluble. At this stage it can turn into sodium urate crystals which occupy the spaces between joints. The crystals irritate the lining of the joints, called the synovium, making it inflamed and painful to move or touch. The build up of crystals is most commonly found in the extremities, in particular the big toe but also the knees and elbows. Crystals can consequently clump together and form visible bumps under the skin known as tophi which can expand and sometimes cause progressive damage to cartilage and bone.

The NHS estimates that around 1 in 45 people live with gout in the UK. Men over the age of 30 years and women over the age of 60 year are more likely to be diagnosed with gout. However, people of all ages can develop the condition and require treatment.

There are several risk factors which might increase your chances of developing this painful arthritic condition. Health problems such as hypertension, diabetes, kidney disease, high cholesterol and osteoarthritis can lead to gout. In turn some medications used to treat these conditions can also be a contributing factor.

Those who consume a diet high in purines found in food and drinks such as red meat, seafood, offal, beer, spirits and sugary drinks may be more likely to be diagnosed. Gout can also run in families. Your doctor may suggest some lifestyle changes to run alongside your treatment. These changes might include losing weight if you are overweight or altering parts of your diet.

Adenuric tablets prevent symptoms by inhibiting the process carried out by the enzyme xanthine oxidase,which produces uric acid. This in turn reduces the overall amount of urate in the body so that crystals are less likely to form.

Adenuric is not prescribed as an immediate relief for gout symptoms but instead as a long term treatment aiming at preventing gout flare ups.

This medicine is not available to buy from our site. We recommend you make an appointment with your GP if you are having symptoms, or need to renew your prescription for this treatment.

Page last reviewed:  Tuesday, May 23 2017
Directions

Follow the instructions provided by your doctor or pharmacist.

  1. Take as directed.
  2. The tablets should be taken orally, with or without food.
  3. We only prescribe this treatment to prevent gout, not to treat an active flare-up.
  4. If you are having a gout attack at the moment you should wait until your symptoms subside before commencing treatment, or speak to your doctor.
  5. Take your dose every day, even if you are not experiencing gout symptoms and do not stop unless your doctor directs you to.

The directions above are only a brief guide, please refer to the patient information leaflet for more detailed instructions.

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Page last reviewed:  Tuesday, May 23 2017
Side effects & Warnings

As with all medicines, Adenuric can cause side effects, although not everyone will experience them.

If you notice any signs of an allergic reaction you should seek emergency medical treatment. Symptoms might include extremely dangerous skin rashes, blisters or shedding usually in a body cavity such as the mouth or genitals. This is often accompanied by a fever, sore throat, fatigue, enlarged lymph nodes, liver enlargement or failure and increase in white blood cell count. Also if you experience muscle pain or weakness, facial swelling or difficulty breathing you should contact your doctor immediately.

Common (1 in 10 people or less):

Diarrhoea, headache, abnormal liver function test results, rash, nausea, swelling due to fluid retention or increased gout symptoms.

Uncommon (1 in 100 people or less):

Decreased appetite, change in blood sugar levels, excessive thirst, increased blood fat levels, weight increase, loss of sex drive, insomnia, sleepiness, dizziness, numbness, tingling, paraesthesia, altered or reduced sense of taste, abnormal ECG result, irregular heart rhythm, heart palpitations, flushing, increased blood pressure, cough, shortness of breath, chest discomfort or pain, upper respiratory tract infection, bronchitis, dry mouth, abdominal pain, wind, heartburn, indigestion, constipation, more frequent passing of stools, sickness, itching, hives, skin inflammation, skin discoloration, small red or purple spot on the skin, red area of skin covered with small bumps, rash, other type of skin conditions, muscle cramp, muscle weakness, bursitis or arthritis, pain in extremity, back pain, blood in the urine, abnormal frequent urination, abnormal urine tests, kidney malfunction fatigue, chest pain, stones in the gallbladder, kidneys or bile ducts, increase in blood thyroid stimulating hormone (TSH) level, abnormal blood test results, erectile dysfunction.

Rare (1 in 1000 people or less):

Muscle damage, swelling of the deeper layers of the skin, especially around the lips, eyes, genitals, hands, feet or tongue, sudden difficulty breathing, high fever and measles-like skin rash, enlarged lymph nodes, liver enlargement, hepatitis, liver failure, raising of the white-cells count in the blood, reddening of the skin, various skin rashes, Stevens-Johnson Syndrome, nervousness, feeling thirsty, tinnitus, blurred or change in vision, hair loss, mouth ulcers, inflammation of the pancreas: common symptoms are abdominal pain, nausea and vomiting, increased sweating, weight loss, increased appetite, loss of appetite, muscle and/or joint stiffness, abnormally low blood cell counts, urgent need to urinate, changes or decrease in urine amount due to inflammation in the kidneys, jaundice.

This is only a summary of potential side effects associated with Adenuric. The enclosed patient information guide can be referred to for a full breakdown.

Taking it with other medications

During your consultation you should tell the doctor whether you are taking or have recently taken any medications even those obtained without a prescription. Medicines of particular importance include theophylline, azathioprine and mercaptopurine.

Conditions to look out for

Your doctor will want to know if you have or have ever had: heart problems, renal disease, an allergic reaction to allopurinol, liver disease, liver function test result abnormalities, Lesch-Nyhan syndrome or any thyroid problems.

Pregnancy and breastfeeding

Do not use this medicine and speak to your doctor if you are pregnant or breastfeeding, or trying to conceive.

Driving and using machinery

This medication may cause side effects such as dizziness, tiredness or sight problems. Do not drive or use machines if you are affected.

Lactose intolerance

Adenuric contains lactose. Tell your prescriber if you have an intolerance to any sugars.

Page last reviewed:  Tuesday, May 23 2017
Please read the patient information leaflet for this medicine fully before use:

Q&A

Can I still drink alcohol?

Drinking alcohol can exacerbate gout symptoms, so you may want to speak to your doctor about reducing your intake before commencing treatment.

Will I still be able to drive?

Adenuric can cause side effects which may impede your driving. If you experience blurred vision, dizziness, sleepiness or a tingling sensation then you should not drive or operate machinery.

Can I take this medicine while pregnant?

You should not use Adenuric and speak to your doctor if you are pregnant, trying to become pregnant or are breastfeeding.

How should I store it?

Keep out of sight and reach of children. Do not exceed the expiry date.

Am I allergic to anything in the medicine?

The ingredients found in Adenuric are febuxostat, lactose monohydrate, microcrystalline cellulose, magnesium stearate, hydroxypropylcellulose, croscarmellose sodium, colloidal hydrated silica. The film coating is made up of opadry II yellow, 85F42129 containing: polyvinyl alcohol, titanium dioxide (E171), macrogols 3350, talc, iron oxide yellow (E172).

Do not take this product if you are allergic to any of these ingredients.

Is it available over-the-counter?

You can only buy Adenuric tablets with a prescription. This is so that a doctor can first assess your suitability.

Is it right for me?

The gout medication you use will be decided upon during your regular review with your GP or specialist.

Please note that we do not offer treatment gout through our online pharmacy. If you require treatment or need to renew your prescription, we recommend you see your GP in person.

Page last reviewed:  Tuesday, May 23 2017
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