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Zyloric tablets contain the active ingredient allopurinol which helps to prevent the inflammatory reaction that causes gout.

Please note that we do not offer gout medications online. If you need to renew your prescription, or are having a gout attack, contact your GP.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

31 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 31 August 2020
Product information

Zyloric tablets are manufactured by Aspen Pharma and use the active ingredient allopurinol to prevent painful gout symptoms. Between 100 and 900 milligrams are usually prescribed daily in order to defend against a gout attack.

  1. Prevents painful gout symptoms 
  2. Branded treatment
  3. Common arthritic condition

Gout is a common arthritic condition which mostly tends to affect men, but can affect women too. It occurs when the body fails to excrete enough of the waste product known as uric acid or urate. This buildup can cause microscopic crystals of sodium urate to form and cluster in and around the spaces in between joints. Over a number of years the accumulation of crystals can eventually start to cause problems. Pain is caused by inflammation of the soft lining of the joint known as the synovium and the formation of tophi, a group of crystals which form an expanding lump which can impede on cartilage and bone sometimes leading to irreversible joint damage.

There are certain lifestyle and health factors that may raise your risk of gout. For example your chances of developing symptoms will increase as you get older; with men more likely to experience symptoms after the age of 30 and women after the age of 60. If you are overweight, have high blood pressure, high cholesterol or diabetes or have a close family member with gout you are more likely to be diagnosed. Beer, spirits or a diet high in purines found in red meat, seafood and offal, can sometimes trigger flares.

The joints which are most commonly affected are the feet, knees, hands and elbows. If you do not seek treatment for gout then you may go on to experience more frequent and more severe episodes. Also, as mentioned earlier, a small amount of gout cases can lead to permanent joint damage so it is important to get treated as soon as possible. Your doctor may also advise you to make some lifestyle changes such as losing weight if you are overweight or altering your diet if you are consuming too much of the potential triggers.

Zyloric is from the group of medicines known as xanthine-oxidase inhibitors. It works to reduce the number of urates in your blood and therefore reduce the likelihood of sodium urate crystals forming. It is used as a preventative measure for those at risk of a gout flare up.

This treatment is not available on our site. If you need to renew your prescription for this item, speak to your doctor.

Page last reviewed:  31/08/2020

Always follow the instructions from your doctor or pharmacist. The directions given to you are to ensure your safety, to minimise side effects and to help you get the best outcome from the product. 

We only prescribe this medication for the purposes of preventing gout symptoms in those who have already been diagnosed with the condition. If you are having an active flare, we recommend you speak to your doctor in person.

  1. Swallow the tablet whole with a drink of water.
  2. Take with food or just after eating.
  3. Make sure that you follow your doctor’s dosage instructions carefully.
  4. Never take more than the prescribed amount. If you take more Zyloric than you should then you will need to see a doctor straight away.
  5. Never take a double dose in order to make up for a missed dose. Instead, take the forgotten tablet as soon as you remember or if it is almost time for your next dose, skip the missed one. 

The directions provided here are only a guide. Prior to commencing treatment, take some time to read and understand the instructions provided in the patient leaflet.

Download PDF

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Zyloric 300 mg

Zyloric 100 mg

Side effects & Warnings

All forms of medication have the potential to cause unwanted side effects. The following side effects will not affect every Zyloric user, nevertheless it is important to make yourself familiar with them in case you need to seek medical attention should they occur.

An allergic response to the medication might include a skin rash, flaking skin, boils or sores on the mouth, wheezing or a tight chest, fever, joint pain and abnormal blood and liver function tests. If you experience any of these side effects stop taking Zyloric straight away and speak to your doctor.

Rare (1 in 1000 people or less):

Joint pain; painful swelling in the neck, armpits or groin; jaundice; nausea or sickness; conjunctivitis; flu-like symptoms; skin changes such as ulcers, blisters or peeling skin and bleeding lips, genitals, eyes, mouth or nose.

Very rare (1 in 10000 people or less):

High temperature, haematuria, higher cholesterol, feeling unwell, weakness, numbness, paralysis, unsteadiness, headache, dizziness, drowsiness, change in vision, chest pain, high blood pressure, slower pulse, male infertility, erectile dysfunction, enlarged breasts, change in bowel habit, change in taste, hair loss, hair discolouration, fits, depression, oedema particularly in the ankles, diabetes.

Taking it with other medications

Inform your doctor during consultation if you are taking or have recently taken any of the following medications: aspirin, epilepsy drugs, theophylline, didanosine, antibiotics, cancer drugs, immunosuppressants, diabetic drugs, diuretics, treatment for heart problems or high blood pressure, anticoagulants or any other gout medication.

Conditions to look out for

Make sure you disclose details of your past medical history during consultation, particularly if you have or have ever had problems with your liver or kidney, high blood pressure or heart problems, or have lactose intolerance.

We do not issue this treatment through our service to patients with active gout symptoms. If you are having a flare-up and require treatment, your doctor will need to examine your symptoms in person.

Pregnancy and breastfeeding

Check with your doctor before using this medication if you are pregnant, breastfeeding or trying to become pregnant.

Driving and using machinery

Do not drive or operate machines if you become tired or dizzy, or experience any other side effects that could inhibit your concentration.

Lactose intolerance

If you have any sugar intolerances, tell your prescriber. This medication contains lactose.

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Zyloric 300 mg

Zyloric 100 mg


Can I still drink alcohol?

You should avoid drinking alcohol when taking treatment for gout as it can be a trigger for an attack.

Will I still be able to drive?

There is a chance that you might experience feelings of giddiness or drowsiness and notice changes in your coordination. If these side effects occur you should not drive or operate machinery.

Can I take this medicine while pregnant?

You should have a discussion with your doctor before you take this product if you are pregnant, trying to conceive or are breastfeeding.

How should I store it?

Keep in the original packaging, under 25°C and away from children.

Am I allergic to anything in the medicine?

Zyloric contains allopurinol, lactose, maize starch, povidone and magnesium stearate. If you have an allergy to any of these ingredients do not take this product.

Is it available over-the-counter?

In order to purchase Zyloric you will need a prescription from a doctor.

Is it right for me?

Your GP will help you to decide on the most suitable treatment at your regular gout review.

Gout medications are not available to buy from our pharmacy. See your GP if you need to renew your prescription for this treatment.

Page last reviewed:  31/08/2020 is rated 4.9 out of 5 by 3209 customers on TrustPilot!
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