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Esomeprazole Magnesium Trihydrate

Nexium is used to relieve heartburn and other conditions related to gastro-oesophageal reflux disease. It is marketed in the UK by AstraZeneca.

Getting prescription help for heartburn is easy with our secure service. Complete a medical questionnaire, and your answers will be assessed by a qualified doctor. Confirmed orders are shipped to arrive the following day.

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Nexium Granules10mg

One sachet of Nexium granules contains 10mg of the functioning ingredient esomeprazole. These are taken as instructed by your prescriber.

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This tablet contains 20mg of esomeprazole. Take according to your prescriber’s instructions.

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These tablets contain 40mg of the active ingredient esomeprazole, and should be taken as directed by your doctor.

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You can highlight a preferred treatment, dose or amount to our prescriber, but to ensure your safety the final decision on any treatment you are offered is always the prescriber's. After your consultation, our prescriber may suggest a different treatment, or dose or amount of treatment (or not recommend treatment at all).

Please note: this service is not to be used in an emergency. Call 999 if you need urgent medical attention.
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Nexium is used to relieve heartburn and other conditions related to gastro-oesophageal reflux disease. It is marketed in the UK by AstraZeneca.

Getting prescription help for heartburn is easy with our secure service. Complete a medical questionnaire, and your answers will be assessed by a qualified doctor. Confirmed orders are shipped to arrive the following day.

This content was reviewed by a clinician on

24 August 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 24 August 2021
Product information


Nexium granules and tablets contain the proton pump inhibitor esomeprazole, which reduces levels of acid generated in the stomach. This eases the symptoms of gastro-oesophageal reflux disease, such as heartburn and acid reflux. The tablets are taken whole with water, while the granules are dissolved in water before being swallowed.

  1. Available as granules and as tablets
  2. Effective remedy for heartburn
  3. Commonly prescribed treatment

Heartburn is one of the more frequently experienced symptoms of a condition called gastroesophageal reflux disease (referred to GORD or GERD). It is an uncomfortable feeling in the chest which is caused when natural acids in the stomach travel against the digestive flow, up into the food pipe or oesophagus. The acid can also reach up to the throat, causing a burning, sour sensation, which is known as acid reflux.

(Occasionally, burning pain in the chest can also be a sign of heart disease, so it is important to see your doctor as soon as possible if you are having this type of pain for the first time, or if you are feeling pain which is more severe than usual.)

GORD occurs when the ring of muscle situated between the oesophagus and stomach becomes loose and allows the acid to secrete from the stomach upwards. There are a number of circumstances which can bring about GORD, such as smoking, eating too much fatty food or drinking too much alcohol or coffee, or being overweight. It can also be caused by stress or pregnancy, and a family history of the problem is thought to be a risk factor.

Those with heartburn can introduce lifestyle changes to reduce the severity of the condition. A healthier diet, exercise, giving up smoking and even raising the head of your bed when sleeping can all help. However, in cases where symptoms persist, and over the counter remedies do not prove to be effective, a prescription medicine may be recommended.

The functioning substance in AstraZeneca Nexium is esomeprazole, which is a proton pump inhibitor. In the body, proton pumps are positioned in the lining of the stomach and it is these that produce digestive acid. Esomeprazole reduces the amount of acid which is generated, preventing it from overflowing into the oesophagus.

Nexium is also used for other conditions related to the production of acid in the stomach, including the prevention and treatment of ulcers in those who take nonsteroidal anti-inflammatory drugs (NSAIDs) on a long term basis, and ulcers in the digestive tract caused by the bacteria helicobacter pylori.

You can renew your prescription for Nexium granules or tablets online in just a few minutes, with our simple consultation service. Take our questionnaire, and a practising doctor will review your case. Once approved, your medication will be dispensed by our UK pharmacy.


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Page last reviewed:  24/08/2021


Read the directions given in the patient information leaflet carefully and follow any special instructions given to you by your clinician. This will help to reduce the chances of side effects and optimise the performance of the product.

  1. Administer the treatment as directed.
  2. Your dosage will be determined by your prescriber, depending on your condition and the severity of symptoms.

Nexium Granules

  1. Each sachet of Nexium granules contains 10mg of esomeprazole.
  2. Empty the sachet into a glass of water. Each sachet should be diluted in 15 ml of water (three teaspoons) so two sachets would require 30 ml of water, and so on.
  3. Stir the water containing the granules and wait a few moments for the mixture to thicken.
  4. Stir the mixture once again then drink. If there are granules left at the bottom of the glass, add a little more water and drink what is left.
  5. Do not allow the mixture to stand for longer than half an hour.

Nexium Tablets

  1. Swallow tablets whole with water.
  2. The tablets can be taken at any time of day, with food or on an empty stomach.
  3. If you have trouble swallowing the tablets, these can also be placed in water and mixed to make taking them easier. To do so, drop the tablets into a glass of water and stir, without crushing. Drink within 30 minutes.

For both versions:

  1. If you forget to take a dose of Nexium, you can take it as soon as you remember, but not if it is almost time for your next dose.
  2. Do not take double doses to compensate for ones you have missed.
  3. If you have missed a dose and your next one is due, omit the one you have missed and take your next dose at the scheduled time.

These directions are provided solely as a guide. Consult the patient information leaflet for more detailed instructions.

Download Nexium tablets patient information leaflet

Download Nexium granules patient information leaflet

Page last reviewed:  24/08/2021
Please read the patient information leaflet for this medicine fully before use:

Nexium Granules 10mg

Nexium 20mg

Nexium 40mg

Side effects & Warnings

Side Effects

Not everyone who takes this medicine will experience side effects, but it is important to be aware of what they are before beginning the course. You should see a doctor straight away if you have an allergic response to this medication, which might include facial swelling, difficulties swallowing or breathing, wheezing or fainting.

Common (1 in 10 people or less):

Vomiting or nausea, wind, stomach ache, constipation, diarrhoea, or headaches.

Uncommon (1 in 100 people or less):

Drowsiness or sleeplessness, changes in liver function, dry mouth, lightheadedness or vertigo, hives, paraesthesia (pins and needles), or swollen feet or ankles. There is also a risk of hip, waist or spine fractures if the treatment is used long term.

Rare (1 in 1,000 people or less):

Blood disorders, disturbed vision, thrush, hair loss, jaundice, hepatitis, pains in the joints or muscles, anxiety or depression, sweating, changes in taste buds, or shortness of breath.

Very rare (1 in 10,000 people or less):

Hallucinations, feelings of anger or hostility, changes to blood count, acute kidney or liver conditions, blistering and peeling of skin, or severe rashes.

The above is only a summary. Please refer to the leaflet for a more detailed list of side effects.

Taking it with other medicines

Make sure that you disclose as much information as possible about other medicines you are taking when completing your questionnaire. It should not be taken alongside nelfinavir, which is prescribed for HIV infection.

Your prescriber will take special care issuing you with this item if you are using any of the following: the HIV antiretroviral atazanavir; diazepam; digoxin; phenytoin, the blood clot inhibitor clopidogrel; rifampicin; tacrolimus; the antidepressants imipramine, citalopram, or clomipramine; erlotinib or methotrexate (both used to treat cancer); the antifungal drugs itraconazole, ketoconazole or voriconazole; cisapride; cilostazol; the blood thinning agents warfarin or coumarin; or natural products that contain extracts of St John’s Wort.

Conditions to look out for

Do not use Nexium if you are allergic to any of the ingredients contained in it, or other proton pump inhibitors such as pantoprazole or lansoprazole. It is particularly important to inform your prescriber if you have kidney or liver disease, or have previously experienced skin irritation or inflammation when using this or similar treatments.

Pregnancy and breastfeeding

You will need to check with your doctor before taking this medication if you are pregnant or trying to conceive.

Do not use Nexium if you are breastfeeding.

Driving and using machinery

If you notice any side effects such as dizziness or sight problems, do not drive or try to use machines.

Sucrose or glucose intolerance

If you have ever been told that you have an intolerance to certain types of sugar, let your prescriber know. Nexium contains sucrose and glucose.

Page last reviewed:  24/08/2021
Please read the patient information leaflet for this medicine fully before use:

Nexium Granules 10mg

Nexium 20mg

Nexium 40mg


Can I still drink alcohol?

It is not thought that Nexium will interact with alcohol. However, excessive alcohol consumption can make heartburn symptoms worse, and is not recommended.

Will I still be able to drive?

Yes, provided you get side effects which may make it difficult to do so. If you do experience side effects, such as feeling drowsy or dizzy, you must refrain from driving and let your doctor know.

Can I take the medicine while pregnant?

Please speak to your doctor before taking this medicine if you are pregnant or are thinking of having a baby. It is not recommended that you take this treatment while breastfeeding, as it is not clear whether or not the medicine can pass into breast milk.

How should I store it?

Keep at room temperature and do not use after the expiry date. Dispose of all unused medicines responsibly by taking them to a pharmacist.

Am I allergic to anything in the medicine?

Nexium tablets contain: esomeprazole, glycerol monostearate 40-55, hyprolose, hypromellose, iron oxide (20mg reddish-brown, yellow, 40mg reddish brown) (E172), synthetic paraffin, magnesium stearate, methacrylic acid ethyl acrylate copolymer (1:1) dispersion 30%, microcrystalline cellulose, macrogol, polysorbate 80, crospovidone, sodium stearyl fumarate, sugar spheres (sucrose and maize starch), talc, titanium dioxide (E171), and triethyl citrate.

The granules contain: esomeprazole, glycerol monostearate 40-55, magnesium stearate, hydroxypropyl cellulose, methacrylic acid – ethyl acrylate copolymer (1:1) 30% dispersion, hypromellose, sugar spheres, talc, polysorbate 80, triethyl citrate, citric acid anhydrous, hydroxypropyl cellulose, yellow iron oxide, crospovidone, glucose, and xanthan gum.

Do not take these medications if you are allergic to any of the above.

Is it available over-the-counter?

No, but now you can renew your prescription for Nexium granules and tablets from our all-in-one online clinic.

Is it right for me?

If you are experiencing heartburn symptoms for the first time, or think your heartburn symptoms may be getting worse, make an appointment to see your GP. They will be able to assess your symptoms, and talk to you about the most suitable medication options.

Renewing your prescription medication for heartburn online is easy with our secure service. Our medical professionals will review your case once you have completed our questionnaire form. They will only issue a prescription for this medication if they are happy that it is suitable for you. Following approval, your order will be fulfilled by our UK based pharmacy and delivered the next day to your door.

Page last reviewed:  24/08/2021 is rated 4.9 out of 5 by 3131 customers on TrustPilot!
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