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Zestoretic is a treatment for high blood pressure made by AstraZeneca. It contains a combination of two ingredients: an ACE inhibitor, and a diuretic.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

31 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 31 August 2020
Product information

Zestoretic is a tablet containing two active ingredients: lisinopril and hydrochlorothiazide. It is used to lower high blood pressure and, in turn, limit the risk of cardiovascular illnesses such as heart attack and stroke. Manufactured by AstraZeneca, there are two different strengths. The dose issued will depend on the severity of your condition and the stage of treatment you are currently undergoing.

  1. Effective treatment
  2. Made by a popular brand
  3. Easy one per day tablet

High blood pressure, in many cases, does not have any distinguishing physical characteristics, like other conditions do. Some people may not even realise that they have it until they encounter severe illnesses, affecting the heart or respiratory system. However, high blood pressure is not uncommon. It is estimated by the NHS that as many of 30 per cent of people in the UK have the condition to an extent.

It is more prevalent in those who are aged 65 and over. But it can affect people in earlier life too. The presence of certain risk factors may make the condition more likely, including: drinking too much alcohol or caffeine, smoking, having a bad diet, being overweight, or not getting enough exercise. Others, meanwhile, may be genetically predisposed to the condition, or experience it as a consequence of another illness, such as diabetes.

The diagnosis of high blood pressure is undertaken through the use of a gauge, which gives a reading in millimetres of mercury (mmHg) as two figures. Systolic pressure is the first figure, and this gives an indication of how much force is being exerted by the heart during a beat. The second is called diastolic pressure, which is taken between beats, and this is a measurement of the resisting quality of the arteries. Blood pressure is thereby given as two numbers; for instance, 120 over 80. Those with two separate consecutive readings which exceed 140 over 90 are said to have high blood pressure.

In most cases, treatment for high blood pressure begins with addressing a person’s dietary and lifestyle habits. Cutting back on smoking, alcohol consumption, salt intake, or introducing a schedule of light exercise, can help to combat the condition. For others, though, prescription medication may be necessary. Zestoretic, as a combination drug, may more typically be issued when those containing just one agent have not succeeded in lowering blood pressure.

The way lisinopril works is to prevent the action of an enzyme, which transforms the angiotensin hormone into angiotensin II. Because angiotensin II can make blood vessels tighten up, stopping this conversion helps to ease tension in the bloodstream, and relieve pressure.

Diuretics such as hydrochlorothiazide function in a slightly different way, but work towards the same end result. Instead, these agents work in the kidneys to increase the amount of potassium and sodium they draw from the blood. These salts pull water with them during this extraction, and the kidneys pass this out through waste. Consequently, water levels in the blood fall, and this helps to reduce pressure too.

Please note this treatment is not available to buy through our site.

Page last reviewed:  31/08/2020


Make sure you follow the directions issued by your doctor when using this product, and that you read the instructions supplied in the accompanying leaflet prior to use. This will help you to get the best possible results from your medication, and also reduce the likelihood of side effects.

  1. Administer as prescribed.
  2. This will usually be one tablet, swallowed whole, once daily. This should be taken at the same time each day.
  3. The starting dose may be 10mg/12.5mg.
  4. Your doctor may adjust your dose after a period of review.
  5. It may be necessary to have your blood pressure measured at regular intervals during use.
  6. Never compensate for a missed dose by taking a double dose. If you forget to take it, do so as soon as you remember. If your next dose is due within a few hours however, you should skip the one you have forgotten and carry on the treatment as normal.
  7. Do not take more than the amount prescribed for you.

Please note that the above is intended only as a guide. More detailed guidance can be located in the patient information leaflet which comes with the medication.

Download Zestoretic patient information leaflet

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Zestoretic 10 10mg/12.5mg

Side effects & Warnings

Side effects

The side effects listed below will not affect everyone who uses this treatment. However, some of them may pose a serious risk to your health, so you should seek medical attention if you encounter any which cause you concern.

If you notice any signs of the following, stop taking this product and notify your doctor immediately: an allergic reaction; or serious liver problems. Consult the leaflet supplied for more information on what form these may take.

Common (1 in 10 people or less):

Headache, dizziness, fainting, diarrhoea, feeling or being sick, cough or kidney problems.

Uncommon (1 in 100 people or less):

Mood swings, tingling, spinning feeling, sleeping difficulty, heart attack or stroke, irregular heartbeat, change of colour in your fingers or toes, runny nose, stomach pain and indigestion, change in liver function, rash, itching, impotence, weakness, feeling dizzy when standing, or tiredness.

Rare (1 in 1,000 people or less):

Dry mouth, hair loss, confusion, hives, psoriasis, blood infection, kidney failure, increase in male breast size.

Very rare (1 in 10,000 people or less):

Fall in blood cells or platelets in the blood, swollen glands, increased immune response, hypoglycaemia, bronchospasm, lung inflammation, sinusitis, inflammation of the pancreas or a reduction in urinary frequency.

The list of side effects provided here is not a complete one. You can find more information in the leaflet which comes with the pack.


Taking it with other medicines

If you are using any other treatments, your doctor needs to be informed during consultation. The following may interact with Zestoretic and render it unsuitable for use, make it less effective, or vice versa: drugs used in high blood pressure; NSAIDs; aliskiren; diuretics; tricyclic and tetracyclic antidepressants; lithium; potassium supplementation products; calcium salts; treatments for diabetes including insulin; desensitization for wasp and bee stings; items used in asthma; cold remedies; immunosuppressants, such as ciclosporin; allopurinol; procainamide; cardiac glycosides; drugs containing gold; amphotericin B; carbenoxolone; corticosteroids; corticotropin; stimulant laxatives; colestyramine and colestipol; tubocurarine; trimethoprim; sotalol; lovastatin; dextran sulphate; or cytostatics.

Conditions to look out for

Let your doctor know if you have any medical conditions, so that they can accurately assess whether this product is safe for you to use.

The presence of some conditions may mean that you are unable to take these tablets. Do not use Zestoretic if you have: had an allergic reaction to similar products, or have angioedema; severe kidney problems; a condition which has resulted in the stopping of passing water; serious liver problems; or diabetes or kidney dysfunction currently being treated with aliskiren.

It may also not be suitable, or be required to take special precautions, in instances where the user has or has ever had the following: stenosis of the aorta, heart valves or the kidney artery; diarrhoea; collagen vascular disease; high cholesterol; systemic lupus erythematosus; hypertrophic cardiomyopathy; low blood pressure; kidney problems; liver problems; or diabetes.

Pregnancy and breastfeeding

This medicine is not recommended during early pregnancy, and should absolutely not be used by anyone who is three or more months pregnant. It is also not recommended for those who are breastfeeding.

If you are pregnant, become pregnant, are trying for a baby, or are breastfeeding, let your doctor know immediately, so that they can discuss more suitable alternatives.

Driving and using machinery

This medication may cause dizziness. This is more likely to happen when you first start using the medicine, or if you begin taking an increased dose. You should wait and see how this medication affects your capacity before attempting to drive or operate machinery.

Do not drive or use machinery if you are affected by any side effects which may inhibit your ability to do so safely.

Food, drink and alcohol

Alcohol use may increase the risk of side effects. Speak to your doctor before taking this medicine for advice on how alcohol may affect it.

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Zestoretic 10 10mg/12.5mg


Can I still drink alcohol?

Drinking alcohol is not recommended for those who are taking high blood pressure tablets such as this one, as it may make it the treatment less effective.

Will I still be able to drive?

Yes, but only if you are able to take these tablets without experiencing significant side effects. If you do notice anything which may make driving difficult or unsafe, you should avoid doing so, and speak to your doctor as soon as possible.

Can I take the medicine while pregnant?

The use of Zestoretic is not advised during early pregnancy, and it is not to be taken at all by anyone who is over three months pregnant. It may also not be suitable for those who are breastfeeding, and your doctor may choose to suggest an alternative form of treatment.

How should I store it?

Store in a safe place below 30°C.

Am I allergic to anything in the medicine?

Contained in this product are the following ingredients: lisinopril, hydrochlorothiazide, calcium hydrogen phosphate dihydrate, magnesium stearate, maize starch, mannitol, pregelatinised starch and iron oxide (E172).

If you are allergic to any of the above, do not use this item.

Is it available over-the-counter?

In order to be able to buy Zestoretic from any pharmacy in the UK, you will require a prescription. Our online consultation service enables you to have your case reviewed by a practising doctor, who will make up an electronic prescription if this item is safe for you.

Is it right for me?

The treatment you use will be determined by your GP following consultation. They will initiate a prescription for the most suitable option, where required.

Please note that we do not sell this medication on our site. To renew your prescription for this treatment, we recommend you contact your GP.

Page last reviewed:  31/08/2020
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