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Tostran is a gel treatment for testosterone deficiency. It contains a synthetic version of the hormone, acting as a replacement therapy.

Tostran is not currently available through our online platform. Should you wish to renew your prescription, please speak to your doctor. 

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

05 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 05 August 2020
Product information

Tostran is a form of testosterone replacement therapy. It is a gel, marketed by Kyowa Kirin. The gel is provided in a canister, and dispensed through a pump. This is applied once daily to the skin on the abdomen or on the inside of the thighs on alternating days. Tostran, which is available to buy on prescription from our pharmacy, is used to treat men with testosterone deficiency.

What is testosterone?

Testosterone is a male sex hormone, produced by the testicles in men, and by the ovaries in women. In men, testosterone contributes towards several sexual functions, such as the production of sperm, and libido. It is also important for the maintenance of healthy bones and muscles.

For the majority of men, testosterone levels will peak during young adulthood and gradually decline with age.

Testosterone deficiency

When someone is testosterone deficient, this is known as male hypogonadism. Some men may have low testosterone levels from a young age. This can result in delayed puberty, slower development of the testicles and body hair, and reduced bone and muscle mass.

It’s also possible, albeit rare, for men to develop low testosterone during adulthood. This is called late onset hypogonadism. There are several factors that can contribute towards a drop in testosterone, such as diabetes, obesity, and liver or kidney disease. Sometimes, however, the exact cause may not be clear.

Symptoms of low testosterone include loss of sex drive, problems with erections, changes in mood, and loss of bone density. In some cases, a man with low testosterone may not display any noticeable symptoms at all.

When to seek advice

It’s advisable to see a doctor if you develop any of the symptoms listed above. Low testosterone may not be the cause, but they will be able to perform any observations they think necessary, and recommend a testosterone test if they think low levels of the hormone could be responsible.

Testing is done by taking a blood sample. You can get tested at your GP surgery, or alternatively, order a test kit online through our site. Men who have confirmed low testosterone levels may not need treatment if they don’t have any symptoms. However, if low testosterone is suspected to be causing the problems described above, then replacement therapy may be recommended.

How does Tostran work?

Tostran contains a manmade version of testosterone, and therefore works by supplementing levels of the hormone in a man who has testosterone deficiency.

The treatment is a gel, which is applied to the insides of the thighs and the abdomen. The active ingredient is taken up through the skin, and helps to ensure testosterone levels stay at an adequate level. It’s likely that someone using Tostran will need to have their testosterone levels checked on a regular basis, to ensure it is working.

How can I buy Tostran online?

Tostran is not currently available through our online service. Please speak to your GP if you would like to renew your prescription. 

Page last reviewed:  05/08/2020

Always follow the directions given by your prescriber, and make sure you read the patient information leaflet fully prior to use.

  1. The typical initiation dose is 3g of gel (equivalent to 60mg of testosterone) daily.
  2. This may be increased depending on your response. The maximum dose is 4g (80mg).
  3. The pump needs to be primed prior to first use. You can do this by holding the canister upright and depressing it eight times. No gel will be produced during the first few depressions. Any gel produced during priming should be discarded.
  4. Once primed, the pump issues a dose of 0.5g (10mg) per depression. So if your dose is 60mg, you’ll need to pump the canister six times to get the dose you need.
  5. You won’t need to prime the pump for subsequent uses (just the first one).
  6. The doctor prescribing the gel will tell you how many depressions to use.
  7. Administer the gel onto clean, unbroken dry skin.
  8. The gel should be applied once daily. Always try to do it at the same time.
  9. It can be rubbed onto the abdomen, or split into equal parts and rubbed onto the inside of both thighs.
  10. The leaflet recommends using both areas on alternating days (abdomen on the first day, both thighs on the second day, abdomen on the third day and so on).
  11. It must not be used anywhere else on the body or on the genitals.
  12. Use one finger to rub the gel in until dry.
  13. Wear loose clothing following application.
  14. Wash your hands after use.
  15. Wait until at least two hours after application to have a bath or a shower.
  16. You will need to have your testosterone levels monitored with blood tests during treatment.
  17. Do not exceed the prescribed dose.
  18. If you miss a dose, do not double up on your next dose to make up for it. Skip the one you have missed and apply the next one as scheduled.

Speak to your pharmacist if you are unsure about any aspect of using this treatment.

Page last reviewed:  05/08/2020
Please read the patient information leaflet for this medicine fully before use:
Side effects and warnings

If you notice any signs of an allergic reaction during the use of this treatment (such as hives, swelling of the face or lips, or difficulty breathing), or if you develop any other side effects that become serious (such as a prolonged erection that does not go away for four hours), you must seek medical attention immediately.

Very common (1 in 10 people or more)

Localised reactions at the application site, including burning, dryness, rash, redness, itching and skin irritation.

Common (1 in 10 people or less)

Swelling of the hands and feet, changes in prostate function, high blood pressure, increased hair production on the body, breast enlargement, rise in red blood cell count.

Other side effects (frequency not stated)

Hair loss, acne, liver problems including jaundice, nausea, changes in sex drive, increased erectile potency and more frequent erections, seborrhoea, mood changes, anxiety, weight fluctuations, cramp, muscular pain, water retention, swelling in the ankles, sleeping problems, priapism (prolonged erections), sperm reduction (at high doses), electrolyte changes (with long-term use) and hyperglycaemia in men with diabetes.

Athletes are warned that this treatment can produce positive results in doping tests.


Taking it with other medicines

Your doctor needs to know about any other medicines you are taking. Make sure you inform them during consultation of any treatments you have recently taken, or are using presently.

This is particularly important if you are using anticoagulants or corticosteroids.

Conditions to look out for

If you have:

  • an allergy to any of the ingredients in this medication
  • or have had breast or prostate cancer, or a suspected case of either

then you must not use Tostran.

The following conditions may increase the likelihood of side effects or complications in men using this treatment. Make sure you tell your doctor during consultation if you have, or have ever had:

  • heart disease
  • liver or kidney disease
  • high blood pressure
  • oedema (swelling) in the hands or feet
  • chronic lung disease
  • sleep apnoea
  • diabetes
  • epilepsy
  • migraines
  • skeletal cancer
  • or blood clotting problems.

Pregnancy and breastfeeding

This treatment should not be used or touched by women.

In particular, pregnant or breastfeeding women must not come into contact with Tostran, as it may harm their child.

Men are advised to avoid having sexual contact with their partner for at least four hours after applying the gel. They should also cover the application site during sex, and ensure they have washed their hands following administration to lower the risk of passing it on to their partner.

Men should also ensure the application sites are covered if in close contact with children, to reduce the likelihood of transferring the gel to them.

If contact with Tostran is suspected in someone else, contact your doctor right away.

Driving and machinery

The treatment should not inhibit your capacity to drive or use machines.

Page last reviewed:  05/08/2020
Please read the patient information leaflet for this medicine fully before use:

Can I still drink alcohol?

This treatment is unlikely to interact with alcohol.

Can I use this medicine if my partner is pregnant?

Yes, but you must take precautions to ensure that your partner does not come into contact with the gel at any time. This means washing your hands after applying it, not engaging in sexual intercourse with your partner for at least four hours after application, and covering the application areas with loose clothing to lower the risk of transfer.

How do I store it?

At room temperature, not above 25°C, out of the reach of children.

Am I allergic to anything in the medicine?

This gel contains the following ingredients: testosterone, propylene glycol ethanol, anhydrous, isopropyl alcohol, oleic acid, carbomer 1382, trolamine, butylhydroxytoluene (E321), purified water and hydrochloric acid.

Do not use it if you allergic to any of the above.

Is it available over-the-counter?

No. You can only buy Tostran in the UK if you have a prescription for it. Before this can be issued, you must have had low testosterone levels confirm by a test.

How can I buy Tostran online?

If you have been advised by a doctor to use testosterone replacement therapy following a test, you can order Tostran by proceeding to our secure consultation facility, and answering the questions provided. After your prescription has been approved by our doctor, it will be fulfilled at our UK pharmacy and sent by tracked parcel. Most orders are delivered within one working day.

If you suspect you may have low testosterone levels but have not been tested, we recommend you speak to your doctor, or consult our page on testosterone test kits.

Page last reviewed:  05/08/2020 is rated 4.9 out of 5 by 3209 customers on TrustPilot!
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