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Malarone is an antimalarial drug made by GlaxoSmithKline. It contains two functioning agents which work to prevent the disease.

If you’re travelling to an area where this medication is recommended and want to buy Malarone online, our speedy consultation and dispensing service enables you to do so. Click ‘buy now’ to take our questionnaire and request your treatment.

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Each tablet contains 250mg of atovaquone and 100mg of proguanil. The number of tablets you order should be at least equal to: (the number of days you're in an at-risk region) + 9.

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Malarone is an antimalarial drug made by GlaxoSmithKline. It contains two functioning agents which work to prevent the disease.

If you’re travelling to an area where this medication is recommended and want to buy Malarone online, our speedy consultation and dispensing service enables you to do so. Click ‘buy now’ to take our questionnaire and request your treatment.

This content was reviewed by a clinician on

14 March 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 14 March 2021
Product information

Malarone is an antimalarial drug, which can be used to either medicate the disease while it is active, or prevent an infection from starting. The manufacturers of Malarone are GlaxoSmithKline, and thanks to its combination of two active ingredients, the treatment is adept at combatting more resilient strains of the disease.

What is malaria?

Malaria is a condition caused by the plasmodium parasite, of which there are four different types. Of the four, plasmodium falciparum malaria is the most deadly, and the variety which Malarone is intended to treat. The parasite is transferred to humans through mosquito bites, and establishes itself in the body by taking over cells in the bloodstream.

Once it has spread to a sufficient degree, symptoms begin to appear; usually after a period of 7-18 days, but this may be longer. These may include diarrhoea, fever and headaches at first. However, serious cases can result in organ failure, and even prove fatal. For this reason, the prevention and treatment of malaria for those travelling to regions where the disease is present should be taken very seriously.

How common is malaria?

It is estimated that approximately 200 million people worldwide will become infected with the disease, and that two thirds of a million of these will result in death; making malaria one of the world’s most dangerous conditions. During the planning stages of your trip, it is important to find out about the presence of malaria in the place you are visiting, so that you can take the appropriate treatment.

How does Malarone work?

The active constituents in Malarone are proguanil and atovaquone. They prevent the parasite from reproducing in the body by inhibiting its capacity to generate a self-sustaining enzyme. This enzyme, which is called dihydrofolate reductase, enables the parasite to copy itself through the development of new DNA material. By blocking the production of this substance, Malarone weakens the parasite. This then leaves it open to the attack from the immune system, which deals with what remains of the parasite.

Is Malarone the right treatment for me?

Because there are numerous different malaria strains, and some have developed a resistance to medication, you will need to check which preventative treatment you should take, well in advance of travel. Different products are advised for different regions. Talk to your GP or your travel clinic for specific guidance.

You can also find more information on NHS FitForTravel.

How many tablets should I order?

For malaria prevention, please note that you will need to start taking this treatment two days before travel and continue taking it for 7 days after you return.

When placing an order for Malarone, please ensure you select the appropriate number of tablets. This should be enough to cover you for the number of days you will be in at-risk area, plus an extra 9.

Number of days being spent in region where malaria is presentNumber of tablets requiredNumber of tablets you can order
Up to 3 days12 tablets12 or 24 tablets
Between 4 and 15 days24 tablets24 or 36 tablets
Between 16 and 27 days36 tablets36 or 48 tablets
Between 28 and 39 days48 tablets48 or 60 tablets
Between 40 and 51 days60 tablets60 or 72 tablets
Between 52 and 63 days72 tablets72 or 84 tablets
Between 64 and 75 days84 tablets84 or 96 tablets

At we also allow people to order the next available pack size up, just in case they want to cover themselves in the event of travel delays.

(So, for example, if someone is planning to be in an at-risk region for 26 days, they will be allowed to order either 36 or 48 tablets.)

How can I get Malarone online?

You can buy Malarone online using our secure consultation service. Take our questionnaire to begin, and your answers will be reviewed by our doctor. Once approved your prescription will be dispensed and shipped from our UK pharmacy, by next-day parcel.

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Page last reviewed:  14/03/2021


Always make sure you follow the directions your prescriber has issued, and read the patient information leaflet prior to use. This will help to minimise the risk of side effects and maximise the effectiveness of the drug.

  1. Administer as directed by your prescriber.
  2. For the prevention of malaria, this will be one tablet taken once a day.
  3. The course should commence 2 days before travel and continue throughout.
  4. You should continue taking it for 7 days following return from an infected area.
  5. For the treatment of the disease while active, 4 tablets once a day for three days may be the prescribed dose. In this case, however, self-treatment is not an option and hospital admission will be necessary.
  6. Swallow tablets whole with food or a milky drink where possible.
  7. Take Malarone at the same time each day.
  8. Do not take more than advised by your prescriber.
  9. If you miss a dose, you should not double up on your next one, but do contact your doctor for advice on what to do next.

These instructions are intended only as a guide, and do not constitute detailed directions. Refer to the leaflet supplied prior to using this medicine.

Page last reviewed:  14/03/2021
Please read the patient information leaflet for this medicine fully before use:

Malarone 250mg/100mg

Side effects & Warnings

Side effects

If you notice any signs of an allergic reaction, skin rash with blisters, Stevens-Johnson syndrome, or any other side effects which concern you, contact your doctor right away.

Very common (1 in 10 people or more):

Diarrhoea, headache, nausea and vomiting, stomach pain.

Common (1 in 10 people or less):

Dizziness, sleeping problems, depression, loss of appetite, fever, rash, or cough.

Uncommon (1 in 100 people or less):

Anxiety, irregular heartbeat, swelling and redness of the mouth, or hair loss.

Rare (1 in 1,000 people or less):

Seeing or hearing things which are not there.

This is not a comprehensive list of the side effects this product may cause. A more detailed account can be located in the patient information leaflet.


Taking it with other medicines

Tell your prescriber if you are taking any other medicines during consultation. Malarone may affect the function of or be compromised by the following treatments: metoclopramide; antibiotics such as tetracycline, rifampicin and rifabutin; efavirenz or other medications for HIV; warfarin and other blood thinning agents; or etoposide.

Conditions to look out for

Disclose your medical history to your prescriber before use. Malarone may not be suitable for you if you have ever had kidney disease.

Pregnancy and breastfeeding

If you are pregnant, planning to become pregnant or breastfeeding, speak to your doctor before taking this medication and prior to travel.

Patients must not breastfeed while taking Malarone.

Driving and using machinery

Some people may experience dizziness while using Malarone. If this happens to you, do not drive or use machines, and see your doctor.

Page last reviewed:  14/03/2021
Please read the patient information leaflet for this medicine fully before use:

Malarone 250mg/100mg


Can I still drink alcohol?

Yes. Alcohol is not thought to affect the way this drug works. However, it is advisable to only drink in sensible amounts, as the the medicine needs to be taken responsibly and on a regular basis.

Will I still be able to drive?

Some users have reported feelings of dizziness when taking this treatment. If you feel as though you may be unable to drive safely, avoid doing so and seek immediate medical attention.

Can I use this medicine while pregnant?

This product is not recommended for those who are breastfeeding, and a doctor may advise against using it if you are pregnant, or suspect you might be.

How do I store it?

In a safe environment out of the reach of children.

Am I allergic to anything in the medicine?

Malarone contains atovaquone, proguanil, poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30, hypromellose, sodium starch glycollate (Type A), magnesium stearate, titanium dioxide (E171), iron oxide red (E172), macrogol 400 and polyethylene glycol 8000.

Is it available over-the-counter?

No. You will need a prescription to buy Malarone in the UK. 

Is it right for me?

The antimalarial you use will depend on which area of the world you are travelling to. Speak to your doctor or local travel clinic for further guidance.

How can I buy Malarone online?

If you have been advised to take this treatment for your trip, you can buy Malarone online through our secure pharmacy platform. Complete our medical questionnaire, and your answers will be reviewed by our doctor. Approved orders are dispensed at our UK pharmacy and shipped by express parcel.

Malarone is a one-a-day tablet treatment. You will need to start the medication two days before your trip, take it throughout your trip, and continue for seven days after your return. So, when choosing your quantity, make sure you select the right amount for your trip. This will be the number of days you’re planning to spend in a region where malaria is present, plus an extra nine.

Page last reviewed:  14/03/2021 is rated 4.9 out of 5 by 3209 customers on TrustPilot!
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