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Lenzetto is a transdermal spray used in hormone replacement therapy for the treatment of menopause symptoms.

Renew your menopause prescription through our simple online service. Complete a short questionnaire and your approved order can be shipped by next-day courier.

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Lenzetto is a transdermal spray used in hormone replacement therapy for the treatment of menopause symptoms.

Renew your menopause prescription through our simple online service. Complete a short questionnaire and your approved order can be shipped by next-day courier.

This content was reviewed by a clinician on

18 March 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 18 March 2022
Product information

Lenzetto is a hormone replacement therapy (HRT) to help treat the symptoms of menopause. It contains the active ingredient estradiol, a synthetic version of the female hormone known as oestrogen. The transdermal spray lets the medication soak through the skin and into the bloodstream. 

The menopause is a natural process that all women will pass through. It tends to start between the ages of 44 and 55 but it can begin earlier. The average age for women in the UK to experience menopause is 51. When the menopause occurs before the age of 40 it is referred to as premature menopause. 

The menopause process can cause numerous symptoms, as the female reproductive system reduces the amount of oestrogen being produced. The ovaries stop releasing eggs and menstrual periods stop. Common symptoms experienced at the time of menopause include insomnia, night sweats, hot flushes, mood swings and recurrent urinary tract infections. 

In some cases the symptoms are mild enough to not warrant any treatment. However, if the symptoms start to impact on day to day life, then there are treatment options available such as HRT. Lenzetto is a transdermal HRT treatment that you can buy through our online pharmacy. 

HRT is usually taken for several years and is reviewed by a doctor on an annual basis. Your doctor will discuss the benefits and risks of the HRT treatment. 

Lenzetto can be used by women with at least six months since their last natural period. It can also be suitable for women who have had surgery to remove their ovaries. Estradiol, the synthetic hormone found in Lenzetto, supplements the loss of natural oestrogen previously produced by the ovaries. The spray is applied to the skin on the inner forearm, here it passes through the skin and into the bloodstream. 

You can purchase Lenzetto transdermal spray through our online prescription renewal service. All you need to do is complete our simple questionnaire so that one of our qualified clinicians can review your answers. Once your order is approved, your treatment will be dispensed by our GPhC-registered pharmacy and shipped by next-day courier. 

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Page last reviewed:  18/03/2022

It is important to follow the instructions enclosed within the patient information leaflet and any advice given by your doctor. This will help to make sure you receive the full benefit of the treatment.  

  1. Only apply the medication to dry, unbroken skin. 
  2.  When an applicator is being used for the first time, you need to prime it. Do this by spraying it three times with the cover on. 
  3.  Take the plastic cover off. 
  4.  Hold the applicator upright and place the plastic cone against the skin on the inner forearm. 
  5.  Fully press the actuator button down once. Hold it before releasing. 
  6.  If another spray is required, move the applicator along so that it is next to the location of the initial spray. 
  7.  Always place the cover back on the applicator. 
  8.  Let the spray dry for two minutes before you get dressed. 
  9.  If you get Lenzetto on any other area of your body, you should wash it with soap and water immediately. 
  10.  Do not allow other people or pets to come into contact with the area for at least 60 minutes.

Full instructions can be found in the patient information leaflet. It is important to make yourself familiar with them before you commence your course of Lenzetto.

Page last reviewed:  18/03/2022
Side effects

Like all medicines, Lenzetto can cause side effects. Not everyone experiences them but if you do, you should speak to your doctor. 

Serious and/or severe side effects require immediate medical attention. These include but are not limited to: sudden chest pain; pain in your chest that spreads to your arm or neck; difficulty breathing; painful swelling and redness in the legs; jaundice; unexpected vaginal bleeding or spotting after using Lenzetto for some time or after you stop treatment; breast changes including dimpling of the breast skin, changes in the nipple, lumps that you can see or feel; painful menstrual periods; dizziness and faintness; changes in speech; changes in vision; or unexplained migraine-like headaches.

Please read the enclosed patient information leaflet for more detail on possible side effects. 

Common (1 in 10 people or less):

Headache, abdominal pain, nausea, rash, itching, irregular uterine bleeding or vaginal bleeding including spotting, breast tenderness, breast pain, weight increase or weight decrease.

Uncommon (1 in 100 people or less):

Hypersensitivity reactions, depressed mood, insomnia, dizziness, vertigo, visual disturbances, palpitations, diarrhoea, indigestion, increased blood pressure, hives, skin irritation, swelling due to fluid retention, muscle pain, breast discolouration, breast discharge, polyps in the uterine or cervix, endometrial hyperplasia, ovary cyst, inflammation of genitals (vaginitis), increased liver enzymes and blood cholesterol, underarm pain

Rare (1 in 1000 people or less):

Anxiety, change in sexual drive, migraine, intolerance to contact lenses, bloating, vomiting, increased body hair, acne, muscle cramps, painful menstruation, premenstrual-like syndrome, breast enlargement, fatigue.

Taking it with other medicines

Please be sure to include details of any medications or treatments you are taking when completing your questionnaire. 

It is possible for some medications to interfere with the efficacy of Lenzetto. These medications include those used to treat: tuberculosis (rifabutin, rifampicin); epilepsy (phenytoin, phenobarbital, and carbamazepine); HIV (nevirapine, ritonavir, efavirenz, nelfinavir); as well as herbal remedies that contain St John’s Wort. 

Conditions to look out for

When you answer the questionnaire, please include details of your past medical history. 

You should not use Lenzetto if you have, or have ever had: breast cancer or any form of cancer which is sensitive to oestrogen, for instance womb cancer; untreated excessive thickening of the womb lining; unexplained vaginal bleeding; blood clots; a heart attack, angina or a stroke; a liver disease when your liver function has not returned to normal; porphyria; or are allergic to any of the ingredients.

Lenzetto may not be suitable for you if you suffer from any of the following conditions such as: fibroids inside your womb; endometriosis; increased risk of developing blood clots; increased risk of getting an estrogen-sensitive cancer; high blood pressure; a liver disorder; diabetes; gallstones; migraine or severe headaches; a disease of the immune system that affects many organs of the body (systemic lupus erythematosus, SLE); epilepsy; asthma; otosclerosis; a very high level of fat in your blood (triglycerides); fluid retention due to cardiac or kidney problems

Regular check-ups

It is important to have regular check ups with your GP when using this treatment. 

HRT and cancer

Please read through the detailed information on HRT and cancer risk in the leaflet provided.

Pregnancy and breastfeeding

Lenzetto is for use in postmenopausal women only. If you become pregnant, stop using Lenzetto and contact your doctor.

Driving and using machinery

Lenzetto has no known effect on the ability to drive or use machines.

Page last reviewed:  18/03/2022

Can I still drink alcohol?

Yes. This treatment should not be affected by alcohol. 

Will I still be able to drive?

Yes, this treatment should not impact your ability to drive. However, should you notice any side effects that may impinge on your driving ability, you should speak to your doctor. 

Can I take the medicine while pregnant?

Lenzetto is not suitable for use in pregnant women. If you become pregnant while using the treatment it should be stopped straight away and you should speak to your doctor. 

How should I store it?

Do not freeze or refrigerate Lenzetto. Keep it in a cool, dry place away from children. 

Am I allergic to anything in this medicine?

Do not use this medication if you are allergic to any of its ingredients: estradiol hemihydrate, octisalate and ethanol. 

Is it available over-the-counter?

You can only buy Lenzetto with a prescription. Our online service allows you to access doctors who are able to review and renew your prescription. 

Is it right for me?

Your GP will be able to discuss your symptoms and decide on a suitable HRT treatment plan. This will then be reviewed on a regular basis but you can always speak to your doctor if you have any questions or concerns about your prescription. 

How can I buy Lenzetto online?

You can now buy your HRT treatment online through our service. Simply complete our medical questionnaire and your order will be reviewed by a doctor. Approved requests will be dispensed by our UK-based pharmacy and then shipped to you by next-day courier. 

Page last reviewed:  18/03/2022
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