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Nuvelle Continuous

Estradiol Hemihydrate/Norethisterone Acetate

Nuvelle Continuous is a combined HRT pill made by Bayer. It can help to alleviate the symptoms of the menopause.

If you’re already taking this treatment, you can renew your prescription and buy Nuvelle online with our remote consultation service. Once approved, your order will be dispensed by a pharmacy based in the UK.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

12 November 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 12 November 2020
Product information

Nuvelle Continuous is a combined hormone replacement therapy manufactured by Bayer. It is supplied in the form of a pill. This is taken every day, and helps to treat symptoms associated with the menopause. It should only be used by those who have not had a natural period for one year or more.

The menopause is a natural part of the ageing process, and can go on for a number of years. Most women will experience it during their late 40s, or their early 50s. It occurs when menstruation begins to draw to a close, meaning that: the ovaries no longer produce an egg each month; and the layering up and shedding of the womb lining becomes less frequent, before it completely stops.

During this time, levels of certain hormones in the body naturally drop. When the presence of oestrogen falls, emotional and physical symptoms can result. These may include vaginal dryness, and consequently, feelings of pain during sex. Headaches are another common symptom, as are night sweats and hot flushes, and difficulty sleeping. Many women undergoing the menopause may also find that their mood tends to change more quickly than normal.

In the majority of instances, these symptoms will not be prominent enough to necessitate treatment. But other cases may be more severe, with these effects causing significant disruption to everyday life. Hormone replacement therapy can help to restore oestrogen levels, and alleviate symptoms.

The active ingredients in Nuvelle Continuous are estradiol and norethisterone. These are synthetic variants of the hormones oestrogen and progesterone. Whereas estradiol, by working in the same way as oestrogen, supplements levels of this hormone in the body; the role of norethisterone in this drug is help maintain a hormonal balance. In certain cases where oestrogen levels are allowed to rise unopposed, the lining of the uterus can thicken to a point where it may prove to be increasingly susceptible to cancer. Norethisterone provides hormonal equilibrium in the body, thus keeping oestrogen levels from rising too high and reducing this risk.

Please note we only supply this treatment on a renewal basis to patients already taking it. See your GP if you think you may be experiencing symptoms of the menopause, and have not spoken to anyone about these before. Your doctor will be able to help you determine a suitable course of treatment, and issue a prescription where needed.

It’s easy to renew your regular prescription and buy Nuvelle Continuous online from our trusted pharmacy. Simply fill in our health questionnaire and one of our registered practitioners will assess your case, and issue a prescription for your order if appropriate. This is then electronically sent to our dispensing pharmacy. Our courier partners will then deliver your item to you via tracked parcel.

Page last reviewed:  12/11/2020


You should always administer your medication in the manner specified by your prescribing doctor, so that you get the best possible results from it. It is also important to follow the guidelines in the patient information leaflet, as this will help you to be aware of the potential side effects and take measures to reduce the likelihood of them occurring.

  1. Take as directed.
  2. This will be one tablet a day, taken consistently at the same time.
  3. Guidance on when to start using this pill can be found in the leaflet.
  4. When taking your tablet, do so by swallowing whole, with water.
  5. Do not take more than the prescribed amount.
  6. If you forget to take your pill, you can do so when you remember providing no more than 12 hours have elapsed since your missed dose. If 12 hours or more have passed, you should skip the dose you have missed and take your next one as normal at the appropriate time.
  7. Never compensate for a missed dose by doubling up.

The directions provided here only constitute a summary of those in the patient information leaflet. Make sure you read these carefully before using this drug.

Page last reviewed:  12/11/2020
Side effects & Warnings

Side effects

It is important to be aware of the side effects this product may induce, as some may necessitate immediate medical attention. Let your doctor know urgently if you experience any signs of the following: breast cancer; excessive growth of the womb lining; endometrial or ovarian cancer; a blood clot in a vein; memory loss if using over the age of 65; heart disease; or a stroke.

Other side effects:

Breakthrough bleeding and spotting, breast pain, tenderness or enlargement, breast discharge, painful periods, premenstrual symptoms, increased size of fibroids in the womb, thrush, indigestion, feeling bloated, flatulence, feeling or being sick, abdominal pain, gallbladder disease, bladder inflammation, porphyria, chorea, angioedema, skin rashes or discolouration, itching, eczema, acne, unusual hair loss or hair growth, headache, dizziness, anxiety or depressive symptoms, fatigue, migraine, palpitations, high blood pressure, inflammation of veins in the legs, fluid retention, weight fluctuations, changes in sex drive, increased appetite, muscle cramps, leg pain, nosebleeds, visual disturbances, discomfort with contact lenses, or aggravation of glucose tolerance.

The above is not a complete account of the side effects associated with this drug. A more detailed list is included in the patient information leaflet.


Taking it with other medicines

Some treatments may cause this product to be less effective, or vice versa. Inform your prescriber when completing our health questionnaire if you are taking medicines for any other conditions, such as: epilepsy, for which you might be using phenobarbital, phenytoin or carbamazepine; tuberculosis, which you might be treating with rifampicin or rifabutin; HIV, such as nevirapine, efavirenz, ritonavir or nelfinavir; or St. John’s wort.

Conditions to look out for

You should not use this therapy if you have or have ever had: breast cancer, or a suspected case of it; oestrogen-reactive cancer, or a suspected case of it; unexplained vaginal bleeding; endometrial hyperplasia which is not being treated; lactose intolerance; a blood clot in a vein; any disorder which could interfere with blood clotting; a heart attack or stroke; liver disease from which your liver function tests have not yet normalised; or porphyria.

Some conditions, such as the following, may also require that you take special care when using this drug. Tell your prescriber if you have a history of: fibroids inside the womb; endometriosis or endometrial hyperplasia; any condition or risk factor which increases your chance of a blood clot or cancer; high blood pressure; liver disorder; diabetes; angioedema; migraines; gallstones; systemic lupus erythematosus; epilepsy; asthma; otosclerosis; triglycerides; or fluid retention resulting from cardiac or kidney problems.

Regular check-ups

Those taking this pill will need to have regular check-ups with their GP, at least once yearly, to ensure that it is working as it should.

HRT and cancer

You can find more information on HRT and cancer risk in the leaflet supplied.

Pregnancy and breastfeeding

This pill must not be used by anyone who is pregnant or breastfeeding. If you become pregnant while taking this medication, stop using it and tell your GP.

Driving and using machinery

Nuvelle should not impede your capacity to drive or use machines.

Lactose intolerance

If you have an intolerance to any sugars, tell your prescriber, as this item contains lactose.

Page last reviewed:  12/11/2020

Can I still drink alcohol?

Yes. It is not thought that alcohol will stop this drug from working properly.

Will I still be able to drive?

Yes. Your capacity to drive should not be hindered by the use of this treatment. However you should avoid driving if you get any side effects which may make doing so dangerous, and notify your doctor.

Can I take the medicine while pregnant?

No. It should not be used by anyone who is pregnant or breastfeeding.

How should I store it?

Keep this product in a safe place at room temperature.

Am I allergic to anything in the medicine?

Do not use Nuvelle if you are allergic to any of the following containing ingredients: estradiol hemihydrate, norethisterone acetate, lactose monohydrate, maize starch, pre-gelatinized maize starch, povidone 25 000, talc, magnesium stearate (E572), methylhydroxypropyl cellulose, macrogol 6000, titanium dioxide (E171) or red ferric oxide pigments (E172).

Is it available over-the-counter?

No. You will need a prescription in order to be able to buy Nuvelle Continuous from any UK pharmacy, including ours. 

To renew your prescription with us, take our online consultation.

Is it right for me?

The HRT medication you use will be decided on during regular consultation with your own GP. They will talk to you about suitable treatments, and start a prescription for you where required.

How can I buy Nuvelle Continuous online?

Getting repeat prescriptions online is easy with our express service. Complete our health assessment today. Once your order is approved by our qualified physician, you can expect to receive it by tracked parcel within one working day.

Page last reviewed:  12/11/2020
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