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Conjugated oestrogens

Premarin is an oestrogen-only HRT pill made by Pfizer. It helps to relieve symptoms of the menopause and reduce the risk of osteoporosis.

To order Premarin online from our trusted UK pharmacy, take our doctor-reviewed consultation. Approved orders are shipped by express parcel, and normally delivered within one working day.

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Premarin is an oestrogen-only HRT pill made by Pfizer. It helps to relieve symptoms of the menopause and reduce the risk of osteoporosis.

To order Premarin online from our trusted UK pharmacy, take our doctor-reviewed consultation. Approved orders are shipped by express parcel, and normally delivered within one working day.

This content was reviewed by a clinician on

14 April 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 14 April 2021
Product information

Premarin is a type of HRT made by Pfizer. It is a single-hormone pill, containing oestrogen, provided in three different doses. The dose you use will be decided on by your doctor, but you will normally start on the lowest, and have your dose increased as required. Premarin is only available to buy online or in person with a prescription from a doctor.

The menopause is a natural change a woman’s body goes through, as its reproductive span comes to an end. In the majority of cases, it will occur between a woman’s mid-forties and mid-fifties, with the average age of onset in the UK being 51. Less commonly, it can occur much earlier, during a woman’s twenties or thirties; this is known as premature menopause.

During the menopause, the levels of certain hormones in the body change. Oestrogen tends to drop, and this can cause several symptoms, such as vaginal dryness, hot flushes, sweating during the night, headaches and mood swings. This drop in oestrogen can also lead to a loss of bone density, called osteoporosis. People with osteoporosis have weaker, more fragile bones, and are more at risk of sustaining a break or a fracture if they fall or become injured.

HRT, or hormone replacement therapy, is a way of supplementing this drop in hormones, and helps to counter these symptoms. Not every woman uses HRT, as some may find that symptoms are not severe enough to warrant treatment. But if a woman feels that symptoms are obstructing everyday life, they may find treatment with HRT beneficial.

The mixture of artificial oestrogens in Premarin work in the body to raise levels of oestrogen, thereby alleviating symptoms such as hot flushes and vaginal dryness, and decreasing the risk of osteoporosis. In some women with osteoporosis, Premarin can also be used as a treatment for the condition if other medicines have not been successful.

Oestrogen-only HRT is normally given to women who have had an operation to remove the uterus, called a hysterectomy. It can also be given to women who have not had this procedure, but in such cases a progesterone only form of HRT will also need to be taken. This is because women who still have a uterus and take oestrogen on its own have an increased risk of endometrial cancer. Progesterone helps to balance out oestrogen levels in the body, and lowers this risk.

With our secure and confidential service, it’s simple to renew your prescription online and buy Premarin from our trusted UK pharmacy. When you order your treatment, you’ll be asked to complete our doctor-reviewed questionnaire. Following authorisation by our clinician, a prescription will be generated and sent to our dispensing pharmacy, where your treatment will be prepared and shipped to you by next-day courier.

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Page last reviewed:  14/04/2021

Read the patient information leaflet fully before using this medication. If you are not sure of anything to do with this treatment, ask your doctor or pharmacist for help.

  1. Take as prescribed by your doctor.
  2. This will in most cases be one pill daily, taken at the same time each day, swallowed whole with water.
  3. If you have had surgery to remove your womb (hysterectomy) you may be prescribed this pill to take on its own.
  4. If you have not had surgery and have an intact uterus, you may be issued a progesterone pill (or patch) in addition to Premarin, to either be taken alongside it every day, or on certain days towards the end of a monthly cycle.
  5. You will normally start on the lowest possible dose. Depending on how you react to the pill and whether it effectively reduces symptoms, your doctor may increase the dose.
  6. If you miss a pill, take it when you remember and carry on the course as normal. Do not take double the amount next time to make up for it.
  7. In women who have not had a hysterectomy, missing a pill may cause some breakthrough bleeding.
  8. If you are also taking a progestogen, you may experience some bleeding on the days you take this. For the first few months of sequential treatment this is normal, and you should notice a gradual reduction in bleeding until it stops. However, if you continue to bleed after three months of commencing treatment or have any heavy bleeding which concerns you, speak to your doctor for advice.

More detailed instructions are provided in the leaflet that comes with the pill.

Page last reviewed:  14/04/2021
Side effects

Side effects

It is vital to be able to recognise the signs of a blood clot if you are taking hormonal treatment, as in some cases the risk of these can be increased. Seek medical attention right away if you notice any redness, pain or swelling in your legs (particularly at the back of the calf or the thigh), become short of breath, or feel dizzy.

You should also seek medical advice urgently if you notice any signs of: an allergic reaction, such as hives, swelling of the throat or face, or a drastic drop in blood pressure; yellowing of the skin or eyes (jaundice); a rise in blood pressure (signified by headache, tiredness or dizziness); a migraine; or chest pain.

The following conditions have been noted more frequently in women who take HRT than in those who don’t: breast cancer, endometrial hyperplasia or cancer, ovarian cancer, heart disease and stroke.

Women using HRT have also reported the following side effects: breakthrough bleeding or spotting; changes in periods; pelvic pain; inflammation of the vagina; discharge from the vagina; increased frequency of thrush; breast pain, tenderness or discharge; feeling nauseous or being sick; headache or migraine; joint pain; leg cramps; dizziness; mood changes; loss of libido; swollen ankles; itchy rash; chloasma; hair loss; excess hair growth; weight fluctuations; high triglycerides; glucose intolerance; dementia; chorea; exacerbation of asthma; hypocalcaemia; jaundice; gallbladder disease; meningioma; inflammation of the colon; painful or bloody diarrhoea; angioedema.


Taking it with other medicines

You should tell your doctor if you are using any other medicines during consultation. Premarin may interact with: anticonvulsant therapy used in epilepsy, such as phenobarbital, phenytoin, or carbamazepine; tuberculosis medicines like rifampicin or rifabutin; HIV treatments such as nevirapine, efavirenz, ritonavir and nelfinavir; antibiotics or antifungal medicines such as erythromycin, clarithromycin, ketoconazole or itraconazole; St. John’s wort; metyrapone; cimetidine; or dexamethasone.

Conditions to look out for

You should not take Premarin if you: have an allergy to anything in it; have or have ever had breast cancer, or suspected breast cancer; have or have ever had endometrial cancer, or any other type of cancer sensitive to oestrogen; have unexplained vaginal bleeding; have excessive thickening of the womb lining and are not receiving treatment for it; have ever had a blood clot in a vein, such as in the legs, or in the lungs; have a blood clotting disorder; have or recently have had a heart attack or stroke, or have angina; have or have previously had liver disease; or have porphyria.

It may be unsuitable for you to use Premarin, or you may need to use it with caution, if you: have fibroids inside your womb; have endometriosis or a history of endometrial hyperplasia; are at increased risk of blood clots; have a family history of oestrogen-sensitive cancer, or are at increased risk of this type of cancer; have high blood pressure or heart disease; have a liver disorder; have kidney disease; have fluid retention; have diabetes; have gallbladder disease or gallstones; get migraine or severe headaches; have lupus; are epileptic; have asthma; have a condition affecting the eardrum and hearing; have low blood calcium levels; or have high levels of fat in the blood.

Regular check-ups

You should make sure you speak to your doctor or practice nurse at least once a year in person to have your menopause treatment reviewed.

HRT and cancer

The risk of certain types of cancer is higher in women using HRT than in those who are not. More information can be found in the leaflet supplied with the treatment.

Pregnancy and breastfeeding

Do not use this treatment if you are pregnant or breastfeeding, or are trying to become pregnant.

If you become pregnant while using this pill, stop taking it and seek medical advice.

Driving and using machines

Your capacity to operate machinery or drive is not likely to be inhibited by this pill.

Lactose intolerance

This pill contains lactose. Speak to your doctor for advice before using it if you are lactose intolerant.

Page last reviewed:  14/04/2021

Can I still drink alcohol?

Yes. The active ingredient in Premarin is not likely to interact with alcohol.

Will I still be able to drive?

You should still be able to drive, provided you do not experience any side effects that may limit your capacity to do so safely.

Can I take the medicine while pregnant?

No. Do not use it if you are pregnant or breastfeeding.

How should I store it?

Keep the pills stored in a safe place, out of the reach of children.

Am I allergic to anything in the medicine?

Premarin contains: conjugated oestrogens, lactose monohydrate, microcrystalline cellulose, magnesium stearate, hypromellose, sucrose, hydroxypropyl cellulose, macrogol, carnauba wax, titanium dioxide (E171), iron oxide black (E172), sunset yellow (E110), quinoline yellow (E104), indigo carmine (E132), red aluminium lake (E129), propylene glycol (E1520) and polysorbate 80.

Do not take it if you are allergic to any of the above.

Is it available over-the-counter?

No. You can only buy Premarin in the UK with a prescription.

How can I buy Premarin online?

If you are not currently taking Premarin or any other HRT, you should speak to your doctor initially, so that they can assess your symptoms and start you on a suitable treatment.

Women looking to renew their prescription for this medication or change to it from another form of HRT can do so through our consultation and pharmacy service. During your order, you will be asked to fill in our medical questionnaire, which will be reviewed by one of our clinicians. Following approval by them, a prescription will be issued and sent electronically to our dispensing pharmacy, where your treatment will be readied and shipped to you by next-day parcel.

Page last reviewed:  14/04/2021
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