Conjugated Oestrogens/Medroxyprogesterone Acetate

Premique is a continuous combined form of hormone replacement therapy, made by Pfizer, and is used to relieve menopausal symptoms.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.
Product information

Premique and Premique Low Dose are hormone replacement therapy tablets manufactured by Pfizer. Both are combined, continuous forms of treatment, used to lessen symptoms of the menopause. Contained in them are synthesised versions of oestrogen and progesterone, which work by helping to restore hormone levels which have naturally fallen.

  1. Effective prevention of symptoms
  2. Available in a low dose
  3. Branded HRT pill

The average age at which a woman goes through the menopause (as posited by the NHS) is 51. But, even though most women will undergo the process in their late 40s or their early 50s, some may experience it as early as their 30s. The menopause is a natural part of getting older, and is characterised by a series of physical developments. These include the cessation of ovulation (the measure by which the ovaries generate an egg, in readiness for pregnancy) and the slowing down and eventual stopping of menstrual bleeding.

In addition to the above, the rate at which the body produces certain hormones also changes. During the menopause, oestrogen levels diminish, and this can cause a variety of emotional, psychological and physical symptoms. These may include hot flushes, headaches, feelings of dryness in the vagina, mood swings, and trouble sleeping. The chances of osteoporosis may also increase postmenopause, as bone integrity can be affected by dropping hormone levels too.

Whereas many may only notice these symptoms infrequently, or experience them to a slight extent; others may find them severe enough to pose a significant problem. In these situations, treatment may be recommended by a doctor, and issued in the form of hormone replacement therapy.

Simply put, Premique treats the above symptoms by supplementing the amount of oestrogen in the body. As it provides a continuous dose, it does not cause a menstrual bleed after a certain period of use. In addition to conjugated oestrogens, the drug also contains medroxyprogesterone acetate, a form of progesterone. This is provided as a countering agent, to stop oestrogen from rising to excessive levels.

We offer HRT on a renewal basis only, to patients undergoing regular monitoring with their GP. If you are not taking treatment for the menopause and are experiencing symptoms, you should see your GP in person.

Premique is available to buy from our online UK pharmacy in two forms; one is a standard dose; whereas the other is a modified-release tablet, which distributes a low dose. The latter may be employed in those instances where a person is taking this type of HRT for the first time, or is sensitive to potential side effects.

Page last reviewed:  09/08/2018


Before using this product, it is essential to make sure that you know how to take it. Follow the directions supplied by your prescriber, and familiarise yourself with the guidelines set out in the patient information leaflet. Doing so will help you maximise the efficacy of the treatment, and reduce the chances of side effects.

  1. Take as directed by your doctor.
  2. In all cases unless otherwise specified, this will be one Premique tablet per day.
  3. Schedule your doses so that you take them at the same time each day.
  4. For advice on when to begin using this drug, refer to the leaflet supplied. Your start time may vary depending on whether you are already using HRT, or if you are still having your period.
  5. Never exceed the amount prescribed for you.
  6. Do not make up for a missed dose with a double dose. If you forget to take your pill at the regular time, you can do so when you remember, provided your next dose is not due. If you have missed a dose and your next one is due, do not worry; leave the missed tablet, and simply carry on taking the course as normal.

Please note that the above is only a summary of the instructions you will need to follow when administering this drug. Refer to those provided in the leaflet prior to use.

Download Premique patient information leaflet

Download Premique low dose patient information leaflet

Page last reviewed:  09/08/2018
Please read the patient information leaflet for this medicine fully before use:

Premique 0.3/1.5mg

Premique 0.625mg/5mg

Side effects & Warnings

Side effects

It is essential to be aware of the side effects that this product may induce, as some may require you to seek urgent medical advice. Visit your nearest doctor or hospital right away if you notice any signs which may be an indication of the following: a heart attack or stroke; an allergic reaction; liver disease; first-time migraine or one which is worse than normal; breast cancer or any type of cancer which is responsive to oestrogen; a blood clot; or rising blood pressure. Detailed information on what these signs look like can be located in the accompanying leaflet.

Very common (1 in 10 women or more):

Breast pain.

Common (1 in 10 women or less):

Breakthrough bleeding or spotting, inflammation of the vagina, period pain, tender or swollen breasts, nipple discharge, depression, muscle and joint aches, leg cramps,
weight fluctuations, or altered triglyceride levels.

Uncommon (1 in 100 women or less):

Thrush, irregular menstrual bleeding, vaginal discharge, feeling sick, bloating, abdominal pain, headache, blood clot in a vein, migraine, dizziness, mood swings, changes in libido, swelling of the face or ankles, itchiness, acne, intolerance to contact lenses, gallbladder disease, or hair loss.

Rare (1 in 1,000 women or less):

Irritability, being sick, changes in breast tissue, increased hair growth, worsening of asthma symptoms, increase in the size of fibroids, ovarian cancer, worsening of epilepsy, heart attack, stroke, or inflammation of the pancreas.

This is not a comprehensive account of the side effects this item may cause. For more information, consult the leaflet supplied.


Taking it with other medicines

Your prescriber needs to know if you are using any other treatments during consultation, as this product may cause interactions in some cases. The function of Premique may affect or be influenced by the following: anticonvulsants for epilepsy, for instance phenobarbital, phenytoin or carbamazepine; antivirals or antibiotics, such as rifampicin, rifabutin, nevirapine, efavirenz, erythromycin, ketoconazole, ritonavir or nelfinavir; St. John’s wort; metyrapone; or aminoglutethimide.

Conditions to look out for

This treatment is not suitable for those who have a history of the following: heart conditions such as angina; heart attack or stroke; blood clots, or any disorder which affects blood clotting; breast cancer, or any type of cancer which responds to oestrogen; porphyria; lactose or sucrose intolerance; recent excessive vaginal bleeding; endometrial hyperplasia; or severe liver disease.

Persons with the following conditions may also be advised to take special care or have regular check-ups when using this medication: endometriosis; uterine fibroids; an increased susceptibility to blood clots; any high risk factor related to breast cancer or other form of oestrogen dependent cancer; high blood pressure; liver or kidney dysfunction; diabetes; gallbladder disease; migraine; systemic lupus erythematosus; epilepsy; hypocalcaemia; hypertriglyceridemia; asthma; or otosclerosis.

Regular check-ups

You will need to have regular reviews with your GP when taking HRT, to ensure it is working as it should.

HRT and cancer

The leaflet contains detailed information on HRT and cancer risk.

Pregnancy and breastfeeding

This pill should not be taken by anyone who is pregnant or breastfeeding. If you become pregnant, stop taking it and see your GP for advice.

Driving and using machines

This medication should not influence your capacity to drive or use machinery.

Lactose and sucrose intolerance

This pill contains lactose and sucrose. Tell your prescriber if you have an intolerance to any sugars.

Page last reviewed:  09/08/2018
Please read the patient information leaflet for this medicine fully before use:

Premique 0.3/1.5mg

Premique 0.625mg/5mg


Can I still drink alcohol?

Yes. It is not likely that the function of this treatment will be affected by alcohol.

Will I still be able to drive?

Yes. You should still be able to drive while using this product. However, do not drive if you notice any side effects which may make doing so dangerous, and seek advice from your doctor as soon as possible.

Can I take the medicine while pregnant?

This item should not be used by anyone who is pregnant or breastfeeding, as it may cause harmful effects.

How should I store it?

In a secure place away from excessive sources of moisture or light, below 25°C.

Am I allergic to anything in the medicine?

Premique tablets contain: conjugated oestrogens, medroxyprogesterone acetate, calcium phosphate tribasic, calcium sulphate, microcrystalline cellulose, carnauba wax, glyceryl monooleate, lactose, magnesium stearate, methylcellulose, macrogol, pharmaceutical glaze, povidone, sucrose, titanium dioxide (E171), stearic acid and colour (E132, indigo carmine) and edible ink containing iron oxide black (E172), shellac, N-Butyl alcohol, propylene glycol and ethyl acetate.

Premique Low Dose carries the following ingredients: conjugated estrogens, medroxyprogesterone acetate, lactose monohydrate, microcrystalline cellulose, hypromellose, magnesium stearate, sucrose, hydroxypropyl cellulose, polyethylene glycol, ethyl acrylate, methacrylate, titanium dioxide (E171), yellow iron oxide (E172), hydroxyethyl cellulose, povidone, polydextrose, maltitol, poloxamer and edible ink consisting of black iron oxide (E172), propylene glycol and hypromellose.

Do not use the above if you are allergic to any containing ingredients.

Is it available over-the-counter?

No. Premique is prescription only, and you will need to undergo consultation with a doctor prior to renewing this item. Our online clinic service, which is staffed by GMC-registered doctors, provides this facility.

Is it right for me?

Which menopause treatment you use will depend on your medical profile. Your GP will discuss options with you during a face-to-face consultation. They will then start a prescription for you where required.


Page last reviewed:  09/08/2018
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