Prempak-C is a hormone replacement therapy pill made by Pfizer. It is applied to the treatment of menopausal symptoms. Prempak-C is available in two doses; the weaker of which may be issued to those who are more prone to side effects. As a sequential medication, a one-month course will contain two different types of tablet; one with oestrogen only; and another with both oestrogen and progesterone.
- Sequential course
- Easy to take tablet
- Branded item from Pfizer
Known to as some as ‘the change of life’, the menopause marks the end of a woman’s period of fertility; following this development, she will not be able to bear children. This is characterised by certain changes taking place in the reproductive system, such as: the stopping of ovulation (the production of an egg by the ovary); and the diminution and eventual halt of menstruation (where the uterine wall lining builds and sheds each month).
A change in the above functions also has the effect of reducing hormone production. Oestrogen levels during menstruation will decrease, and this drop will commonly bring about certain emotional and physical effects. Although not everyone will experience these to an extent which bothers them, some will endure more severe instances, and look to treatment for help.
The symptoms most typically encountered during and after the menopause include: mood swings, headaches, hot flushes, increased nighttime perspiration, and difficulty sleeping. An increased risk of osteoporosis may also be present, as oestrogen-deficiency can cause reduced bone strength.
Hormone replacement therapy is available in a range of different forms. Prempak-C is one such type, and is available to buy from our UK-based pharmacy. It contains a man-made version of oestrogen, which prevents symptoms by augmenting those levels in the body which have naturally fallen.
It also contains an artificial form of progesterone, called norgestrel. The role of this hormone is to regulate the presence of oestrogen, and keep it under control (excess levels of oestrogen can lead to the onset of endometrial hyperplasia and, in some cases, cancer). When applied together in the treatment of menopausal symptoms, these agents are referred to as combined HRT.
When using HRT, it is vital to follow the directions supplied; both by your prescriber, and according to the manufacturer’s leaflet. Doing so will help you to reduce the likelihood of side effects and increase the effectiveness of the medicine.
- Use according to your prescriber’s instructions.
- This will be one tablet, taken at the same time every day.
- These should be swallowed whole, with water.
- Prempak-C is a sequential treatment, which means that a month’s course consists of 28 tablets with different levels of hormones. It is therefore important to make sure you take these pills in the correct order.
- The blister strip is marked with arrows and days of the week to help you keep track.
- The best time to begin taking this treatment depends on whether you are switching from another type of HRT. For more guidance, refer to the accompanying leaflet.
- In the event that you forget to take your pill, try to take it when you remember. Do not make up for a missed dose by doubling up on your next one. If you have missed a dose and your next administration is due, skip the one you have forgotten and carry on the course as normal.
The directions listed here are only intended as a guide. More detailed instructions are supplied in the patient information leaflet.
Not everyone who uses this treatment will get side effects. However, it is still important to be aware of the nature and likelihood of these, as some may necessitate urgent medical attention. Tell your doctor right away if you think you may be experiencing any signs of the following: an allergic reaction; cancer of the breasts, ovaries, or womb lining; a blood clot; heart attack; stroke; memory loss if using over the age of 65; heart disease; or liver disease. You can locate more detailed information on what forms these signs may take by reading the patient information leaflet.
Very common (1 in 10 people or more):
Common (1 in 10 people or less):
Inflammation of the vagina, period pain, breakthrough bleeding or spotting, breast tenderness or swelling, depression, aching joints or muscles, leg cramps, altered levels of fat in the blood, or weight fluctuations.
Uncommon (1 in 100 people or less):
Irregular menstrual flow, vaginal discharge, thrush, nausea, dizziness, bloating, stomach pain, headache, migraine, blood clots in the veins, anxiety, increased or decreased libido, swollen face or ankles, itching, acne, hair loss, intolerance to contact lenses, or gallbladder problems.
Rare (1 in 1,000 people or less):
Exacerbation of asthma or epilepsy, irritability, increased hair growth, vomiting, growth of fibroids, ovarian cancer, heart attack, stroke, pancreatitis, or skin disorders.
Please note that the list provided here is not a comprehensive account of the side effects this product may induce. More can be found by consulting the leaflet.
Taking it with other medicines
Some products may inhibit the function of Prempak-C, or vice versa. Let your doctor know if you are using any other treatments, including the following: anticonvulsants such as phenobarbital, phenytoin or carbamazepine; antibiotics for tuberculosis, including rifampicin and rifabutin; antivirals for HIV, such as nevirapine, efavirenz, ritonavir or nelfinavir; St. John’s wort; metyrapone; or aminoglutethimide.
Conditions to look out for
Refrain from the use of this treatment if you have or have ever had: a blood clot in a vein; a disorder which affects blood clotting; a heart attack or stroke; any unexplained cases of vaginal bleeding; excessive development of the endometrial lining; intolerance to lactose; liver disease; porphyria; or breast cancer, or other form of cancer which might be susceptible to oestrogens.
It may be the case with other conditions that you will need to use this medication under close supervision. Disclose any information pertaining your current and past medical state when undergoing consultation for this item.
You will need to have periodic checks with your doctor (typically at least once a year) to make sure the treatment is working as it should.
HRT and cancer
More information on HRT and cancer risk can be found in the leaflet provided.
Pregnancy and breastfeeding
This pill must not be taken during pregnancy or breastfeeding. Stop taking this treatment and inform your GP immediately if you become pregnant.
Driving and using machinery
It is unlikely that this pill will inhibit your capacity to drive or use machinery.
Lactose or sucrose intolerance
This treatment contains sucrose and lactose monohydrate. Tell your prescriber if you have an intolerance to any sugars.
Can I still drink alcohol?
Yes. Alcohol should not make this treatment any more or less effective.
Will I still be able to drive?
Yes. It is not likely that your judgment or motor skills will be impaired by the use of this drug. But, if you notice any side effects which may make it unsafe for you to drive, you should avoid doing so and speak to your GP.
Can I take the medicine while pregnant?
No. It is not suitable for those who are pregnant or suspect they could be, or are breastfeeding.
How should I store it?
Store it in a safe place, at room temperature.
Am I allergic to anything in the medicine?
These tablets are comprised of the following ingredients: conjugated oestrogens, norgestrel, lactose, methylcellulose, magnesium stearate, sucrose, glyceryl mono-oleate, macrogol, carnauba wax, calcium sulphate anhydrous, microcrystalline cellulose, pharmaceutical glaze (shellac), titanium dioxide (E171), stearic acid, purified water, shellac (E904), ethanol, N-Butyl alcohol, propylene glycol (E1520), ammonia solution, ethyl acetate, iron oxide black (E172), erythrosine (E127), sunset yellow (E110), indigo carmine (E132), povidone, sodium benzoate, quinoline yellow (E104), starch, calcium carbonate, and bleached wax.
Do not take Prempak-C if you are allergic to any of the above.
Is it available over-the-counter?
You can only buy Prempak-C if you have a prescription for it. This is because a doctor will need to make sure before you use it that it is suitable.
If you are looking to renew your prescription, take our short medical survey to have your case reviewed by a practising healthcare professional.
Is it right for me?
The HRT product you use will be determined by your GP. They will talk to you about the options available, and initiate a prescription for treatment where suitable.
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