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Zumenon is an oestrogen-only form of HRT. It is a pill marketed in the UK by Mylan, and can be used in single-hormone HRT (in women who have had a hysterectomy), or in addition to a progestogen in combined HRT (in women with an intact uterus).

Our private prescription service enables you to buy Zumenon online. Take our questionnaire to start your consultation, and your case will be reviewed by one of our registered practitioners. Approved orders are shipped by next-day parcel from our UK pharmacy.

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Contains 1mg of estradiol. Take as directed by your doctor.

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This pill contains 2mg of estradiol. Take as prescribed.

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Zumenon is an oestrogen-only form of HRT. It is a pill marketed in the UK by Mylan, and can be used in single-hormone HRT (in women who have had a hysterectomy), or in addition to a progestogen in combined HRT (in women with an intact uterus).

Our private prescription service enables you to buy Zumenon online. Take our questionnaire to start your consultation, and your case will be reviewed by one of our registered practitioners. Approved orders are shipped by next-day parcel from our UK pharmacy.

This content was reviewed by a clinician on

14 April 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 14 April 2021
Product information

Zumenon is a HRT pill containing a form of oestrogen called estradiol. It can be taken on its own by women who have been hysterectomised (had surgery to remove their uterus) but will normally be taken in conjunction with a progesterone by women who haven’t had this procedure. Mylan market Zumenon in the UK, and it is a prescription only treatment.

Most women will encounter the menopause between the ages of 45 and 55 (the average age at which it occurs among UK women is 51). It marks the end of the period during which a woman is fertile, and the level of oestrogen produced by the body begins to change. This can result in various symptoms, such as hot flushes, mood swings and dizziness. Menstrual bleeding will start to become less regular, before eventually coming to a stop. A drop in oestrogen can also lead to loss of bone density, meaning that bones become weaker and more prone to breaks and fractures.

Not all women will experience these symptoms to a degree that they have a significant impact on their day-to-day life; and as such, many women will prefer not to use treatment. But there are prescription medicines that can help to alleviate menopause symptoms. Hormone replacement therapy works by increasing the level of oestrogen in the body, and this supplements falling levels of the hormone, reducing the severity of symptoms. It also reduces the risk of osteoporosis.

There are two main types of HRT; combined and single. Combined HRT refers to those regimes where progesterone is given in addition to oestrogen, and works to counter-balance levels of the hormone (oestrogen when given on its own in women with an intact uterus can increase the risk of certain types of cancer).

Oestrogen-only therapy tends to be given to women who have had a hysterectomy. Zumenon contains oestrogen only, so can be used as a single HRT option, or in combined HRT when taken alongside a progestogen.

Women experiencing menopause symptoms for the first time should see their doctor initially. They will be able to go through the different treatment options, and offer guidance on which is likely to be the most suitable.

You can easily renew your prescription for HRT and buy Zumenon online through our confidential pharmacy platform. To start your consultation, take our questionnaire, and one of our doctors will review your answers. After your order has been approved by them, your prescription will be prepared at our UK pharmacy and shipped to you by 24 hour courier. Most medications are delivered within one working day of consultation.

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Page last reviewed:  14/04/2021

Take this treatment as directed by your prescriber, and read the instructions in the leaflet fully before use.

  1. If you have had surgery to remove your uterus, you will likely be advised to take this pill on its own (single HRT).
  2. Women who have not had a hysterectomy will normally be issued a progestogen to take alongside the pill either every day (if using continuous combined therapy) or on the last 10 or 14 days of each month (if using sequential combined therapy).
  3. The usual dose is one pill daily.
  4. Swallow your tablet whole with water.
  5. If you are switching from a cyclical (or sequential) form of HRT, you should finish the course you are on and start taking Zumenon on the first day of your next cycle.
  6. If you are not taking another form of HRT and it has been at least six months since your last menstrual bleed, or are switching from continuous HRT, you can start using Zumenon on any day.
  7. When taking Zumenon as part of sequential therapy, you may have some bleeding or spotting for the first few months of taking it. However, if you continue to have bleeding after the first few months of use, you should speak to your doctor.  
  8. If you miss a pill, you can take it when you remember if it has been less than 12 hours since your missed dose. If it has been more than 12 hours, you should skip the one you have missed and take your next pill at the usual scheduled time (discarding the missed pill).
  9. Do not exceed the dose prescribed.

If you are unsure of anything when taking this treatment, ask your pharmacist or your doctor for advice.

Page last reviewed:  14/04/2021
Please read the patient information leaflet for this medicine fully before use:

Zumenon 1mg

Zumenon 2mg

Side effects

Side effects

If you develop any side effects that become serious, or notice any signs of a blood clot (swelling or pain in the leg, difficulty breathing or dizziness), an allergic reaction (hives, swelling of the face or throat, or breathing problems) heavy or painful menstrual bleeding, heart attack or stroke, you should seek immediate medical attention.

Additionally, you should speak to your doctor if you develop unexpected bleeding after some time on HRT, or if this continues after stopping HRT.

Common (1 in 10 women or less):

Headache, feeling sick, leg cramps, abdominal pain, pelvic pain, unscheduled bleeding or spotting, wind, feeling weak, weight changes, rash or itching.

Uncommon (1 in 100 women or less):

Hypersensitivity reaction such as skin rash, itching, skin redness, hives, erythema nodosum, low mood, vaginal thrush, high blood pressure, swelling of the ankles, feet or fingers, water retention, peripheral vascular disease, varicose veins, blood clots in the legs or lungs, gall bladder disorder, back pain, indigestion, anxiety, dizziness, sight problems, palpitations, breast pain or tenderness.

Rare (1 in 1,000 women or less):

Irritation when wearing contact lenses, premenstrual tension, migraine, vomiting, bloatedness,  excess hair growth, acne, muscle cramps, vaginal discharge, tiredness, swelling of the breasts, change in sex drive.

Very rare (1 in 10,000 women):

Reduction in red blood cells which can cause anaemia.

Side effects that have been reported in association with estradiol treatment include:

Fibroids in the womb getting bigger, chorea, worsening of epilepsy, blood clots in the arteries, pancreatitis, gastroesophageal reflux disease, liver disorders, chloasma, target-shaped rash, skin discolouration, swelling of the skin around face and throat, urinary incontinence, painful or lumpy breasts.

Please consult the leaflet provided for more information on side effects.


Taking it with other medicines

Let your prescriber know about any medications you are using.

Zumenon may interact with: treatments used in epilepsy, such as phenobarbital, phenytoin and carbamazepin; tuberculosis medicines such as rifampicin or rifabutin; HIV medicines, such as nevirapine, efavirenz, ritonavir and nelfinavir; St John’s Wort; tacrolimus and cyclosporin; fentanyl; or theophylline.

Conditions to look out for

You should not use Zumenon if you: have or have ever had breast cancer, or a suspected case; have cancer which is sensitive to oestrogens, such as cancer of the womb lining, or a suspected case; have unexplained vaginal bleeding; have untreated excessive thickening of the womb lining; have or have ever had a blood clot in a vein, for example in the legs, or in the lungs; have a blood clotting disorder; have or recently have had a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina; have or have ever had a liver disease from which your liver function has not recovered; have porphyria; have an allergy to oestradiol or any of the other ingredients in Zumenon; still have your womb but are not also taking progesterone.

Inform your doctor if you have or have ever had any of the following, as they may affect your treatment regime, or you may need to have check-ups more often while taking this treatment: fibroids inside your womb; endometriosis; endometrial hyperplasia; any condition which increases the risk of of a blood clot; any risk factors for oestrogen sensitive cancers such as breast cancer; high blood pressure; any type of liver disorder; diabetes; gallstones; migraine or severe headaches; lupus; epilepsy; asthma; otosclerosis; high triglycerides; or water retention.

Regular check-ups

When taking this treatment, you will need to have annual check-ups with your GP or practice nurse to monitor your symptoms and review how well HRT is working.

HRT and cancer

The hormone in this treatment can slightly increase the risk of certains types of cancer, such as breast cancer, in some women. Please refer to the leaflet for more information on this.

Pregnancy and breastfeeding

Do not use Zumenon if you are pregnant, breastfeeding or trying to get pregnant.

Driving and using machines

It is not likely that this medicine will inhibit your capacity to drive or use machinery.

Lactose intolerance

This treatment contains lactose. If you have an intolerance to some sugars, you should speak to your doctor before using it.

Page last reviewed:  14/04/2021
Please read the patient information leaflet for this medicine fully before use:

Zumenon 1mg

Zumenon 2mg


Can I still drink alcohol?

Yes. You should still be able to drink alcohol, as it is not thought to interact with this medicine.

Will I still be able to drive?

Provided you experience no side effects which hinder your ability to do so, yes. However, if you feel as though you are unable to drive safely, do not drive and ask your doctor for advice.

Can I take the medicine while pregnant?

No. Do not use this pill if you are pregnant or breastfeeding.

How should I store it?

Keep this treatment in a secure place, out of the reach of children.

Am I allergic to anything in the medicine?

The pills contain: lactose, hypromellose, maize starch, colloidal anhydrous silica, magnesium stearate, hypromellose, talc, macrogol 400, titanium dioxide (E171), red, black and yellow iron oxides (E172).

Do not take this pill if you are allergic to any of the above.

Is it available over-the-counter?

No. A prescription is required for this treatment.

How can I buy Zumenon online?

Women who haven’t used HRT before and are experiencing menopause symptoms should see their doctor in the first instance, so that the range of treatment options available can be discussed.

You can renew your prescription for Zumenon and buy HRT online using our secure consultation facility. Orders are checked by a practising doctor, before being dispensed at our GPhC-registered pharmacy and shipped by tracked parcel. Most orders are delivered within one working day.

Page last reviewed:  14/04/2021 is rated 4.9 out of 5 by 3162 customers on TrustPilot!
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