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Mycoplasma genitalium (Mgen) and ureaplasma urealyticum (UU) are bacteria that can cause infections in the reproductive tract. They are not strictly classed as STIs, but can be passed on through sex.

  1. Cause urethritis in men and cervicitis in women
  2. But sometimes display no symptoms at all
  3. Treated with antibiotics

Patients who have tested positive for these infections can buy Mycoplasma and ureaplasma treatment online. To begin your consultation, click ‘buy now’ and take our medical questionnaire.

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Mycoplasma-Ureaplasma treatment

Mycoplasma-Ureaplasma treatment

  1. Preferred treatment for Mycoplasma
  2. Effective at fighting off infection
  3. 10 day course

Mycoplasma genitalium (Mgen) and ureaplasma (UU) are types of bacteria which can cause genital infections in both men and women. While they are not specifically labelled as STIs, they can be transmitted through sexual contact. Mgen and UU do not always cause symptoms, but in cases where they do, these may include pain during sex or urination, and discharge from the penis or vagina. Both of these infections were only discovered comparatively recently, so less is known about them than other types of bacterial infection.

They are detected through urine or swab testing, and treated with antibiotics. As of 2018, the recommended treatment for Mycoplasma genitalium in the UK is a course of Doxycycline, followed by Azithromycin.

How common are Mycoplasma and Ureaplasma?

It’s not entirely clear.

Mycoplasma genitalium is thought to be one of the most prevalent causes of non-gonococcal urethritis (infection of the urethra not caused by gonorrhoea). According to official figures it is found in conjunction with Chlamydia trachomatis 11-50% of the time. Mycoplasma can sometimes be a difficult bacteria to identify and therefore analyse for antibiotic susceptibilities, as it grows very slowly.

Ureaplasma is thought to be quite a common bacteria, and in some cases can exist harmlessly in the urinary tract. However, like Mycoplasma it can also lead to symptoms, and later complications, if it results in an infection and spreads.

The risk of contracting Mycoplasma or Ureaplasma from a sexual encounter is not currently known, but they are considered to be less contagious than chlamydia. Transmission is thought to most commonly occur through vaginal sex; the risk from oral and anal sex is believed to be far lower.

What are the symptoms of Mycoplasma and Ureaplasma?

Urethritis, which both of these infections can cause, is characterised by frequent urination, a burning sensation while urinating, or pain during intercourse or ejaculation. In men, it can cause discharge from the penis. In women, the bacteria can cause mucopurulent cervicitis, which is characterised by pelvic pain, abnormal vaginal bleeding and a pale discharge.

However, data provided from sexual clinic attendees suggests that the majority of female cases are asymptomatic (don’t cause any symptoms), whereas the opposite is true for men.

Mycoplasma infections can cause persistent symptoms if they are not properly treated. According to the International Union against Sexually Transmitted Infections (IUSTI), around 40% of males with recurrent nongonococcal urethritis test positive for Mycoplasma genitalium.

Mycoplasma is thought to increase the risk of transmitting other STIs, such as HIV; so it’s important to identify the infection and get treatment where required.

How are Mycoplasma and Ureaplasma treated?

With antibiotics.

Mycoplasma and ureaplasma are less well understood than many other bacteria. Their management and treatment have not been universally agreed upon by doctors and clinicians around the world. Various combinations of antibiotics are used in different countries and even the best combinations aren’t 100% effective.

There were no specific UK guidelines until very recently. In 2018, the British Association for Sexual Health and HIV (BASHH) published their management recommendation, advising the use of Doxycycline for 7 days, followed by Azithromycin for 3 days.

If you have any of the symptoms described above or think you may have come into contact with someone that has Mycoplasma or Ureaplasma, you should get tested. This is done with a urine or swab sample, and is available at sexual health clinics as well as some GPs. You can also order a test kit online from us.

Can I get Mycoplasma and Ureaplasma treatment online?

You can order treatment through our consultation service if you have received a positive test result. A doctor will review your prescription request and, once approved, your treatment will be issued at our UK-based dispensing pharmacy. Most orders are delivered in one working day.

Sex after Mycoplasma and Ureaplasma infections

If you test positive for either Mycoplasma or Ureaplasma, there are several steps to take before it is completely safe to re-engage in sexual activity. Firstly, it is important that you consult with a doctor or a sexual health specialist who will be able to prescribe the appropriate treatment. Once your course of treatment has concluded, we then recommend waiting for three weeks to allow all traces of the bacterial infection to disappear. After this it is then advisable to take a second test to confirm there is no longer a presence of any infection. 

Page last reviewed:  26/04/2022
Types of Treatment

Types of Treatment

Mgen and UU are bacterial infections, and as such can be treated with antibiotic medicine.

Opinions have differed on the best type of antibiotic to use in the treatment of mycoplasma genitalium, as it has shown resistant qualities to some.

In 2018, BASHH released new recommendations. For uncomplicated cases of mycoplasma genitalium, they advise:  

  • Doxycycline 100mg, twice daily for seven days

followed by

  • Azithromycin 1g as a single dose on day 8

followed by

  • Azithromycin 500mg once daily on days 9 and 10.

This is the treatment currently offered by Treated.com for people who have a positive test result for Mycoplasma genitalium.

In cases where these aren’t suitable or contraindicated, or in the case of a complicated infection, another antibiotic called Moxifloxacin may be given. However, we do not provide this treatment.

How does it work?

Like most antibiotics, Doxycycline and Azithromycin work by preventing the infection-causing bacteria producing proteins it needs to spread itself. This means that the bacteria cannot grow and the isolated infection will die. Doxycycline is an example of a Tetracycline, which are commonly used to treat infections of the genital tract. Azithromycin is a type of antibiotic called a macrolide, and is effective against a wide variety of bacteria.

What are the side effects?

The most common side effect of Azithromycin is diarrhoea. Other possible side effects include; headaches, feeling sick and abdominal pain.

Consult the leaflets provided with the medicine for more information on side effects.

Can I take them with other medications?

It is vital to inform your doctor what other medicines you are taking, as this could affect your treatment and its suitability. For example, Azithromycin should not be taken with ergot alkaloids (such as ergotamine), which are used to treat migraines. Both of these antibiotics may also be affected by antacids, as they could reduce the absorption of the drug in the gut. Again, you should consult the leaflet provided for more on how other medicines affect the function of these treatments.

Page last reviewed:  26/04/2022
Questions and Answers

How do I know if I have Mycoplasma or Ureaplasma?

It isn’t possible to know without getting tested. If you have symptoms of urethritis, such as pain when going to the toilet or during sex, or discharge from the penis or vagina, you should get tested. You should also take a test if your sexual partner has had a confirmed diagnosis.

Generally, if you’re sexually active, it’s good practice to get tested regularly anyway. You can do this at a sexual health clinic, and the service is offered by GPs.

Home test kits for STIs are also available through our site.

Do Mycoplasma and Ureaplasma always cause symptoms?

Not always. Exactly how often it is symptomless is not known, but it is understood to be a sizeable percentage of cases; particularly so for women.

What does treatment involve?

Doxycycline (7 days) followed by Azithromycin (3 days) is the first-line option. If this is not suitable, then another antibiotic may be recommended.

When is it safe to have sex again? 

Only after you have waited for three weeks after concluding your course of treatment and then taking another test to confirm there is no longer a presence of bacterial infection.

What happens if it isn’t treated?

Again, it isn’t clear whether these conditions require treatment for every person who gets them. What is known is that pregnant women who test positive for ureaplasma have a slightly higher chance of going into labour too early, so if you’re female and planning to conceive then treatment is definitely recommended.

At present it isn’t known for certain whether Ureaplasma or Mycoplasma have a direct effect on male and female fertility, as there has been relatively little research conducted into these infections.

Can I buy Mycoplasma or Ureaplasma treatment online?

If you have tested positive for these infections, yes. You can buy treatment online through our UK pharmacy service. Take our questionnaire to have your case reviewed by our prescriber. Medications are shipped in secure packaging by next-day delivery.

If you suspect you may have an infection but haven’t been tested yet, you should arrange to do this as soon as possible.

Page last reviewed:  26/04/2022

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This content was reviewed by a clinician on

26 April 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 26 April 2022
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