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Mycoplasma-Ureaplasma treatment

Azithromycin + Doxycycline

The Mycoplasma Ureaplasma treatment pack contains two antibiotic medications used to treat Mycoplasma genitalium (Mgen) and Ureaplasma (urealyticum) UU infections. They work by preventing the bacteria from generating a protein it needs to spread.

You can buy the Mycoplasma and Ureaplasma treatment pack online if you have tested positive for an infection. Take our questionnaire and upload your test result, and your order will be reviewed by our doctor.

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Doxycycline, Azithromycin100mg/500mg

The pack contains 14 x 100mg Doxycycline tablets and 4 x 500mg Azithromycin tablets. Take as directed.

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The Mycoplasma Ureaplasma treatment pack contains two antibiotic medications used to treat Mycoplasma genitalium (Mgen) and Ureaplasma (urealyticum) UU infections. They work by preventing the bacteria from generating a protein it needs to spread.

You can buy the Mycoplasma and Ureaplasma treatment pack online if you have tested positive for an infection. Take our questionnaire and upload your test result, and your order will be reviewed by our doctor.

This content was reviewed by a clinician on

16 November 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 16 November 2021
Product information

The Mycoplasma and Ureaplasma treatment pack contains two antibiotics. Doxycycline is a tetracycline medicine, whereas Azithromycin is a macrolide antibiotic medicine. Both are generic tablets used to treat a wide variety of bacterial infections. Among these are Mycoplasma genitalium (Mgen) and Ureaplasma urealycitum (UU).

When used to treat Mycoplasma genitalium and ureaplasma, Doxycycline is taken for seven days (1 x 100mg tablet twice daily), then Azithromycin is taken for 3 days (2 x 500mg tablets on day 8 and 1 x 500mg tablet on days 9 and 10).

What are Mycoplasma and Ureaplasma?

Mycoplasma genitalium (Mgen) and ureaplasma urealycitum (UU) are pathogenic bacteria which can cause infections in the urethral and reproductive tract. They can often be present in addition to other infection-causing bacteria. For instance, Mycoplasma might be found in conjunction with chlamydia when someone has an infection.

Both infections are often asymptomatic, so can be present without being noticed. They both grow very slowly and belong to the family of smallest organisms that are currently known, which can make them difficult to identify and diagnose.

Mycoplasma genitalium and ureaplasma can cause nongonococcal urethritis (NGU). This is characterised by various symptoms, such as:

  • discharge from the penis in men, or from the vagina in women
  • pain during or after sex (and vaginal bleeding after sex in women)
  • swelling of the vagina
  • pain during urination
  • and pain in pelvis.

The presence of these bacteria can also increase the risk of HIV transmission.

How are they transmitted?

Mycoplasma and ureaplasma are most commonly transmitted through vaginal sex, but can be passed on via oral and anal sex as well. There are no reliable figures available on transmission rates. Even so, the infections are thought to be highly contagious (although not to the same extent as chlamydia).

How are Mycoplasma and Ureaplasma infections diagnosed?

Both infections can be detected through a urine test. In women, they may show up on a swab test. It is important to get tested if you think you have an infection caused by Mgen or UU. Because such an infection may not always cause symptoms, you should also get checked if you have a sexual partner who has developed symptoms, or if they have had a positive test result.

Regular testing (once a year or more) is generally recommended for people who are sexually active with more than one person.

Testing services are available at GUM clinics, and some GP surgeries. You can also buy an STI test kit online from our site, which tests for Mycoplasma and Ureaplasma, as well as chlamydia and gonorrhoea.

It’s unclear at present whether someone carrying the bacteria but who is asymptomatic will necessarily require treatment. However, where the bacteria is present and causing symptoms, or in people where the bacteria could pose a risk (such as in couples trying to conceive) treatment is likely to be recommended.

There is no universally agreed first-line treatment for Mycoplasma and Ureaplasma at the moment. Both bacteria have shown resistant qualities to some antibiotics.

However, the British Association for Sexual Health and HIV (BASHH) recently released guidance recommended a course of Doxycycline followed up by Azithromycin to treat uncomplicated cases of Mycoplasma genitalium.

How do Doxycycline and Azithromycin work?

The drugs stop the bacteria responsible for the infection generating an enzyme which it needs to grow and sustain itself. Once the infection can no longer spread, the immune system kills off the bacteria.

Patients with a positive test result can buy Mycoplasma and Ureaplasma treatment online through our confidential service. Take our questionnaire to have your prescription request reviewed by our doctor. After your order has been authorised, your treatment will be dispensed at our UK pharmacy and shipped by tracked next-day parcel.

Sex after Mycoplasma genitalium (Mgen) and ureaplasma urealycitum (UU)

If you test positive for Mgen or UU, we recommend consulting with a health professional and seeking treatment. Once your prescribed course of treatment has concluded, we then advise patients to wait for three weeks and then perform another test to confirm Mgen or UU are no longer present. Only after this is it completely safe to re-engage in sexual activity.

Select dose
Page last reviewed:  16/11/2021

Ensure you follow the directions your prescriber provides, and read the patient information leaflet before use.

  1. Take the medicine as prescribed.
  2. On days 1-7, take one Doxycycline 100mg tablet twice daily.
  3. On day 8, take two Azithromycin 500mg tablets as a single dose.
  4. On days 9 and 10, take one Azithromycin 500mg tablet once daily.
  5. Swallow the tablets whole with water.
  6. Make sure you complete the course, even if your symptoms go away before you’ve finished it.
  7. Do not take more than your doctor tells you to.
  8. Never make up for a missed dose with a double dose. If you forget to take your medicine, continue the prescribed course as planned.

The directions supplied here are only intended as a guide. More detailed information can be found the leaflet provided.

If you aren’t sure of anything, ask your doctor.

Page last reviewed:  16/11/2021
Please read the patient information leaflet for this medicine fully before use:

Doxycycline, Azithromycin 100mg/500mg

Side effects

Side effects

Like any medication, Azithromycin and Doxycycline may cause side effects. If you experience any of these tell your doctor. If you develop any signs of:

  • an allergic reaction, such as swelling of the face, hives or difficulty breathing
  • jaundice (yellowing of the skin or eyes)
  • rash or fever
  • peeling of the skin
  • rash
  • blisters or bleeding on the lips, face, or genitals (Stevens-Johnson syndrome)
  • irregular heartbeat
  • heart rhythm disturbances
  • weakness and breathlessness
  • persistent diarrhoea with blood or mucus in the stool
  • stomach pain which travels to the back (pancreatitis)
  • kidney pain or problems passing urine
  • fits or seizures
  • or pain in the upper right section of the stomach

seek medical attention right away.


Very Common (1 in 10 people or more):


Common (1 in 10 people or less):

Headache, nausea or vomiting, pain in the abdomen, changes in white blood cell count, low blood bicarbonate.

Uncommon (1 in 100 people or less):

Oral thrush, vaginal infections, fungal infections, bacterial infections, throat inflammation, breathing difficulties, runny nose, allergic reactions, loss of appetite, anxiety, insomnia, feeling dizzy, sight problems, ear problems, palpitations, hot flushes, recurring fever, chills or sore throat, lung infection, oedema, problems swallowing, nose bleeds, digestive problems, constipation, rash, bone and joint pain, urinary pain, weakness, vaginal bleeding.

Rare (1 in 1,000 people or less):

Liver function abnormalities, feeling agitated, skin sensitivity to light.

Frequency unknown:

Blood clotting problems, mood swings, fainting, loss of smell or taste, low blood pressure, joint pain, tongue discolouration, reduced hearing, myasthenia gravis.


Below is a selection of the side effects listed for Doxycycline. If you notice any of these or are concerned, see a doctor as soon as you can.

Skin reactions such as circular, irregular red patches or a rash with flushing, fever, blisters or ulcers; peeling and swelling that looks like a burn; sensitivity to sunlight or sunburn; increased pressure in the skull causing headaches, or vision problems; swollen tongue; watery or bloody diarrhoea; fever; cramps; low blood pressure; aching joints or muscles; palpitations; signs of blood disorders such as tiredness, weakness, easy bruising or an infection; porphyria; discolouration of thyroid tissue; changes in liver function tests; hepatitis; liver failure; increase in urea in the blood; jaundice; pancreatitis; discolouration or underdevelopment of teeth; loosening of nails; Jarisch-Herxheimer reaction causing fever, chills, headache, muscle pain and skin rash; inflammation or ulcers of the gastrointestinal tract; feeling or being sick; diarrhoea; loss of appetite; ringing or buzzing noise in the ear; soreness and itching of the rectal or genital area; yeast infection of the anus or genitals.

The above is not a complete list of side effects. For more detailed information, consult the patient information leaflets.


Conditions to look out for

These drugs may not be suitable for people with certain medical conditions. Inform your doctor of your medical history during consultation, so that they can make an informed decision about your treatment and suggest an alternative where necessary.

This is particularly important if you have, or have ever had: liver problems; kidney problems; a heart condition; low potassium or magnesium levels in the blood; myasthenia gravis; lupus; porphyria; or migraine.

Taking it with other medicines

If you are using any other treatments, make sure you let your doctor know.

Azithromycin may interact with: theophylline; warfarin (or other blood thinners); ergotamine; cyclosporin; digoxin; antacids; cisapride; terfenadine; medicines for irregular heartbeat; statins; alfentanil; or astemizole.

Doxycycline may interact with or reduce the effectiveness of: penicillin; rifampicin; anticoagulants such as warfarin; quinapril; kaolin; sucralfate; oral contraceptives; barbiturates; ergotamine or methysergide; typhoid vaccine; carbamazepine, phenytoin, primidone or other antiepileptics; ciclosporin; methoxyflurane; methotrexate; antacids; or retinoids.

Pregnancy and breastfeeding

This treatment is not recommended for use in breastfeeding or expectant mothers. Consult your GP for further advice before taking this medicine.

Driving and machinery

It is not likely that your ability to drive will be affected by these medicines. However, Azithromycin may cause dizziness and fits. If you are affected by these or experience other side effects that may inhibit your coordination, do not drive or operate machinery.

Page last reviewed:  16/11/2021
Please read the patient information leaflet for this medicine fully before use:

Doxycycline, Azithromycin 100mg/500mg


Can I still drink alcohol?

Alcohol can reduce the effectiveness of Doxycycline, so you should avoid consumption until after you have completed the course.

Will I still be able to drive?

If you develop any adverse effects which impair your judgment or motor functions, then you should not drive and contact your doctor immediately.

Can I take this medicine while pregnant?

It isn’t recommended. Speak to your doctor for advice if you are pregnant or breastfeeding.

When is it safe to have sex?

Only after your treatment has concluded and you have waited three weeks before taking a second confirmatory test. 

How do I store it?

In a safe place out of the reach of children.

Am I allergic to anything in the medicine?

Azithromycin contains: azithromycin, croscarmellose sodium (E468), magnesium stearate (E572), microcrystalline cellulose (E460), silicium dioxide, (E551), poloxamer, povidone (E1201), talc, waterfree lactose, hypromellose (E464), hydroxypropylcellulose, macrogol and titanium dioxide (E171).

Doxycycline contains: sucrose, maize starch, crospovidone, basic butylated methacrylate copolymer (Eudragit E100), purified talc, the colourings E171, E132 and E172, shellac, propylene glycol, ammonium hydroxide and potassium hydroxide.

The ingredients listed are those in the versions marketed by Actavis (Azithromycin) and Kent (Doxycycline). They are generic drugs however, so these ingredients may vary depending on the version you are issued. Always check the paper leaflet with your medicine to check that there is nothing in it that you are allergic to.

Some version of Azithromycin may not be suitable for you if you are allergic to nuts.

Is it available over-the-counter?

No. You will need a prescription before you can buy Azithromycin and Doxycycline from a UK pharmacy.

How can I buy Mgen or UU treatment online?

You can only buy this treatment from our UK pharmacy if you have a positive test result. If you suspect you have an infection, but haven’t been tested yet, you can arrange to have this done through your GP surgery or at a sexual health clinic. Test kits are also available online through our site.

If you have a positive test result, take our questionnaire to start your doctor consultation. Once they have approved your prescription, your order will be dispensed at our pharmacy and your medicine shipped to you in secure, discreet packaging. Most orders are delivered within one working day of approval from our doctor.

Page last reviewed:  16/11/2021 is rated 4.9 out of 5 by 3256 customers on TrustPilot!
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