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Domperidone is a tablet used to relieve nausea, and works by easing the digestive processes in the stomach.

PLEASE NOTE: As this treatment is a generic medicine, the brand of the product you receive may be different to the one shown in the picture.

Our consultation service enables you to buy Domperidone online. When your order has been approved by our doctor, it will be dispensed and shipped from our UK pharmacy.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

30 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 30 August 2020
Product information

Domperidone is a tablet used to relieve feelings of nausea, and is made by Milpharm. It is the generic version of the pill known as Motilium. Usually, the tablets are taken three times per day, for no more than 7 days. They work by easing the passing of food through the digestive system. This helps to treat both short term feelings of sickness, and other cases lasting for up to two weeks. In addition to this, it can help to release trapped wind.

Nausea is a condition where the body’s vomiting reflex is heightened by internal or external stimulus, resulting in the need to be sick. This stimulus sends messages to the vomiting centre in the brain, via the CTZ, or chemoreceptor trigger zone, telling the body that it needs to expel vomit. This then causes the spasms in the stomach which cause sickness.

The stimulus can be one of any number of factors, with examples being those chemicals released during a migraine, conflicting signals brought on by opposing sensory information (such as in travel sickness), or the presence of an irritant in the stomach.

In some cases, the ‘digestive rhythm’ of the stomach can become upset, resulting in food travelling the wrong way back up into the oesophagus, and causing said irritation. This then expedites the sending of signals to the brain which induce the vomiting reflex.

Many cases of nausea might pass without the need for medical advice. However, those who experience consistent issues when performing a certain task while going about their daily lives or after eating a meal, should have their condition checked by a doctor. Not only will they be able to identify any underlying causes, they may also be able to prescribe a treatment which can reduce symptoms.

The way Domperidone works is to help muscles at the top of the stomach to contract, and relieve tension in those found lower down in the digestive tract. This makes it easier for food to pass through, and reduce the likelihood of irritating signals being sent to the brain. Domperidone also inhibits the function of a chemical neurotransmitter in the brain called dopamine, which communicates with the vomiting centre and encourages feelings of sickness.

If you have not used Domperidone before, we recommend you see your GP in person before ordering this treatment online. They will discuss your nausea symptoms with you, and suggest the most suitable form of medication (if any is required).

Patients who have used Domperidone before can get their prescription renewed through our site quickly and simply. Click ‘buy now’ to start your consultation. Once your request has been authorised by one of our GMC-registered doctors, your treatment will be dispensed at our pharmacy and shipped to you by next-day parcel.

Page last reviewed:  30/08/2020


It is crucial to follow the directions issued by your prescriber when administering this treatment, and to read the patient information leaflet beforehand. Doing so will enable you to reduce the chances of side effects and maximise the benefits of the tablet.

  1. Use as directed.
  2. For the treatment of nausea and vomiting, three tablets a day are usually taken.
  3. Take before food if possible.
  4. Symptoms should get better within 3-4 days of treatment.
  5. Do not take for more than 7 days.
  6. If symptoms persist, you should seek advice from your doctor.
  7. Do not exceed the prescribed amount.
  8. If you miss a dose, try to take it as soon as you can. If your next dose is due, however, you should skip the one you have missed and take your administration at the normal time.

The above forms only a summary of the instructions you will need to follow when using this item. For further guidance, please refer to the patient information leaflet provided.

Page last reviewed:  30/08/2020
Please read the patient information leaflet for this medicine fully before use:

Domperidone 10mg

Side effects & Warnings

Side effects

Like other medicines, this item may cause side effects. You should seek medical attention as a matter of urgency if you notice any signs of an allergic reaction, involuntary spasming or an increased heartbeat.

Common (1 in 10 people or less):

Dry mouth.

Uncommon (1 in 100 people or less):

Anxiety, loss of interest in sex, sleepiness or headache, diarrhoea, rash or itchiness, painful or tender breasts or discharge, or a general feeling of weakness.

Other side effects (frequency not known):

Hives, eye movement disorder, urination problems, swollen breasts (including in men), interruption periods, abnormal liver function test results.

There have been rare reports of side effects related to heart function associated with this treatment, such as increased heart rhythm, irregular heartbeat and cardiac arrest. If you notice any signs of the above, such as palpitations, a tight chest or an increase in heart rate, stop taking the treatment and seek immediate medical advice.

This is not a complete list of the side effects associated with this medication. Refer to the leaflet supplied for more detailed information.


Taking it with other medicines

Make sure you tell your prescriber when filling in our medical questionnaire about any other treatments you are currently using. This item may interact with ketoconazole or various types of antibiotic.

Do not use Domperidone if you are also using: antifungal treatment of any kind; antibiotics; high blood pressure or heart medications; antidepressants; antipsychotic medicines; treatments for cancer; HIV treatment; treatments for gastrointestinal problems; allergy medicines; or antimalarials.

Conditions to look out for

Make sure you tell your prescriber about your medical history, including any conditions you have or have had previously, during consultation.

It is not suitable for those who have: bloody, black or tarry bowel movements; evidence of an intestinal tear; or a type of tumour called a prolactinoma; moderate or severe liver disease; heart failure; prolonged QT interval; low blood potassium or magnesium levels.

It may also not be safe for use by those who have or have ever had: liver or kidney problems; lactose intolerance; or increased susceptibility to any heart rhythm disorders.

Pregnancy and breastfeeding

This medicine is not available through our service to patients who are pregnant or breastfeeding. 

If you are pregnant, breastfeeding or think you might be pregnant, speak to your doctor before you use this product.

A small amount of domperidone can be transferred to breast milk. Your doctor will decide whether using this medication is necessary.

Food, drink or alcohol

This medication should be taken before meals.

Driving and machinery

Do not drive or operate machines if you notice side effects such as sleepiness, confusion or a reduction in movement control.

Lactose intolerance

Domperidone contains lactose. If you have an intolerance, speak to your doctor before you take this medication.

Page last reviewed:  30/08/2020
Please read the patient information leaflet for this medicine fully before use:

Domperidone 10mg


Can I still drink alcohol?

It is not thought that alcohol interacts directly with this treatment. However, alcohol can exacerbate feelings of nausea and digestive discomfort, so you should not consume alcohol if you are taking this medication.

Will I still be able to drive?

Yes, but only if you experience no side effects which may make doing so dangerous. If you do, avoid driving and consult your doctor for advice as soon as possible.

Can I use this medicine while pregnant?

It may not be suitable in these cases. Talk to your doctor in person if you are pregnant or breastfeeding, as they may need to suggest an alternative form of treatment.

How do I store it?

Make sure this item is kept in an environment below 25°C, and safely out of the reach of children.

Am I allergic to anything in the medicine?

This product contains: domperidone maleate, microcrystalline cellulose, lactose monohydrate, maize starch, povidone K30, sodium lauryl sulphate, silica colloidal anhydrous, and magnesium stearate.

Do not use it if you are allergic to any of these ingredients.

Is it available over-the-counter?

You will require consultation with a doctor before you are able to buy Domperidone from any UK pharmacy. This is so that they can make sure it is safe for you to use.

How can I buy Domperidone online?

If you haven’t taken Domperidone before, speak to your doctor in person before using it for the first time.

To renew your prescription for Domperidone, take our questionnaire. Your order will be checked by one of our GMC-registered prescribers, who will issue a prescription for you on approval, and send this to our pharmacy to be dispensed. Shipping on all orders is made by tracked courier, so you can follow the progress of your parcel.

Page last reviewed:  30/08/2020
Product review

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