• Domperidone

Domperidone is a tablet manufactured and marketed in the UK by Milpharm. It is used to relieve nausea, and works by easing the digestive processes in the stomach.

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This tablet contains 10mg domperidone. It is most typically taken in adult cases four times per day, with one of these doses being taken at night, for the period specified by your prescriber.

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Domperidone is a tablet used to relieve feelings of nausea, and is made by Milpharm. It is the generic version of the pill known as Motilium. Usually, the tablets are taken four times per day for a specified period. They work by easing the passing of food through the digestive system. This helps to treat both short term feelings of sickness, and other cases lasting for up to two weeks. In addition to this, it can help to reduce heartburn and trapped wind.

  1. Alleviates nausea
  2. Helps better digestion
  3. Simple four a day tablet

Nausea is a condition where the body’s vomiting reflex is heightened by internal or external stimulus, resulting in the need to be sick. This stimulus sends messages to the vomiting centre in the brain, via the CTZ, or chemoreceptor trigger zone, telling the body that it needs to expel vomit. This then causes the spasms in the stomach which cause sickness.

The stimulus can be one of any number of factors, with examples being those chemicals released during a migraine, conflicting signals brought on by opposing sensory information (such as in travel sickness), or the presence of an irritant in the stomach.

In some cases, the ‘digestive rhythm’ of the stomach can become upset, resulting in food travelling the wrong way back up into the oesophagus, and causing said irritation. This then expedites the sending of signals to the brain which induce the vomiting reflex.

Many cases of nausea might pass without the need for medical advice. However, those who experience consistent issues when performing a certain task while going about their daily lives or after eating a meal, should have their condition checked by a doctor. Not only will they be able to identify any underlying causes, they may also be able to prescribe a treatment which can reduce symptoms.

The way Domperidone works is to help muscles at the top of the stomach to contract, and relieve tension in those found lower down in the digestive tract. This makes it easier for food to pass through, and reduce the likelihood of irritating signals being sent to the brain. Domperidone also inhibits the function of a chemical neurotransmitter in the brain called dopamine, which communicates with the vomiting centre and encourages feelings of sickness.

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How to use Domperidone

It is crucial to follow the directions issued by your prescriber when administering this treatment. Doing so will enable you to reduce the chances of side effects and maximise the benefits of the tablet. Prior to use, it is also advisable to read the patient information leaflet.

  1. Use as directed.
  2. For the treatment of nausea and vomiting which lasts for a period of less than 48 hours, four tablets a day are taken. One of these should be taken at night.
  3. In more continual cases where feelings of sickness arise after the consumption of food, the dosage is the same.
  4. If symptoms persist for more than two weeks, you should seek advice from your doctor.
  5. Do not exceed the prescribed amount.
  6. If you miss a dose, try to take it as soon as you can. If your next dose is due, however, you should skip the one you have missed and take your administration at the normal time.

The above forms only a summary of the instructions you will need to follow when using this item. For further guidance, please refer to the patient information leaflet provided.

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Domperidone side effects

Like other medicines, this item may cause side effects. You should seek medical attention as a matter of urgency if you notice any signs of an allergic reaction, involuntary spasming or an increased heartbeat.

Common (1 in 10 people or less):
Dry mouth.

Uncommon (1 in 100 people or less):
Anxiety, loss of interest in sex, sleepiness or headache, diarrhoea, rash or itchiness, painful or tender breasts or discharge, or a general feeling of weakness.

Other side effects (frequency not known):
Hives, eye movement disorder, urination problems, swollen breasts (including in men), interruption periods, abnormal liver function test results.

This is not a complete list of the side effects associated with this medication. Refer to the leaflet supplied for more detailed information.

Taking it with other medicines

Make sure you tell your prescriber when filling in our medical questionnaire about any other treatments you are currently using. This item may interact with ketoconazole or various types of antibiotic.

Conditions to look out for

It is not suitable for those who have: bloody, black or tarry bowel movements; evidence of an intestinal tear; or a type of tumour called a prolactinoma. It may also not be safe for use by those who have or have ever had: liver or kidney problems; lactose intolerance; or increased susceptibility to any heart rhythm disorders.


Q&A: our Domperidone discussion forum

Can I still drink alcohol?

Technically, yes. It is not thought that alcohol interacts directly with this treatment. However, alcohol can exacerbate feelings of nausea and digestive discomfort, so we would therefore strongly recommend against consuming alcohol, particularly in large amounts, if you are taking this medication.

Will I still be able to drive?

Yes, but only if you experience no side effects which may make doing so dangerous. If you do, avoid driving and consult your doctor for advice as soon as possible.

Can I use this medicine while pregnant?

It may not be suitable in these cases. Tell your prescriber if you are pregnant or breastfeeding, as they may choose to suggest an alternative form of treatment.

How do I store it?

Make sure this item is kept in an environment below 25°C, and safely out of the reach of children.

Am I allergic to anything in the medicine?

This product contains: domperidone maleate, microcrystalline cellulose, lactose monohydrate, maize starch, povidone K30, sodium lauryl sulphate, silica colloidal anhydrous, and magnesium stearate.

Do not use it if you are allergic to any of these ingredients.

Is it available over-the-counter?

You will require consultation with a doctor before you are able to buy Domperidone from any UK pharmacy. This is so that they can make sure it is safe for you to use. Complete our medical survey to have your case reviewed by one of our registered practitioners.

Is it right for me?

It takes just a couple of minutes to fill in our health questionnaire. This will help us to determine whether or not Domperidone is suitable for you to use. If it is, our doctor will issue a prescription for the item and send this electronically to our dispensing pharmacy. Following approval, your order will then be prepared and shipped to your home via tracked courier.


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