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Synalar/Synalar and Neomycin/Synalar and Clioquinol

Synalar is a treatment used to relieve skin conditions, such as psoriasis. It contains a type of drug called a corticosteroid which alleviates irritation.

This treatment is not available to buy from our pharmacy. We recommend you see your GP if you are seeking to renew your prescription for this item.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

23 September 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 23 September 2020
Product information

Synalar is a treatment for skin conditions such as psoriasis, and is marketed in the UK by GP Pharma. A number of different versions are available, including: Synalar 1 in 4 cream; 1 in 10 cream; Synalar gel; and Synalar N ointment. They are all topical medicines which help to alleviate skin irritation.

  1. Cream, gel or ointment available
  2. Simple to use topical treatment
  3. One week duration of use

Psoriasis is a condition which causes patches of irritation to appear on the skin. These will usually include redness, itchiness, and the appearance of scaly flakes. Breaks in the skin may also develop and sometimes, infection can occur too. It is a condition which affects around two percent of the UK population, and is a chronic one.

Flare-ups can be induced by a number of triggers, including stress, smoking, drinking excessive amounts of alcohol, a reaction to medication or hormonal changes taking place. The cause of psoriasis has not been definitively identified, but it is thought to be the result of the immune system attacking otherwise healthy skin cells, and causing replacement skin cells to generate before they are required. This causes inflammation and irritation in the area affected, and as the cells travel to the surface of the skin, the outer layer begins to flake off.

Symptoms typically appear on the elbows, knees, lower back and on the scalp, but they can occur in other areas too. How the condition is treated will usually depend on the severity of symptoms, and how much these are impacting the patient’s quality of life.

Topical corticosteroids are a popular choice for those instances which are mild to moderate. In Synalar, the functioning ingredient fluocinolone acetonide works by inhibiting the effects of inflammatory chemicals. This reduces symptoms in the affected area, soothing irritation and helping the skin to heal. Synalar N ointment also contains an antibiotic called neomycin sulphate, which helps to clear up any signs of infection which be present. It does this by attacking the offending bacteria and preventing its ability to grow.

Synalar is available to buy in several different strengths, and the version which you use will depend on the severity of symptoms. The 1 in 10 cream is the lowest concentrated dose, followed by the 1 in 4 cream, with the gel and the ointment being the highest.

We do not provide Synalar through our service at this time. If you are experiencing symptoms but have not seen a doctor in person, you should make an appointment with your GP. They will be able to initiate a prescription for you if required.

Page last reviewed:  23/09/2020

You should familiarise yourself with the instructions provided prior to use, and make sure you follow the directions given by your prescriber. Doing so will enable you to get the best possible results from your medication and reduce the likelihood of side effects.

  1. Use as directed by your doctor.
  2. In most cases, this will be a thin layer applied to the area affected two or three times per day.
  3. The maximum duration of treatment is usually seven days.
  4. Gently rub in the cream, gel or ointment.
  5. It is advisable to use the treatment at the same time each day.
  6. Do not exceed the amount prescribed for you.
  7. Forgotten doses should be applied as soon as you remember, unless it is time for your next dose. In this case, skip the one you have missed and carry on the course as normal.

The above constitutes only a summary of the directions you will need to follow when using this treatment. For more information, consult the leaflet provided.


Page last reviewed:  23/09/2020
Please read the patient information leaflet for this medicine fully before use:

Synalar N ointment 0.025%

Synalar 1 in 4 Cream 0.00625%

Synalar Gel 0.025%

Synalar cream 0.025%

Side effects & Warnings

Please be aware that not everyone who uses these items will experience side effects. However, it is still important to be aware of these so that you can seek medical attention in the event that they occur.

Tell your doctor right away if you notice: any signs of an allergic reaction, such as swelling or hives; irritation where the ointment has been applied; worsening of acne, rosacea and dermatitis around the mouth; patches of pale skin; or localised increased hair growth.

Some side effects associated with prolonged or excessive use include: stretch marks; thinning of the skin or visible small veins; roundness of the face; muscle wasting; fluid retention; damage to the kidneys; or impaired hearing.

For more information on side effects, consult the leaflet supplied.

Taking it with other medicines

Inform your prescriber if you are using any other treatments during consultation.

Conditions to look out for

These products should not be used for: rosacea; acne; nappy rash; perioral dermatitis; or on the ears if the eardrum is damaged.

Let your prescriber know if you have any other conditions which may affect your capacity to use this treatment safely.

Pregnancy and breastfeeding

Speak to your GP before using this medicine. If you are pregnant, breastfeeding or planning to become pregnant, you should only use Synalar if your doctor deems it absolutely necessary.

Driving and using machinery

It is not likely that this treatment will interfere with your driving or capacity to use machines.

Page last reviewed:  23/09/2020
Please read the patient information leaflet for this medicine fully before use:

Synalar N ointment 0.025%

Synalar 1 in 4 Cream 0.00625%

Synalar Gel 0.025%

Synalar cream 0.025%


Can I still drink alcohol?

Yes, provided your doctor allows it. In some cases, the effect of antibiotics such as in Synalar N can be inhibited by alcohol, so always check before use.

Will I still be able to drive?

Yes. These items are not likely to compromise your motor skills or judgment. But, if you notice any side effects which may affect your ability to drive, refrain from doing so and let your doctor know.

Can I take the medicine while pregnant?

Talk to your doctor before using these or any other treatments if you are pregnant, breastfeeding or trying to become pregnant, as they may not be suitable.

How should I store it?

Store these products in safe environment below 25°C.

Am I allergic to anything in the medicine?

Synalar 1 in 4 and 1 in 10 both contain the following: fluocinolone acetonide, benzyl alcohol, cetostearyl alcohol, citric acid, liquid paraffin, polysorbate 60, propylene glycol, purified water and sorbitan monostearate.

In Synalar gel are the following ingredients: fluocinolone acetonide, carboxypolymethylene, citric acid, disodium edetate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, purified water and triethanolamine.

The ingredients of Synalar N ointment are: fluocinolone acetonide, neomycin sulphate, lanolin, liquid paraffin, propylene glycol, and white soft paraffin.

Do not use these items if you are allergic to any of the respective constituents contained in them.

Is it available over-the-counter?

You will need a prescription in order to be able to buy any of these medicines. This is so that a doctor can ensure it is the most suitable treatment for your symptoms.

Is it right for me?

The treatment you use will be determined following examination of your symptoms in person, either with your GP or specialist. They will initiate a prescription for treatment where required.

We do not provide this item online. If you are looking to renew your prescription, we recommend you speak to your GP in person.

Page last reviewed:  23/09/2020 is rated 4.9 out of 5 by 3131 customers on TrustPilot!
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