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Emtricitabine/tenofovir disoproxil

Truvada is an antiviral drug used in pre exposure prophylaxis (PrEP). It contains two active ingredients (emtricitabine and tenofovir disoproxil) and helps to lower the risk of HIV transmission.

You can buy Truvada online from our pharmacy, but because we only stock this version of the drug to order, it may take longer than 24 hours to reach you. We also have Generic PrEP available, and most orders for this are delivered from our UK pharmacy within one working day.

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Emtricitabine/Tenofovir Disoproxil200mg/245mg

Generic PrEP. This tablet contains 200mg emtricitabine and 245mg tenofovir disoproxil. The standard dose is one tablet a day, taken with food. Shipped in one working day.

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Contains 200mg emtricitabine and 245mg tenofovir disoproxil. One tablet should be taken each day with food. Please note that we only stock the branded version of this treatment according to orders we receive, so your order will take more than 24 hours to reach you.

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Truvada is an antiviral drug used in pre exposure prophylaxis (PrEP). It contains two active ingredients (emtricitabine and tenofovir disoproxil) and helps to lower the risk of HIV transmission.

You can buy Truvada online from our pharmacy, but because we only stock this version of the drug to order, it may take longer than 24 hours to reach you. We also have Generic PrEP available, and most orders for this are delivered from our UK pharmacy within one working day.

This content was reviewed by a clinician on

08 June 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 08 June 2021
Product information

Truvada is a prescription medication made by Gilead and used in pre exposure prophylaxis, referred to as PrEP. It is a type of antiviral treatment called an ‘antiretroviral’, and works by inhibiting the activity of an enzyme the virus requires to develop. It is a tablet taken once a day which reduces the risk of HIV transmission.

If you have not used PrEP before, you will need to take a test to confirm your HIV status first. Testing is available from your local GUM clinic, or you can order a test kit through our service.

(Read more on what you need to do before you take PrEP.)

If you are already taking this treatment or have used it before, and want to buy PrEP online, you can do so using our secure prescription service. We work with GMC-registered doctors, who review every prescription request made through our site. Approved orders are dispensed and shipped at our UK-based pharmacy.

Persons using the treatment to lower their HIV risk should note that it doesn’t completely eliminate the risk of transmission. They will still need to practice safe sex, by taking precautions such as using a condom, to help ensure their risk is as low as possible.

This drug is available from our pharmacy only to patients who are taking it for PrEP. You will need to speak to your own GP if you are using a similar drug to treat HIV and want to renew your prescription.

How is HIV transmitted?

HIV is a condition which can be transferred from one person to another via semen, vaginal fluid, anal fluid, or blood. This means it can be transmitted through unprotected sex, or through the use of shared needles or syringes; however, unprotected sex is thought to be the more common route of transmission in the UK.

Does HIV cause any symptoms?

The virus does not cause particularly distinctive symptoms during its early stages. Someone who is infected may notice flu-like symptoms, but these are easy to confuse with other illnesses. If it is not treated, the virus can cause significant damage to the immune system (leading to acquired immune deficiency syndrome, or AIDS), rendering it unable to defend against infections and illness.

How is HIV treated?

There is presently no cure for human immunodeficiency virus, or HIV. Once infected, the aim of treatment is to suppress the virus as much as possible, so it cannot develop. This is given in the form of antiretrovirals, which stop the function of an enzyme in the body, called reverse transcriptase. The virus uses this enzyme to grow; without it, the virus cannot reproduce.

Truvada is only indicated for use as in PrEP. It can’t be taken by people who are HIV positive, who will require different treatment.

How does Truvada work?

Truvada contains two active ingredients, called emtricitabine and tenofovir disoproxil. These work in a similar way to the drugs used in HIV treatment; by limiting conditions in the body for the virus to develop. However, Truvada is only intended for pre exposure use, to reduce the risk of HIV transmission.

Our secure pharmacy facility enables you to renew your PrEP prescription online. Every request is checked by a registered doctor before being dispensed at our UK pharmacy. Shipping on all orders is made is by tracked courier.

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Page last reviewed:  08/06/2021

Please also read our page on what to do before starting PrEP.

Take the medication as instructed by your prescriber. Before using the treatment, make sure you read the patient information leaflet provided.

There are a few different methods of PrEP use. Below, we’ve included the instructions for daily use. This is effective for both vaginal and anal sex. However, you should always take PrEP as your doctor has directed.

(You can find more info on our page explaining the different ways of taking PrEP.)

PrEP daily use

  1. One tablet should be taken each day.
  2. Truvada should reach its full efficacy after 7 days of starting to take it.
  3. It should ideally be taken with food where possible.
  4. The tablet can be crushed and mixed with 100ml of water if you have trouble swallowing whole tablets.
  5. You should take the medicine at the same time each day.
  6. Do not take more than the amount recommended by your doctor. If you do, let your doctor know immediately.
  7. It is important to ensure you do not miss a dose.
  8. If you forget to take Truvada, and realise within 12 hours of your usual dose time, you should take it as soon as possible (with food ideally). You should then take your next tablet at the usual time.
  9. If you forget to take Truvada but do not realise until 12 or more hours have passed since your usual dose time, then you should skip the dose you have missed and take your next one at the usual time.
  10. If you are sick (vomit) within an hour of taking this tablet, take another. If you vomit more than one hour after taking Truvada, you do not need to take another tablet.
  11. You should not stop taking Truvada without consulting your doctor first.

If you are unsure of anything to do with this medicine, speak to your doctor or pharmacist.

More detailed directions can be found in the leaflet supplied.

Page last reviewed:  08/06/2021
Please read the patient information leaflet for this medicine fully before use:

Emtricitabine/Tenofovir Disoproxil 200mg/245mg

Truvada 200mg/245mg

Side effects

If you notice any signs of:

  • an allergic reaction, such as swelling of the lips, face or throat, or hives;
  • lactic acidosis, such as rapid deep breathing, drowsiness, or nausea or vomiting;
  • inflammation;
  • infection;
  • immune disorders, such as muscle weakness, or weakness starting in the hands and feet and travelling up the trunk of the body, palpitations, tremor or hyperactivity;
  • or any other side effects that become serious;
    seek medical advice immediately.

Very common (more than 1 in 10 people):

Diarrhoea, being sick, feeling sick, dizziness, headache, rash, weakness, or abnormal test results for phosphate or creatine kinase.

Common (up to 1 in 10 people):

Stomach pain, sleep disruption, abnormal dreams, indigestion, feeling bloated, flatulence, rashes (with red spots or blotches, or blistering and swelling of the skin),
itchiness, changes in skin colour (such as darkening of the skin in patches), wheezing, swelling or feeling light-headed, abnormal blood cell count, increased triglycerides, bile or sugar in the blood, liver and pancreas problems.

Uncommon (up to 1 in 100 people):

Inflammation of the pancreas causing stomach pain, swelling of the face, lips, tongue or throat, anaemia, muscle pain or weakness due to kidney damage, abnormal blood potassium and creatinine levels, urinary changes.

Rare (up to 1 in 1,000 people):

Lactic acidosis, fatty liver, yellow skin or eyes, itching, abdominal pain, kidney inflammation, urinating frequently and feeling thirsty, kidney failure, damage to
kidney tubule cells, softening of the bones, back pain caused by kidney problems.

Frequency unknown

Osteonecrosis leading to joint stiffness, joint aches and pains (especially of the hip, knee and shoulder), and difficulty with movement. Let your doctor know if you notice any of these symptoms.

The above information is not comprehensive. Consult the leaflet for more information on side effects.


Taking it with other medicines

Let your doctor know during consultation if you are using or have recently used any other medications.

Truvada should not be taken by anyone who is taking other treatments which also contain the same active ingredients, emtricitabine and tenofovir disoproxil fumarate, or medicines containing tenofovir alafenamide, lamivudine or adefovir dipivoxil.

It is important to tell your doctor if you are using didanosine, aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, interleukin-2, cidofovir, non-steroidal anti-inflammatory drugs, protease inhibitors, ledipasvir/sofosbuvir or sofosbuvir/velpatasvir.

Conditions to look out for

If you are allergic to any of the ingredients in this drug, do not use it.

Tell your doctor during consultation if you have or have ever had: kidney problems, or liver disease such as hepatitis (you will need to know your hepatitis infection status before using Truvada).

If you are over 65

Speak to your doctor first before taking Truvada.

Lactose intolerance

This drug contains lactose. If you have any intolerances to sugars, tell your doctor.

HIV testing

If you are sexually active, it is important to be tested for HIV and other STIs regularly.

Truvada can only reduce your risk of infection if you are HIV negative when you start using it. Make sure you get tested before taking Truvada.

Please note that people who are HIV positive will need to take this drug alongside one or more other antiretroviral medicines.

The incubation period for HIV can last for up to several weeks, so tests do not always identify recent infections.

The following symptoms might be signs of a recent infection. If you notice any of the below, either in the weeks before starting Truvada or when taking it, inform your doctor:

  • high temperature or fever
  • headache
  • aching joints or muscles
  • being sick
  • diarrhoea
  • tiredness
  • rash
  • sweating in the night
  • swollen lymph nodes

Pregnancy and breastfeeding

Speak to your doctor before taking this medication if you are pregnant, think you could be pregnant or are planning to become pregnant.

Women taking Truvada who are able to become pregnant should ensure they use contraception to avoid becoming pregnant.

Do not breastfeed while using this medication.

Driving and machinery

This treatment may cause dizziness. If you are affected by this, do not drive or use machines.

Safe sex and other precautions

The risk of HIV can be further reduced by the following:

  • practising safe sex (using a condom);
  • getting tested for other STIs (other infections can increase the risk of HIV);
  • not sharing any items which contain body fluids (razors or dental cleaning equipment, such as toothbrushes);
  • not sharing or re-using needles.

Speak to your doctor for further guidance.

Page last reviewed:  08/06/2021
Please read the patient information leaflet for this medicine fully before use:

Emtricitabine/Tenofovir Disoproxil 200mg/245mg

Truvada 200mg/245mg


Can I still drink alcohol?

There is no specific information on interactions with alcohol given in the patient information leaflet.

However, you should ensure you keep alcohol consumption within sensible levels. This will help to make sure you take the medication at the right time, and practice safe sex.

Will I still be able to drive?

Dizziness is a possible side effect of Truvada. If you become dizzy, do not drive.

Can I take this medicine while pregnant?

If you are pregnant or planning to become pregnant, you will need to speak to your doctor for further guidance before commencing use of Truvada.

Women taking Truvada should not breastfeed.

How do I store it?

In a safe place out of the reach of children, at room temperature.

Am I allergic to anything in the medicine?

The tablets contain: emtricitabine, tenofovir disoproxil, croscarmellose sodium, glycerol triacetate (E1518), hypromellose (E464), indigo carmine aluminium lake (E132), lactose monohydrate, magnesium stearate (E572), microcrystalline cellulose (E460), pregelatinised starch (gluten free) and titanium dioxide (E171).

If you are allergic to any of the ingredients listed, do not use Truvada and contact your doctor.

Is it available over-the-counter?

No. PrEP is only available on prescription.

I think there’s a possibility I’ve been exposed to HIV, will I be able to take this medication?

No, Truvada should never be used in these circumstances. It only reduces the likelihood of contracting HIV if it is used in the correct way. For people who have HIV, it is used in conjunction with other treatments. If there is a chance you’ve been exposed to this infection, it is important you consult with a doctor or specialist sexual health nurse. They may prescribe Post-Exposure Prophylaxis (PEP). Make sure you do this as soon as possible, and absolutely within 48 hours of having sex. 

How can I get PrEP online?

If you have not taken PrEP before, you will need to be tested for HIV before use. Make an appointment with your GUM clinic to arrange this. HIV test kits are also available online through our service.

Patients looking to buy or renew their existing prescription for Truvada or PrEP can do so online, through our secure consultation facility. Every order is reviewed confidentially by a practising doctor, before being dispensed at our UK pharmacy and shipped by tracked delivery.

Page last reviewed:  08/06/2021 is rated 4.9 out of 5 by 3209 customers on TrustPilot!
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