Pevanti is a corticosteroid that is prescribed to treat inflammation caused by conditions such as asthma, eczema and arthritis. It is manufactured and marketed by Mercury Pharmaceuticals Limited.
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Pevanti is a corticosteroid prescribed to treat inflammation, often caused by autoimmune conditions like allergies, asthma or arthritis. It’s normally given as a relatively high dose to start with, and tapered off to a lower dose over the course of several weeks. The generic name for Pevanti is prednisolone, and it is manufactured by Mercury Pharmaceuticals.
There are lots of conditions that can cause inflammation, including eczema, asthma, rheumatoid arthritis and inflammatory bowel disease. In autoimmune conditions like these, inflammation might be induced by a trigger, which the body’s defences then respond to.
What is asthma?
Asthma can be mild in some and very serious in others. It occurs when the airways swell and produce extra mucus, making it difficult to breathe. In less serious cases this can be a little more than an irritant, but for others, it can become impossible to breathe. Asthma flare-ups can have several triggers, including exercise or reactions to specific irritants. Although it can’t be cured, it can be managed with treatment and lifestyle changes. However asthma can change over time, so regular check-ups are a must.
Is eczema the same as psoriasis?
Skin disorders, such as eczema and psoriasis, often cause severe rashes and deeply irritated skin. The two conditions are not the same, but there are many similarities and both can be treated with corticosteroids. Psoriasis is caused by a reaction of the immune system, which attacks healthy cells as if they were a foreign invader, thus causing the symptoms. The exact causes of eczema are partly unknown, although an immune reaction is thought to play a role in symptoms.
What is rheumatoid arthritis?
Rheumatoid arthritis is a painful condition whereby the body’s immune system begins attacking the joints. This classifies it as an auto-immune condition, which means it can only be managed not cured. Unlike osteoarthritis, which is caused by the wear and tear of lubricating tissue in the joints, rheumatoid arthritis can occur at a much younger age. The condition can lead to deformities of the joints and even erosion of the bone itself.
What is ulcerative colitis?
Ulcerative colitis is an inflammatory bowel disease. It occurs in the large intestine, producing varying sized ulcers. It can lead to an assortment of symptoms, such as dehydration, anaemia, swelling of the eyes, liver disease and a higher risk of bowel cancer. It is not exactly known what causes ulcerative colitis, but genetics and long-term response to infections are thought to be contributing factors.
What is lupus?
Lupus is another auto-immune condition that causes inflammation. It can be systemic, causing fever, hair loss, joint pain, sensitivity to sunlight, stomach issues, sores, rashes and extreme fatigue. While there is not thought to be a single contributing factor for the cause of lupus, some think it’s caused by genetics, with certain medications believed to increase the risk of triggering it. Lupus tends to come and go, with flare ups and periods of remission lasting anywhere between a few days to several years. For some, it is a chronic condition, whereby symptoms are always present.
Diagnosis will depend on the condition itself. For skin conditions like eczema, a doctor will simply inspect the area that has a rash. For other conditions like lupus, you may need blood tests, x-rays and biopsies. Treatment is again dependent on the condition
As with all corticosteroids, Pevanti works by reducing inflammation, easing symptoms and helping tissue to heal and rebuild. It does this by prohibiting the release of inflammatory causing substances. This then stops the body from attacking healthy cells.
How can I buy Peavanti?
Pevanti is not available to buy over the counter, so you will need a prescription in order to obtain treatment. If you want to renew your prescription, our prescribers may be able to do following a video consultation, but only with access to your Summary Care Record. If you are concerned you may have an autoimmune condition or want to speak to a professional about eczema or arthritis symptoms, our registered clinicians can offer advice, fit notes, access to specialists and prescriptions.
How you take Pevanti will depend on what condition it is being used to treat. It is essential that you follow your doctor’s instructions closely in order to get the full benefits of your treatment. You should also read the patient information leaflet that comes with the medication before taking it.
- Always take tablets whole
- Swallow tablets with water
- Adult dosages are typically between 20mg and 60mg at the beginning of treatment
- This will often be reduced or ‘tapered’ down over the course of a few weeks
- Certain conditions might warrant a higher starting dose
- If you forget a dosage, carry on as normal and let your doctor know. Do not double your next dose to make up for it
- If you take too much Pevanti you should seek immediate medical assistance
- It’s best to take Pevanti after breakfast at the same time each morning
All medications come with the possibility of side effects. Although in the vast majority of cases these are unlikely to occur, some side effects can be serious and will require immediate medical assistance. You should therefore keep an eye out for the following symptoms and react accordingly should they appear:
Swollen face, swollen tongue, swollen lips, swollen body, difficulty breathing, collapsing and severe abdominal pain.
The following mental health issues have been reported by around 5 in 100 people who have taken Pevanti and should be reported immediately.
Depression, suicidal thoughts, mania, mood swings, high anxiety, severe insomnia, hallucinations, deep confusion, loss of memory, personality changes and feeling addicted to Pevanti.
While the following symptoms have been reported, there is no accurate data relating to their frequency.
Increased blood pressure, diarrhoea, heart failure in those with heart conditions, sore throat, oral thrush, nausea, indigestion, bloating, weight gain, brittle bones, stomach ulcers (causing bleeding), increased appetite, indigestion, weak muscles, dizziness, insomnia, headaches, acne, thinning skin, unusual hair growth, increased risks of epileptic symptoms in those with the condition, red and purple lines on the skin, slow healing wounds, irregular menstruation, altered blood glucose, reduced growth in children and adolescents, water retention, salt retention, low potassium, renal crisis in those with scleroderma (auto-immune condition), blood clots, increased white blood cell count, increased pressure within the eye, thinning eye tissue, eye bulging, altered vision, increased risk of cataracts and recurrence of previous infections.
Conditions to look out for
Before you start treatment with Pevanti, it is of utmost importance that you inform your doctor of any pre-existing conditions you are currently suffering from and any you have experienced in the past. Failure to do so may increase the risk of worsening the condition, and other treatment may be deemed more suitable.
The following conditions make use of Pevanti unsuitable:
Allergies to any of its ingredients, systemic infections that are currently not being treated and a herpes infection of the eye.
The following conditions, while not ruling out the possibility of treatment with Pevanti, do come with further risks. Your doctor will need to weigh up the risks and benefits involved with treatment and may decide that another course of action would be more appropriate:
Bipolar disorder, depression related to steroid use in the past, mental illnesses, epilepsy, diabetes, kidney problems, high blood pressure, liver conditions, issues with the heart, blood clots (including a history of blood clots), glaucoma, myasthenia gravis (a muscle disorder), stomach ulcers, ever experienced muscle problems with steroids in the past, been in contact with someone with chickenpox, have had TB (Tuberculosis), shingles, have been in contact with someone with measles and scleroderma (an auto-immune disorder).
Taking it with other medications
All substances can interact with others in the body, so if you are taking other medications, including herbal supplements, it is imperative that you tell your doctor before starting treatment.
You should not take Pevanti after some vaccinations as it may affect how the vaccine itself works.
The following drugs may make Pevanti unsuitable for use with:
Ritonavir and cobicistat (HIV), blood thinners (such as warfarin), diabetic (such as insulin), epileptic (such as carbamazepine and phenytoin), asthmatic (such as salbutamol and salmeterol), anti-inflammatories (such as aspirin and ibuprofen), medications containing oestrogen (such as the contraceptive pill), fungal infections (such as rifampicin, ketoconazole and erythromycin), blood pressure (such as bendroflumethiazide and furosemide), ciclosporin (an immunosuppressant), methotrexate (arthritis) and mifepristone (an abortion medication).
Pregnancy and breastfeeding
If you are breastfeeding, pregnant or are thinking of becoming pregnant in the near future, you should inform your doctor before starting treatment with Pevanti. This is due to the fact that it has been linked with suppressed growth of the foetus, particularly within the first 12 weeks of pregnancy.
Driving and using machinery
If you get any side effects that affect your capacity to drive, such as dizziness or impaired vision, avoid driving and speak to your doctor.
Food, drink and alcohol
You should avoid eating real liquorice while taking Pevanti as it can increase the levels of corticosteroids in the system. There are no issues with consuming alcohol while taking Pevanti.
Pevanti has been seen to have no effect on fertility levels in men or women.
How long does it take to work?
This will depend on the condition and its severity. As no two people are exactly the same, there is no way to be accurate when assessing when you might feel better, but for some it is a matter of just a few days.
How should I store it?
You should always keep medication out of the reach of children and stored in an area that does not exceed 25°C. Medication should never be disposed of with household waste as this can affect the environment. Ask your pharmacist for advice when disposing Pevanti.
Can I buy Pevanti over the counter?
No, you will always need a prescription in order to buy Pevanti online or over the counter.
How can I buy Pevanti online?
You can buy Pevanti through our service if you have previously had it prescribed to you by your doctor. Please note that before prescribing Pevanti we will need to access your summary care record (SCR) in order to ensure the safety of the treatment.
On Treated Live, you can book a video consultation at your convenience. Our clinicians can provide fit notes, access to specialist services, advice and, if appropriate, a prescription for treatment.
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