A New Treated is Coming. Read more.
Registered Pharmacy
24hr Free Delivery
No Registration Needed

Lisinopril Hydrochlorothiazide


Lisinopril / Hydrochlorothiazide is a generic version of the treatment also known as Zestoretic, and is used in high blood pressure.

+3400 Trustpilot reviews
PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

10 March 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 10 March 2022
Product information

Lisinopril/Hydrochlorothiazide, sometimes shortened to Lisinopril/HCTZ, is a generic combination treatment for high blood pressure, made by Teva. The branded version is known as Zestoretic. It consists of two agents: an ACE inhibitor; and a type of drug called a diuretic. It may be prescribed in those cases where the use of one product alone has not sufficed in alleviating the condition.

  1. Helps reduce high blood pressure 
  2. Combination drug, added effectiveness
  3. Easy to administer oral tablet

High blood pressure is thought by the NHS to affect over a quarter of people in the UK. It is not a condition which is easy to notice, as it does not necessarily cause any outwardly physical symptoms. Those who do display signs may notice that they get more headaches, and feel tired more often. But the real reason why high blood pressure is a health risk is because it poses a threat of cardiovascular illness, such as atherosclerosis, angina, heart attack, and stroke.

No one cause is responsible for high blood pressure. The condition is more common in people as they become older, and is particularly prevalent in those over the age of 65. It can sometimes be the result of a genetic predisposition; for instance if you have a relative with blood pressure, you may be more likely to develop it yourself.

There are other factors which can also contribute to the condition however, and these are largely related to diet and lifestyle. The consumption of too much alcohol, caffeine or salt, smoking, lack of physical activity and being overweight are all considered by experts to be high risk influences.

A doctor will usually start by addressing these factors when treating high blood pressure. However, in those cases where doing so has not succeeded in bringing down blood pressure, they may advise prescription treatment.

The two ingredients in Lisinopril/HCTZ are lisinopril and hydrochlorothiazide, and these agents work in different ways to lower blood pressure. Lisinopril is an ACE inhibitor, which functions by preventing the action of an enzyme. Angiotensin, a hormone in the body which helps to regulate blood pressure, is transformed by this enzyme into angiotensin II, which can cause result in the constriction and tightening up of blood vessels. Lisinopril lowers blood pressure by preventing this transformation from taking place, and easing tension in blood vessels.

Hydrochlorothiazide works by increasing the amount of salts the kidneys extract from the blood and excrete through urine. With this process, the amount of water in the blood also falls, as salt draws water with it during extraction. This also helps to lower pressure in the blood.

Please note that this medicine is not available to buy from our pharmacy.

Page last reviewed:  10/03/2022


Prior to using this treatment, make sure you understand the directions issued by your prescriber as well as the user instructions provided in the patient information leaflet. Adhering to these will help you to maximise the efficacy of the product, and lessen the risk of side effects.

  1. Take as directed by your prescriber.
  2. In most cases, this will be a single dose taken every day. The amount will be determined by your doctor, based on your response to the course.
  3. The maximum dose per day is 40mg/25mg.
  4. You will need to have your blood pressure monitored on a frequent basis while using this item.
  5. Swallow tablets whole, preferably with water.
  6. Do not take more than the amount prescribed for you.
  7. In the event that you forget to take your tablet, provided that your next dose is not due, you can take it when you remember. If your next dose is due, skip the missed dose, take your next administration as scheduled and carry on the treatment as normal. Do not make up for it by taking double the amount.

The above constitutes only a summary of the directions you will need to follow when using this item. Refer to the leaflet supplied before use, and ask your doctor or pharmacist if you require further guidance.


Page last reviewed:  10/03/2022
Please read the patient information leaflet for this medicine fully before use:

Lisinopril/Hydrochlorothiazide 10mg/12.5mg

Lisinopril/Hydrochlorothiazide 20mg/12.5mg

Side effects & Warnings

Side effects

It is important to know about the potential side effects of any treatment before use, as some may be harmful and require medical assistance. Let your doctor know straight away if you notice any signs of the following: an allergic reaction, which might be characterised by swelling of the lips, face or neck, or hives; pancreatitis; heart attack or stroke; Stevens-Johnson Syndrome; toxic epidermal necrolysis; hepatitis; a persistent and dry cough; muscle pain or cramps, and an increased heart rate; or a low white cell count in the blood. More information can be located in the patient information leaflet.

Common (1 in 10 people or less):

Headache, tiredness, lethargy, feeling or being sick, kidney problems, or diarrhoea.

Uncommon (1 in 100 people or less):

Feelings of weakness, vertigo, altered sensations of taste, dry mouth, indigestion, abdominal pain, rash, itching, gout, chest pain, palpitations, poor circulation, coldness in the fingers and toes, muscle spasming, pins-and-needles, impotence, mood swings, or difficulty sleeping.

Rare (1 in 1,000 people or less):

Muscle and joint pain, fever, pain and inflammation of blood vessels, sensitivity to light or other skin problems, unusual bleeding, bruising, sore throat, mouth or throat ulcers, anaemia, psoriasis, male breast enlargement, confusion, hair loss, or kidney failure.

Very rare (1 in 10,000 people or less):

Decrease in blood platelets, swollen lymph nodes, increased immune response, breathing difficulties, sinusitis, inflammation of the lungs, urinary difficulty, swelling in the lining of the gut, skin problems, increased sweating, or fall in blood sugar.

The above is only a selection of the possible side effects recorded for this product. For a more comprehensive account, refer to the accompanying leaflet.


Taking it with other medicines

Some treatments may not be suitable for use in conjunction with this drug. Let your prescriber know about these when undergoing consultation. Lisinopril/HCTZ may interact with or be rendered less effective by the following: diuretics such as furosemide, torasemide, or amiloride; non-steroidal anti-inflammatory drugs including aspirin or ibuprofen; gold preparations; sympathomimetics, for example adrenaline, noradrenaline, or ephedrine; tablets for the treatment of diabetes; allopurinol; ciclosporin; lovastatin; procainamide; cytostatics; immunosuppressants; amphotericin B; other drugs to reduce blood pressure; tricyclic antidepressants, for instance amitriptyline; antipsychotics, such as chlorpromazine; carbenoxolone; corticosteroids such as prednisolone; corticotropine; laxatives; calcium supplements; cardiac glycosides like digoxin; cholesterol reducing drugs, such as colestyramine or colestipol; sotalol; potassium supplements; lithium; or trimethoprim.

Conditions to look out for

Do not use Lisinopril/HCTZ if you have or have ever had: severe liver or kidney dysfunction; an allergy to other ACE inhibitors or sulphonamides; angioedema; or diabetes which is being treated with aliskiren.

You also need to let your prescriber know if you are of Afro-Caribbean descent, or have a history of the following conditions, as the treatment may not be suitable, or you may need to have your administration adjusted: diarrhoea; an imbalance of blood salts; heart valve disease or an enlarged heart; liver or kidney problems; diabetes; gout;, bronchial asthma; or systemic lupus erythematosus.

Please note that if you compete in professional sports, hydrochlorothiazide is a prohibited substance and may show up in anti-doping screening.

Pregnancy and breastfeeding

This medication must not be used by anyone who is three or more months pregnant, and is not recommended for use during the first trimester. It is also not recommended for breastfeeding mothers.

If you are pregnant, planning to become pregnant or are breastfeeding, speak to your doctor. They will advise you on other suitable treatment options.

Driving and using machinery

Potential side effects include dizziness and tiredness. If you are affected by these, you should not drive or operate heavy machinery.

Page last reviewed:  10/03/2022
Please read the patient information leaflet for this medicine fully before use:

Lisinopril/Hydrochlorothiazide 10mg/12.5mg

Lisinopril/Hydrochlorothiazide 20mg/12.5mg


Can I still drink alcohol?

It is not recommended, as drinking alcohol may increase the chances of side effects.

Will I still be able to drive?

Yes, but only if after you have taken an initial dose you have found that it does not cause side effects. If you think your ability to drive may have been compromised by the treatment, you should not drive and approach your doctor for guidance.

Can I take the medicine while pregnant?

It is not suitable for use by those who are more than three months pregnant, and is not recommended for use in earlier stages. It may also not be safe to be taken during breastfeeding, and a doctor may suggest alternative forms of treatment. Let your prescriber know during consultation if either of the above applies to you.

How should I store it?

Keep in a secure environment below 30°C.

Am I allergic to anything in the medicine?

This item contains: lisinopril, hydrochlorothiazide, pregelatinised starch, maize starch, calcium hydrogen phosphate anhydrous, mannitol and magnesium stearate. Do not use it if you are allergic to any comprising ingredients.

Is it available over-the-counter?

No. This medication is prescription only.

Is it right for me?

Your doctor will discuss the available high blood pressure medicines with you during your consultation, and issue a prescription for the most suitable, if required. Regular reviews and blood pressure tests with your GP are integral to ensuring treatment remains effective.

Page last reviewed:  10/03/2022
Treated.com is rated 4.9 out of 5 by 3424 customers on TrustPilot!
A simple process
Getting the treatment you need has never been easier with our speedy and simple online service.
  • Search for your medicine

    Find the treatment you need.
  • Fill in a simple questionnaire

    A GMC-registered doctor or a pharmacy prescriber will review your answers.
  • 24h delivery to your door

    Next-day delivery. Every order is sent by tracked courier.
  • Repeat ordering is easy

    We keep your details secure so you can reorder with ease.

No matches found. You can find all our treatments here