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Zestril is a tablet for high blood pressure. It is made by AstraZeneca and contains lisinopril, which is an ACE inhibitor.

The doctors who staff our private consultation facility can renew your prescription for this medicine for you, so that you can buy Zestril online. Approved orders are shipped from our UK pharmacy by next-day courier.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

26 April 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 26 April 2022
Product information

Zestril is a type of tablet used for high blood pressure. The active constituent is a drug called an ACE inhibitor, which works in the body to prevent an enzymatic conversion which can cause blood pressure levels to rise. The manufacturers of Zestril are a company called AstraZeneca, who offer the tablets in varying strengths.

  1. ACE inhibitor for high blood pressure
  2. Reduces risk of associated illness
  3. Easy to take oral tablet

High blood pressure is not a condition which is caused by any one particular factor. It is more common in older people, particularly those over the age of 65, and there are a number of potential contributory components. Persons who are overweight are thought to be at increased risk of developing high blood pressure, as are those who consume high amounts of salt, alcohol or caffeine, or smoke. It may also be more likely to strike in instances where a person doesn’t get enough physical exercise.

The condition can often go unnoticed, as it does not produce immediately apparent symptoms in the majority of cases. But, if left undiagnosed and unattended to, it can result in respiratory problems, such as angina, or even a heart attack or stroke. High blood pressure is not uncommon in the UK, with the NHS estimating that around 30 per cent of people nationwide are affected by it.

One of the preliminary actions a practitioner will utilise in treating high blood pressure is to get the patient to address those lifestyle issues which may be contributing towards it. This includes curbing alcohol intake, quitting smoking, implementing a programme of exercise, or the introduction of a healthy, balanced, low-salt diet. In some circumstances, however, these measures may not be enough to bring blood pressure down to normal levels, and prescription treatment may be required.

Measuring blood pressure is an important part of treatment, as it gives an indication of which methods are or are not proving effective. A gauge provides two figures, in millimetres of mercury (mmHg) to determine pressure levels. The first figure provides a systolic reading, which indicates the force being used by the heart to pump blood out; while the second, the diastolic figure, is a measurement of the resistant pressure being exerted by the arteries. The condition is defined as being present in those instances where a blood pressure gauge gives a reading of 140 over 90 or above, on two consecutive separate occasions.

Lisinopril helps to lower blood pressure by inhibiting the action of the angiotensin converting enzyme. This agent is responsible for the transformation of angiotensin, which is a hormone, to angiotensin II. This latter stage hormone can cause blood vessels to contract and become tense. By stopping this conversion, lisinopril reduces the prevalence of this advanced form of angiotensin, and eases pressure in the blood vessels.

If you have high blood pressure but are not currently taking treatment, or if you feel your current treatment regime is not effective, you should see your GP. They will be able to address your medication programme and work with you to find a suitable solution.

Getting your repeat prescription online is simple with our consultation facility. We work with GMC-registered doctors, who will assess your case and issue a prescription where suitable. When they have authorised your order, this will be sent to our UK pharmacy to be fulfilled, before being shipped to you by tracked next-day courier.

Page last reviewed:  26/04/2022


Make sure you follow the directions issued by your prescriber when using Zestril, and that you also read the instructions supplied in the patient information leaflet. This will help you to get the most out of your treatment limit the risk of potential side effects.

  1. Take the tablets according to your prescriber’s directions.
  2. In most cases, the initiation dose for the treatment of high blood pressure will be one 10mg tablet, once a day.
  3. Following a period of review, a doctor may choose to increase this to 20mg.
  4. Those using this tablet after a cardiac event such as heart failure or heart attack may be issued a smaller dose.
  5. Swallow each tablet whole with water. Try to do so at the same time each day.
  6. You will need to have your blood pressure levels monitored at regular intervals while using this product.
  7. Do not take more than the amount prescribed for you.
  8. If you develop a persistent dry cough when using Zestril, tell your doctor.
  9. If you miss a dose, do not compensate by taking double the amount at your next scheduled administration. Provided your next dose is not due soon, you can take it when you remember. If your next dose is due however, you should omit the one you have missed and carry on the course as normal.

The above is provided only as a guide. Detailed instructions can be located in the accompanying leaflet.

Page last reviewed:  26/04/2022
Please read the patient information leaflet for this medicine fully before use:

Zestril 5mg

Zestril 10mg

Zestril 20mg

Side effects & Warnings

Side effects

The appearance of certain side effects may necessitate immediate medical attention. These include anything indicative of: an allergic reaction; severe skin disorder; or liver or kidney dysfunction. Consult the patient information leaflet to find out more about what these signs look like.

Common (1 in 10 people or less):

Headache, dizziness, kidney problems, diarrhoea, a persistent dry cough, or feeling or being sick.

Uncommon (1 in 100 people or less):

Mood changes, discolouration or numbness in the fingers or toes, changes in the way things taste, drowsiness, vertigo, insomnia, stroke, increased heartbeat, runny nose, stomach pain, indigestion, skin rash, itching, erectile problems, weakness, significant drop in blood pressure, heart attack, irregularities in liver function test results, or hallucinations.

Rare (1 in 1,000 people or less):

Feelings of confusion, hives, dry mouth, hair loss, psoriasis, altered sense of smell, or the development of breasts in men.

The list of associated side effects provided is not a comprehensive one. A more detailed account can be located in the leaflet supplied.


Taking it with other medicines

It may not be suitable for use in conjunction with certain other products, as these may cause interactions and prevent Zestril from working properly, or vice versa. Let your doctor know if you are using any other treatments, including the following: drugs to help lower blood pressure; aliskiren; water tablets; drugs for blood clots; beta-blockers, such as atenolol and propranolol; desensitising agents for insect stings; nitrates; NSAIDs; aspirin; antidepressants, including lithium; gold; anything which suppresses the immune system; potassium supplements; insulin or other drugs for diabetes; products for asthma; cold remedies; allopurinol; or procainamide.

Conditions to look out for

Do not take Zestril if you: have ever had a bad reaction to other ACE inhibitors; or are taking aliskiren for diabetes or a kidney condition. It may also not be suitable for require special administration in those with a history of: narrowing of the aorta, heart valves or the kidney artery; increase in thickness of the heart muscle; collagen vascular disease; low blood pressure; kidney problems or dialysis; liver problems; diabetes; diarrhoea or sickness; or high cholesterol being treated with LDL apheresis.

Those who are of Afro-Caribbean ethnicity should also notify their prescriber, as they may find Zestril less effective or be more prone to angioedema, and require their administration to be monitored. 

Pregnancy and breastfeeding

The use of this medicine is not recommended during early pregnancy or during breastfeeding, and anyone who has been pregnant for three months or more must absolutely not use it.

If you are pregnant, become pregnant, or are trying to conceive or are breastfeeding, see your GP in person. They will advise you on suitable alternative treatments.

Driving and using machinery

Dizziness may occur in some when using this treatment. Do not drive or use machinery if this affects you.

When you start this treatment or begin taking a higher dose on the instruction of your GP, you will need to wait and observe if you are affected by dizziness or other side effects before attempting to drive or work machinery.

Page last reviewed:  26/04/2022
Please read the patient information leaflet for this medicine fully before use:

Zestril 5mg

Zestril 10mg

Zestril 20mg


Can I still drink alcohol?

The consumption of alcohol, particularly in large amounts, is not recommended for those using this product, as it may prove counteractive to it effects.

Will I still be able to drive?

Yes, but only if after taking the medication for the first time, or having your administration increased, you experience no significant side effects which may make it dangerous to do so. If you do, refrain from driving and let your doctor know.

Can I take the medicine while pregnant?

It is not suitable in any case for those who are more than three months pregnant, and the use of it during early pregnancy is strongly not advised. It is also not recommended for use during breastfeeding. If you are pregnant or breastfeeding, let your practitioner know, as they may suggest an alternative form of treatment.

How should I store it?

In a safe environment below 30°C, out of the reach of children.

Am I allergic to anything in the medicine?

The ingredients of this product are as follows: lisinopril, mannitol, calcium hydrogen phosphate dihydrate, maize starch, pregelatinised starch, magnesium stearate and red iron oxide (E172). Do not take it if you are allergic to any of these components.

Is it available over-the-counter?

You will require a prescription in order to buy Zestril online or in person in the UK. 

Is it right for me?

If you have high blood pressure, your doctor will discuss your treatment plan with you during your regular review. If medication is required, they will initiate a prescription for the most appropriate.

It’s simple renewing your prescription with our online doctor facility. Take our questionnaire, and our prescriber will assess your case. Once they have approved your order, it will be sent to our pharmacy to be dispensed. We’ll ship your order by next-day parcel, so that you can expect to receive it within one working day of consultation.

Page last reviewed:  26/04/2022
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