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Crestor is a statin made by AstraZeneca, issued in the form of a tablet. It is employed in the treatment of high cholesterol.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

31 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 31 August 2020
Product information

What is Crestor?

Crestor is a tablet used to medicate high cholesterol, and is manufactured by AstraZeneca. It is taken as a single daily dose. Administration typically begins with a small dose before this is gradually increased, according to its effectiveness, over a period of weeks.

  1. Effective in reducing risk of heart disease
  2. Taken as one daily dose 
  3. Branded medication

High cholesterol occurs when fats which the liver produces increase to a point where they may cause the arteries to become narrower. This doesn’t cause any immediate physical symptoms, but can pose a number of health risks, such as: an increased susceptibility to heart disease, heart attacks, and stroke.

A number of lifestyle factors can contribute to high cholesterol. These include a poor diet, which is composed too much of saturated fats, lack of exercise, excessive alcohol consumption and smoking. You are also more likely to have high cholesterol if you have diabetes, high blood pressure, or liver or kidney disease. However, genetics can play a role too. Persons with a family history of cardiovascular disease may be more prone to high cholesterol.

Statins are an effective form of treatment for high cholesterol. Crestor belongs to this category of drugs, and contains a functioning constituent called rosuvastatin calcium. This works by lowering the amount of cholesterol the body produces.

The liver is responsible for generating fats called lipids, which are essential in helping the body to perform various functions. These are carried around the body through the bloodstream, by proteins. When lipids join with these proteins, they form something called lipoproteins, of which there are two types: high and low density. These are also commonly referred to as good and bad cholesterol, respectively.

Low density lipoproteins, or LDLs, are responsible for transporting fats out from the liver to those cells that require them. However, excessive amounts can cause these fats to gather and accumulate in arterial walls, thus increasing the chances of illness. Rosuvastatin calcium works by interfering with the function of an enzyme in the liver, which facilitates the production of LDLs. By doing so, it decreases the levels of bad cholesterol present in the body, and reduces the risk of consequential illness.

Crestor dosages

Crestor 5mg

This is the lowest available dose. 5mg may be issued as an initiation dose in cases where the patient is:

  • of Asian descent;
  • over 70;
  • has moderate kidney problems;
  • or is at risk of side effects such as muscle pain.

Crestor 10mg

10mg is the typical starting dose for most patients. However, the dose someone starts on will usually be determined by their cholesterol level, and their risk of heart attack or stroke, in addition to the factors described above. Someone who starts on 5mg may have their administration raised to 10mg in some instances.

Crestor 20mg

A doctor may choose to increase a patient’s dose from 10mg to 20mg in some cases, depending on how effective the lower dose is. Between these changes, a prescriber will wait for at least four weeks before altering the dose.

Crestor 40mg

This dose is the maximum available, and is only issued to patients who have found the lower doses to be less than sufficient, and who also have a high risk of heart attack or stroke.

Order on prescription

Please note that this product is not available through our site. If you are seeking high cholesterol treatment, we recommend you see your GP in person.

Page last reviewed:  31/08/2020


Always take your medication in the manner prescribed. This will help you to get the best possible results from your treatment. Following the instructions provided in the patient information leaflet will also contribute towards limiting the possible risk of side effects.

  1. Take as directed.
  2. For the treatment of high cholesterol, your starting dose may be 5mg or 10mg per day, depending on your overall health or cholesterol level.
  3. After a period of use, a doctor may choose to review your condition and adjust your dose as required.
  4. The tablets are administered as a single daily dose.
  5. Swallow each pill whole with water.
  6. You should try to take Crestor at the same time each day.
  7. It can be taken with or without food.
  8. You will need to go to your doctor to have your cholesterol levels monitored on a regular basis.
  9. Never exceed the prescribed dose.
  10. If you miss a dose, do not worry and carry on the course as normal. Do not compensate by taking double the amount at your next scheduled administration.

The above is only a brief summary of the instructions you will be required to follow when using this item. Read the directions supplied in the leaflet before taking it.

Download Crestor patient information leaflet

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Crestor 5mg

Crestor 10mg

Crestor 20mg

Crestor 40mg

Side effects & Warnings

Side effects

It is essential to be aware of the side effects the use of this item may result in, so that you can notify your doctor if you notice anything which concerns you. Get medical attention right away if you think you may be having an allergic reaction, or if you experience any abnormal muscular aches or pains which do not go away after a short time.

Common (1 in 10 patients or less):

Headache, stomach pain, constipation, feeling sick, muscular pain, weakness, dizziness, increased protein concentration in the urine, or diabetes.

Uncommon (1 in 100 patients or less):

Rash, itching or other skin problems.

Rare (1 in 1,000 patients or less):

Inflamed pancreas, increased presence of liver enzymes in the blood, allergic reaction or muscle damage.

Very rare (1 in 10,000 patients or less):

Jaundice, itching, hepatitis, blood in the urine, feelings of numbness, joint pain, loss of memory, or breast enlargement in men.

The above list is not an exhaustive one. Please refer to the patient information leaflet to find a more detailed account of the side effects this product may induce.


Taking it with other medicines

Inform your prescriber during consultation if you are taking any treatments for other conditions. Crestor may interact with or be rendered less effective by the following: ciclosporin, warfarin, clopidogrel, fibrates such as gemfibrozil or fenofibrate, other statins such as ezetimibe, indigestion remedies, erythromycin, fusidic acid, oral birth control, hormone replacement therapy, or ritonavir with lopinavir
or atazanavir.

Conditions to look out for

The presence of some conditions may make this drug unsuitable for use. Do not use it in any form if you have or have ever had: liver or kidney disease; or persistent or unexplained aches or pains in the muscles.

Additionally, do not take the 40mg dose of this product if you: have moderate kidney problems; have a dysfunctional thyroid gland; regularly consume large amounts of alcohol; or are of Asian origin.

If any of the following conditions apply to you, you should also let your doctor know, as you may be required to take special precautions when using this treatment. Tell your prescriber if you: frequently drink large amounts of alcohol; or if you have or have ever had: problems with your kidneys or your liver; lactose intolerance; a family history of muscle problems; or a disorder of the thyroid gland.

Pregnancy and breastfeeding

This medicine should not be used during pregnancy or breastfeeding. If you become pregnant, stop taking this treatment and tell your doctor immediately.

Driving and using machinery

This product may cause dizziness in some users. If you are affected by any side effects such as this, do not drive or use machinery, and speak to your doctor.

Page last reviewed:  31/08/2020
Please read the patient information leaflet for this medicine fully before use:

Crestor 5mg

Crestor 10mg

Crestor 20mg

Crestor 40mg


Can I still drink alcohol?

It is advisable to refrain from consuming large amounts of alcohol during the use of this treatment, as it may cause liver problems.

Will I still be able to drive?

Yes, provided that you do not experience any side effects which may make it unsafe to do so. If you do, then you should not drive and contact your doctor as soon as possible.

Can I take the medicine while pregnant?

It is not suitable for women for who are pregnant or breastfeeding.

How should I store it?

Keep Crestor in a safe place below 30°C.

Am I allergic to anything in the medicine?

Crestor contains the following components: rosuvastatin, lactose monohydrate, microcrystalline cellulose, calcium phosphate, crospovidone, magnesium stearate, hypromellose, triacetin, titanium dioxide (E171), red iron oxide (E172) and yellow iron oxide (E172). Do not use it if you are allergic to any of these ingredients.

Is it available over-the-counter?

You can only buy Crestor on prescription, as a doctor will need to make sure it is safe for you before you use it.

Is it right for me?

Your GP will determine the most suitable treatment for you during your regular review. They will initiate a prescription for this item where required.

Please note this treatment is not available to buy through our site.


Page last reviewed:  31/08/2020 is rated 4.9 out of 5 by 3131 customers on TrustPilot!
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