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Estradiol hemihydrate/drospirenone

Angeliq is a pill used in hormone replacement therapy, made by Bayer. It is a combined continuous treatment, containing a version of progesterone and a version of oestrogen.

This item is not available from our pharmacy. Speak to your doctor in person if you think you might require treatment for symptoms of the menopause.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

12 November 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 12 November 2020
Product information

Angeliq is a pill from Bayer used to help alleviate symptoms of the menopause. It is a combined form of hormone replacement therapy (HRT), which means that it contains two different synthetic hormones: in this case estradiol (which is a form of oestrogen) and drospirenone (a form of progesterone). HRT is prescription only, and needs to be issued by a doctor. Angeliq is no longer available from our online pharmacy. There are a number of alternatives that we do provide: Kliovance, Premique, Femoston Conti and Indivina.

The menopause is a natural process the female body goes through. Most women will experience it from the age of 45 or over (51 is the average age at which women in the UK tend to start); however some may go through it at a much younger age (this is called premature menopause).

In simple terms, it marks the end of the period during which a woman is fertile. As such, the cyclical production of hormones that help to prepare the body to conceive change. When the secretion of these hormones, progesterone and oestrogen, start to become less regular, this can cause several symptoms to occur.

These can include physical symptoms, such as: hot flushes in the face, neck and chest; headaches; problems sleeping; increased sweating during sleep; dryness in the vagina; and reduced libido. Postmenopausal women are also more susceptible to loss of bone density, making bones more prone to breaks and fractures (osteoporosis). Emotional and psychological symptoms of the menopause include: increased feelings of anxiety; mood swings; and difficulty focussing or concentrating.

The initial sign of the menopause that most people notice is a change in menstrual bleeding. Periods may be heavier or lighter than usual, or occur with more or less frequency. Menstruation ceases after the menopause, meaning that postmenopausal women will not have periods.

Some women may not feel that treatment is necessary, but HRT can help if symptoms are interfering with everyday life. In women who are perimenopausal (in the earlier stages of the menopause) sequential treatment tends to be preferred; whereas continuous treatment is recommended in women who have not had a period for at least a year. Combined HRT is used in women with an intact uterus; whereas women who have had a hysterectomy are more likely to be prescribed oestrogen-only HRT.

Angeliq is an example of a combined continuous treatment. The synthetic versions of progesterone and oestrogen in the pill help to relieve symptoms by supplementing falling levels of these hormones.

If you are not currently taking HRT and want to start, you should speak to your doctor in the first instance. They will be able to talk you through the different options available based on your symptoms and medical profile, and start you on a suitable dose.

You can renew your prescription for hormone replacement therapy and buy Angeliq online with our secure consultation facility. Fill in our medical questionnaire to have your request reviewed by our doctor, and once your order is approved, a prescription will be generated and dispensed by our UK pharmacy.

Page last reviewed:  12/11/2020

Please read the patient information leaflet fully before use. If you are unsure of anything, ask your doctor or pharmacist for help.

  1. Take as directed by your prescriber.
  2. This will usually be one pill taken at the same time each day.
  3. Swallow your pill whole with water or milk.
  4. You can start the treatment at least 12 months after your last natural period.
  5. If you are switching from another form of HRT, you must finish the course you are on first before starting Angeliq.
  6. If you forget to take Angeliq and remember less than 24 hours after your missed pill, you can take the pill you have missed, and then take your next one at the regular time.
  7. However, if you forget to take Angeliq and remember more than 24 hours after your missed pill, leave the one you have missed, and continue to take the pill as normal from the next dose.
  8. Women who miss more than one pill may have some irregular bleeding.
  9. Do not exceed the prescribed dose.

More detailed instructions can be found in the leaflet provided.

Page last reviewed:  12/11/2020
Please read the patient information leaflet for this medicine fully before use:

Angeliq 1mg/2mg

Side effects and warnings

Side effects

The risk of blood clots is higher in women who take HRT than in those who don’t. It is important to know what the signs of a blood clot are, so that you can seek immediate medical attention if you notice them. These include: swelling, pain or tenderness in the legs; sudden chest pain; and breathing problems.

You should also stop taking the treatment and seek medical help right away if you become pregnant, or develop: signs of a stroke (partial paralysis, sight problems, dizziness or loss of balance); jaundice (yellowing of the skin or eyes); an increase in blood pressure (which can cause headache, tiredness and dizziness); migraine symptoms for the first time; or any signs of an allergic reaction, such as difficulty breathing or swelling of the face or lips.

Very common (1 in 10 or more):

Breakthrough or unexpected menstrual bleeding, tenderness in the breasts, or breast pain.

Common (1 in 10 or less):

Depression, mood swings, anxiety, headache, stomach pain, feeling sick, non-cancerous breast tumor or cell development in the cervix, swollen breasts, enlarged uterine fibroids, vaginal discharge, lethargy, irregular periods.

Uncommon (1 in 100 or less):

Weight fluctuations, loss of appetite, rise in fat levels in the blood, difficulty sleeping, lower sex drive, pins and needles, loss of concentration, dizziness, eye or sight problems, palpitations, blood clot, high blood pressure, migraine, inflamed or varicose veins, feeling breathless, digestive problems, diarrhoea, constipation, change in liver function, skin problems, hair loss, excessive hair growth, backache, joint and muscle pain, urinary tract infections, thickening of the endometrium, dry vagina, itching or burning in the vagina, breast lump, cervical or ovarian disorders, pelvic pain, water retention, or non-cancerous tumor in the womb.

Rare (1 in 1,000 or less):

Anaemia, vertigo, tinnitus, gallstones, inflammation of the fallopian tubes, discharge from the nipples, feeling cold.

This is not an exhaustive list of side effects. For more information please consult the leaflet provided.


Taking it with other medicines

Tell your prescriber if you are using any prescription, non-prescription or remedial treatments during your consultation.

Angeliq may interact with treatments for: epilepsy (such as barbiturates, phenytoin, primidone or topiramate); tuberculosis (such as rifampicin); HIV or hepatitis C (nevirapine, efavirenz, nelfinavir or ritonavir); pain (NSAIDs); high blood pressure or cardiovascular disease (such as ACE inhibitors); fungal infections (antifungals); bacterial infection (antibiotics): or grapefruit juice, or St John’s wort.

Conditions to look out for

You should tell your doctor about any conditions you have, or have had previously, so that they can ensure this treatment is suitable.

Do not use this medicine if you have or have ever had: breast cancer or suspected breast cancer; cancer or suspected cancer which is sensitive to oestrogens, such as endometrial cancer; unexplained vaginal bleeding; excessive thickening of the womb lining that is not being treated; a blood clot in a vein (thrombosis) such as in the legs (deep venous thrombosis), or in the lungs (pulmonary embolism); a blood clotting disorder; a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina; liver disease from which your liver function has not yet returned to normal; porphyria; severe kidney disease or acute kidney failure; an allergy to oestrogens, progestogens or any of the other ingredients in the pill.

It may not be suitable and require close monitoring if you have, or have ever had: fibroids inside your womb; endometriosis; endometrial hyperplasia; an increased risk of developing blood clots; an increased risk of getting an oestrogen-sensitive cancer; high blood pressure; a liver disorder; diabetes; gallstones; migraine or severe headaches; a disease of the immune system such as lupus; epilepsy; asthma; a disease affecting the eardrum and hearing; high triglyceride levels in the blood; or fluid retention due to cardiac or kidney problems.

Regular check-ups

You must have regular appointments with your GP or practice nurse to ensure that the menopause treatment you are taking it still suitable. It is recommended that you have these at least every 12 months.

HRT and cancer

Studies have shown that some types of HRT increase the risk of certain cancers. More information on this can be found in the patient information leaflet.

Pregnancy and breastfeeding

This pill is not suitable for women who are pregnant, breastfeeding or trying to get pregnant.

Driving and using machines

It is not likely that this pill will inhibit your capacity to drive or use machinery.

Page last reviewed:  12/11/2020
Please read the patient information leaflet for this medicine fully before use:

Angeliq 1mg/2mg


Can I still drink alcohol?

Yes. The function of this medicine is not affected by alcohol.

Will I still be able to drive?

Yes, provided you experience no side effects which may make driving difficult. If you do, seek medical advice as soon as you can.

Can I take the medicine while pregnant?

No. It is not suitable for use during pregnancy.

How should I store it?

Out of the reach of children, at room temperature.

Am I allergic to anything in the medicine?

Angeliq contains: estradiol hemihydrate, drospirenone, lactose monohydrate, maize starch, pregelatinised maize starch, povidone and magnesium stearate, hypromellose, macrogol 6000, talc, titanium dioxide (E171) and red ferric oxide (E172).

Do not use it if you are allergic to any of these ingredients.

Is it available over-the-counter?

No, this treatment is prescription only. You can renew your prescription for Angeliq or switch to it from another form of HRT through our service.

How can I buy Angeliq online?

If you’re experiencing menopause symptoms and aren’t currently taking HRT, you should speak to your GP or practice nurse. They will be able to discuss the different treatments with you, and help you decide on an appropriate course.

To buy Angeliq online or renew your prescription for this medication, complete our doctor-reviewed questionnaire. Orders are dispensed by our UK pharmacy following approval, before being shipped by next-day express parcel.

Page last reviewed:  12/11/2020 is rated 4.9 out of 5 by 3250 customers on TrustPilot!
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