Oestradiol / levonorgestrel

FemSeven Sequi and FemSeven Conti, both from Teva, are combined hormone replacement therapies with the active ingredients estradiol and levonorgestrel. They help relieve symptoms of the menopause.


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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.
Product information


FemSeven Sequi and FemSeven Conti are transdermal patches utilised in hormone replacement therapy (HRT) marketed in the UK by Teva. Containing forms of both oestrogen and progesterone (estradiol and levonorgestrel), they are suitable for treating women who have not undergone a hysterectomy. FemSeven Sequi is a sequential form of HRT, while FemSeven Conti is continuous.

  1. Simple, non invasive course of treatment
  2. Patch applied once a week
  3. Administers effective relief of symptoms

A significant development in the female life cycle, the menopause generally begins between the ages of 45 to 55, though it can occur for some women in their late thirties or early sixties. The ovaries stop generating eggs and periods become less frequent before eventually stopping altogether. The levels of the female sex hormones oestrogen and progesterone also diminish quickly and considerably.

One of the consequences of these changes is a variety of widely recognised symptoms, some of which are experienced by most women at some point during this process. They can include sleeplessness, anxiety, joint pain, tiredness, sudden flushes of heat, palpitations, headaches and urinary infections. These symptoms start to manifest themselves before periods stop, and can continue for quite some time afterwards.

For some women this can be a very difficult time, especially if menopausal symptoms are severe. In a number of cases it can hinder an individual’s ability to live a normal day to day life. It is under these circumstances that a course of HRT would be recommended. FemSeven Sequi and FemSeven Conti are two popular types of this therapy and are both available to buy online from our UK pharmacy.

Combined HRT is given to women who have not had the medical procedure where the womb is removed (hysterectomy). Oestrogen only HRT is not suitable for women who have not had a hysterectomy because oestrogen on its own encourages excess growth of the womb lining. This is known as endometrial hyperplasia and can lead to cancerous growths in the womb. The progesterone used in combined HRT tempers the levels of oestrogen and reduces this risk, though it does not eliminate it completely.

FemSeven Sequi patches are used sequentially. For the first two weeks of each month patches containing just estradiol are used, after which patches containing estradiol and levonorgestrel are utilised for the second two weeks of the cycle. Towards the end of the second phase some menstrual bleed is normal and it is for this reason that the treatment is given to women who are still having irregular periods.

FemSeven Conti is a continuous form of HRT; all of these patches contain both estradiol and levonorgestrel and are applied in an unbroken weekly schedule. This patch does not produce and monthly bleed and is therefore appropriate for women who have already had their last period.

The patches are transdermal, which mean they release a consistent, measured dose of hormones into the bloodstream through the skin. Both types of patch are worn for a week on an area of the skin on the lower part of the body which is clean, dry and does not contain any cuts.

Page last reviewed:  27/07/2018


A patient information leaflet will be included with your medicine with detailed instructions on how to use the patches. Make sure you read it before starting the course and follow any special instructions given to you by your medical practitioner. Adhering to the directions as closely as possible will help ensure the medicine is effective and minimise side effects.

FemSeven Sequi:

  1. The patches are divided into two types; phase one patches only contain estradiol, and phase two patches contain both estradiol and levonorgestrel. You should apply a phase one patch for the first two weeks of your monthly cycle, and a phase two patch for the second two weeks of your cycle.
  2. Some light bleeding similar to that experienced during the menstrual cycle is normally experienced towards the end of the second phase. It usually lasts for between four and five days.
  3. You must apply the patches in the correct sequence.

FemSeven Sequi and FemSeven Conti:

  1. The adhesive patches are applied every seven days to a clean, dry, undamaged area of the skin on the lower body.
  2. Use on a different area of skin every week, and do not apply to the breasts.
  3. Full, illustrated instructions on how to apply the patch are included in the patient information leaflet.
  4. If a patch falls off in between a seven day period, apply a new one and continue the schedule as normal.
  5. If you forget to change your patch on the correct day, change as soon as you remember then carry on with the treatment programme as before.
  6. You should not use more than one patch at a time to compensate for a missed dose.
  7. Swimming, showering and bathing should not affect the patches but you should wait an hour after applying before doing so.

These directions are an overview of how to use this item. You should read the patient information leaflet for a complete set of instructions.


Page last reviewed:  27/07/2018
Please read the patient information leaflet for this medicine fully before use:

FemSeven 50mcg/7mcg

FemSeven 50mcg/10mcg

Side effects & Warnings

Side Effects

Not everyone who uses this medicine will experience any side effects. Nonetheless, you should be aware of what they are in case you do, especially as some of them require immediate medical attention. You should stop using this item right away and see your doctor if you become pregnant or notice any of the following: symptoms of jaundice which could indicate a liver disease (yellowing of the whites of the eyes or skin); a rise in blood pressure, which may be signalled by dizziness, headaches or tiredness; onset of migraines when you do not usually get them; or signs of a blood clot such as difficulty breathing, sudden chest pains, or swelling or redness in the legs.

FemSeven Sequi:

Skin irritation where the patch has been applied is very common and usually disappears within a few days of removing the patch. This side effect is not serious.

Common (1 in 10 people or less):

Painful, tender breasts or tightness in the breasts, feeling and being sick, irregular spotting or bleeding, changes in libido, headaches.

Uncommon (1 in 100 people or less):

Excess growth of the womb lining, migraines, vertigo, benign tumours in the breast, uncomfortable periods, abdominal pains and bloating, high blood pressure, water retention, fluctuations in body weight, fatigue, leg cramps.

Rare (1 in 1,000 people or less):

Jaundice, depression, gallstones, fibroids in the womb.

FemSeven Conti:

Very Common (1 in 10 people or more)

Tenderness in breasts, skin irritation where patch has been used, spotting or bleeding.

Common (1 in 10 people or less):

Breast pain, indigestion, headaches.

Uncommon (1 in 100 people or less):

Weight gain or loss, retention of fluid, leg cramps, tiredness, nausea, abdominal pain, lightheadedness, bloatedness, high blood pressure, benign breast growths, depression, endometrial hyperplasia.

Rare (1 in 1,000 people or less):

Gallstones, jaundice, womb fibroids.

These lists of side effects are not extensive. For a full list of side effects you should read the patient information leaflet supplied with your medicine.


Taking it with other medicines

When filling in your online consultation, please tell us about any other medication you are already taking. The effectiveness of FemSeven Sequi and FemSeven Conti could be impaired if you are taking antiretrovirals for HIV infection (nevirapine, ritonavir, efavirenz and nelfinavir), antibiotic treatments for tuberculosis like rifampicin or rifabutin, antiseizure drugs for epilepsy (phenytoin, phenobarbital and carbamazepine) or natural herbal remedies which have St John’s Wort as an ingredient.

Conditions to look out for

You should not use this product if you have any of these conditions or have had them in the past: any cancer that is dependent on oestrogen for its development, for example, breast or ovarian cancer; you have had bleeding from your vagina that is unexplained; a venous thromboembolism (blood clot) or a blood clotting disorder; excessive growth of the womb lining that is not being treated; angina, stroke or heart attack; a liver disease where the function of the liver has not returned to its previous level; any form of the rare hereditary blood disease porphyria; or if you are allergic to any of the ingredients.

If you have had any of the following your prescriber may require you to have more frequent check ups as these conditions can return or worsen upon using this item; a family history of oestrogen responsive cancer; benign tumours in the womb (fibroids); a history of endometrial hyperplasia or endometriosis; gallstones; high blood pressure; a susceptibility to blood clots or conditions relating to blood clots; systemic lupus erythematosus; otosclerosis; high levels of blood fat; diabetes; a liver disorder; asthma; or epilepsy.

Regular check-ups

You will need to have regular checks with your (usually at least once a year) to monitor how well HRT is working.

HRT and cancer

More information on HRT and risk of cancer is located in the leaflet provided with the treatment.

Pregnancy and breastfeeding

This product must not be used during pregnancy or breastfeeding. If you become pregnant, stop using it and see your GP as soon as possible.

Driving and using machinery

This treatment is not likely to interfere with your capacity to drive or use machines.

Page last reviewed:  27/07/2018
Please read the patient information leaflet for this medicine fully before use:

FemSeven 50mcg/7mcg

FemSeven 50mcg/10mcg


Can I still drink alcohol?

There is nothing to suggest that drinking alcohol will interfere with this medicine.

Will I still be able to drive?

Yes, but you should stop driving if you experience any side effects that affect your ability to do so, and see your doctor.

Can I take the medicine while pregnant?

This medicine is not for use by women who are pregnant. If you become pregnant while using this treatment, stop at once and speak to your doctor.

How should I store it?

Below 30°C and out of the reach of children. Dispose of the product responsibly and do not use after the use by date.

Am I allergic to anything in the medicine?

The active ingredients of FemSeven Sequi are estradiol hemihydrate in the phase one patches and estradiol hemihydrate and levonorgestrel in the phase two patches. The active ingredients in the FemSeven Conti patches are estradiol hemihydrate and levonorgestrel.

The other ingredients contained in both types of patch are transparent polyethylene terephthalate, styrene-isoprene-styrene copolymer beads, glycerin esters of

hydrogenated resin acids, and siliconised polyethylene terephthalate. If you are allergic to any of the ingredients you should not use this treatment.

Is it available over-the-counter?

No, but to buy FemSeven from our UK pharmacy you don’t have to book an appointment or visit the chemist in person. You can buy or renew your prescription to FemSeven Sequi or FemSeven Conti online by completing a short questionnaire and have it delivered to you if the medicine once approved by our doctor.

Is it right for me?


Speak to your doctor if you think you may be experiencing symptoms of the menopause. They will be able to assess your symptoms, and advise on a treatment programme for you when necessary.

Page last reviewed:  27/07/2018
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