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FemSeven

Oestradiol

FemSeven is a skin patch used in hormone replacement therapy. It is currently available as FemSeven Conti, known as a continuous combined therapy for the treatment of menopause symptoms.

You can renew your prescription and buy FemSeven Conti patches online using our secure service. Once your request has been approved, you’ll receive your treatment in just 24 hours. If you are looking to buy FemSeven Sequi please consult our ‘Which HRT should I Use?’ page for helpful information on alternatives.

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FemSeven Conti50mcg/7mcg

FemSeven Conti patches release 50mcg estradiol and 7mcg levonorgestrel per day.

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FemSeven50mcg

FemSeven 50 patches release a dose of 50mcg estradiol into the body per 24 hours.

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FemSeven is a skin patch used in hormone replacement therapy. It is currently available as FemSeven Conti, known as a continuous combined therapy for the treatment of menopause symptoms.

You can renew your prescription and buy FemSeven Conti patches online using our secure service. Once your request has been approved, you’ll receive your treatment in just 24 hours. If you are looking to buy FemSeven Sequi please consult our ‘Which HRT should I Use?’ page for helpful information on alternatives.

This content was reviewed by a clinician on

23 August 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 23 August 2021
Product information

FemSeven is a transdermal patch used in hormone replacement therapy (HRT), and is marketed in the UK by Teva. FemSeven is an oestrogen-only form of HRT, intended for women who have had a hysterectomy. It can also be used by women who have not had this procedure, but must be given alongside a progestogen (as part of a combined HRT course) in such cases. 

FemSeven Sequi and FemSeven Conti are combined forms of hormone replacement therapy, containing both oestrogen and progesterone. Conti is a continuous therapy (where both hormones are issued steadily throughout the month and Sequi is a cyclical or sequential therapy (where progesterone is only given on certain days of the month) but is not currently available. 

What is combined HRT used to treat? 

Combined therapy is indicated for women who have not had a hysterectomy. During the earlier stages of the menopause, it’s more typical for someone to start on sequential therapy, before progressing onto continuous therapy after they have not had a natural period for a year or more.

The menopause generally begins between the ages of 45 to 55, though it can occur for some women in their late thirties or early sixties. During this phase, the ovaries stop generating eggs and periods become less frequent before eventually ceasing altogether. The levels of the female sex hormones oestrogen and progesterone produced by the body also diminish quickly.

One of the consequences of this change in hormone levels is a variety of widely recognised symptoms, some of which are experienced by most women at some point during the menopause. They can include sleeplessness, anxiety, joint pain, tiredness, sudden flushes of heat, palpitations, headaches and an increased tendency to develop urinary infections. These symptoms start to manifest themselves before periods stop, and can continue for quite some time afterwards.

Not all women use treatment for menopause symptoms; but some women may find HRT helpful.

How does FemSeven work? 

The active ingredient in FemSeven is estradiol. This works in a very similar way to oestrogen, supplementing levels of the hormone in the body and helping to alleviate symptoms. It is used on its own in women who have had surgery to remove their womb, but needs to be given alongside a progestogen in women with an intact uterus.

In FemSeven Conti and FemSeven Sequi, levonorgestrel, a type of progesterone, is also given through the patch. This type of therapy, known as combined therapy, is for women who have not had a hysterectomy. 

The patches are transdermal and applied once weekly. They release a consistent, measured dose of oestrogen into the bloodstream through the skin.

Can I buy FemSeven online? 

Using our service to buy FemSeven online is easy if you don’t have time to renew your repeat prescription in person. When you complete our consultation, one of our UK qualified practitioners will review your answers. If your request is approved, your treatment will be dispensed at our UK pharmacy before being shipped by our express courier partners for you to receive the following day.

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Page last reviewed:  23/08/2021
Directions

Directions

A patient information leaflet will be included with your medicine with detailed instructions on how to use the patches. Make sure you read it before starting the course and follow any special instructions given to you by your medical practitioner. Adhering to the directions as closely as possible will help ensure the medicine is effective and minimise side effects.

  1. FemSeven (oestrogen only HRT) is recommended for women who have had a hysterectomy. Women who have not had a hysterectomy will also need to take a progestogen.
  2. FemSeven Sequi (sequential combined HRT) is recommended for women with an intact uterus who are perimenopausal (in the earlier stages of menopause).
  3. FemSeven Conti (continuous combined HRT) is indicated for women with an intact uterus who are postmenopausal and have not had a period for 12 months or more.
  4. If you are taking sequential combined HRT and switching to FemSeven or FemSeven Conti, you should start using it the day after your withdrawal bleed has finished.
  5. If you are taking sequential combined HRT and changing to FemSeven Sequi, finish the pack of the treatment you are currently on first.
  6. Otherwise, you can begin using FemSeven on any day which is convenient.
  7. The patches are applied and left on for seven days at a time. You should apply a new one after seven days without a break.
  8. To apply the patch, first remove it from the pouch according to the diagram in the leaflet.
  9. Peel off the S-shaped protective layer, avoiding touching the adhesive part of the patch.
  10. The buttocks, hips or abdomen are recommended application sites.
  11. Apply the patch to the skin, holding down with the palm of your hand for 30 seconds or more.
  12. Do not apply to the breasts.
  13. The patch can be removed by lifting one side and pulling. It should then be folded in half and discarded.
  14. If you apply too many patches, simply remove the extra patch.
  15. If you forget to change it, do so when you remember, then continue applying it as normal.
  16. Do not use a double dose to compensate for a forgotten dose.

These directions are an overview of how to use this item. More detailed instructions and diagrams on how to apply the patches are included in the leaflet.

Page last reviewed:  23/08/2021
Please read the patient information leaflet for this medicine fully before use:

FemSeven 50mcg

FemSeven Conti 50mcg/7mcg

Side effects & Warnings

Side effects

Not everyone who uses this medicine will experience any side effects. Nonetheless, you should be aware of what they are in case you do, as some of them require immediate medical attention.

You should stop using FemSeven right away and see your doctor if you become pregnant or notice any of the following: symptoms of jaundice which could indicate a liver disease (yellowing of the whites of the eyes or skin); a rise in blood pressure, which may be signalled by dizziness, headaches or tiredness; onset of migraines when you do not usually get them; or signs of a blood clot such as difficulty breathing, sudden chest pains, or swelling or redness in the legs.

In FemSeven:

Very common (1 in 10 people or more):

Itching, redness, eczema, swelling or skin pigmentation changes.

Common (1 in 10 people or less):

Headache, discomfort in the breasts.

Uncommon (1 in 100 people or less):

Hair changes, increased perspiration, joint pain, leg cramps, dizziness, tingling in fingers or toes, migraine, anxiety, appetite increase, depression, difficulty sleeping, nervousness, nausea, indigestion, abdominal pain, vomiting, blood pressure changes, chest pain, problems with veins, vaginal discharge, breakthrough bleeding, fatigue, weight changes.

Rare (1 in 1,000 people or less):

Exacerbation of fibroids in the womb.

In FemSeven Conti or Sequi:

Very common (1 in 10 people or more):

Skin irritation where the patch is applied, tender breasts, bleeding or spotting.

Common (1 in 10 people or less):

Pain in the breasts, headache, indigestion.

Uncommon (1 in 100 people or less):

Fluid retention, weight fluctuations, fatigue, leg cramps, dizziness, migraine, stomach cramps, bloating, nausea, high blood pressure, endometrial hyperplasia, breast tissue changes, depression.

Rare (1 in 1,000 people or less):

Gallstones, jaundice, uterine fibroids.

Reported more widely in women taking HRT:

Gallbladder disease, skin disorders, cholasma, erythema nodosum, rash with target-shaped reddening or sores.

This list of side effects is not exhaustive. For more comprehensive information, please read the patient information leaflet supplied with your medicine.

Warnings

Taking it with other medicines

FemSeven may interfere or interact with: antiretrovirals for HIV infection (nevirapine, ritonavir, efavirenz and nelfinavir); antibiotic treatments for tuberculosis like rifampicin or rifabutin; antiseizure drugs for epilepsy (phenytoin, phenobarbital and carbamazepine); or natural herbal remedies which have St John’s Wort as an ingredient.

Conditions to look out for

You should not use this product if you have any of these conditions or have had them in the past: any cancer that is dependent on oestrogen for its development, for example, breast or ovarian cancer; you have had bleeding from your vagina that is unexplained; a venous thromboembolism (blood clot) or a blood clotting disorder; excessive growth of the womb lining that is not being treated; angina, stroke or heart attack; a liver disease where the function of the liver has not returned to its previous level; any form of the rare hereditary blood disease porphyria; or if you are allergic to any of the ingredients.

If you have had any of the following your prescriber may require you to have more frequent check ups as these conditions can return or worsen upon using this item; a family history of oestrogen responsive cancer; benign tumours in the womb (fibroids); a history of endometrial hyperplasia or endometriosis; gallstones; high blood pressure; a susceptibility to blood clots or conditions relating to blood clots; systemic lupus erythematosus; otosclerosis; high levels of blood fat; diabetes; a liver disorder; asthma; or epilepsy.

Regular check-ups

You will need to have regular checks with your (usually at least once a year) to monitor how well HRT is working.

HRT and cancer

More information on HRT and risk of cancer is located in the leaflet provided with the treatment.

Pregnancy and breastfeeding

This product must not be used during pregnancy or breastfeeding. If you become pregnant, stop using it and see your GP as soon as possible.

Driving and using machinery

This treatment is not likely to interfere with your capacity to drive or use machines.

Page last reviewed:  23/08/2021
Please read the patient information leaflet for this medicine fully before use:

FemSeven 50mcg

FemSeven Conti 50mcg/7mcg

Q&A

Can I still drink alcohol?

There is nothing to suggest that drinking alcohol will interfere with this medicine.

Will I still be able to drive?

Yes, but you should stop driving if you experience any side effects that affect your ability to do so, and see your doctor.

Can I take the medicine while pregnant?

This medicine is not for use by women who are pregnant. If you become pregnant while using this treatment, stop at once and speak to your doctor.

How should I store it?

Below 30°C and out of the reach of children. Dispose of the product responsibly and do not use after the use by date.

Am I allergic to anything in the medicine?

FemSeven patches contain estradiol, and are made using transparent polyethylene terephthalate foil, styreneisoprene-styrene block copolymer, glycerine esters of completely hydrogenated resins.

FemSeven Conti and Sequi patches contain estradiol and levonorgestrel, and are made with transparent polyethylene terephthalate (PET) foil (backing layer), styrene-isoprene-styrene block copolymer, glycerin esters of completely hydrogenated resin acids (adhesive matrix) and siliconized transparent polyethylene terephthalate (PET) foil (protective layer).

Do not use them if you are allergic to any of the stated ingredients.

Is it available over-the-counter?

No, but to renew your FemSeven prescription with our UK pharmacy you don’t have to book an appointment or visit the chemist in person. Complete our consultation, and once your item is approved by our doctor, your medication will be delivered by express courier.

Is it right for me?

If you are experiencing menopause symptoms but are not currently taking HRT, you will need to speak to your GP in person to discuss treatment options.

Can I buy FemSeven online?

If you are already using this treatment and want to buy FemSeven online, or are taking another form of HRT and would like to switch to this one, you can take our consultation to have a doctor review your case. If the treatment is safe and suitable, our doctor will issue a prescription to be dispensed at our UK based pharmacy. Once your order has been shipped, and you’ll receive it by courier service in just 24 hours.

FemSeven Sequi is not currently available. If you are looking for this treatment please refer to our ‘Which HRT?’ page for help on finding an alternative, or speak to your GP.

Page last reviewed:  23/08/2021
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