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Nerisone is a topical corticosteroid used to treat certain types of skin condition, such as psoriasis.

This treatment is not available through our service. We recommend you see your doctor in person to be prescribed this item.

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.

This content was reviewed by a clinician on

30 August 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 30 August 2020
Product information

Nerisone is a topical medicine used in psoriasis, and other skin conditions. It contains an agent called a corticosteroid, and this helps to reduce inflammation and alleviate irritable symptoms. Made by Bayer, Nerisone is only available to buy in the UK with a prescription.

  1. Available as a cream or ointment
  2. Reduces inflammation
  3. Facilitates healing

There are three different versions of this medicine: Nerisone Cream is for patches of irritation caused by a skin condition which is also weeping; Nerisone Ointment is used on very dry irritation; whereas Nerisone Oily Cream is used for those outbreaks which fall between these instances, which are neither very dry or weeping.

Psoriasis is a chronic condition characterised by periods of flare-up and remission. The most commonly associated symptoms are red, irritated patches of skin, susceptible to flaking and itchiness. Someone with psoriasis may also notice the appearance of scaly patches, and in rare cases, infected pustules may also develop.

The NHS estimates that around two out of every 100 people in the UK is living with the condition. Most of the time, a person will encounter their first episode before the age of 35, although it has been known to occur for the first time later in some. It is still a condition which is not completely understood, but it is thought to have something to do with the immune system.

Sometimes, the immune system perceives a threat, such as an infection, where there is none present. This results in the body releasing defensive chemicals, which inhabit an affected area and cause inflammation. In psoriasis, this is thought to result in new skin cells developing at an accelerated rate, before the old ones are ready to be shed. When these skin cells rise to the surface, flakes occur, along with other symptoms mentioned above.

Certain triggers can induce a psoriasis outbreak. These include stress, smoking, drinking too much alcohol, or reaction to medication. Sometimes, a flare-up can also come about as a result of an infection. When treating the condition, a doctor may discuss the potential trigger with the patient and advise them to minimise exposure to this as appropriate.

They may also issue a corticosteroid, such as Nerisone, to help get symptoms under control. The functioning constituent of this item is diflucortolone valerate, which works by inhibiting the activity of inflammatory chemicals in the body, released by the immune system. In doing this, the steroid helps to soothe irritation and ease symptoms.

We do not provide this medication online. If you are not currently taking psoriasis treatment or have not had your symptoms examined by a doctor, we recommend you make an appointment with your GP.

We also recommend you speak to your GP if you are seeking to renew your prescription for this product.

Page last reviewed:  30/08/2020

You should always read and make sure you understand the accompanying instructions carefully when using any medicine, and follow the directions given by your prescribing doctor. This will aid you in maximising the efficacy of the treatment and also in lowering the risk of possible side effects.

  1. Use as directed.
  2. Wash your hands before use.
  3. Administer a thin layer to the area affected.
  4. The typical dose is two applications per day.
  5. It should not be used for more than one to two weeks.
  6. Where used on the face, it should not be used for more than five days.
  7. Never exceed the prescribed dose.
  8. If you miss a dose, do not make up for it by applying double the amount next time. Simply carry on the treatment as before.

More detailed instructions can be located in the leaflet supplied.

Download PDF


Page last reviewed:  30/08/2020
Please read the patient information leaflet for this medicine fully before use:

Nerisone 0.10%

Side effects & Warnings

Being aware of the potential side effects this medication may cause is crucial, so that you can take the appropriate action in the event that they occur.

If you notice any signs of an allergic reaction, such as swelling of the face, eyes, lips, throat or tongue, or hives, you should seek medical attention as soon as possible.

After use, your skin might feel like it is burning, itching or irritated, and also become red or flushed.

Notify your doctor if you experience any of the following: thinning of the skin on or around the treated area; acne; stretch marks; inflammation of the skin around the mouth; groupings of fine blood vessels becoming prominent under the skin; increased hair growth; or glaucoma.

More information on side effects can be found in the supplied leaflet.

Taking it with other medicines

Inform your doctor during consultation if you are using any other treatments.

Conditions to look out for

Let your doctor know if you have any of the following, as you may not be able to use this treatment: rosacea; inflammation around the mouth; an eye disease; acne; a condition in the genital/anal area; a viral skin condition such as cold sores, herpes, shingles or chickenpox; glaucoma; a bacterial or fungal infection which is not receiving treatment; skin irritation on the lower legs related to circulatory problems; leg ulcers as you may have an increased risk of allergic reaction.

Please note that Nerisone may make some types of psoriasis worse. Detail your symptoms to your prescriber during consultation so that they can accurately determine that this treatment is suitable for you.

Pregnancy and breastfeeding

You should not use this product unless your doctor deems it necessary if you are pregnant, breastfeeding, or trying to conceive. Speak to your doctor for further advice.

This treatment should not be applied to the breasts if used during breastfeeding.

Driving and using machinery

This product is not likely to inhibit your capacity to drive or use machines.

Page last reviewed:  30/08/2020
Please read the patient information leaflet for this medicine fully before use:

Nerisone 0.10%


Can I still drink alcohol?

Yes. This medication is not thought to be affected adversely by the consumption of alcohol. However, excessive consumption may make psoriasis symptoms worse, and so should be avoided when using this product.

Will I still be able to drive?

Yes. This medication is not likely to affect the user’s ability to drive. Those who experience any side effects which could inhibit their ability to drive should, however, refrain from doing so and seek medical advice immediately.

Can I take the medicine while pregnant?

It may not be suitable for those who are pregnant, breastfeeding or trying to become pregnant. In such cases, you should discuss the use of this medication with your doctor prior to use.

How should I store it?

Keep it in a safe place at a temperature below 25° C.

Am I allergic to anything in the medicine?

The ingredients of Nerisone Ointment are: diflucortolone valerate, heavy liquid paraffin, white soft paraffin, microcrystalline wax, and castor oil (hydrogenated).

Nerisone Cream consists of: diflucortolone valerate, polyoxyl-40-stearate [E431], stearyl alcohol, heavy liquid paraffin, white soft paraffin, disodium edetate, carbomer, sodium hydroxide, methyl parahydroxybenzoate [E218], propyl parahydroxybenzoate [E216] and purified water.

In Nerisone Oily Cream are the following: diflucortolone valerate, white beeswax, heavy liquid paraffin, white soft paraffin, Dehymuls E and purified water.

Do not use the above items if you are allergic to any of the substances contained therein.

Is it available over-the-counter?

You will need a prescription in order to be able to buy Nerisone Cream, Ointment or Oily Cream.

Is it right for me?

Psoriasis treatment has to be initiated following a consultation undertaken in person. If you have not used treatment before, see your GP or specialist for further advice.

We do not provide this treatment through our online service. See your GP if you looking to renew your prescription for this medication.

Page last reviewed:  30/08/2020 is rated 4.9 out of 5 by 3131 customers on TrustPilot!
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