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The active ingredient found in Adartrel, called ropinirole, relieves the unpleasant or irritating sensations associated with restless leg syndrome. This, in turn, removes the urge to move the legs, or other limbs. 

You can order Adartrel using our online service. Take our questionnaire to have your prescription request evaluated by one of our GMC-doctors or GPhC-prescribers. Following approval, your medication will be dispensed at our UK pharmacy and shipped to you within one working day.

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This content was reviewed by a clinician on

12 November 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 12 November 2020
Product information

Adartrel is a branded treatment for restless leg syndrome. Iit is manufactured by GlaxoSmithKline (GSK). The active ingredient in Adartrel, ropinirole, is a dopamine antagonist. Medicines in this class relieve the symptoms of restless leg syndrome. These symptoms are characterised by unpleasant, irritable or even painful sensations in the legs or other limbs. By reducing these symptoms, the desire to move the limbs is reduced in turn. This helps to reduce muscle activity while asleep. 

Restless leg syndrome, also known as Willis-Ekbom disease, is a condition which affects the central nervous system. It causes a compelling urge to move the legs, though it can affect the arms too. 

Symptoms of restless leg syndrome will include the irresistible desire to move, particularly the legs. It can also cause unpleasant and uncomfortable crawling sensations in the fees, ankles, calves and thighs. These symptoms can become worse during the evening, and can interrupt sleep. The condition is associated with uncontrollable jerking of the limbs, medically known as periodic limb movements in sleep (PLMS). The symptoms can range from moderate to severe, and can be present consistently or at different times in the day. Restless leg syndrome can be distressing and in more extreme cases, it can interfere with a person’s daily routine and quality of life. 

There isn’t always a clear cause of restless leg syndrome. It can be inherited and run through families. Some medical professionals believe that the cause of restless leg syndrome could surround a chemical called dopamine, a naturally produced hormone in the brain. This is because dopamine has a role to play in muscle movement, and it is thought it could have something to do with the involuntary jerks associated with restless leg syndrome. In rarer cases, restless leg syndrome may be the symptom of a pre-existing health condition, such as iron deficiency or a kidney problem. Furthermore, 1 in 5 women who enter into the third trimester of their pregnancy will experience symptoms of restless leg syndrome - though this typically clears up following birth. 

Restless leg syndrome has no known cure, but can be treated effectively in most cases. Certain lifestyle changes may help, these can include adopting a healthy sleep routine, quitting smoking and exercising regularly. In more severe cases of restless leg syndrome, medicinal treatment may be prescribed to help regulate dopamine levels or, in cases where it is caused by iron deficiency, iron supplements. Anyone can experience restless leg syndrome, though it’s more commonly observed in women and those of middle age. 

Restless leg syndrome only requires treatment if the lifestyle changes mentioned above haven’t worked or if the symptoms are becoming distressing. Leaving RLS untreated doesn’t alter the course of the condition, for example treatment with Adartrel won’t make the condition deteriorate any faster or slower compared to no treatment. It is worth noting that Adartrel usually helps people with RLS but the improvement is relatively short-lived, Adartrel shouldn’t be taken for more than 6 months, taking it for longer than this does not provide much benefit and can sometimes make the condition worse.

If you’re looking to renew your prescription for Adartrel, which treats restless leg syndrome, then you can do so using our online facility. Simply take our medical questionnaire to have your symptoms evaluated by a member of our qualified medical team. Pending approval, we’ll ship your order in discreet, tracked packaging.

Select dose
Page last reviewed:  12/11/2020

It’s important you always take medication in the way it has been prescribed. Speak with your doctor or pharmacist if you’re unsure. 

  1. Take as instructed. 
  2. Dosage may vary depending on the severity of symptoms. 
  3. You may be issued a lower, starting dose. The lowest dose of Adartrel is 0.25mg. 
  4. Your doctor should oversee your course of treatment. 
  5. Your dose may be increased if symptoms do not improve. 
  6. Swallow whole, with water. 
  7. You do not have to take this tablet with food, but doing so may reduce the chances of developing nausea. 
  8. Try to take it at the same time every day. This can be a time of day prior to when you know your symptoms become more severe. 
  9. If you forget to take a dose, skip it and then take a new pill the next day at the normal time. 
  10. Speak to your doctor if you miss several doses. 
  11. Do not stop taking this treatment without speaking to your doctor first. 

For more detailed guidance on how to take Adartrel, read the patient information leaflet that comes with each treatment pack.

Page last reviewed:  12/11/2020
Please read the patient information leaflet for this medicine fully before use:
Side effects

Like all medication, Adartrel can cause some side effects. Most people will not be affected, but it’s important to familiarise yourself with what side effects can look like should you encounter them. If you’re unsure, speak with a doctor. 

Very common (more than 1 in 10 people)

Vomiting, nausea.

Common (up to 1 in 10 people)

Feelings of nervousness, fainting, drowsiness, fatigue, dizziness, pain in the stomach, an increase in the severity of RLS symptoms, swelling of the legs, feet and/or hands. 

Uncommon (up to 1 in 100 people)

Confusion, hallucinations, feeling faint or dizzy - particularly when standing up.

Very rare side effects (up to 1 in 1000) 

Changes in liver functionality, feeling sleepy or tired during the day, falling asleep suddenly, sometimes without prior feelings of tiredness. 

Frequency unknown

Allergic reaction, of which symptoms can include redness, rash, itching, wheezing, difficulty breathing, coughing, inflammation of the mouth, lips, throat and tongue, hives, other psychotic conditions in conjunction with hallucinations, such as extreme confusion, delusions or paranoia, aggression, treatment dependence, called dopamine dysregulation syndrome, mental health conditions such as depression, anxiety, apathy, reduced energy, sweating and withdrawal symptoms after treatment conclusion. 

Furthermore, some people, the frequency of which is unknown, may experience the inability to not act impulsively. This can take several forms, including harming yourself or others, gambling excessively despite financial consequences, changed sexual desire, uncontrolled spending and binge eating. 

It’s very important you make a medical professional aware if you notice any of the severe side effects listed above. 


Taking it with other medicines

You must disclose to your prescriber any medication you’ve taken, or taken recently, in order for them to properly assess its suitability. When certain medications interact, they can interfere with the effectiveness of others or cause certain side effects. 

Particularly make your doctor or prescriber aware if you take fluvoxamine, an antidepressant, any medication for mental health related conditions, hormonal replacement therapy, the antibiotics ciprofloxacin and enoxacin, any medication which blocks dopamine in the brain, vitamin K antagonists and Warfarin. 

Conditions to look out for 

You must tell your prescriber if you suffer with any pre-existing medical conditions. It’s especially important to mention if you’ve had, or ever had, liver disease, a severe heart problem or condition, mental health conditions, unusual or impulsive behaviour, an addictive nature or if you’re intolerant to sugar or lactose. 

Pregnancy and breastfeeding 

Adartrel is not recommended if you are pregnant, nor if you are breastfeeding. If you’re already taking Adartrel and you become pregnant, you must speak with your doctor immediately. 

Driving and using machinery

This medication can cause certain side effects such as drowsiness, tiredness and hallucinations. In extremely rare instances, it can cause people to fall asleep unexpectedly. If you experience any of these side effects, you should not drive or operate machinery. Speak with your doctor or pharmacist if you’re unsure. 

Food, drink and alcohol

Taking this medicine with food can reduce the risk of feeling nauseous. You should not drink alcohol while taking this treatment. 

Lactose intolerance

Adartrel contains small traces of lactose. If you have an intolerance to lactose, do not take this treatment. 

Page last reviewed:  12/11/2020
Please read the patient information leaflet for this medicine fully before use:

Can I still drink alcohol?

No, you must refrain from drinking alcohol while you take this treatment. 

Will I still be able to drive? 

Not if you encounter certain side effects associated with this medication, most commonly tiredness and drowsiness. You must not drive if you experience these side effects. Your doctor may adjust your dose to try to reduce these side effects. 

Can I take this medicine while pregnant?

You should tell your doctor or prescriber if you’re pregnant, breastfeeding or planning to conceive. Adartrel will typically not be prescribed for women who are pregnant or breastfeeding.

How should I store it? 

Away from children, at no more than 25 degrees in a cool, dry environment. 

Am I allergic to anything in the medicine? 

Do not take this medication if you’re allergic to its active ingredient, ropinirole. Other ingredients may include lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate. 

Film coat: 

0.25 mg tablet: hypromellose, macrogol 400, titanium dioxide (E171), polysorbate 80 (E433) 

0.5 mg tablet: hypromellose, macrogol 400, titanium dioxide (E171), iron oxide yellow (E172), iron oxide red (E172), indigo carmine aluminium lake (E132) 

2 mg tablet: hypromellose, macrogol 400, titanium dioxide (E171), iron oxide yellow (E172), iron oxide red (E172)

Is it available over the counter? 

No, this medication can only be obtained if a prescription has been issued by a doctor or prescriber. 

How can I buy Adartrel online? 

Take our medical questionnaire to have your prescription request reviewed by one of our GMC-doctors or GPhC-prescribers. We dispense from a UK-registered pharmacy. All orders are processed by a third-party, next-day, courrier.

Page last reviewed:  12/11/2020 is rated 4.9 out of 5 by 3131 customers on TrustPilot!
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