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Reviewed on December 11, 2023. by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Next review due on December 11, 2025.
Estrace is an estrogen-only treatment to help you with the symptoms of menopause. It comes as an oral tablet or vaginal cream, so you can pick the one that suits your needs.
Our experts will work with you to find the perfect treatment for your needs and for your life. Don’t do menopause alone. We’re here to support you when you get Estrace online.
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Estrace is a type of HRT (hormone replacement therapy) available as either a tablet or vaginal cream. Both forms contain the active ingredient estradiol, which is a synthetic estrogen. Although primarily used to treat the symptoms of menopause (like hot flashes, mood changes and vaginal dryness), it can also be used as part of some cancer treatments and to help prevent bone loss (osteoporosis).
Estrace tablets should be taken alongside a progestin if you haven’t had a hysterectomy, and only for as long as it helps your symptoms for. Ideally, your treatment should be reviewed every three-to-six months to see if your dose can be lowered, or to see if treatment can be stopped entirely. Estrace vaginal cream might be safer to use on a more long-term basis because the risks are lower. And it can be used without a progestin, even if you haven’t had a hysterectomy.
How does Estrace work?
Menopause can happen for one of two reasons: either through age, where your body stops producing eggs and you stop getting periods, or through a medical procedure that stops your ovaries from working (called ‘medically induced menopause’). In either case, the amount of estrogen that circulates in your body decreases. This decrease in estrogen is what causes your symptoms. Estrace works to counteract these symptoms by, quite simply, supplying your body with estrogen, making up the deficit.
Another common risk associated with the menopause is decreased bone density, called osteoporosis. Estrace tablets can also help to reduce and prevent this bone loss, though other treatments may be recommended if you have no other symptoms. Similarly, Estrace tablets can help with vaginal symptoms like vaginal dryness, but the vaginal cream will be better for you if this is the main symptom you’re getting.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Alexandra Cristina Cowell on December 11, 2023. Next review due on December 11, 2025.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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How to take Estrace for menopause
Make sure to follow the instructions given to you by your doctor when taking Estrace.
How to take Estrace tablets
Take one tablet a day, with water (your doctor will help you decide the dose that’s right for you) Swallow it whole — don’t chew or crush it.
How to use Estrace Vaginal Cream
Estrace Vaginal Cream comes with an applicator to help you insert it into your vagina.
Wash and dry your hands well.
Remove the cap from the cream.
Hold the applicator with your index finger on top of the plunger and screw the threaded end onto the open nozzle of the vaginal cream tube.
Hold the cream and the applicator vertically so you can clearly see the numbered dose reader on the applicator.
Gently squeeze the tube from the bottom to push your prescribed dose of cream into the applicator.
When your dose has been reached, unscrew the tube from the applicator and replace the cap.
To deliver the cream, lie on your back with your legs spread apart and insert the applicator deep into your vagina.
Press the plunger downwards to its original position, then remove the applicator.
Clean the applicator with mild soap and warm water.
What are the different forms and doses of Estrace?
Estrace comes in either tablets for systemic (whole body) menopause symptoms (like hot flashes and mood changes), or a vaginal cream for local symptoms, like vaginal dryness or atrophy (weakening).
In terms of doses, you can take the tablet as either a 0.5mg, 1mg or 2mg dose. The one you’re prescribed will be the lowest one to treat your symptoms.
And the cream is available in one strength: 0.01%, of which you can measure doses of 1g, 2g, 3g or 4g into the applicator. Again, the dose you’re prescribed will be the lowest one that helps your symptoms.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Alexandra Cristina Cowell on December 11, 2023. Next review due on December 11, 2025.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Estrace: FAQ
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Why should I buy Estrace online with Treated?
Answer:
Menopause is a natural part of life, but that doesn’t mean you have to face it alone. Tell us a little about your health, and our experts will recommend the treatments that are right for you. From there, just pick the one that suits you best. And if you can’t decide? Our doctor will pick something out for you. But the care doesn’t end once you’ve bagged your meds. We’ll check in throughout your treatment journey to see how you’re doing, and if you’ve got any questions at all — just reach out and drop us a line. We’ll be happy to help.
How is Estrace different to other treatments for menopause?
Answer:
Estrace is a form of estrogen-only HRT, whereas some other HRTs may also contain progesterone. These are called ‘combined HRT’, and they’re more suitable for women who haven’t had a hysterectomy. If you take Estrace tablets but haven’t had a hysterectomy, you’ll need to take a separate progestin to help protect yourself against womb cancer. Vaginal HRT is always estrogen-only, but it may come in different forms. Some vaginal HRTs may come as gels or pessaries, and so you may have to use them differently, but they’ll largely do the same job. If you’re looking for a HRT option that you don’t need to remember to use every day, then you might want to consider HRT patches. These are sticky patches that you put on your skin like a band-aid, and they work for a few days to deliver medicine into your body. You’ll use one or two a week, which you might find more convenient than sticking to a daily regimen.
How well does Estrace work for menopause symptoms?
Answer:
In a 2018 study of 576 postmenopausal women with vaginal dryness, vaginal estradiol was found to reduce vaginal dryness and improve vaginal pH versus placebo after 10 weeks.[1] And for oral estradiol, the majority of studies have found that it significantly improves symptoms for postmenopausal women. Research indicates that it can also reduce stress levels and improve bone health. [2]
Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Cristina writes content for Treated, and reviews content produced by our other writers to make sure it’s clinically accurate.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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