• Alprostadil

MUSE is a rapid-acting treatment for erectile dysfunction. It is a urethral suppository, designed to be applied to the tip of the penis. offer a safe and reliable private prescription service. We work with GMC-registered doctors and ship approved medicines by tracked courier. Find out if MUSE is suitable for you by taking our short online questionnaire.

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500 micrograms is the typical starting dose for most men. This dose may be continued if it provides sufficient effects.


This is the maximum dose, and may be issued if smaller doses have proved ineffective.


This may be used in cautionary cases where the user has displayed an increased sensitivity to higher doses.

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MUSE is an erectile dysfunction treatment, manufactured by Meda pharmaceuticals. The name of the treatment is an acronym for ‘Medicated Urethral System for Erections’. It is designed as a localised treatment for ED, and this facility enables it to work in as little as 10 minutes.

  1. Begins to work within 10 minutes of application
  2. Offers localised treatment for ED
  3. Erections last for between 30 and 60 minutes

The treatment is a urethral suppository, which means you apply it by administering it to the end of the penis. The working ingredient in this medication is a synthetic hormone, called alprostadil. Also found in Caverject, alprostadil performs a similar function in the body to prostaglandin E1 (PGE1).

An erection occurs when a sequence of chemical responses in a man’s body take place, most typically when he becomes aroused. These chemical responses enable muscle walls in the blood vessels near the penis to relax, and this process then initiates a rush of blood to the penis, resulting in an erection.

When this sequence is interrupted by circulation problems or other factors, such as diabetes or anxiety, then it can be difficult for the individual to achieve and preserve an erect penis. In cases where the issue persists, this is called erectile dysfunction in medical terms, but it can also be referred to as impotence.

Erectile dysfunction can affect younger men, but it is more common in older men. It is estimated that roughly 40 per cent of men over 60 and fifty per cent of men over 70 will experience the condition. This might be due to decreased circulation, which can result in a lack of adequate blood flow.

Those who experience the problem at a younger age tend more often to develop the condition through stress; whether it is through indirect anxiety related for instance to work; or that more directly related to the act of sex itself. It is not uncommon for the anxiety which comes with being with a new partner and being eager to impress to induce erectile hesitancy.

Treatment for erectile dysfunction aims to ease the flow of blood to the penis. Alprostadil does this by mimicking the action of PGE1, which helps to relieve tension in blood vessels around the penis, and increase blood flow. This enables the person using the treatment to get and stay erect for longer during sex. In the case of MUSE, this synthetic hormone is released into the inside of the penis via the applicator, and absorbed by the urethral wall.

MUSE is a little more complex to apply than more conventional ED treatments, such as oral tablets: but the benefits of this method of application are that it gets to work incredibly quickly, and is preferable for those who prefer not to use injections or swallow whole pills.

The medication is designed to work as part of a sexual experience, and therefore requires the user to be sexually aroused in order for it to work at its optimum.

The functioning agent in MUSE is a man-made hormone called alprostadil. This works in much the same way to prostaglandin E1 (PGE1), which is a naturally-occurring substance in the body.

Firstly, PGE1 performs an important function in allowing blood vessels and muscular tissue around the penile area to loosen, facilitating the easier flow of blood to the penis during moments of sexual arousal. Secondly, in order to maintain an erection, other blood vessels need to restrict the flow of blood leaving the penis and help it to stay there, and PGE1 also assists with this process.

Impotence can be caused by numerous circumstances. Stress, conditions like diabetes, and decreased circulation can all contribute to erectile dysfunction. In cases where someone is experiencing ED, medication can expedite the biological processes required to obtain an erection by helping the user to achieve a regular pattern of blood flow.

MUSE is available in 250, 500 or 1000 microgram doses. The version you are prescribed will be determined by whether you have used this or any other ED treatment before, and whether those medicines proved effective.

The typical introductory dose is 500 micrograms. This may be increased, decreased or kept the same, depending on how you react to the treatment.

Please note that there is currently no generic version of this medication on the market in the UK. Any website which claims to offer a cheaper, generic alternative should not be trusted, as they may be offering counterfeit or unstable products. When buying MUSE online in the UK, always use a GPhC registered pharmacy, and ensure that the treatment you are buying is branded.

If you think MUSE can assist you in your sex life, take our consultation today. You will be presented with a medical survey, and a doctor will analyse your answers. If they believe the treatment is a suitable one for you, they will issue a prescription which our UK-based dispensing pharmacy will fulfil. Your order will then be shipped by 24-hour courier.

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How to use MUSE

To be effective, it is important to ensure you apply MUSE as instructed by your doctor, and that you follow the step-by-step guide supplied with the medicine. Doing so may also help to limit the risk of possible side effects.

  1. The treatment is easier to administer if you have a moist urethral passage. Before application, it is advisable to visit the toilet to urinate.
  2. Be aware that the tip of the MUSE applicator is sterile, so try to avoid contact after taking it out of the protective pouch.
  3. Massage the penis to help it extend to it’s full length, before very gently inserting the applicator into the tip of the penis. If this causes pain or discomfort, carefully extract the applicator and slowly re-insert.
  4. Once in place, push the button on the end of the applicator and hold it there for at least five seconds.
  5. Very carefully and slightly move the applicator from side to side, to release the contents.
  6. Then, gently pull out the applicator and ensure there is no liquid left inside.
  7. Roll your penis between two open hands to help the medication achieve optimum urethral coverage.
  8. Sit for 10 minutes to allow the medication to work. 
  9. Never exceed the amount prescribed by our physician, and never apply the medicine more than twice in any one 24-hour period, or more than seven times in a seven-day period.

Read the directions carefully before using this medication, and ask your doctor for advice if you are still unsure.

Download MUSE patient information leaflet

MUSE side effects

In the case of MUSE and all other treatments for erectile dysfunction, it is vital before using them to be knowledgeable of the potential side effects they might cause, so that you can take the appropriate steps if you experience them later on.

Common (1 in 10 people)
Burning feeling inside the urethra, or feelings of pain and discomfort.

Uncommon (1 in 100 people):
Dizziness, testicular pain, low blood pressure, pain in the partner’s vagina, headaches.

Rare (1 in 1000 people):
Perineal pain, swollen veins in the legs, increased heart rate, fainting, urinary tract infections, prolonged erections (priapism).

This is not a full list of potential side effects. For a more complete account, refer to the information leaflet supplied or speak to your doctor.

If you experience a prolonged erection or any other side effects, it is imperative to seek immediate medical attention.

Taking it with other medicines

If you are using prescription, over-the-counter or even remedial medication, you should notify your doctor prior to or during consultation for MUSE. Do not start or stop using any of these medications without first checking with your prescribing physician.

Alprostadil may amplify or inhibit the effects of: aliskiren; clonidine; diazoxide; alpha-blockers including tamsulosin and doxazosin; beta-blockers including atenolol and propranolol; calcium-channel blockers, for instance diltiazem and nifedipine; minoxidil; nitrate-based medications; diuretics; hydralazine; methyldopa; moxonidine; losartan and valsartan.

Please note that the information provided here is not a comprehensive account of the restrictions which apply to this drug. If you want to know more, speak to your doctor or refer to the patient information for this product.

Conditions to look out for

Please tell your prescriber if you are prone to or have had the following conditions in the past, as they may affect your suitability for this drug: heart problems; any condition which might make you susceptible to priapism; inflammation or infection of the urethra or penis; penile abnormalities such as Peyronie’s disease; narrow urethral passage.

Q&A: our MUSE discussion forum

Can I still drink alcohol?

You can drink alcohol while using most treatments for impotence. However, because this treatment has very specific application instructions, and because alcohol consumption can be a contributing factor to erectile dysfunction, we would advise against it.

Will I still be able to drive?

While this medication should not directly affect your ability to drive, you should refrain from doing so if you experience any side effects which might affect your judgment or motor skills.

How should I store it?

In a dry, safe place out of the reach of children, below 30°C, and in the original packaging so it cannot be taken by mistake.

Am I allergic to anything in the medicine?

The two ingredients used to make MUSE are alprostadil and macrogol. Do not take this medicine if you are allergic to these substances.

Is it available over-the-counter?

No. You will need to undergo consultation with a doctor prior to using this medicine to ensure that it is safe for you. At, we work with GMC-registered doctors to help ensure your well-being and safety. They will review your order, and only issue a treatment if they think it does not pose a risk to your health.

Is it right for me?

There’s only one way to find out: take our medical questionnaire. A qualified doctor will analyse your case and make a decision based on your answers. If they are satisfied that MUSE can help you, they will draw up an electronic prescription, which our UK-based pharmacy will fulfil. You can expect to receive your treatment within one working day of approval.

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