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MUSE is a rapid-acting treatment for erectile dysfunction. It is a urethral suppository, designed to be applied to the tip of the penis.

We offer a safe and reliable private prescription service, enabling you to buy MUSE online. Each order is reviewed by a practising doctor or pharmacy prescriber. Approved orders are dispensed at our UK pharmacy.

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The price below are inclusive of your consultation, prescription, the medicine itself and secure next-day shipping from our UK pharmacy.

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MUSE is a rapid-acting treatment for erectile dysfunction. It is a urethral suppository, designed to be applied to the tip of the penis.

We offer a safe and reliable private prescription service, enabling you to buy MUSE online. Each order is reviewed by a practising doctor or pharmacy prescriber. Approved orders are dispensed at our UK pharmacy.

This content was reviewed by a clinician on

26 April 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 26 April 2022
Product information

MUSE is an erectile dysfunction treatment, manufactured by Mylan. The name of the treatment is an acronym for ‘Medicated Urethral System for Erections’. It is designed as a localised treatment for ED, and this facility enables it to work in as little as 10 minutes.

  1. Begins to work within 10 minutes of application
  2. Offers localised treatment for ED
  3. Erections last for between 30 and 60 minutes

The treatment is a urethral suppository, which means you apply it by administering it to the end of the penis. The working ingredient in this medication is a synthetic hormone, called alprostadil. Also found in Caverject, alprostadil performs a similar function in the body to prostaglandin E1 (PGE1).

Please note that you can only order MUSE online from our UK pharmacy if you have used it before. Prior to first use, a doctor will need to show you how to administer MUSE; so if you have not used it before, you should see your GP in person.

What is ED? 

An erection occurs when a sequence of chemical responses in a man’s body take place, most typically when he becomes aroused. These chemical responses enable muscle walls in the blood vessels near the penis to relax, and this process then initiates a rush of blood to the penis, resulting in an erection.

When this sequence is interrupted by circulation problems or other factors, such as diabetes or anxiety, then it can be difficult for the individual to achieve and preserve an erect penis. In cases where the issue persists, this is called erectile dysfunction in medical terms, but it can also be referred to as impotence.

How common is ED? 

Erectile dysfunction can affect younger men, but it is more common in older men. It is estimated that roughly 40 per cent of men over 60 and fifty per cent of men over 70 will experience the condition. This might be due to decreased circulation, which can result in a lack of adequate blood flow.

Those who experience the problem at a younger age tend more often to develop the condition through stress; whether it is through indirect anxiety related for instance to work; or that more directly related to the act of sex itself. It is not uncommon for the anxiety which comes with being with a new partner and being eager to impress to induce erectile hesitancy.

How does MUSE help ED? 

Treatment for erectile dysfunction aims to make it easier for blood to flow to the penis. Alprostadil does this by mimicking the action of PGE1, which helps to relieve tension in blood vessels around the penis, and increase blood flow. This enables the person using the treatment to get and stay erect for longer during sex. In the case of MUSE, this synthetic hormone is released into the inside of the penis via the suppository applicator, and absorbed by the urethral wall.

MUSE is a little more complex to apply than more conventional ED treatments, such as oral tablets: but the benefits of this method of application are that it gets to work incredibly quickly, and is preferable for those who prefer not to use injections or swallow whole pills.

The medication is designed to work as part of a sexual experience, and therefore requires the user to be sexually aroused in order for it to work at its optimum.

MUSE active ingredient - alprostadil suppository

The active ingredient in MUSE is a man-made hormone called alprostadil. This works in much the same way to prostaglandin E1 (PGE1), which is a naturally-occurring substance in the body.

Firstly, PGE1 performs an important function in allowing blood vessels and muscular tissue around the penile area to loosen, facilitating the easier flow of blood to the penis during moments of sexual arousal. Secondly, in order to maintain an erection, other blood vessels need to restrict the flow of blood leaving the penis and help it to stay there, and PGE1 also assists with this process.

Impotence can be caused by numerous circumstances. Stress, conditions like diabetes, and decreased circulation can all contribute to erectile dysfunction. In cases where someone is experiencing ED, medication can expedite the biological processes required to obtain an erection by helping the user to achieve a regular pattern of blood flow.

What doses of MUSE are available? 

MUSE is available in 250, 500 or 1000 microgram doses. The version you are prescribed will be determined by whether you have used this or any other ED treatment before, and whether those medicines proved effective.

The typical introductory dose is MUSE 500 microgram urethral sticks. This may be increased, decreased or kept the same, depending on how you react to the treatment.

What to look out for when buying MUSE online

Please note that there is currently no generic version of this medication on the market in the UK.

When buying MUSE for ED online in the UK, always use a GPhC registered pharmacy, and ensure that the treatment you are buying is branded.

If you have used this medication before, you can renew your MUSE prescription online with our simple, confidential service. Take our questionnaire, and one of our clinical staff will assess your responses. Once approved, our UK pharmacy will issue your item and ship it via secure courier.

Select dose
Page last reviewed:  26/04/2022


To be effective, it is important to ensure you apply MUSE as instructed by your doctor, and that you follow the step-by-step guide supplied with the medicine. Doing so may also help to limit the risk of possible side effects.

  1. A doctor will need to show you how to use MUSE prior to first use.
  2. The treatment is easier to administer if you have a moist urethral passage. Before application, it is advisable to visit the toilet to urinate.
  3. Be aware that the tip of the MUSE applicator is sterile, so try to avoid contact after taking it out of the protective pouch.
  4. Massage the penis to help it extend to it’s full length, before very gently inserting the applicator into the tip of the penis. If this causes pain or discomfort, carefully extract the applicator and slowly re-insert.
  5. Once in place, push the button on the end of the applicator and hold it there for at least five seconds.
  6. Very carefully and slightly move the applicator from side to side, to release the contents.
  7. Then, gently pull out the applicator and ensure there is no liquid left inside.
  8. Roll your penis between two open hands to help the medication achieve optimum urethral coverage.
  9. Sit for 10 minutes to allow the medication to work. 
  10. Never exceed the amount prescribed by our physician, and never apply the medicine more than twice in any one 24-hour period, or more than seven times in a seven-day period.

You must not take recreational drugs if you are using erectile dysfunction medicine, as this can be very dangerous.

Read the directions carefully before using this medication, and ask your doctor for advice if you are still unsure.

Page last reviewed:  26/04/2022
Please read the patient information leaflet for this medicine fully before use:

MUSE 1mg

MUSE 500mcg

Vitaros 3mg/g

Side effects & Warnings

Side effects

In the case of MUSE and all other treatments for erectile dysfunction, it is vital before using them to be knowledgeable of the potential side effects they might cause, so that you can take the appropriate steps if you experience them later on.

Common (1 in 10 people):

Burning feeling inside the urethra, or feelings of pain and discomfort.

Uncommon (1 in 100 people):

Dizziness, testicular pain, low blood pressure, pain in the partner’s vagina, headaches.

Rare (1 in 1000 people):

Perineal pain, swollen veins in the legs, increased heart rate, fainting, urinary tract infections, prolonged erections (priapism).

This is not a full list of potential side effects. For a more complete account, refer to the information leaflet supplied or speak to your doctor.

If you experience a prolonged erection or any other side effects, it is imperative to seek immediate medical attention.

Taking it with other medicines

If you are using prescription, over-the-counter or even remedial medication, you should notify your doctor prior to or during consultation for MUSE. Do not start or stop using any of these medications without first checking with your prescribing physician.

Alprostadil may amplify or inhibit the effects of: aliskiren; clonidine; diazoxide; alpha-blockers including tamsulosin and doxazosin; beta-blockers including atenolol and propranolol; calcium-channel blockers, for instance diltiazem and nifedipine; minoxidil; nitrate-based medications; diuretics; hydralazine; methyldopa; moxonidine; losartan and valsartan.

Please note that the information provided here is not a comprehensive account of the restrictions which apply to this drug. If you want to know more, speak to your doctor or refer to the patient information for this product.

Conditions to look out for

Please tell your prescriber if you are prone to or have had the following conditions in the past, as they may affect your suitability for this drug: heart problems; any condition which might make you susceptible to priapism; inflammation or infection of the urethra or penis; penile abnormalities such as Peyronie’s disease; narrow urethral passage.

Recreational drugs

You must not take recreational drugs if you are planning to use MUSE. Doing so can be very dangerous and cause a severe harmful reaction.

Pregnancy and breastfeeding

MUSE should not be used by women.

If your partner is pregnant or may be pregnant, you will need to use a condom when using MUSE.

Talk to your doctor for advice before using MUSE if your partner is breastfeeding.

Driving and using machinery

Possible side effects include dizziness. Do not drive or operate machines if you are affected by any side effects that may inhibit your capacity to do so safely.

Page last reviewed:  26/04/2022
Please read the patient information leaflet for this medicine fully before use:

MUSE 1mg

MUSE 500mcg

Vitaros 3mg/g


Can I still drink alcohol?

You can drink alcohol while using most treatments for impotence. However, because this treatment has very specific application instructions, and because alcohol consumption can be a contributing factor to erectile dysfunction, we would advise against it.

Will I still be able to drive?

While this medication should not directly affect your ability to drive, you should refrain from doing so if you experience any side effects which might affect your judgment or motor skills.

How should I store it?

MUSE will be delivered to you in a cold-pack. The product should be immediately placed in a fridge in order for the manufacturer’s expiration date to remain valid. It can also be kept out of the fridge in a safe place below 30°C but under these circumstances it should be used within 14 days. Always keep away from children and in the original packaging.

Am I allergic to anything in the medicine?

The two ingredients used to make MUSE are alprostadil and macrogol. Do not take this medicine if you are allergic to these substances.

Is it available over-the-counter?

No. You will need to undergo consultation with a doctor prior to using this medicine to ensure that it is safe for you.

Is it right for me?

Patients who have not used MUSE before should speak to their doctor in person. They will need to provide advice and demonstrate how to use the medication before first use.

Where to purchase MUSE

Men looking to renew their MUSE prescription online can do so using our confidential service. All orders are checked by either a GMC-registered doctor or a pharmacy prescriber, and approved orders are dispensed at our regulated pharmacy. Shipping on all medicines is made by tracked courier, so in most cases you’ll receive your package in just one working day.

Page last reviewed:  26/04/2022
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