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Yacella is a combined contraceptive pill, which contains synthetic versions of the female hormones oestrogen (ethinylestradiol) and progesterone (drospirenone).

If you would like to buy Yacella online, fill out our quick and simple questionnaire. Pending approval from one of our GMC-registered doctors or GPhC-registered pharmacy prescribers, your order will be processed by our UK pharmacy and shipped using 24-hour delivery.

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Yacella is a combined contraceptive pill, which contains synthetic versions of the female hormones oestrogen (ethinylestradiol) and progesterone (drospirenone).

If you would like to buy Yacella online, fill out our quick and simple questionnaire. Pending approval from one of our GMC-registered doctors or GPhC-registered pharmacy prescribers, your order will be processed by our UK pharmacy and shipped using 24-hour delivery.

This content was reviewed by a clinician on

08 June 2021
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 08 June 2021
Product information

Yacella is a combined contraceptive pill. It contains two active ingredients called ethinylestradiol and drospirenone which are synthetic versions of oestrogen and progesterone respectively. Essentially, these additional hormones work by preventing ovulation from happening (this means that no egg is released from the womb for fertilisation). A course of Yacella is taken over 21 days. 

In order to understand how contraceptive pills work, it is first important to establish how ovulation normally takes place during pregnancy. Eggs mature in the ovaries every month as a result of the menstrual cycle, and one of these eggs will leave the ovary and travel through the fallopian tube to the uterus, where sperm can make contact with it after sexual intercourse. 

The contraceptive pill functions by altering the balance of hormones. The increased presence of oestrogen and progesterone stops the egg from being released by the ovaries. It acts by affecting the cervix and womb lining. The mucus in the cervix is made thicker by the increased presence of these hormones. This makes it much harder for the sperm to reach an egg. Even if the sperm are able to overcome this and reach an egg, the hormones found inside the contraceptive pill also work by thinning the womb lining. This would make it incredibly difficult for a fertilised egg to implant itself there and begin the process of growth. 

Withdrawal bleeding may happen after a course of Yacella. This is likely to happen sometime during the seven day period when Yacella is not taken. It is unlikely, but it is also possible to not bleed at all during the seven days after taking Yacella. It is not usually an indication of a problem but if it keeps happening, you may want to contact your GP. When the body adjusts to taking the pill, breakthrough bleeding can occur which is when you bleed whilst taking the pill. Most of the time, it will stop within two or three months, but if it is becoming a recurrent issue then you should contact your GP. 

Combined contraceptive pills are a very common and effective form of contraception. Only around three in 1,000 women become pregnant from taking the course of the pill correctly. In some women it can also improve acne and relieve premenstrual tension. It can make periods lighter, but may also increase their frequency. 

You can use our online pharmacy to buy Yacella. If you do not have the time to visit your GP to get a prescription, our service can be a helpful and quick alternative. Once you have completed a questionnaire as part of the online consultation, and one of our doctors has reviewed it, your medication will be dispatched within one day.

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Page last reviewed:  08/06/2021

No one form of contraception has a guaranteed 100% success rate. However, if you take Yacella exactly as prescribed it will be about 99% effective. 

In contraception terms, 99% effective means that out of 100 women taking a form of contraception over a year, only one will become pregnant.

  1. > Take one tablet of Yacella once a day for 21 days consecutively.
  2. > You should take the tablet at the same time each day.
  3. > Each tablet is marked specifically with the corresponding day of the week it is to be taken on. 
  4. > You can take the tablet either with or without food.
  5. > Once you have taken Yacella for 21 consecutive days, stop taking it for a subsequent 7 days.
  6. > After this 7 day abstention time, begin the course again the following day.
  7. > If you forget to take a tablet, take the one you have missed as soon as you remember. Contact your GP if you are unsure, and consult the instructions on the patient leaflet attached with the medication.
  8. > If you’re more than 12 hours late taking a missed pill, you should use extra protection, such as a condom, for the next 7 days.

These instructions are intended as an informative guide for taking Yacella. There is more detailed information available on the patient leaflet provided with the medication.

Page last reviewed:  08/06/2021
Side effects

Like any medication, Yacella can cause certain side effects. Not everyone will experience them, but it is important to be aware of them in case they are severe, so that you know when you should seek medical attention. 

Common (1 in 10 people or less):

Common symptoms may include tenderness in the breasts, pain in the breast, bleeding between periods, menstrual disorders, headache and migraines, nausea, depressive episodes or a vaginal yeast infection.

Uncommon (1 in 100 people or less):

High or low blood pressure, vomiting, diarrhoea, weight loss or gain, breast enlargement or a skin rash.

Rare (1 in 1000 people or less):

A blood clot in a vein/artery, an allergic reaction, skin conditions such as erythema nodosum or a hearing impairment.

The side effects listed above give an outline of some of the possible outcomes of taking Yacella. This is not a comprehensive list, and there are more details about these side effects in the patient information leaflet which is provided with the Yacella packaging. If you experience any of these side effects, contact your GP about whether you need to change to a different pill or stop completely.


Taking it with other medicines

It is important to let your doctor or pharmacist know if you have recently taken or are currently taking other medication. They will be able to tell you if Yacella is suitable. Make them aware if you take any medication for epilepsy, such as barbiturates, carbamazepine, phenytoin, primidone, oxcarbazepine, tuberculosis treatment, treatments for HIV infections like ritonavir, nevirapine or any other infections, antibiotics such as griseofulvin, penicillin, tetracycline, high blood pressure in the blood vessels in the lungs and the herbal remedy St. John's wort. 

Conditions to look out for

You must make your prescriber aware if you have ever had a blood clot in a blood vessel of your legs, or deep vein thrombosis, blood clots in the lungs or any other area of the body, if you have any condition that may affect your blood clotting such as protein C deficiency, protein S deficiency, antithrombin-III deficiency, Factor V Leiden or antiphospholipid antibodies, if you have recently undergone an operation or have had to be off your feet for an irregular period of time, if you have ever had a heart attack or stroke, angina pectoris, transient ischaemic attack,  severe diabetes that may have caused blood vessel damage, very high blood pressure, high cholesterol levels, a type of migraine known as ‘migraine with aura’, inflammation of the pancreas, liver disease, damaged liver function, if you have kidney failure or your kidneys do not work at capacity, if you have had a tumour in the liver, breast cancer, or a cancer of the genital area, unexplained vaginal bleeding. Lastly, if you are allergic to any of the ingredients found in this medication (the active ingredients are ethinylestradiol and drospirenone) then it is unsuitable for you. 

You must also make them aware if you have a close family member who has suffered with breast cancer, if you have ever had a disease of the gallbladder, depression, diabetes, Crohn’s disease, or chronic inflammatory bowel disease, sickle cell anemia, elevated levels of fat in the blood or a family history of this, if you have recently given birth, a condition called superficial thrombophlebitis, varicose veins, epilepsy, any disease that may affect your natural defence system, any disease that was the result of pregnancy or related in some way to the sexual reproductive hormones, chloasma or  hereditary angioedema.

It is also important to mention any medical condition that isn’t listed here. It is vital you never withhold any of your medical history from your doctor or prescriber. 

Pregnancy and breastfeeding 

If you are planning on having a baby or you think that you might be pregnant, you should contact your GP as soon as possible. It is not recommended to breastfeed while taking Yacella.

Driving and machinery

There is no information which suggests that taking Yacella interfere with the ability to drive or operate machinery. 

Contraception and cancer risks

It has been observed that breast cancer is slightly more common in women who use combined pills, but it has not been proven whether this is caused by the treatment or not. You can read more about Yacella and cancer in the patient leaflet.

Lactose intolerance

Yacella contains lactose monohydrate, so you should not take it if a doctor has told you that you are allergic to certain sugars.

Page last reviewed:  08/06/2021

Can I still drink alcohol?

There is nothing to suggest that it is not safe to drink alcohol whilst taking Yacella.

Will I still be able to drive?

You should be okay to drive whilst taking Yacella. However, if you experience any side effects due to driving, then contact your GP for advice.

Can I take the medicine while pregnant?

Yacella is not suitable if you are trying to have a baby or planning on it. Contact your GP if you have any questions about pregnancy and Yacella.

How should I store it?

There are no specific storage instructions, but keeping it in the original packaging is advised.

Am I allergic to anything in the medicine?

Yacella contains drospirenone and ethinylestradiol. The other ingredients include maize starch, lactose monohydrate, povidone K25, magnesium stearate, crospovidone, E102, E110 and E132.

If you are allergic to any of these ingredients then you should not take Yacella.

Is it available over-the-counter?

You need a prescription to purchase Yacella in the UK. You can get a prescription from your GP or from one of our doctors by filling in the online consultation form.

Can I buy Yacella online?

To purchase Yacella online, you can use our consultation service. After you have filled out the questionnaire and one of our GMC-registered doctors has reviewed your answers, your medication will be dispatched within one day of ordering. 

Page last reviewed:  08/06/2021
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