Estradiol/Nomegestrol Acetate

Zoely is a pill used to provide birth control, manufactured by Merck Sharp and Dohme. It is a 28-day tablet which mimics function of hormones in the body.

Zoely is likely to be out of stock until 2020. There are no direct alternatives available at present, however similar contraceptive pills, such as Qlaira and Yasmin, are available through our service.

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In each strip of tablets are: 24 pills containing 2.5 mg nomegestrol acetate and 1.5 mg estradiol (as hemihydrate); and four pills containing no active ingredient (placebos). These are taken daily as directed.

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Zoely is a pill used to provide birth control, manufactured by Merck Sharp and Dohme. It is a 28-day tablet which mimics function of hormones in the body.

Zoely is likely to be out of stock until 2020. There are no direct alternatives available at present, however similar contraceptive pills, such as Qlaira and Yasmin, are available through our service.

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Product information

Zoely is an oral birth control pill made by Merck Sharp and Dohme. It is taken every day, and prevents pregnancy by supplementing the body’s natural levels of the hormones progesterone and oestrogen, with synthetic hormones, called nomegestrol acetate and estradiol. In doing this, it prevents the process of ovulation, and reduces the likelihood of pregnancy.

  1. Simple to take one a day tablet
  2. Provides 99% effective protection
  3. Adept at reducing menstrual tension

Hormones perform an important function in the body, by regulating when it is ready to conceive. As levels of progesterone and oestrogen raise and lower each month, conditions in the reproductive system change to allow for a baby. One phase the body goes through is ovulation. This is where the ovary releases an egg, which is then available for fertilisation by male sperm.

The egg, whether it has been fertilised or not, travels to the uterus. If fertilised, it implants on the uterine wall; if it isn’t, it simply disintegrates and is discharged along with the lining of the uterine wall (known also as the endometrium) though menstrual bleeding. Hormones play a role in this aspect of the conception process too; oestrogen manages the build up of the uterine wall lining, while progesterone is responsible for its shedding each month.

Levels of these hormones are topped up as they fall by those supplied through contraceptive medicine; nomegestrol and estradiol thereby trick the body into thinking that the peak time for conception has already passed. This stops ovulation from happening, and makes the lining of the uterus less receptive to egg implantation. It also makes the natural mucus found inside the vagina thicker, and this stops sperm from being able to move around as easily once inside.

Zoely is currently out of stock and is not likely to be available until 2020. Alternative contraceptive pills are available through our service, such as Qlaira and Yasmin, however they are not directly identical. If you have concerns or questions about changing your contraceptive pill from Zoely to an alternative you should speak to your regular GP.

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Page last reviewed:  17/05/2019


For Zoely to be effective, it must be taken in the correct manner. This means following the directions issued by your prescriber, and adhering to the instructions set out in the patient information leaflet. Doing this will also help to reduce the chances of side effects.

  1. Administer as instructed by your doctor.
  2. This will typically be one pill per day, at the same time each day.
  3. In each strip of tablets is 24 active tablets and 4 inactive tablets.
  4. Take these as directed by the arrows on the strip.
  5. It is advisable to start taking your pill on the first day of your period.
  6. Swallow tablets whole, with water if necessary.
  7. Do not exceed the prescribed amount.
  8. If you forget to take your pill, refer to the instructions in the leaflet provided. Speak to your doctor or family planning nurse if you are still not sure.

These directions are only supplied as a guide. For detailed instructions, consult the leaflet supplied.

Download Zoely patient information leaflet

Page last reviewed:  17/05/2019
Please read the patient information leaflet for this medicine fully before use:

Zoely 2.5mg

Side effects & Warnings

Side effects

This product may cause side effects, some of which may require medical attention. If you display any signs of an allergic reaction, a blood clot, breast cancer, heart attack, stroke, or liver disease, then contact your nearest hospital immediately. Details can be found in the patient information leaflet.

Very common (1 in 10 people or more):
Irregular periods or acne.

Common (1 in 10 people or less):
Reduced interest in sex, depression, headache or migraine, feeling or being sick, heavy menstrual periods, weight fluctuations, breast pain or pelvic pain.

Uncommon (1 in 100 people or less):
Increased appetite, fluid retention, flushing, swollen abdomen, increased perspiration, hair loss, itching, dry or oily skin, heaviness in limbs, larger breasts, premenstrual syndrome, pain during intercourse, vaginal dryness, irritability or increased liver enzymes.

Rare (1 in 1,000 people or less):
Harmful blood clots, mini-stroke or temporary stroke-like symptoms known as a transient ischaemic attack.

The side effects listed here are not a comprehensive account. More information is available in the leaflet supplied.


Taking it with other medicines

Let your prescribing doctor know if you are using any other treatments during consultation. Zoely may stop the following from working properly, or vice versa: epilepsy medicines, for instance primidone, phenytoin, phenobarbital, topiramate, felbamate, carbamazepine or oxcarbazepine; rifampicin; treatments for HIV infections such as ritonavir, nevirapine, nelfinavir or efavirenz; griseofulvin; bosentan; St. John’s wort; ketoconazole; or lamotrigine.

Conditions to look out for

Disclose your medical history to your prescriber prior to the use of this product. It is not suitable for those who have or have ever had the following: heart attack or stroke; any kind of blood clot; very high blood pressure; severe diabetes; any illness which inhibits blood clotting such as protein C deficiency, protein S deficiency, antithrombin – III deficiency, Factor V Leiden or antiphospholipid antibodies; high levels of fat in the blood; hyperhomocysteinaemia; migraine with aura; inflammation of the pancreas; severe liver disease; tumour in the liver; cancer of the breast or the genital organs; or an episode of vaginal bleeding for which your doctor could not distinguish a cause.

Pregnancy and breastfeeding

Women who are pregnant should speak to their doctor before they use any medication. Zoely should not be used by women who are pregnant or think they could be pregnant. It is not recommended for use by those who are breastfeeding. If you want to take the pill when breastfeeding, you should contact your GP.

Driving and machinery

Zoely should not interfere with your ability to drive or use machines.

Contraception and cancer risks

It is important to familiarise yourself with the information in the patient guide. Here you will find details on the pill and cancer risks.

Lactose intolerance

This product contains lactose. If your GP has explained that you have an intolerance to some sugars, you should speak to them before you take Zoely.

Page last reviewed:  17/05/2019
Please read the patient information leaflet for this medicine fully before use:

Zoely 2.5mg


Can I still drink alcohol?

Yes. You can drink alcohol while taking Zoely.

Will I still be able to drive?

Yes. This pill is not known to affect the driving capacity of the user. However, if you notice any side effects which could make it unsafe for you to drive, you should not drive and speak to your doctor.

Can I take the medicine while pregnant?

No. You should not take this or any other combined birth control pill if you are pregnant, or suspect you may be. It is not recommended for those who are breastfeeding. If you are currently breastfeeding, let your practitioner know when filling in our health questionnaire, as they may prefer to suggest an alternative form of contraception.

How should I store it?

Keep it in a safe environment at room temperature.

Am I allergic to anything in the medicine?

In this pill are the following ingredients: nomegestrol acetate, estradiol, lactose monohydrate, cellulose microcrystalline (E460), crospovidone (E1201), talc (E553b), magnesium stearate (E572), silica colloidal anhydrous, poly(vinyl alcohol) (E1203), titanium dioxide (E171), macrogol 3350, iron oxide yellow (E172) and iron oxide black (E172). Do not use it if you are allergic to any of these substances.

Is it available over-the-counter?

In the UK, you can only buy Zoely if you have a prescription for it. This can be obtained by undergoing our fast and simple consultation process.

Is it right for me?

Talk to your GP if you want to know if this pill is right for you. If you aren’t already using the pill, they will be equipped to help you choose the most appropriate form of hormonal birth control.

It’s simple to get a repeat prescription for Zoely by filling in our confidential five-minute questionnaire. Every order made through our site is checked by a qualified practitioner prior to approval. Confirmed orders are then dispensed and shipped direct to your home. Based in the UK, our pharmacy only uses express courier services, so that you can expect to receive your medication within one working day of successful consultation.

Page last reviewed:  17/05/2019

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