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Xenical

Orlistat

Xenical is a licensed medication in the UK and is manufactured by Roche. A doctor can issue it on prescription for weight loss, and it is available in capsule form.

If you’re looking for a prescription service to buy Xenical online, fill in our short questionnaire and one of our GMC-registered clinicians will review your case. If Xenical is a suitable treatment for you, our regulated pharmacy will dispense your medication. All approved orders are delivered within 24 hours by tracked courier. The listed price for our products includes the cost of your treatment, the consultation and express delivery on Mondays to Fridays.

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120mg

One Xenical capsule contains 120mg of orlistat. These are taken with meals, up to a maximum of three times per day.

You can highlight a preferred treatment, dose or amount to our prescriber, but to ensure your safety the final decision on any treatment you are offered is always the prescriber's. After your consultation, our prescriber may suggest a different treatment, or dose or amount of treatment (or not recommend treatment at all).

Please note: this service is not to be used in an emergency. Call 999 if you need urgent medical attention.
Order now, and get it by Tuesday 1st December

Xenical is a licensed medication in the UK and is manufactured by Roche. A doctor can issue it on prescription for weight loss, and it is available in capsule form.

If you’re looking for a prescription service to buy Xenical online, fill in our short questionnaire and one of our GMC-registered clinicians will review your case. If Xenical is a suitable treatment for you, our regulated pharmacy will dispense your medication. All approved orders are delivered within 24 hours by tracked courier. The listed price for our products includes the cost of your treatment, the consultation and express delivery on Mondays to Fridays.

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Product information

How Xenical can help you lose weight 

Xenical is a regulated slimming tablet that is used to treat weight loss. It contains an active ingredient called orlistat, which attaches itself to enzymes in the digestive system (lipases) and prevents the gut from digesting some of the fat that is consumed with meals. Rather than the body absorbing this fat, the fat is removed as a waste product in your stool. 

Orlistat is the generic version of Xenical. Because it’s the non-branded version of the drug, it’s slightly cheaper, but otherwise its functionality is the same. 

Although Xenical can be an effective inhibitor, it only stops a proportion of the fat that you consume from being absorbed by the body (nearly one third). It therefore needs to be used in conjunction with regular exercise and eating more healthily in order for you to benefit from it. 

It’s recommended that you should only use Xenical if your body mass index (BMI) falls within one of two criteria: either your BMI is 30 or above, or your BMI is 28 or above and you also have a health condition that could be better managed by losing weight (for example, diabetes or high blood pressure). 

If you haven’t lost 5% of your weight in 3 months since the start of treatment with this medication, your course of treatment should be stopped. 

Your BMI is the most commonly used indicator to determine if you are a healthy weight. You can check to see if you are a healthy weight by using the NHS BMI healthy weight calculator

For the majority of adults, your BMI is established according to the following categories:

  • 18.5-24.9 means that you are a healthy weight
  • 25-29.9 means that you are overweight
  • 30-39 means that you are obese
  • 40 or above means that you are severely obese

It’s important to note that BMI is not used to diagnose obesity; it only provides an indication as to whether you are a healthy weight. 

Obesity is a term that’s used to describe someone who is very overweight, and who has a lot of body fat. It’s prevalent in the UK, with around 1 in 4 adults and 1 in every 5 children between the ages of 10 and 11 thought to be affected. Obesity is typically triggered by consuming more calories, especially those found in fatty and sugary foods, than you burn off during physical exercise. The body stores this excess energy as fat. 

It can result in a number of serious and life-endangering health conditions, including type 2 diabetes, coronary heart disease, certain forms of cancer, such as breast cancer and bowel cancer, and stroke. Obesity may also impact on your quality of life and cause psychological difficulties, including depression and low self-esteem. Given the risks involved, therefore, it’s very important to take steps to address it. 

In terms of treatment measures, eating a healthy diet and moderating your calorie intake, joining a weight loss group and activities such as fast walking, jogging, swimming and tennis for between 2.5-5 hours a week can all help you to lose weight. 

If making changes to your lifestyle does not prove to be effective, Xenical may be recommended to you by your prescribing doctor. 

If you’re looking to purchase Xenical online, fill in the questionnaire on our website and one of our registered clinicians will review your answers. If Xenical is an appropriate treatment for you, your order will be processed by our regulated pharmacy and delivered to your door within 24 hours by special courier. 

How should I take Xenical?

You should always take Xenical as prescribed by your clinician. The standard dose is one 120mg capsule taken with each of your three main meals every day. You can take it just before, during, or up to one hour after a main meal, and it should be swallowed with water. 

Taking Xenical if you are pregnant is not advisable, and it should not be used if you are breastfeeding, as whether traces of the treatment pass into breast milk is unclear. 

You should also avoid taking Xenical if you are allergic to its active ingredient, orlistat, or to any of the other ingredients in this treatment. For more information, you can consult your prescribing doctor, or locate the ingredients as detailed in the patient information leaflet that comes with your medication. 

Xenical is unsuitable for you if you have chronic malabsorption syndrome (insufficient absorption of nutrients from the digestive tract) or cholestasis (liver disorder). 

How effective is Xenical? 

Clinical studies and clinical trials have shown that Xenical is effective for some people, with a significant number of participants losing 5% or more of their baseline body weight after 12 weeks of treatment, and 10% or more of their baseline body weight after one year. It’s less effective in other cases, however, and your prescribing doctor may need to explore alternative treatments with you. 

In order to get the most benefit from Xenical, it’s important that you regulate the amount of fatty food that you eat, as consuming additional fat cancels out the effects that Xenical can have. 

In terms of frequency, you should take the treatment with each of your three main meals daily, but only where your main meals contain fat. If you miss a main meal or have a main meal that doesn’t contain any fat, you do not need to take a dosage of Xenical. 

Research indicates that obesity can increase your risk of getting cancer, including two of the most common forms of cancer: bowel cancer and breast cancer in women. Reducing your intake of fat, then, through refining your dietary habits, and using a weight loss treatment like Xenical, where required, may lessen the likelihood of cancer developing. 

You can order Xenical online on our website. Having filled in our simple questionnaire for the treatment, one of our General Pharmaceutical Council (GPhC) registered clinicians will review your order, and it will be dispensed from our regulated pharmacy if it is suitable for you. Your order will be delivered to your door by special courier, using our 24-hour delivery service. 

What lifestyle changes should I make when taking Xenical? 

To get the maximum benefit from Xenical, you should combine taking the treatment with reducing the number of calories in your diet, and exercise. Exercise not only allows the body to stay at a healthy weight, but it can help to prevent and manage over 20 conditions, including reducing your risk of developing Type 2 diabetes by 40%. 

Chief Medical Officers advise that adults should carry out at least 150 minutes of moderate-intense physical activity every week. This can be split up into 5 sessions of 30 minutes per week, for instance.  Even a small amount of exercise is better than none at all, and as little as 10 minutes at a time can be advantageous. 

Moderate-intensity activity is any physical activity that increases the rate of your heart and breathing. Examples include brisk walking, cycling, swimming and dancing. 

The intensity of your exercise can also be increased. Rather than doing 150 minutes of moderate-intense activity, you can halve this to 75 minutes of vigorous-intensity activity a week, should you wish to. 

Vigorous-intensity activity consists of exercise where your breathing is very hard, your pulse is significantly elevated and you may not be able to converse with someone else. For instance, running, the majority of competitive sports and circuit training. 

Implementing a food plan can help you to get the nutrients and nutrition that your body requires to maintain good health. Xenical should be consumed as part of a controlled calorie diet that includes at least 5 portions of fruit and vegetables every day. You should aim to opt for foods and drinks that are lower in fat and sugar (as well as added sugar in drinks) where you can, such as reduced fat cheese and plain, low-fat yoghurt. 

30% of the calories that you consume whilst taking Xenical should come from fat, and your fat, protein and carbohydrate intake should be spread across each of your three, daily main meals

If you’re looking for input on how to create a specific food plan, the NHS Eatwell Guide can help you to make adjustments to your diet.

Quitting certain habits such as smoking can also allow you to make healthy changes to your lifestyle. Smoking is one of the UK’s largest causes of death and illness, with approximately 78,000 people dying every year as a consequence of it, and many others living with serious smoking-related health conditions. 

Smoking can lead to cancer developing in many parts of the body, from the lungs to the mouth to the bowel, as well as increase other health risks, such as having a stroke, suffering a heart attack or developing coronary heart disease, peripheral vascular disease (damaged blood vessels) and cerebrovascular disease (damaged arteries that provide blood to the brain). 

What other health conditions may require treatment with Xenical?

Xenical is primarily used to treat obesity, but it’s also sometimes prescribed to people who are obese and have additional health conditions, such as type 2 diabetes and high blood pressure. 

Type 2 diabetes is triggered by a lack of the hormone insulin in the body, which in turn is usually caused by being overweight. This results in blood sugar (glucose) levels in the body becoming too high, which without treatment and management through lifestyle changes can lead to serious health complications, including heart disease and stroke, nerve damage, sores and infections in the feet, loss of vision and blindness, and problems with the kidneys. 

Xenical, as a weight loss treatment, may help people to lose weight and therefore manage their blood sugar levels better. If your BMI is 28 or above and you have type 2 diabetes, Xenical may be a suitable treatment for you. However, your prescribing clinician may suggest that you try to make adjustments to your lifestyle first, such as altering your diet and exercising more, before exploring the use of weight loss treatments such as Xenical. 

High blood pressure, or hypertension, is a very common condition in the UK, with around one third of adults understood to have it. Many people may be unaware of this however, as it doesn’t often present any symptoms. The only way to determine if your blood pressure is high is to have your blood pressure checked. 

You’re more likely to develop high blood pressure if you:

  • are overweight
  • are over 65 years old
  • are of African or Caribbean descent
  • have a relative who has high blood pressure
  • eat an excessive amount of salt and not enough fruit and vegetables
  • do not exercise enough
  • drink an excessive amount of caffeine or alcohol
  • smoke
  • Do not sleep enough, or if your sleep is interrupted

Making changes to your lifestyle, such as following a healthy diet, reducing your alcohol intake, and losing weight if you are overweight, can help to prevent and reduce high blood pressure. Xenical, as a weight loss treatment, may be prescribed by your doctor if you are overweight and have high blood pressure.

How to buy Xenical online 

If you would like to purchase Xenical online, you can fill in our short questionnaire and one of our GPhC-registered clinicians will review your order. If Xenical is a suitable treatment for you, your order will be dispensed by our regulated pharmacy and shipped to your door using our 24 hour delivery service. 

Xenical is usually issued at a dosage strength of 120mg on prescription

Our UK health prescribers recommend that you take a multivitamin supplement alongside treatment with Xenical, as this medication can restrict the absorption of supplements of certain fat soluble nutrients; in particular, beta-carotene and Vitamin E. 

Because we are a private service, UK patients aren’t eligible for reimbursement when they purchase this treatment through us. However, some people may be entitled to the treatment on an NHS prescription. Speak to your GP to find out more. 

What consequences can being overweight have? 

Physical effects

Being overweight can increase your risk of developing serious health conditions that can be a risk to life, including type 2 diabetes, coronary heart disease, certain cancers, such as breast cancer and bowel cancer, and stroke

It can also cause high blood pressure and high cholesterol, which is an excess amount of the fatty substance, cholesterol, in the blood. Too much cholesterol can obstruct your blood vessels, and increase the likelihood of heart problems or having a stroke. 

Psychological effects 

Besides the physical effects that being overweight can have, it may also have a psychological impact on people who experience it, and serve as a trigger for mental health difficulties such as depression and low mood, and low self-esteem. This can have repercussions on peoples’ relationships with friends and family, and cause feelings of isolation. It may also affect someone’s confidence. 

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Page last reviewed:  12/11/2020 | Next review due:  06/03/2019
Directions

Directions

  1. Take Xenical as prescribed and instructed by your doctor.
  2. The standard dose is one 120mg capsule taken with each of your three main meals every day. 
  3. You can take the capsule right before, during or up to one hour after a meal. 
  4. Swallow the capsule with water.
  5. You should take Xenical alongside a well-balanced, calorie-controlled diet, that is rich in fruit and vegetables, and 30% of the calories should come from sources of fat.
  6. Your day-to-day intake of fat, carbohydrate and protein should be spread over three meals.
  7. For maximum benefit from the treatment, avoid consuming food that contains fat between meals, such as biscuits, chocolate and savoury snacks.
  8. Xenical is only effective if you have consumed dietary fat. As a result, if you miss a main meal or if you have a meal that doesn’t contain any fat, you don’t need to take the treatment.
  9. If you have not taken xenical as prescribed by your clinician, let your clinician know. If you don’t inform them about this, they may think that the treatment is ineffective or unsuitable for you, and change your treatment unnecessarily. 
  10. If you have not lost a minimum of 5% of your body weight after 12 weeks of treatment, your doctor will discontinue your course of Xenical. 
  11. Xenical has been analysed in clinical studies of up to 4 years in duration. 
Page last reviewed:  12/11/2020 | Next review due:  06/03/2019
Please read the patient information leaflet for this medicine fully before use:

Xenical 120mg

Side effects & Warnings

What secondary effects can Xenical have?

If you experience any symptoms of an allergic reaction, or any other side effects that become severe, seek medical advice immediately. This includes itching, a rash, wheals (elevated, itchy skin patches that are paler and redder than surrounding skin), severe breathing difficulties, nausea, vomiting and feeling unwell. 

Xenical can trigger harmless changes in your bowel habits, such as fatty or oily stools, as a result of the removal of undigested fat in your faeces. This may be more likely to happen if  Xenical is taken alongside a diet which is high in fat. 

Your daily intake of fat should be distributed evenly over three main meals; if Xenical is taken with a meal very high in fat, it can make gastrointestinal effects more likely.

In order to get the maximum benefit from Xenical, you should follow the nutrition program as recommended to you by your prescribing clinician. As is the case with any weight-control program, over-consumption of fat and calories may restrict any weight loss effect. 

Very common side effects (1 in 10 people or more):

Headache, abdominal pain or discomfort, urgent or increased need to open the bowels, flatulence (wind) with discharge, oily discharge, oily or fatty stools, liquid stools, low blood sugar levels (experienced by some people with type 2 diabetes).

Common side effects (1-10 people out of 100):

Rectal pain/discomfort, soft stools, incontinence (stools), bloating (experienced by some people with type 2 diabetes), tooth or gum disorder, irregular menstrual cycle, tiredness.

Side effects with an unknown frequency:

Allergic reactions. Primary symptoms are itching, rash, wheals (slightly elevated, itchy skin patches that are paler or redder than surrounding skin), severe difficulty in breathing, nausea, vomiting and feeling unwell. Skin blistering (including blisters that burst); Diverticulitis; bleeding from the back passage (rectum); increases in the levels of some liver enzymes may be found in blood tests; Hepatitis (inflammation of the liver). Symptoms may include yellowing skin and eyes, itching, dark coloured urine, stomach pain and liver tenderness (indicated by pain under the front of the rib cage on your right hand side), sometimes with loss of appetite. You should stop Xenical if these symptoms occur and inform your prescribing doctor. Gallstones; Pancreatitis (inflammation of the pancreas); Oxalate nephropathy (build up of calcium oxalate which may lead to kidney stones); effects on clotting with anticoagulants.

Contraindications and Xenical

You should tell your prescribing clinician about any health conditions you have or have had previously. 

Do not take Xenical if: you are allergic (or hypersensitive) to orlistat or to any of the other ingredients in the treatment; you have chronic malabsorption syndrome (inadequate absorption of nutrients from the digestive tract); you have cholestasis (liver disorder); you are breastfeeding. 

There may be a link between the use of Xenical and the development of renal stones in people who have chronic kidney disease. If you have or have had problems with your kidneys, inform your prescribing doctor before starting treatment. 

Weight loss can impact on the dose of medications that you may take for other health conditions (such as high cholesterol or diabetes). It’s important that you discuss any medications that you are taking with your prescribing doctor. The dosages for these treatments may need to be changed in accordance with any weight loss

Can Xenical cause interactions with other medicines?

You should inform your prescribing clinician if you are taking or have recently taken any other medications, including medications which you have not been prescribed. 

The following treatments may interact with Xenical, so you should tell your prescribing doctor if you are taking any of them: anticoagulant drugs (such as warfarin); ciclosporin; iodine salts and/or levothyroxine; amiodarone; medicines to treat HIV; medicines for depression, psychiatric disorders or anxiousness.

Xenical reduces the absorption of supplements of some fat soluble nutrients, particularly beta-carotene and vitamin E. You should therefore follow your doctor’s advice and maintain a well-balanced diet rich in fruit and vegetables. Your prescribing clinician may suggest that you take a multivitamin supplement alongside Xenical. 

Xenical may not be suitable to take with anticonvulsivant treatment, as it may decrease the absorption of antiepileptic drugs, which can result in convulsions. If you think that the frequency or severity of your convulsions has changed whilst taking Xenical together with antiepileptic drugs, speak to your prescribing clinician immediately. 

Xenical is not recommended for people who take acarbose (an anti-diabetic drug used to treat type 2 diabetes mellitus).

Is Xenical safe to take if you are pregnant or breastfeeding?

It is not advisable to take Xenical if you are pregnant, nor if you are breastfeeding, as it is unclear as to whether trace amounts of the treatment can be found in breastmilk. For any further information, you should consult your prescribing clinician.

Is it safe to drive and use machines whilst taking Xenical?

There is no evidence to support that Xenical impairs your ability to drive or operate machinery. 

Xenical with food, drink and alcohol

Xenical can be used immediately before, during, or up to one hour after a main meal. The capsule should be taken with water. 

Can Xenical affect your fertility?

There is no clinical data available in terms of any potential effects of Xenical on fertility. It is advisable however that you use an additional form of contraception if you are taking this treatment, as oral contraception may be compromised if you develop severe diarrhoea.

Page last reviewed:  12/11/2020 | Next review due:  06/03/2019
Please read the patient information leaflet for this medicine fully before use:

Xenical 120mg

Q&A

How should I store Xenical?

Xenical should be kept out of sight and reach of children

Can I get Xenical or Orlistat on the NHS?

Orlistat is available on the NHS, but is usually only prescribed to people whose BMI is over 30, and having exhausted other methods of weight loss. 

Is Xenical available to buy over the counter?

No. Xenical is a prescription-only medication. 

Should I buy Xenical or Orlistat?

Both Xenical and Orlistat have exactly the same functionality. The only difference between the two is cost: Xenical, as the branded product, is slightly more expensive than the generic. 

An alternative treatment to Xenical and Orlistat is Alli. It works in the same way and contains the same active ingredient, but is available without a prescription. It’s not as strong as Xenical and Orlistat (60mg, as opposed to 120mg) but is the cheapest to purchase of the three. 

To buy Xenical online, fill in our questionnaire and one of our GPhC-registered prescribers will review your order. If Xenical is suitable for you, it will be delivered to your door within 24 hours by tracked courier. 

Page last reviewed:  12/11/2020 | Next review due:  06/03/2019
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