Mupirocin ®
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Reviewed on Jul 24, 2026. by Dr. Joseph Palumbo Senior Medical Adviser Registered with NPI (No. 1043478878) Next review due on Jul 23, 2029.
Dr. Joseph Palumbo

Last updated on Jul 24, 2026.

Daily antibiotic ointment to fight off angular cheilitis infections.

  • Mupirocin is a topical antibiotic that you’ll apply up to three times each day to treat skin infections like angular cheilitis.

  • It’s prescribed off-label for angular cheilitis, which means that while it’s not officially licensed for it, it’s a safe and effective treatment.

Price checker

2%
$89.95 22 g
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $89.95
    Save $0.00 each order
Mupirocin Mupirocin calcium

What is Mupirocin?

Mupirocin ointment is an antibiotic that’s licensed to treat skin infections like impetigo, and prescribed off-label for angular cheilitis. Angular cheilitis is an infection caused by moisture getting trapped in the corners of your mouth, which provides perfect conditions for bacteria like Staphylococcus to grow.

How does Mupirocin work?

Mupirocin works by interfering with bacteria’s production of essential proteins and RNA.[1] Without them, the bacteria can’t grow or spread, and your body is able to clear up the remaining infection.

How do Mupirocin doses work?

Mupirocin ointment is only available in one strength, which is 2% w/w. 2% w/w means that for every gram of treatment, 2% (0.02 g) is made up of its active ingredient.

What is the active ingredient in Mupirocin?

Mupirocin takes its name from its active ingredient, mupirocin calcium. It’s a generic medicine, which means that while it contains the same active ingredient and works in the same way as its branded counterparts (like Bactroban and Centany), it’s usually available for cheaper.

Treated trusted source:

  1. Erwin, D.Z. Chen, P. (2024). Mupirocin. StatPearls. Treasure Island (FL): StatPearls Publishing
Dr. Joseph Palumbo 29191
This page was medically reviewed by Dr. Joseph Palumbo on July 23, 2026. Next review due on July 23, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Mupirocin Mupirocin calcium

How to take Mupirocin

You should always stick to your prescriber’s instructions when using Mupirocin. You’ll typically apply the ointment three times a day. Some things to keep in mind when using Mupirocin are:

  • Always wash your hands first
  • Apply a small amount of Mupirocin to the affected area
  • You can apply a bandaid or dressing to the treated area (unless you’ve been instructed to leave it uncovered)
  • Wash your hands after use
Dr. Joseph Palumbo 29191
This page was medically reviewed by Dr. Joseph Palumbo on July 23, 2026. Next review due on July 23, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Mupirocin Mupirocin calcium

Mupirocin isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Mupirocin Mupirocin calcium

Mupirocin: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are there any Mupirocin alternatives?

Answer:
Centany is the branded version of Mupirocin, which means it uses the same active ingredient and works in the same way as Mupirocin – it’s just the packaging and price that might be a bit different.

If your angular cheilitis is caused by a fungal infection and not bacteria, Mupirocin won’t work to treat it. Instead, you’ll need a topical antifungal like Nystatin, Clotrimazole or Ketoconazole to clear up your infection.

And if you’re looking for a treatment to ease the inflammation, itching, and discomfort caused by an angular cheilitis infection, a mild corticosteroid like Hydrocortisone can help provide relief from your symptoms.

How effective is Mupirocin for angular cheilitis?

Answer:
Mupirocin has proven to be an effective treatment for infectious skin diseases caused by Staphylococcus, the bacteria responsible for angular cheilitis. In one study of 132 individuals, 64.4% of participants were cured of their skin condition after using Mupirocin.[1]

Do I need a prescription for Mupirocin?

Answer:
Yes, you’ll need a prescription from a healthcare professional before you’re able to use Mupirocin. It’s because it’s an antibiotic, and using antibiotics when they’re not needed can contribute to antibiotic resistance. This means they might not be as effective in the future if you do need to use them.

How long does it take Mupirocin to work for angular cheilitis?

Answer:
You should notice an improvement in your skin within three to five days of using Mupirocin. One study found that the average time before the effect of Mupirocin was noticeable was around two or three days.[1] If your condition hasn’t improved after five days of using Mupirocin, speak to your doctor – you might need to try using a different treatment.

What should I do if I make a mistake when taking Mupirocin?

Answer:
If you’ve forgotten to apply a dose of Mupirocin, just use it as soon as you remember. But if it’s less than an hour till your next dose, skip it and carry on as normal. Never apply extra Mupirocin to make up for missed doses.

Does Mupirocin cause side effects?

Answer:
Mupirocin can come with a risk of associated side effects, just like any medicine you use. While it’s very rare, if you notice a raised and itchy rash, swelling on your face or in your mouth, difficulty breathing, or you lose consciousness, stop using Mupirocin right away and get medical attention – these could be signs of an allergic reaction.

The most common side effect of Mupirocin is a burning sensation where you’ve applied the treatment. If you’re looking for more information on Mupirocin’s possible side effects, speak to your doctor or check the patient package insert.

Can I get Mupirocin through private health insurance?

Answer:
You should always check the formulary of your health insurance provider, which is the list of medications they’ll offer coverage for. Because Mupirocin is off-label for angular cheilitis, many insurers won’t offer coverage for it for this purpose.

But if you can’t get Mupirocin for angular cheilitis through your insurance, they may offer an alternative treatment. If not, you should still be able to get a Mupirocin prescription through an online pharmacy service – you’ll just need to answer a few questions about your health to make sure it’s a suitable treatment for you.

Treated trusted source:

  1. Sun, J. et al. (2024). Mupirocin for Skin Infection: Clinical Experience from China. Infection and Drug Resistance. 17. pp. 3955-3966.M

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