Nystatin
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$84.95 15 g tube
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Reviewed on Jul 9, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Registered with GPhC (No. 2241935) Next review due on Jul 02, 2029.
Dr Alexandra Cristina Cowell

Last updated on Jul 09, 2026.

Prescription-strength antifungal cream that targets infection.

  • Nystatin is an antifungal cream that clears skin infections to help heal angular cheilitis.

  • Angular cheilitis causes painful, cracked skin at the corners of your mouth. Because this area is often moist, it creates the perfect breeding ground for fungal infections, which can worsen your symptoms and make infected, cracked skin harder to treat.

Price checker

100,000 units/g
$84.95 15 g tube
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $84.95
    Save $0.00 each order
Nystatin Nystatin

What is Nystatin?

Nystatin is a cream you apply directly to the skin around your mouth. It can clear fungal infections, such as Candida, which is often present when people have angular cheilitis.[1]

Although oral fungal infections primarily occur inside your mouth, they can spread to the moist areas on the side of your mouth and cause angular cheilitis or make its symptoms worse.

Applying Nystatin daily can help kill the underlying fungus and allow your body to repair red, cracked skin at the sides of your mouth.

How does Nystatin work?

Nystatin binds to ergosterol, a molecule which acts like a building block for fungal cells. Ergosterol preserves the integrity of fungi, which allows a fungal infection to grow and spread.

By binding to it and tearing open the cell wall of fungal membranes, Nystatin causes fungal cells to leak and eventually die. So applying the cream directly to infected skin can help clear the fungus, allowing your body to repair the damaged skin and improve angular cheilitis symptoms.

What doses of Nystatin are there?

Nystatin cream contains 100,000 units per gram.

The usual dose is to apply a thin layer of cream to affected areas twice a day, but your doctor will tell you exactly how much cream you need to use each day.

How long does Nystatin cream take to work?

Usually, you’ll notice that your skin starts to heal between 24-72 hours after first starting treatment with the cream.

But fungal infections can sometimes take up to two weeks to clear, so even if your angular cheilitis symptoms start to improve, it’s important you use the cream for as long as your doctor advises you to.

Treated trusted source:

  1. Federico, J.R., Basehore, B.M. and Zito, P.M. (2023). Angular Cheilitis.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on July 02, 2026. Next review due on July 02, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Nystatin Nystatin

How to take Nystatin

Wash your hands before each application of cream.

If you can, keep the area of skin around your mouth as dry as possible, by gently patting it.

Apply a thin layer of cream to your finger tips, and gently rub it into the skin around your mouth.

Wash your hands after each application, to reduce the chances of spreading a fungal infection to other areas of your body.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on July 02, 2026. Next review due on July 02, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Nystatin Nystatin

Nystatin isn’t suitable for everyone, and there are some things to be aware of when using it.

Here’s all the official info about your medication. If anything is unclear, let your physician know and they can talk with you about it.

Nystatin Nystatin

Nystatin: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Is Nystatin similar to other angular cheilitis treatments?

Answer:
Angular cheilitis is often managed with antifungals or corticosteroids.

Antifungal medications like Nystatin treat angular cheilitis when it’s caused by a yeast overgrowth, which is often the cause. Although some cases of angular cheilitis can be bacterial, around 93% of the time it’s caused by Candida albicans.[1]

Azoles, such as clotrimazole or ketoconazole, are commonly prescribed as alternatives to using Nystatin. Like Nystatin, they work by destroying fungus.

Corticosteroids are prescribed to manage symptoms directly, by reducing inflammation and soreness and helping to speed up healing.

Do I need a prescription for Nystatin?

Answer:
Nystatin is a prescription-only treatment. Before you can start using it, your doctor will make sure it seems like the most effective option for managing your angular cheilitis.

Will my angular cheilitis clear up without using Nystatin?

Answer:
Mild cases of angular cheilitis might clear up without the need for medication, but usually it’s a secondary infection that occurs as a result of bacteria or fungi that gets trapped in the saliva at the sides of your mouth.

So more often than not, you’ll need to treat the root cause of angular cheilitis so your skin can heal properly. Symptoms of bacterial angular cheilitis can often share similarities with those caused by a yeast overgrowth, so it’s best to speak to a doctor about how best to treat yours.

Will Nystatin cause side effects?

Answer:
Nystatin might cause mild skin irritation and redness when you first apply it. This should settle down as your body gets used to the cream.

If you develop any severe reactions such as sudden hives or an abnormal rash, seek urgent medical attention at your nearest hospital’s emergency department.

Can I get Nystatin through private health insurance?

Answer:
Health insurance plans can vary widely, and can be determined by factors such as the state you’re in, or the type of plan you’ve signed up for.

With this in mind, it’s always worth speaking to your providers before starting a treatment such as Nystatin, so you know exactly what is and isn’t covered. Some plans offer partial coverage if they don’t cover the entire costs of medications.

If Nystatin isn’t included in your plan, you’ll have to pay for it out of pocket by ordering it from an online pharmacy and prescription service.

Treated trusted source:

  1. Brizuela, M. and Daley, J.O. (2025). Angular Cheilitis. Nih.gov.

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