Amoxicillin Clavulanate Potassium ®
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Reviewed on Dec 23, 2025. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Next review due on December 23, 2028.
Dr Alexandra Cristina Cowell

Last updated on Dec 23, 2025.

Treats infections that may resist standard antibiotics in two weeks.

  • Amoxicillin Clavulanate Potassium is a combined antibiotic. Amoxicillin targets and treats the infection, while clavulanic potassium reduces the bacteria’s ability to resist treatment.

  • It’s prescribed off-label for impetigo. This means that it’s thought to be a safe, effective, and well-tolerated treatment – but it isn’t officially licensed for this purpose.

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875mg/125mg
$84.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $84.95
    Save $0.00 each order
Amoxicillin Clavulanate Potassium Amoxicillin Claculanate Potassium

What is Amoxicillin Clavulanate Potassium?

It’s a combination antibiotic that’s used off-label to treat impetigo. It combines amoxicillin with a beta-lactamase inhibitor called clavulanate potassium to fight off antibiotic-resistant bacteria. You’ll usually take it for 14 days to clear up impetigo infections.

How does Amoxicillin Clavulanate Potassium work?

The two active ingredients in Amoxicillin Clavulanate Potassium work together to fight off persistent impetigo infections. Amoxicillin binds to specific proteins that help link substances called peptidoglycans together which is crucial for the structure of the bacterial cell wall. Without this, the cell wall becomes unstable and the bacteria cannot survive.[1]

Clavulanate Potassium doesn’t fight off the bacteria directly, but instead ‘protects’ amoxicillin so it can do its job. Some bacteria have developed resistance to antibiotics like amoxicillin by producing specific enzymes that break down a key component of the antibiotic. Clavulanic potassium extends amoxicillin’s coverage, and reduces the bacteria’s resistance to it, so it’s more likely to be effective.[1]

How do Amoxicillin Clavulanate Potassium doses work?

Amoxicillin Clavulanate Potassium comes in two doses, a lower dose containing 500 mg of amoxicillin and 125 mg clavulanate potassium, and a higher dose containing 875 mg amoxicillin and 125 mg clavulanate potassium. We only stock the 875/125 mg dose for treating impetigo.

What are the active ingredients in Amoxicillin Clavulanate Potassium?

It’s a generic medication that’s named after its two active ingredients: amoxicillin and clavulanate potassium (sometimes called clavulanic acid).

Amoxicillin is an antibiotic, and clavulanate potassium enhances the effects of it.

Treated trusted source:

  1. Evans, J. Hanoodi, M. Wittler, M. (2024). Amoxicillin Clavulanate. StatPearls. Treasure Island (FL): StatPearls Publishing.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on December 23, 2025. Next review due on December 23, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Amoxicillin Clavulanate Potassium Amoxicillin Claculanate Potassium

How to take Amoxicillin Clavulanate Potassium

Always follow your prescribing physician’s instructions when taking Amoxicillin Clavulanate Potassium. Generally, you’ll take one tablet every 12 hours for 14 days to clear up persistent impetigo infections. You should take your tablet with a meal or a snack to help improve the absorption of the medicine, and to reduce the risk of stomach ache, nausea and vomiting.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on December 23, 2025. Next review due on December 23, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Amoxicillin Clavulanate Potassium Amoxicillin Claculanate Potassium

Amoxicillin Clavulanate Potassium isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Amoxicillin Clavulanate Potassium Amoxicillin Claculanate Potassium

Amoxicillin Clavulanate Potassium: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are there any alternatives to Amoxicillin Clavulanate Potassium for impetigo?

Answer:
Yes. Amoxicillin Clavulanate Potassium is an off-label treatment for impetigo, and is usually only prescribed if other treatments haven’t been effective, or if your impetigo is particularly persistent. Topical antibiotics (like Mupirocin) are usually the first port of call for impetigo treatment, as they have a lower risk of side effects.

FDA-approved oral antibiotics are usually the next treatment in line for more extensive or severe cases – or when topical treatments haven’t been effective. These can include Cephalexin, Dicloxacillin, Sulfamethoxazole/Trimethoprim, or Clindamycin.

How effective is Amoxicillin Clavulanate Potassium at treating impetigo?

Answer:
Amoxicillin Clavulanate Potassium has proven to be an effective treatment for impetigo in clinical trials. A study comparing the efficacy of amoxicillin alone with Amoxicillin Clavulanate Potassium found the combined antibiotic was more effective than its lone counterpart. There was a marked improvement in 71% of recipients after two days, and 95% of patients after five days in the combined group, compared to 44% and 68% after two and five days in the amoxicillin group.[1]

Do I need a prescription for Amoxicillin Clavulanate Potassium?

Answer:
Yes. Amoxicillin Clavulanate Potassium is an antibiotic that was developed because of rising antibiotic resistance in certain strains of bacteria. Taking it when you don’t need to can increase these bacteria’s resistance to Amoxicillin Clavulanate Potassium, so it won’t work as it should when you do need it. This is why a doctor will need to make sure it’s the right treatment for you before you take it.

How long does it take Amoxicillin Clavulanate Potassium to treat impetigo?

Answer:
It can help you feel better within just two or three days, as the antibiotic will start fighting bacteria as soon as you take it. But you should always finish your full course of antibiotics, even if you feel better, because it will reduce the risk of reinfection (and thus the chances you’ll have to take another course of antibiotics to clear it up again).

What should I do if I make a mistake when taking Amoxicillin Clavulanate Potassium?

Answer:
If you take too much Amoxicillin Clavulanate Potassium, you should speak to your doctor as soon as possible. Symptoms of overdose can include stomach ache, nausea, vomiting, and diarrhea.

If you forget to take an Amoxicillin Clavulanate Potassium tablet, you can take it as soon as you remember. But make sure to wait at least four hours before your next dose. Never take a double dose to make up for missing a tablet.

Are there any Amoxicillin Clavulanate Potassium side effects?

Answer:
This medicine can cause side effects, just like any medicine you might take. If you get any of the following symptoms, stop taking Amoxicillin Clavulanate Potassium right away and speak to your doctor:

  • Skin rash

  • Raised red or purple spots on the skin (inflamed blood vessels)

  • Fever, joint pain, swollen glands in your neck, armpit, or groin

  • Swelling in the face or throat

  • Difficulty breathing

  • Loss of consciousness

  • Chest pain

  • Watery diarrhea with blood and mucus

  • Severe, ongoing pain in your stomach

  • Repeated vomiting, abdominal pain, lethargy, diarrhea, and low blood pressure


The most common side effect, affecting more than one in 10 people, is diarrhea. Other common side effects (affecting up to one in 10 people) are thrush, nausea, and vomiting.

This isn’t a complete list of all of the potential side effects associated with Amoxicillin Clavulanate Potassium. If you have any questions or concerns, check out the patient package insert, or contact your physician.

Can I get Amoxicillin Clavulanate Potassium through private health insurance?

Answer:
If a doctor has prescribed Amoxicillin Clavulanate Potassium to treat your impetigo, you should be able to get it through your health insurance. It’s generally covered by most plans, including Medicare Part D and Medicaid. But it’s always best to speak to your insurance provider and take a look at their formulary to see whether or not they cover treatment. They may only cover part of the cost of treatment, or only provide coverage if you get it from a specific healthcare provider.

But if you can’t get it through your health insurance, you should still be able to obtain it through an online pharmacy service once a clinician has checked that it’s the right treatment for you.

Treated trusted source:

  1. Dagan, R. Bar-David, Y. (1989). Comparison of amoxicillin and clavulanic acid (augmentin) for the treatment of nonbullous impetigo. The American Journal of Diseases of Children. 143(8). pp. 916-918.

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