Atovaquone + Proguanil
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Reviewed on May 19, 2025. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Registered with GPhC (No. 2241935) Next review due on May 19, 2028.
Dr Alexandra Cristina Cowell

Last updated on May 19, 2025.

Treat and prevent malaria.

  • Atovaquone + Proguanil is an antimalarial treatment that kills the malaria parasite. It’s typically taken daily to prevent malaria.

  • The generic version of Malarone, it’s suitable for use in most regions where malaria is present.

Atovaquone + Proguanil Atovaquone + Proguanil

What is Atovaquone + Proguanil?

Atovaquone + Proguanil (AP) is a combination medicine that helps prevent malaria. You normally take it once daily until you have left the infected area for one week.

How does Atovaquone + Proguanil work?

Atovaquone and proguanil, the two active ingredients, have antimalarial properties. It prevents and treats malaria by killing the parasite that causes it.[1]

Will I get side effects using Atovaquone + Proguanil?

You might experience side effects when taking Atovaquone + Proguanil, but not everyone does. Some of the common side effects include:

  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain

Taking it with food or milk might ease the side effects.

What doses of Atovaquone + Proguanil (AP) are there?

AP is available in one dose of 250mg of atovaquone and 100mg of proguanil for adults, although there is a dose available for children weighing more than 11lb (5kg) containing 62.5mg of atovaquone and 25mg of proguanil.

To prevent malaria, you’ll take one tablet daily and continue taking it one week after leaving the infected area.

Which countries can I use Atovaquone + Proguanil in?

Atovaquone + Proguanil can be taken in any country. Because it’s a combination treatment, it makes it difficult for the parasite to develop resistance to it. But it’s a good idea to check with your doctor first and ensure that it’s the best treatment for the area you’re visiting

Do I still need to take extra precautions when using Atovaquone + Proguanil?

Yes, you should take extra precautions when traveling to an infected country. While Atovaquone + Proguanil will protect you from malaria, it won’t deter mosquitoes. So you should use an insect repellent and a sleep net to keep the mosquitos away.

Treated trusted source:

  1. Medlineplus.gov. (2023). Atovaquone and Proguanil: MedlinePlus Drug Information.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on May 19, 2025. Next review due on May 19, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Atovaquone + Proguanil Atovaquone + Proguanil

How to take Atovaquone + Proguanil

Swallow one tablet whole with water. It’s best taken with a milky drink or some food for better absorption.

Try to take it around the same time each day; setting an alarm can help remind you.

I made a mistake taking Atovaquone + Proguanil, now what?

If you vomit one hour after taking it, take another dose right away.

If you forget to take a dose, take it as soon as you remember. But if it’s close to the next dose, skip the missed dose. Don’t take a double dose to make up for a missed one.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on May 19, 2025. Next review due on May 19, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Atovaquone + Proguanil Atovaquone + Proguanil

Atovaquone + Proguanil isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Atovaquone + Proguanil Atovaquone + Proguanil

Atovaquone + Proguanil: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How long does Atovaquone + Proguanil take to work?

Answer:
This depends on whether you're treating or preventing malaria.

To prevent malaria, you should take one tablet around two days before you visit the infected area and continue to take it daily for another week after you’ve left the infected area.

To treat malaria, you’ll usually take four tablets daily for three days – but you’ll also need to seek urgent medical attention at your nearest hospital.

Can I drink alcohol while taking Atovaquone + Proguanil?

Answer:
Yes, you can drink alcohol while taking Atovaquone + Proguanil, but you should drink in moderation.

Alcohol can worsen your side effects and may weaken your immune system, which can make it harder to fight an infection.

Is Atovaquone + Proguanil an antibiotic?

Answer:
No, Atovaquone + Proguanil isn’t an antibiotic. It's in a category of drugs called antiprotozoal agents, some of which are used to treat and prevent malaria.

While some malaria treatments are used alongside antibiotics, you shouldn't take them with Atovaquone + Proguanil, as some antibiotics can lower its effectiveness.

Will Atovaquone + Proguanil prevent malaria?

Answer:
Yes, Atovaquone + Proguanil can prevent malaria.

In one study, patients taking Atovaquone + Proguanil daily had a 100% prevention rate. It was also found to be a well-tolerated drug, with most patients reporting only headaches and abdominal pain.[1]

Does Atovaquone + Proguanil interact with any drugs?

Answer:
Check with your doctor before taking antivirals and antibiotics while on Atovaquone + Proguanil, as some of them can lower the effectiveness.

Always disclose any medication you’re taking to your clinician so they can make sure the treatment is safe for you.

Can I get Atovaquone + Proguanil through private health insurance?

Answer:
Most private healthcare plans cover malaria, like Atovaquone + Proguanil, but there may be some that only cover specific brands. So if you’re looking to get Atovaquone + Proguanil and have private health insurance, you should check your plan to make sure it’s covered.

If you’re traveling abroad for work, your employer may cover the cost of your treatment – but you should check with them first in case they have a preferred provider.

If Atovaquone + Proguanil isn’t covered, your insurance may cover a similar version. Otherwise, you can get it from some online prescription and pharmacy services.

Treated trusted source:

  1. McKeage, K. and Scott, L.J. (2003). Atovaquone/Proguanil. Drugs, 63(6), pp.597–623.

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