Ketoconazole
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Reviewed on Apr 29, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Registered with GPhC (No. 2241935) Next review due on April 24, 2029.
Dr Alexandra Cristina Cowell

Last updated on Apr 29, 2026.

Effective antifungal cream.

Ketoconazole is an antifungal cream that helps treat angular cheilitis. It comes in a 2% cream that’s applied twice daily for up to six weeks.

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$89.95
  • Prices include:
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Ketoconazole Ketoconazole

What is Ketoconazole?

Ketoconazole is an antifungal cream that helps treat infections like angular cheilitis, an inflammatory condition that causes painful blisters and sores on the corners of your mouth. It’s commonly caused by an overgrowth of Candida, a type of yeast that lives on your skin. While angular cheilitis can heal on its own, using antifungals can speed up recovery.

Ketoconazole is prescribed off-label for angular cheilitis, meaning it hasn’t been approved yet by the FDA for this condition. But there’s enough clinical data to show it’s safe and effective for it.

How does Ketoconazole work?

Ketoconazole works by blocking the action of an enzyme called cytochrome P450 14α-demethylase. This enzyme helps the fungi make important components it needs to grow and survive, like ergosterol This helps your immune system clear the infection more easily.<sup>[1]</sup>

Will I get side effects with Ketoconazole?

You might get side effects with Ketoconazole, but it’s not guaranteed. It’s common to experience itchiness, redness, or a burning sensation where the cream is applied. This is usually a mild reaction that goes away pretty quickly. Other side effects may include eczema or urticaria (commonly known as hives), but these are uncommon. If any of the side effects worsen or persist, let your doctor know.

What forms of Ketoconazole are there?

Ketoconazole comes in many forms, including cream, tablets, and shampoo. For angular cheilitis, the cream is typically prescribed. The other forms help treat different conditions, such as psoriasis (off-label).

What concentration does Ketoconazole cream come in?

Ketoconazole is available as a 2% cream. It’s typically applied twice a day for up to six weeks. After this, use as needed.

Treated trusted source:

  1. Sinawe H, Casadesus D. 2023. Ketoconazole. PubMed. Treasure Island (FL): StatPearls Publishing. 
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on April 24, 2026. Next review due on April 24, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Ketoconazole Ketoconazole

How to use Ketoconazole

To use Ketoconazole:

  • Wash the affected area and dry it.
  • Apply a thin layer of cream to the infected and surrounding area.
  • Wash your hands after application.

It’s important you keep a separate towel and clothing while you’re infected to avoid spreading the infection to other people.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on April 24, 2026. Next review due on April 24, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Ketoconazole Ketoconazole

Ketoconazole isn’t suitable for everyone, and there are some things that you need to be aware of when taking it. 

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Ketoconazole Ketoconazole

Ketoconazole: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How fast does Ketoconazole take to heal angular chelitis?

Answer:
It depends on how severe your infection is. In mild cases, it can take several days to see improvements or for your infection to heal fully. But in more severe cases, it might take up to two weeks or longer with consistent use of Ketoconazole for your infection to completely heal.

Additionally, recurrence is common with angular cheilitis, so if you notice symptoms returning after you have healed, reapply Ketoconazole and contact your doctor.

Is Ketoconazole available without a prescription?

Answer:
No, Ketoconazole is only available with a prescription from your doctor. This is so they can check it's safe and effective for you. They'll also monitor your health to make sure everything is fine.

How does Ketoconazole compare with Clotrimazole?

Answer:
Ketoconazole and Clotrimazole are two antifungal treatments that help treat fungal infections. They both come in various forms, including tablets and creams. Currently, there are no studies comparing how well they work for angular cheilitis specifically. But in one study, when the two were compared for athlete's foot (a different fungal skin infection), both were found to be effective and easy to use.[1]

Everyone responds to treatments differently, so if you try one and it doesn’t work, trying the other might be better for you.

Can I get Ketoconazole through private health insurance?

Answer:
It depends on your private insurance plan. Certain insurers only cover specific medications, so it’s always best to ask your provider whether they cover your preferred treatment.

If Ketoconazole isn’t covered, you can always get it from an online service at your own expense.

Treated trusted source:

  1. Suschka, S., et al. (2002). Clinical comparison of the efficacy and tolerability of once daily Canesten® with twice daily Nizoral® (clotrimazole 1% cream vs. Ketoconazole 2% cream) during a 28-day topical treatment of interdigital tinea pedis. Mycoses, 45(3-4), 91-96. 

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