Doxycycline
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Reviewed on May 20, 2025. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Registered with GPhC (No. 2241935) Next review due on May 20, 2028.
Dr Alexandra Cristina Cowell

Last updated on May 20, 2025.

Helps treat and prevent malaria.

Doxycycline is taken daily to treat and prevent malaria. It’s used with quinine to help it work better.

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100mg
$89.95
  • Prices include:
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    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

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Doxycycline Doxycycline

What is Doxycycline?

Doxycycline is an antibiotic that’s typically used alongside quinine (a common malaria medication) to help treat malaria.[1]

It’s not a first-line treatment for malaria, and is typically only recommended when other treatments haven’t worked or aren’t suitable for you.

How does Doxycycline work?

Doxycycline belongs to a class of antibiotics called tetracyclines. It inhibits bacterial growth, which weakens the bacteria, helping prevent and treat infections.[2]

Doxycycline can’t treat malaria on its own, you’ll need to take it with quinine, which kills the malaria parasite.

Can I drink alcohol while taking Doxycycline?

It’s best to avoid alcohol while taking Doxycycline, as it can make it less effective and may increase your risk of side effects. Alcohol can also weaken your body’s ability to fight infections, so it’s best to avoid it.

Will I get side effects using Doxycycline?

There’s a chance of experiencing side effects when taking Doxycycline. Some common ones include:

  • Feeling sick
  • Vomiting
  • Inflammation of the heart
  • Photosensitivity
  • Headaches
  • Diarrhea

Another relatively common and serious side effect is skin photosensitivity (sensitivity to light), affecting around 2 in 100 people who take doxycycline. It manifests as severe sunburn, redness, itchy skin, or a rash after sun exposure.[3] If you experience this, contact your doctor immediately.

The side effects should go away once you stop treatment. If you have any concerns, contact your doctor.

What doses of Doxycycline are there?

Doxycycline is only available in a single strength: 100mg. It’s taken twice daily alongside quinine for seven days to treat malaria.

To prevent malaria, start taking it 2 days before you leave, take it every day you’re away and continue to do so for four weeks after getting home.

Treated trusted source:

  1. NICE. (n.d.). Malaria treatment.
  2. Patel, R.S. and Parmar, M. (2023). Doxycycline Hyclate. www.ncbi.nlm.nih.gov. StatPearls Publishing.
  3. Velušček, M., Bajrović, F.F., Strle, F. and Stupica, D. (2018). Doxycycline-induced photosensitivity in patients treated for erythema migrans. BMC Infectious Diseases, 18(1).
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on May 20, 2025. Next review due on May 20, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Doxycycline Doxycycline

How to take Doxycycline

Take one capsule with plenty of water. Taking it while sitting or standing will help it reach your stomach more easily and reduce your risk of side effects.

Take it at the same time every day for best results.

If you notice Doxycycline upsets your stomach, taking it with food can help.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on May 20, 2025. Next review due on May 20, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Doxycycline Doxycycline

Doxycycline isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Doxycycline Doxycycline

Doxycycline: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How long does Doxycycline take to work?

Answer:
If you’re taking it to treat malaria (alongside quinine), it can work within seven days.[1]

Whereas if you’re taking it to prevent a malaria infection, take it every day you’re away, and for an additional four weeks after getting home. Studies show that taking malaria medication daily works more than 90% of the time.[1]

Does Doxycycline interact with other medications?

Answer:
You should let your clinician know if you’re taking:

  • Penicillin

  • Antacids

  • Oral zinc

  • Oral bismuth

  • Oral calcium

  • Anti-blood clotting medications

  • Oral contraceptives


Some medications can interfere with Doxycycline's absorption, while others are affected by Doxycycline.

How does Doxycycline differ from other medications for malaria?

Answer:
Doxycycline doesn't directly treat malaria. Instead, it’s used alongside quinine, which kills the parasite that causes malaria.

The first-line treatment for malaria is Artemether/lumefantrine (Coartem), but if that isn’t available, atovaquone-proguanil (Malarone) is often used. These drugs interfere with the parasite's main energy source energy and ability to make important molecules for its genetic material , which weakens it, making it easier for your body to kill.[2]

Quinine and antibiotics are used when both Coartem and Malarone aren’t effective.[2]

Can I get Doxycycline through private health insurance?

Answer:
Most private healthcare plans cover antibiotics, like Doxycycline, but there may be some that only cover specific brands. So if you’re looking to get Doxycycline and have private health insurance, you should check your plan to make sure it’s covered.

If Doxycycline isn’t covered, your insurance may cover a similar version. Otherwise, you can always get Doxycycline from an online prescription and pharmacy service.

Can I get Doxycycline over the counter?

Answer:
No. Like all antibiotics, you’ll need a prescription for Doxycycline. This is so they can check it's safe and effective for you.

Treated trusted source:

  1. Tan, K. R., Magill, A. J., Parise, M. E., & Arguin, P. M. (2011). Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis. The American Journal of Tropical Medicine and Hygiene, 84(4), 517.
  2. CDC (2024). Treatment of Uncomplicated Malaria. Malaria.

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