Neupro transdermal patches contain rotigotine and are used to offer relief to those diagnosed with restless legs syndrome (RLS).

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PLEASE NOTE: This treatment is not available through our online pharmacy service. This page is for information only. If you are experiencing any of the symptoms related to the condition(s) this medication treats, we strongly recommend that you see your GP in person.
Product information

Neupro is used to treat restless legs syndrome. The treatment is a transdermal patch used to supply a regulated amount of the active ingredient rotigotine. The patches are placed directly on the skin for 24 hours.

Restless legs syndrome is a fairly common condition affecting the nervous system. Up to one in ten people in the UK are thought to be affected. Those diagnosed with the condition report unpleasant feelings in the calves, feet and thighs resulting in an overwhelming compulsion to move the legs. RLS can occur at any age and is not gender specific although females are twice as likely to develop it. RLS can be caused by an underlying medical condition such as kidney failure or anaemia, however, in many cases there are no obvious causes behind the symptoms. Reduced dopamine signalling in the brain is thought to contribute to the condition.

Those who have mild restless legs symptoms may not require treatment. Small lifestyle changes and trying certain relaxation techniques can sometimes be enough to ease the condition. When the painful sensation occurs you can try the following: exercises such as yoga or tai chi; going for a walk; taking a hot bath; massaging your legs or applying a hot or cold compress to the muscles. Not smoking, regular exercise and adopting a bedtime routine can also be of benefit. If you notice a pattern between certain stimulants and your RLS symptoms occurring then you should try and avoid them as much as possible.

RLS cannot be cured but it can be treated with dopamine agonists (boosters) such as Neupro. Neupro is often used to treat moderate to severe cases that do not have a known cause. Neupro transdermal patches use the active ingredient rotigotine which stimulates dopamine signalling in the brain. The link between dopamine levels and RLS is not fully understood. However, dopamine is a neurotransmitter which is used to help pass messages between nerves and thus keep the body functioning as normal. If RLS is not treated it can affect sleep.

If you are experiencing restless legs syndrome for the first time, we recommend you see your GP in person.

Please note we do not provide this medication through our site.

Page last reviewed:  09/08/2018


If you are unsure how to use this medicine, check with your doctor or pharmacist before you commence treatment.

  1. Use only as instructed.
  2. Treatment usually starts with a low dose which is gradually increased week by week, as directed by your doctor, until you reach a maintenance dose.
  3. Neupro patches are applied directly to the skin. They should be replaced on a daily basis.
  4. The sticky side of the patch should be applied to clean, dry and healthy skin. Suitable areas include the shoulder, upper arm, stomach, thigh, hip and flank.
  5. Always remove the old patch before you apply a new one. The new patch should be placed on a different area of skin. The patch should not be applied to the same area of skin within 14 days.
  6. You should aim to change the patch at the same time of day.
  7. Avoid applying the patch to areas where it could be removed by tight clothing.
  8. Do not use skin products on or near the area where the patch will be situated.
  9. Should you need to apply the patch to a hairy area of skin, it should be shaved three days prior to applying the patch.
  10. If a patch falls off, apply a new one for the rest of that day and replace at your usual time the next day.

The directions here are only a summary. Further details can be found in the patient information leaflet. If you are unsure how to use this product speak to your doctor or pharmacist.

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Page last reviewed:  09/08/2018
Please read the patient information leaflet for this medicine fully before use:

Neupro 2mg

Neupro 3mg

Neupro 1mg

Side effects & Warnings

Side effects

Not everyone who uses Neupro will experience side effects. However, it is important to be aware of them should you develop a reaction. If you notice any swelling of the face, lips or tongue contact your doctor straight away.

Very common (1 in 10 people or more):

Nausea, skin irritations, fatigue or headaches.

Common (1 in 10 people or less):

Sickness, heartburn, irritability, sleepiness, allergic reaction, increased sex drive, itchiness, high blood pressure, swelling of legs and feet or inability to control urges to carry out an action that might be harmful.

Uncommon (1 in 100 people or less):

Dizziness, disorientation and agitation.

Rare (1 in 1000 people or less):

Aggression, compulsive eating, delusion and delirium.

Frequency unknown:

Dopamine dysregulation syndrome (DDS).

The side effects information provided here is only a brief guide. For full details please refer to the patient guide supplied with the package.

Taking it with other medicines

It is important that you fully disclose current or recent use of any medications. This product is not suitable for use alongside antipsychotics or metoclopramide as it can change their efficacy. If Neupro is taken at the same time as levodopa there is a chance that side effects may become more severe.

Conditions to look out for

You will need to speak to your doctor or pharmacist if you have a history of liver problems. If you are required to undergo a magnetic resonance imaging (MRI) scan or cardioversion treatment you will need to remove your patch beforehand.

Pregnancy and breastfeeding

Do not use Neupro if you are pregnant or breastfeeding. Speak to your doctor for advice if this applies to you, or if you are trying to conceive.

Driving and using machinery

Possible side effects of Neupro include drowsiness. Do not drive or use machines if you are affected.

Food, drink and alcohol

You must talk to your doctor before administering this medication if you plan to drink alcohol while using it.

Page last reviewed:  09/08/2018
Please read the patient information leaflet for this medicine fully before use:

Neupro 2mg

Neupro 3mg

Neupro 1mg


Can I still drink alcohol?

You should speak to your doctor to find out whether it is safe for you to drink alcohol when using Neupro patches.

Will I still be able to drive?

There is a possibility that this medication can cause you to feel sleepy or fall asleep very suddenly. If you are prone to this side effect you should not drive or operate machinery, as doing so could be dangerous.

Can I take the medicine while pregnant?

The effects of Neupro on unborn babies is unknown. Therefore if you are pregnant, planning a pregnancy or are breastfeeding you should speak to your doctor or pharmacist.

How should I store it?

Keep away from children and do not store above 25°C. Used patches should be folded so that the sticky side is inwards and placed back into the original sachet before being safely disposed of.

Am I allergic to anything in the medicine?

The following ingredients are used in Neupro: rotigotine, poly(dimethylsiloxane, trimethylsilyl silicate)-copolymerisate, povidone K90, sodium metabisulphite (E223), ascorbyl palmitate (E304) and DL-α-tocopherol (E307). The backing layer contains: polyester film, siliconized, aluminized, colour coated with a pigment (titanium dioxide (E171), pigment yellow 95, pigment red 166) layer and imprinted (pigment red 144, pigment yellow 95, pigment black 7). The release liner is made of transparent fluoropolymer coated polyester film.

You should not use this product if you are allergic to any of its ingredients.

Is it available over-the-counter?

No. You need a prescription from a doctor to be able to purchase Neupro skin patches. 

Is it right for me?

Talk to your GP to find out. They will be able to refer you for tests where required, and issue treatment after reviewing your symptoms.

Please note we do not supply this product through our site.

Page last reviewed:  09/08/2018

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