A New Treated is Coming. Read more.
Registered Pharmacy
24hr Free Delivery
No Registration Needed

Restless legs syndrome

Restless legs syndrome (RLS) affects the nervous system causing a strange tingling, itching or burning sensation usually in the thighs, calves and feet. It results in the uncontrollable urge to move the legs and can disturb sleep.

  1. Thought to affect 1 in 10 people in the UK
  2. Symptoms can range from mild to severe
  3. Treatable with dopamine agonists

If you’re looking to renew your prescription and buy restless legs syndrome treatment online, our private consultation and pharmacy service lets you do so safely and conveniently.

  • UK prescribers
  • 24 hour delivery
  • Secured payment

0 product result(s) for Restless legs syndrome



  1. Eases restless legs symptoms
  2. Available in a number of strengths
  3. Generic version of Adartrel and Requip


  1. Effective treatment for restless legs syndrome
  2. Usually taken once a day
  3. Available in tablet form


  1. Applied directly to the skin
  2. Preferable for those who don’t like tablets
  3. Work for 24 hours


  1. Tablets to ease RLS symptoms
  2. Various strengths available
  3. Trusted branded medication


  1. Dopamine agonist
  2. Treats restless leg syndrome
  3. Generic treatment


  1. Dopamine agonist
  2. Treats restless leg syndrome
  3. Branded version of ropinirole

Restless legs syndrome is also known as Willis-Ekbom disease and is a fairly common nervous system condition. People who have restless legs syndrome or RLS report unpleasant feelings often likened to a burning, tingling, cramping or throbbing sensation in the legs. Although symptoms are most often noticed in the legs they can also be found in the arms, head and torso as well

It is thought that up to ten per cent of the UK population receives an RLS diagnosis at some point during their life. It can develop at any time and in anybody. Women are more likely to be diagnosed than men and pregnant women in particular are more susceptible, especially during the final trimester. It is also possible to have secondary restless legs syndrome as a result of an underlying medical condition such as iron deficiency anaemia, diabetes, rheumatoid arthritis or kidney failure. Idiopathic RLS has been found to run in families due to an identified faulty gene. In these cases the symptoms tend to appear before the age of 40. 

Neurologists have been led to believe that RLS is linked to the part of the brain called the basal ganglia. This part of the brain relies on neurotransmitters called dopamine to send signals to the rest of the body regarding movement. If the dopamine receptors are damaged incorrect messages can be sent to the muscles resulting in involuntary movements. Dopamine levels decrease naturally throughout the day which offers an explanation for RLS being more prevalent in the evening. RLS symptoms can be eased through certain relaxation techniques. Common advice includes going for a walk, stretching the affected muscle(s), doing some exercise such as yoga, massaging the area, taking a hot bath, using a hot or cold compress and distracting the mind with other activities. 

Certain lifestyle aspects can trigger restless legs symptoms but are not thought to be causes. These triggers include being overweight, smoking, too much stress, a lack of exercise and some medications. RLS can sometimes be resolved by addressing these lifestyle factors. However, treatment is often suggested for those with moderate to severe RLS where a cause has not been established. Untreated RLS can lead to anxiety, depression and insomnia, therefore it is important to receive treatment if symptoms become unmanageable. 

Dopamine agonists can be used to treat frequent and painful bouts of restless legs symptoms. Examples are Mirapexin, Pramipexole  Ropinirole and Neupro. They all work in a similar way by targeting neurotransmitter receptors in the brain and restoring dopamine levels. Regulated dopamine levels should reduce symptoms. Mirapexin and Ropinirole are tablets which are usually taken once a day; whereas Neupro comes in the form of patches that deliver the medication through the skin. 

Getting your RLS prescription renewed is simple with our private consultation service. To buy restless legs medication online, take our questionnaire, and one of our prescribers will review your request for treatment. Orders are dispensed at our UK pharmacy and shipped by next-day courier.

Page last reviewed:  26/04/2022
Types of Treatment

Mild cases of restless legs syndrome (or RLS) can be self-managed with lifestyle changes. Doctors often advise that RLS patients quit smoking if they are a smoker. Taking up regular exercise and getting into a regular sleeping routine can also help, as can avoiding stimulants like caffeine. 

When restless legs symptoms flare up you can sometimes ease them by walking, stretching, applying a hot or cold compress, taking a hot bath, massaging the area or practising relaxation techniques. 

The symptoms of restless legs can sometimes be an indication of an underlying medical condition such as anaemia or kidney disease. So if you’re getting symptoms for the first time, you should speak to your doctor.

RLS treatment is usually advised for those living with moderate to severe cases and also when no known cause has been established. 

More severe cases can be treated with dopamine agonists such as Pramipexole (branded as Mirapexin), Ropinirole (brand names Requip and Adartel) and Rotigotine (Neupro). Pramipexole and Ropinirole tend to be oral tablets, usually taken once a day; whereas Neupro treatment contains rotigotine and comes in the form of transdermal patches that are placed in direct contact with the skin.

How do they work?

Dopamine plays an important role in transmitting instructions regarding movement to the rest of the body. Dopamine agonists are used to treat restless legs symptoms as insufficient levels of dopamine are often noted with the condition. Dopamine agonists act on the neurotransmitters in the brain, stabilising dopamine levels and thereby reducing symptoms.

What are the side effects?

The potential side effects caused by the three different types of dopamine agonists that you can buy from our online pharmacy are fairly similar. The most common reactions include nausea, vomiting and headaches. For more details on side effects you should refer to each relevant product page.

Can I take them with other medications?

It is highly important to disclose your current or recent use of any other medications when consulting with our prescriber. Some drugs may interact with restless legs treatment. 

Page last reviewed:  26/04/2022
Question and Answers

What’s the difference between the medications?

Prampiexole, Ropinirole and Rotigotine are known as dopamine agonists. 

Mirapexin, Pramipexole, Requip and Adartrel and Ropinirole are produced as tablets that are taken orally. However, Neupro treatment is used as a patch which is placed onto the skin in order to deliver a regular amount of treatment transdermally. Neupro can be a good alternative for patients who are unable to tolerate swallowing tablets.

Should I take Mirapexin, Ropinirole or Neupro?

It depends on the treatment initiated by your doctor. To renew your prescription, or if you do not currently take treatment or are having symptoms for the first time, you should see your GP in person.

Are there different side effects?

The side effects are for the most part the same for all three medications and these might include nausea, sickness, dizziness and headaches. However, they do differ slightly so it is best to make yourself familiar with side effects by thoroughly reading the patient information leaflet.

How can I buy restless legs syndrome treatment online?

Take our questionnaire to get your consultation started. Once our prescriber has reviewed your answers, they’ll be able to renew your existing prescription or recommend treatment. We work with GMC-registered doctors and UK pharmacy prescribers, to help ensure your safety. 

Page last reviewed:  26/04/2022

Consultation. Prescription. Delivery. Satisfaction.

  • UK prescribers
  • Genuine Medication
  • 24hr Delivery
  • Secure Payment & Data
  • Registered Pharmacy
  • Easy Repeat Orders

We promise to keep your details secure and private. We will never sell your information or share it with third parties. Whatever treatment you buy online from us, we will send in plain, unmarked packaging via our secure courier service.

Delivery on all items is included in the price. After your order has been dispatched, you’ll be supplied with a tracking number, allowing you to follow the progress of your items every step of the way. We deliver to anywhere in the UK, so whether you’re in London, Birmingham, Manchester, Glasgow or Cardiff, your order will be at your door within just 24 hours of approval from our doctor.

This content was reviewed by a clinician on

26 April 2022
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 26 April 2022
A simple process
Getting the treatment you need has never been easier with our speedy and simple online service.
  • Search for your medicine

    Find the treatment you need.
  • Fill in a simple questionnaire

    A GMC-registered doctor or a pharmacy prescriber will review your answers.
  • 24h delivery to your door

    Next-day delivery. Every order is sent by tracked courier.
  • Repeat ordering is easy

    We keep your details secure so you can reorder with ease.
Related pages

No matches found. You can find all our treatments here